David N. Weissman, M.D.
	National Institute for Occupational Safety and Health Division of Respiratory Disease Studies Graduate Training: Northwestern University Medical School Fellowship: Northwestern University
	Mailstop H-2900 1095 Willowdale Road Morgantown, WV 26505	Email: dweissman@cdc.gov Phone: 304-285-5749 Fax: 304-285-5861

Research Interests:

Dr. Weissman's research interests relate to understanding the influences of host and environmental factors on pulmonary inflammatory and immune responses. He is particularly interested in antibody responses to inhaled and aspirated antigen. Two model systems are currently being used to study pulmonary immunity in his laboratory. The first uses intrapulmonary instillation of antigen via a bronchoscope to study human pulmonary immunity, with current studies focusing on understanding pulmonary immunotoxic effects of cigarette smoking. The second uses an animal model of the occupational lung disease silicosis to study abnormal pulmonary immunomodulation of antibody production and cellular immunity in this condition.

Pharmaceutical Research:

Centocor, Inc.: "Centocor: HA-1A Efficacy in Septic Shock," Harakh V. Dedhia, M.D., PI.

Denver Biomaterials, Inc.: "Denver Pleural Catheter Study," Geoffrey Graeber, M.D., PI.

Glaxo Pharmaceuticals: "Salmeterol Quality of Life Outcomes in Asthma," Marvin R. Balaan, M.D., PI.

Miles Pharmaceuticals, Inc.: "Anti-TNF Monoclonal Antibody for Septic Shock," Harakh V. Dedhia, M.D., PI.

Pfizer, Inc.: "Monoclonal Antibody E5 for Severe Sepsis," Harakh V. Dedhia, M.D., PI.

Zeneca, Inc.: "Safety and Efficacy of Diprivan in patients with multiple organ failure," Harakh V. Dedhia, M.D., PI.

Selected Publications:

• BOOKS EDITED:
  
  
  1. Banks DE, Weissman DN. Indoor air pollution: an allergy perspective. Immunol Allergy Clin N Amer 14:483-699, 1994.
     
     
  2. Weissman DN, Huy JM. Occupatonal infectious diseases. Clin Occup Environ Med 2(3):475-675, 2002 (published in 2003).
     
     
  3. Upfal MJ, Krieger GR, Phillips SD, Guidotti TL, Weissman D. Terrorism: biological, chemical, and nuclear. Clin Occup Environ Med 2:169-473, 2003.
     
     
• BOOK CHAPTERS:
  
  
  1. Weissman DN, Schuyler MR. Biological agents: immunologically-mediated diseases. In: Samet J, Spengler J, eds. Indoor air pollution. Baltimore: Johns Hopkins University Press; 1991.
     
     
  2. Weissman DN, Landreth KS, Wilson NW. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Kaiser LR, Senior RM, eds. Pulmonary Diseases and Disorders - Third Edition. New York: McGraw-Hill Book Company; 1998.
     
     
  3. Banks DE, Weissman DN. Silicosis and Coal Worker's Pneumoconiosis. In: Schwartz MI, King TE, eds. Interstitial Lung Diseases - 3rd Edition. St. Louis: Mosby Year Book; 1998.
     
     
  4. Weissman DN, Huy JM. Occupational infectious diseases: still a challenge. Clin Occup Environ Med 2(3):663-668, 2002 (published in 2003).
     
     
  5. Weissman DN, Wagner GR. Silicosis. In: Weinberger SE, ed. UpToDate in Pulmonary and Critical Care Medicine. Wellesley, MA: UpToDate, Inc.; 2004 (online publication).
     
     
  6. Weissman D, Wagner GR. Silicosis. In: Levy BS, Wagner GR, Rest KM, Weeks JL, eds. Preventing Occupational Disease and Injury. Washington, DC: American Public Health Association; 2005.
     
     
  7. Weissman DN, Landreth KS, Wilson NW. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency. In: Fishman AP, Elias JA, et al. Pulmonary Diseases and Disorders - Fourth Edition. New York, NY: McGraw-Hill Book Company (in press, 2007).
     
     
  8. deShazo RD, Weissman DN. Pneumoconiosis. In: Rakel RE, Bope ET, Conn’s Current Therapy 2009. Philadephia, PA: Elsevier (in press, 2007).
     
