Research Interests:
The general focus of my research has entailed investigations concerning the clinical pharmacology of both cytokines and anti-cancer drugs. Most of the work has involved evaluation of anti-cancer drug pharmacometrics and pharmacogenetics in humans. The techniques typically entail: chromatography (HPLC +/- MS), pharmacometric modeling, and RT-PCR. The types of studies I have participated in range from those which involve traditional cytotoxic drugs in the high-dose setting to phase I (first in human) investigations of molecularly targeted agents.

I am also involved in the design and conduct of early phase treatment-related and research-related clinical trials in patients with cancer. Recent areas of focus include: development and evaluation of a drug to prevent fluorpyrimidine-induced palmar-plantar erythrodysesthesia; evaluation of drug dosing in obese patients; and elucidation of genetic factors related to chemotherapy-associated cognitive dysfunction.

My long term research goals include developing clinically feasible approaches which improve the selection and dosing of anti-cancer drugs for individual patients.

Other Affiliation Bio's:
School of Pharmacy
Biochemistry