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David N. Weissman, M.D.

National Institute for Occupational Safety and Health Division of Respiratory Disease Studies

Graduate Training: Northwestern University Medical School
Fellowship: Northwestern University

Mailstop H-2900
1095 Willowdale Road
Morgantown, WV 26505
Email: dweissman@cdc.gov
Phone: 304-285-5749
Fax: 304-285-5861

Research Interests:

Dr. Weissman's research interests relate to understanding the influences of host and environmental factors on pulmonary inflammatory and immune responses. He is particularly interested in antibody responses to inhaled and aspirated antigen. Two model systems are currently being used to study pulmonary immunity in his laboratory. The first uses intrapulmonary instillation of antigen via a bronchoscope to study human pulmonary immunity, with current studies focusing on understanding pulmonary immunotoxic effects of cigarette smoking. The second uses an animal model of the occupational lung disease silicosis to study abnormal pulmonary immunomodulation of antibody production and cellular immunity in this condition.

Pharmaceutical Research:

  • Centocor, Inc.: "Centocor: HA-1A Efficacy in Septic Shock," Harakh V. Dedhia, M.D., PI.
  • Denver Biomaterials, Inc.: "Denver Pleural Catheter Study," Geoffrey Graeber, M.D., PI.
  • Glaxo Pharmaceuticals: "Salmeterol Quality of Life Outcomes in Asthma," Marvin R. Balaan, M.D., PI.
  • Miles Pharmaceuticals, Inc.: "Anti-TNF Monoclonal Antibody for Septic Shock," Harakh V. Dedhia, M.D., PI.
  • Pfizer, Inc.: "Monoclonal Antibody E5 for Severe Sepsis," Harakh V. Dedhia, M.D., PI.
  • Zeneca, Inc.: "Safety and Efficacy of Diprivan in patients with multiple organ failure," Harakh V. Dedhia, M.D., PI.

Selected Publications:

Books Edited:

  1. Banks DE, Weissman DN. Indoor air pollution: an allergy perspective. Immunol Allergy Clin N Amer 14:483-699, 1994.
  2. Weissman DN, Huy JM. Occupatonal infectious diseases. Clin Occup Environ Med 2(3):475-675, 2002 (published in 2003).
  3. Upfal MJ, Krieger GR, Phillips SD, Guidotti TL, Weissman D. Terrorism: biological, chemical, and nuclear. Clin Occup Environ Med 2:169-473, 2003.

Book Chapters:

  1. Weissman DN, Schuyler MR. Biological agents: immunologically-mediated diseases. In: Samet J, Spengler J, eds. Indoor air pollution. Baltimore: Johns Hopkins University Press; 1991.
  2. Weissman DN, Landreth KS, Wilson NW. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Kaiser LR, Senior RM, eds. Pulmonary Diseases and Disorders - Third Edition. New York: McGraw-Hill Book Company; 1998.
  3. Banks DE, Weissman DN. Silicosis and Coal Worker's Pneumoconiosis. In: Schwartz MI, King TE, eds. Interstitial Lung Diseases - 3rd Edition. St. Louis: Mosby Year Book; 1998.
  4. Weissman DN, Huy JM. Occupational infectious diseases: still a challenge. Clin Occup Environ Med 2(3):663-668, 2002 (published in 2003).
  5. Weissman DN, Wagner GR. Silicosis. In: Weinberger SE, ed. UpToDate in Pulmonary and Critical Care Medicine. Wellesley, MA: UpToDate, Inc.; 2004 (online publication).
  6. Weissman D, Wagner GR. Silicosis. In: Levy BS, Wagner GR, Rest KM, Weeks JL, eds. Preventing Occupational Disease and Injury. Washington, DC: American Public Health Association; 2005.
  7. Weissman DN, Landreth KS, Wilson NW. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency. In: Fishman AP, Elias JA, et al. Pulmonary Diseases and Disorders - Fourth Edition. New York, NY: McGraw-Hill Book Company (in press, 2007).
  8. deShazo RD, Weissman DN. Pneumoconiosis. In: Rakel RE, Bope ET, Conn’s Current Therapy 2009. Philadephia, PA: Elsevier (in press, 2007).

Publications:

http://www.ncbi.nlm.nih.gov/pubmed/?term=weissman+dn