David Williamson, Ph.D.
	Assistant Professor of Exercise Physiology Graduate Training: Ball State University Fellowship: Penn State University
	Office:8320 -HSS Lab:3145 -HSN PO Box 9227 Morgantown, WV 26506	Email: dwilliamson@hsc.wvu.edu Phone: 304-293-2434 Fax: 304-293-7105

Research Interests:

My current research is concentrated on understanding the effects of high levels of circulating blood lipid on the regulation of skeletal muscle function and morphology.  More specifically, I am interested in determining the signaling mechanisms (e.g. AMP kinase and mTOR pathways) responsible for these skeletal muscle alterations.  These studies rely primarily upon the ob/ob mouse model, and will soon examine other models of dyslipidemia (e.g. ApoE and LDLR deficient mice), as well as cell culture approaches.

Selected References:

1. Bax signaling mediates palmitate-induced apoptosis in C2C12 myotubes. Peterson, J., J.Wang, R. Bryner, D.L. Williamson, S.A. Alway. Am. J. Physiol. 295:E1307-14, 2008.
2. Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Williamson, D.L., S.R. Kimball, and L.S. Jefferson.  Am. J. Physiol. 291:E80–E89, 2006.
   
3. Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signaling to regulatory mechanisms of mRNA translation in mouse muscle. Williamson, D.L., N. Kubica, S.R. Kimball, and L.S. Jefferson.  J. Physiol. 573:497-510, 2006.
4. Acute treatment with TNF-alpha attentuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism.  Williamson, D.L., S.R. Kimball, and L.S. Jefferson.  Am. J. Physiol. 289:E95-E104, 2005.
5. Immediate response of mammalian target of rapamycin (mTOR)-mediated signaling following acute resistance exercise in rat skeletal muscle.  Bolster, D.R., N. Kubica, S.J. Crozier, D.L. Williamson, P.A. Farrell, S.R. Kimball, and L.S. Jefferson.  J. Physiol. 553:213-220, 2003.
6. Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle.  Williamson, D., P. Gallagher, M. Harber, C. Hollon, and S. Trappe.  J. Physiol. 547:977-87, 2003.
7. Reduction in hybrid single muscle fiber proportions with resistance training in humans.  Williamson, D.L., P.M. Gallagher, C.C. Carroll, U. Raue, and S.W. Trappe. J. Appl. Physiol. 91:1955-1966, 2001.

Lab Personnel Josh Drake - Masters of Science Student in Exercise Physiology
	Dr. David Williamson and Josh Drake, Graduate Student in Exercise Physiology