     
• PUBLICATIONS:
  
  
  1. Banks DE, Tarlo SM, Masri F, Rando RJ, Weissman DN. Bronchoprovocation tests in the diagnosis of isocyanate-induced asthma. Chest 1996; 109:1370-1379.
     
     
  2. Wilt JL, Banks DE, Weissman DN, et al. Reduction of lung dust burden in pneumoconiosis by whole-lung lavage. J Occ Env Med 1996; 38:619-624
     
     
  3. Weissman DN, Ma JKH, Rojanasakul Y, Hubbs AF. Immune dysfunction in silicosis: a hypothesis. Appl Occup Environ Hyg 1996; 11:962-965.
     
     
  4. Farr RW, Short S, Weissman D. Fulminant hepatitis during herpes simplex infection in apparently immunocompetent adults - report of two patients and review of the literature. Clin Infec Dis 1997; 24(6):1191-1194.
     
     
  5. Weissman DN. Allergy skin testing for the chest physician. Advance for Managers of Respiratory Care 1997; 6(4):49-54 (not peer-reviewed).
     
     
  6. Rojanasakul Y, Weissman DN, Xianglin Shi, Castranova V, Ma JKH, Liang W. Antisense inhibition of silica-induced tumor necrosis factor in alveolar macrophages. J Biol Chem 1997; 272(7):3910-3914.
     
     
  7. Aronoff SC, Massengale RD, Yankaskus JR, Weissman DN, Cuff C. Reduced IL-8 production by cystic fibrosis airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 1999; 20:1073-1080.
     
     
  8. Weissman DN, Lewis DM. Is specific antibody determination diagnostic for asthma attributable to low-molecular-weight agents? Occ Med: State of the Art Rev 2000; 15:385-397.
     
     
  9. Huang S, Huang P, Weissman DN. The effects of smoking on pulmonary IgA and immune response to antigen in young smokers. Chin J Prev Med 2000; 34:294-296.
     
     
  10. Huang SH, Hubbs AF, Stanley CF, Vallyathan V, Schnabel PC, Rojanasakul Y, Ma JKH, Banks DE, Weissman DN. Immunoglobulin responses to experimental silicosis. Toxicol Sci 2001; 59:108-117.
      
      
  11. Antonini JM, Roberts JR, Clarke RW, Yang HM, Barger MW, Jernigan MR, Ma JYC, Weissman DN. Effect of age on respiratory defense mechanisms and pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenes. Chest 2001; 120:240-249.
      
      
  12. Ortega HG, Daroowala F, Petsonk EL, Lewis D, Berardinelli S, Jones W, Kreiss K, Weissman DN. Evaluation of respiratory symptoms among crab processing workers in Alaska: epidemiological and environmental assessment. Amer J Indus Med 2001; 39:598-607.
      
      
  13. Weissman DN, Hubbs AF, Huang SH, Stanley CF, Rojanasakul Y, Ma JKH. IgG subclass responses in experimental silicosis. J Environ Pathol Toxicol Oncol 2001; 20(Suppl. 1):67-74.
      
      
  14. Shao J, DeHaven J, Lamm D, Weissman DN, Runyan K, Malanga CJ, Rojanasakul Y, Ma JKH. A cell-based drug delivery system for lung targeting: I. Preparation and pharmacokinetics. Drug Delivery 2001; 8:61-69.
      
      
  15. Shao J, DeHaven J, Lamm D, Weissman DN, Runyan K, Malanga CJ, Rojanasakul Y, Ma JKH. A cell-based drug delivery system for lung targeting: II. Therapeutic activities on B16-F10 melanoma in mouse lungs. Drug Delivery 2001; 8:71-76.
      
      
  16. Weissman DN. Epidemiology of asthma: severity matters. Chest 2002; 121:6-8.
      
      
  17. Ortega HG, Banks DE, Carter D, Weissman DN. Use of specific inhalation challenge in the evaluation of workers at risk for occupational asthma. Chest, 2002; 121:1317-1322.
      
      
  18. Meade BJ, Weissman DN, Beezhold D. Latex allergy: past and present. Int Immunopharmacol 2002; 2:225-238.
      
      
  19. Saxena RK, Weissman D, Simpson J, Lewis DM. Murine model of BCG lung infection: Dynamics of lymphocyte subpopulations in lung interstitium and tracheal lymph nodes. J Biosci 2002; 27:143-53.
      
