Shyama Masilamani, Ph.D.
	Research Assistant Professor Graduate Training: West Virginia University Fellowship: Ohio State University, National Institutes of Health NHLBI/LKEM
	Office: Room 3143A Lab: Room 3042A PO Box 9105 Morgantown, WV 26506	Email: smasilamani@hsc.wvu.edu Phone: 304-293-1693 Fax: 304-293-5103

Research Interests:

Current studies focus on 1) pregnancy regulation of volume homeostasis and blood pressure control; 2) sex steroid actions on renal function; 3) aldosterone-mediated actions on cardiovascular and renal function.  These studies utilize a wide variety of technical approaches including:  1) in vivo intrarenal siRNA knock down; 2) Chronic measurement of blood pressure with radio telemetry: 3) renal tubular profiling of sodium transporters and channels using Western blotting for quantitation of protein density, qPCR of RNA levels and immunohistochemistry for cellular localization; 4) conscious chronically catheterized rat model allows us to look at electrolyte excretion in intact, unstressed rat. 

Selected Publications:

1. Masilamani, L. Castro and C. Baylis.  Pregnant rats are refractory  to the natriuretic actions of atrial natriuretic peptide. Am. J.  Physiol. Dec; 267 (Regulatory Integrative Comp. Physiol. 36): R1611-R1616, 1994.
2. Masilamani S., and C. Baylis. The acute pressure-natriuresis response blunted and the blood pressure response reset in the normal pregnant rat.  Am. J. Obstet. Gynecol. Aug; 179(2): 486-91 1998.
3. Masilamani S, Wang X, Kim G-H, Heddwen Brooks, Nielsen J, Nielsen S, Nakamura K, Stokes J, Knepper M.  Time course of changes in renal NHE3, NKCC2, NCC, NaKATPase and ENaC expression with dietary NaCl restriction.  Am. J. Physiol Renal  Physiol. 2002; Oct; 283 (4): F648-57. 12217855.
4. Knepper MA, Kim GH, Masilamani S.  Renal tubule sodium transporter abundance profiling in rat kidney: Response to aldosterone and variations in NaCl intake.  Ann NY Acad Sci 2003 Apr;986:562-569. 12763890.
5. Kakizoe Y, Kitamura K, Wakida N, Ko T, Maekawa A, Miyoshi T, Shiraishi N, Adachi M, Masilamani S, and Tomita K. Aberrant ENAC Activation in Dahl Salt-Sensitive Rats.  J. Hypertension 2009 Aug;27(8): 1679-89. 19458538.
6. Zheng Z, Musselman TM, Berry CR, McGuire E, Habenicht R, Nguyen AT, Masilamani S.  Regionalized Regulation of the Bumetanide-Sensitive Cotransporter by 17 b Estradiol. Steroids 2010 Nov;75(11):760-5. Epub 2010 May 24. 20580730.
7. West C, Zhang Z, Ecker G, Masilamani S.  Increased Renal a Epithelial Sodium Channel (ENaC) Protein and Increased ENaC Activity in Normal Pregnancy. American Journal of Physiology 2010 Nov;299(5):R1326-32. Epub 2010 Aug 4.