Our Research Interests:

Identifying clinically important biomarkers for individualized diagnosis, prognosis, and therapeutics of human cancer. Other current interests: Non-small Cell Lung Cancer and Breast Cancer.

Ongoing Research Support:

R01LM009500 Guo (PI) 9/15/08-9/14/11
NIH/NLM
A Novel Computational Framework for Individualized Clinical Decision-Making.
To develop a gene selection system by integrating state-of-the-art feature selection algorithms for identifying
new biomarkers from high through-put data, and a novel methodology to construct molecular prognostic
models for individualized clinical decision-making.
Role: PI

P20RR16440 Gibson (PI) 9/01/01-6/30/11
NIH/NCRR
CoBRE in Signal Transduction
To establish a Center of Biomedical Research Excellence (CoBRE) in Signal Transduction and Cancer.
Role: Project Director

P20RR16440 Gibson (PI) 8/26/09 – 8/25/11
NIH/NCRR
Cobre for Signal Transduction and Cancer: NCRR ARRA Supplement – Translational.
This research will develop an accurate prognostic model by combing patient gene expression profiles,
demographic, clinical, pathological, and social ecological factors to predict lung cancer recurrence.
Furthermore, regulatory factors in lung cancer progression will be explored using microRNA approaches.
Role: Project Director

No assignment # 1/1/09-12/31/09
WVU Institutional PPG Seed Grant
Mechanisms of lung carcinogenesis induced by heavy metals.
This institutional grant supports the research for an external P01 application to investigate 1) mechanisms and
interacting pathways in heavy metals induced carcinogenesis in lung epithelial cells and a xenograft mouse
model, and 2) the identification of a prognostic signature in cells transformed by heavy metals.
Role: Investigator

Completed Research Support

RDG NT10017W Guo (PI) 1/1/06-12/31/06
West Virginia University Award
A Novel Computational Model System for Accurate Prognosis of Lung Cancer.
To establish a computational model system to construct molecular prognostic models for lung cancer.
Role: PI

DAMD17-02-1-0621 Jame Abraham (PI) 10/1/02–9/30/08
DOF, Army, Office of Research & Development
Project: Randomized Trial of Neuroprotective Effects of Erythropoietin in Patients Receiving Adjuvant
Chemotherapy for Breast Cancer: Positron Emission Tomography and Neuropsychological Study
Role: sub-contractor