      
  20. Al-Humadi NH, Siegel PD, Lewis DM, Barger MW, Ma JY, Weissman DN, Ma JK. Alteration of intracellular cysteine and glutathione levels in alveolar macrophages and lymphocytes by diesel exhaust particle exposure. Environ Health Perspect 2002; 110:349-53.
      
      
  21. Saxena RK, Weissman DN, Saxena QB, Simpson J, Lewis DM. Kinetics of changes in lymphocyte sub-populations in mouse lungs and after intrapulmonary infection with M. bovis (Bacillus Calmette-Guerin) and identity of cells responses. Clin Exp Immunol 2002; 128:405-410.responsible for IFN
      
      
  22. Weissman DN, Lewis DM. Allergic and latex specific sensitization: route, frequency, and amount of exposure required to initiate IgE production. J Allergy Clin Immunol 2002; 110:S57-S63.
      
      
  23. Al-Humadi NH, Siegel PD, Lewis DM, Barger MW, Ma JY, Weissman DN, Ma JKH. The effect of diesel exhaust particles (DEP) and carbon black (CB) on thiol changes in pulmonary ovalbumin allergic sensitized brown Norway rats. Exp Lung Res 2002; 28:333-349.
      
      
  24. Howell MD, Weissman DN, Meade BJ. Latex sensitization by dermal exposure can lead to airway hyper-reactivity. Int Arch Allergy Immunol 2002; 128:204-211.
      
      
  25. Yin XJ, Schafer R, Ma JY, Antonini JM, Weissman D, Siegel PD, Barger MW, Roberts JR, Ma JK. Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). I. Effects of DEPs on early pulmonary responses. Environ Health Perspect 2002;110(11):1105-11.
      
      
  26. Yin XJ, Schafer R, Ma JY, Antonini JM, Roberts JR, Weissman DN, Siegel PD, Ma JK. Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats. Environ Health Perspect. 2003 Apr;111(4):524-30.
      
      
  27. Saxena RK, Saxena QB, Weissman DN, Simpson JP, Bledsoe TA, Lewis DM. Effect of diesel exhaust particulate on bacillus Calmette-Guerin lung infection in mice and attendant changes in lung interstitial lymphoid subpopulations and IFNgamma response. Toxicol Sci. 2003 May;73(1):66-71.
      
      
  28. Rao GV, Tinkle S, Weissman DN, Antonini JM, Kashon ML, Salmen R, Battelli LA, Willard PA, Hubbs AF, Hoover MD. Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx. J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52.
      
      
  29. Hogan MB, Weissman DN, Hubbs AF, Gibson LF, Piktel D, Landreth KS. Regulation of eosinophilopoiesis in a murine model of asthma. J Immunol. 2003 Sep 1;171(5):2644-51.
      
      
  30. Biagini RE, Schlottmann SA, Sammons DL, Smith JP, Snawder JC, Striley CA, MacKenzie BA, Weissman DN. Method for simultaneous measurement of antibodies to 23 pneumococcal capsular polysaccharides. Clin Diagn Lab Immunol. 2003 Sep;10(5):744-750.
      
      
  31. Zeiss CR, Gomaa A, Murphy FM, Weissman DN, Hodgson M, Foster D, Dejativongse S, Colella K, Kestenberg K, Kurup VP, Bush RK, Chiu AM, Kelly KJ, Fink JN. Latex hypersensitivity in Department of Veterans Affairs health care workers: glove use, symptoms, and sensitization. Ann Allergy Asthma Immunol. 2003 Dec;91(6):539-45.
      
      
  32. Hettick JM, Kashon ML, Simpson JP, Siegel PD, Mazurek GH, Weissman DN. Proteomic profiling of intact mycobacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Chem. 2004 Oct 1;76(19):5769-76.
      
      
  33. Trout D, Weissman DN, Lewis D, Brundage RA, Franzblau A, Remick D. Evaluation of hypersensitivity pneumonitis among workers exposed to metal removal fluids. Appl Occup Environ Hyg. 2003 Nov;18(11):953-60.
      
      
  34. Nicolaysen P, Klink KJ, Shriver E, Knutsen F, Hubbs AF, Depree G, Siegel PD, Weissman DN, Whitmer M, Meade BJ. Local and systemic toxicity in mice following subcutaneous implantation of latex penrose drains. J Toxicol - Cut Ocular Toxicol 2004; 23:233–248.
      
      
  35. Bang KM, Weissman DN, Wood JM, Attfield MD. Tuberculosis mortality by industry and occupation in the United States, 1990-1999 Int J Tuberc Lung Dis 2005; 9(4):1-6.
      
      
  36. Akpinar-Elci M, Stemple KJ, Enright PL, Fahy JV, Bledsoe TA, Kreiss K, Weissman DN. Induced sputum evaluation in microwave popcorn production workers. Chest. 2005 Aug;128(2):991-7.
      
      
  37. Friedman LN, Nash ER, Bryant J, Henry S, Shi J, D’Amato J, Khaled GH, Russi MB, O’Connor PG, Edberg SC, Pisani MA, Cain HC, Tanoue L, Weissman DN. High rate of negative tuberculin and QuantiFERON® tests in individuals with histories of past-positive skin tests. Infect Control Hosp Epidemiol. 2006 May;27(5):436-41.
      
      
  38. Selgrade MK, Lemanske RF Jr, Gilmour MI, Neas LM, Ward MD, Henneberger PK, Weissman DN, Hoppin JA, Dietert RR, Sly PD, Geller AM, Enright PL, Backus GS, Bromberg PA, Germolec DR, Yeatts KB. Induction of asthma and the environment: what we know and need to know. Environ Health Perspect. 2006 Apr;114(4):615-9.
      
      
  39. Yeatts K, Sly P, Shore S, Weiss S, Martinez F, Geller A, Bromberg P, Enright P, Koren H, Weissman D, Selgrade M. A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research. Environ Health Perspect. 2006 Apr;114(4):634-40.
      
      
  40. Boyce PD, Kim JY, Weissman DN, Hunt J, Christiani DC. pH increase observed in exhaled breath condensate from welding fume exposure. J Occup Environ Med. 2006 Apr;48(4):353-6.
      
      
  41. Brandt M, Brown C, Burkhart J, Burton N, Cox-Ganser J, Damon S, Falk H, Fridkin S, Garbe P, McGeehin M, Morgan J, Page E, Rao C, Redd S, Sinks T, Trout D, Wallingford K, Warnock D, Weissman D. Mold prevention strategies and possible health effects in the aftermath of hurricanes and major floods. MMWR Recomm Rep. 2006 Jun 9;55(RR-8):1-27.
      
      
  42. Earnest GS, Reed LD, Conover D, Estill C, Gjessing C, Gressel M, Hall R, Hudock S, Hudson H, Kardous C, Sheehy J, Topmiller J, Trout D, Woebkenberg M, Amendola A, Hsiao H, Keane P, Weissman D, Finfinger G, Tadolini S, Thimons E, Cullen E, Jenkins M, McKibbin R, Conway G, Husberg B, Lincoln J, Rodenbeck S, Lantagne D, Cardarelli J; Centers for Disease Control and Prevention. Engineering and public health at CDC. MMWR Morb Mortal Wkly Rep. 2006 Dec 22;55 Suppl 2:10-3. 5
      
      
  43. Hettick JM, Kashon ML, Slaven JE, Ma Y, Simpson JP, Siegel PD, Mazurek GN, Weissman DN. Discrimination of intact mycobacteria at the strain level: a combined MALDI-TOF MS and biostatistical analysis. Proteomics. 2006 Dec;6(24):6416-25.
      
      
  44. Bang KM, Weissman DN, Pinheiro GA, Antao VC, Wood JM, Syamlal G. Twenty-three years of hypersensitivity pneumonitis mortality surveillance in the United States. Am J Ind Med. 2006 Dec;49(12):997-1004.
      
      
  45. Akpinar-Elci M, Yucesoy B, Elci OC, Weissman DN. Noninvasive assessment of cytokines in occupational respiratory diseases. Recent Patents Inflam Allergy Drug Disc 2007 Jun;1(2):100-107.
      
      
  46. Beezhold DH, Green BJ, Blachere FM, Schmechel D, Weissman DN, Velickoff D, Hogan MB, Wilson NW. Prevalence of sensitization to indoor fungi in West Virginia. Allergy Asthma Proc 2007, in press.