Department Publications:

Zhou, X., Zhang, M. and Agazie, YM. Molecular Mechanism for SHP2 in Mediating HER2-Induced Signaling and Cell Transformation. J. Biol. Chem., in press.   Xueping Zhou, Michael R. Miller, Md Motaleb, Nyles W. Charon, Pingnian He. 2009. Spent culture medium from virulent Borrelia burgdorferi increases permeability of individually perfused microvessels of rat mesentery. Public Library of Science – One, in press.   M.A. Chellaiah and M.D. Schaller. 2009. Activation of Src kinase by PTP-PEST in Osteoclasts- Comparative Analysis of the Effects of Bisphosphonate and Protein Tyrosine Phosphatase Inhibitor on Src Activation in vitro. J Cell. Physiol., in press.   S.M. Palmer, M.P. Playford, S.W. Craig, M.D. Schaller and S.L. Campbell. 2009. Lipid Binding to the Tail Domain of Vinculin: Specificity and the Role of the N and C termini. J Biol. Chem. 284:7223-7231.   Wonderlin, W.F.. 2009. Constitutive, translation-independent opening of the protein-conducting channel in the endoplasmic reticulum. Pflugers Arch. 457:917-930.   Yu JJ. 2009. Unlocking the Molecular Mechanisms of DNA Repair and Platinum Drug Resistance in Cancer Chemotherapy. Current Drug Therapy 4:19-28.   Yu JJ, Liang XB, Yan QW, Reed E, Fojo AT, Guo Y, He Q and Mueller MD. 2009. Chk2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance. In: Bonetti, A.; Leone, R.; Muggia, F.; Howell, S.B. (Eds.) Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. New York, Humana Press, Chapter 22, p189-194.   Zhou, X. and Agazie, Y. M. 2008. Inhibition of SHP2 in Breast Cancer Cells Leads to Mesenchymal to Epithelial Transition and Induces Reversion to a Normal Mammary Epithelial Phenotype, Cell Death Differ 15:988-96.   Zhou, X., Coad, J., Ducatman, B. and Agazie, Y. M. 2008. The SHP2 Protein is Overexpressed in Breast Cancer Cell Lines and Infiltrating Ductal Carcinoma of the Breast, Implying its Involvement in Breast Cancer Development. Histopathology 53: 389-402.   Frisch, S.M. 2008. Caspase-8: Fly or Die. Cancer Res. 68: 4491-4493.   K. Sarma, R. Margueron, A. Ivanov, V. Pirotta and D. Reinberg. 2008. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol. Cell. Biol. 28:2718-31.   L. Zeng; K. L. Yap; A.V. Ivanov; X. Wang; S. Mujtaba; O. Plotnikova; F.J. Rauscher, III; M.-M. Zhou. 2008. Structural Insights into Human KAP1 PHD Finger-Bromodomain and Its Role in Gene Silencing. Nature Structural and Molecular Biology 15: 626-33.   Apopa, P. L., He, X., and Ma, Q. 2008. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J. Biochem. Mol. Toxicol. 22:63-76.   He, X., Chen, M.G., and Ma, Q. 2008. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol. 21:1375-1383.   Zhao, Z., He, X., Bi, Y., Xia, Y., Tao, N., Li Li, and Ma, Q. 2008. Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo, in human promyelocytic leukemic cells, and ex vivo in human blood neutrophils. Drug Metabolism and Disposition in press. DMD Fast Forward. Online publication on November 24, 2008 as doi: 10.1124/dmd.108.023192.   He, X., Kan, H., Cai, L., and Ma, Q. 2008. Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. Journal of Molecular and Cellular Cardiology in press. Online publication on November 1, 2008 as doi:10.116/j.yjmcc. 2008.10.007.   Zhao, Z., Mao, Z., Bi, Y., Xia, Y., Tao, N., Li, L., He, X., and Ma, Q. 2008. Induction of CYP4F3 in white blood cells from benzene-poisoning patients and human HL60 cells. Proceedings of the 17th International Symposium on Microsomes and Drug Oxidations. Medimond S.r.l., Bologna, Italy, pp. 103-107.   He, X. and Ma, Q. 2008. Induction of metallothionein 1 by arsenic via metal-activated transcription factor 1. Critical role of the carboxyl cysteine thiol groups in arsenic sensing. J. Biol. Chem. Submitted   Ma, Q. and Lu, A.Y.H. 2008. The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. Current Drug Metabolism 9:374-383.   Ma, Q. 2008. Ah receptor: xenobiotic response meets inflammation. Blood 112:928-929.   Ma, Q. 2008. Xenobiotic-activated receptors: from transcription, to drug metabolism, to disease. Chem. Res. Toxicol. 21:1651-1671.   J.M. Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, G.K. Ostrander. 2008. “Chemical carcinogenesis in fishes” in The Toxicology of Fishes, R.T. Di Biulio and D.E. Hinton, eds. P.531-644.   Rao AV, Younis IR, Sand GJ, Spasojevic I, Adams DJ, Decastro CM, Gockerman JP, Peterson BL, Petros WP, Moore JO, Rizzieri DA. 2008. Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia. Leuk Lymphoma 49:1523-1529.   Younis IR, Elliott M, Peer CJ, Cooper AJL, Pinto JT, Konat GW, Kraszpulski M, Petros WP, Callery PS. 2008. Dehydroalanine analog of glutathione: An electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. J Pharmacol Exp Ther 327:770-776.   Armstrong AJ, Creel P, Turnbull J, Moore C, Jaffe TA, Haley S, Petros W, Yenser S, Gockerman JP, Sleep D, Hurwitz H, George DJ. 2008. A phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer. Clin Cancer Res 14:6270-6276.   Beasley GM, Petersen RP, Yoo J, McMahon N, Aloia T, Petros W, Sanders G, Cheng TY, Pruitt SK, Seigler H, Tyler DS. 2008. Isolated Limb Infusion for In-Transit Malignant Melanoma of the Extremity: A Well-Tolerated but Less Effective Alternative to Hyperthermic Isolated Limb Perfusion. Ann Surg Oncol 15:2195-2205.   Cooper AJL, Younis IR, Niatsetskaya ZV, Krasnikov BF, Pinto JT, Petros WP, Callery PS. 2008. Metabolism of the cysteine S-conjugate of busulfan involves a ß-lyase reaction. Drug Metabol Dispos 36:1546-52.   Younis IR, Malone S, Friedman HS, Schaaf LJ, Petros WP. Enterohepatic recirculation model of irinotecan (CPT-11) & metabolite pharmacokinetics in patients with glioma. Cancer Chemother Pharmacol., in press.   Czito BG, Cohen DP, Kelsey CR, Lockhart AC, Bendell JC, Willett CG, Petros WP, D'Amico TA, Truax R, Hurwitz HI. 2008. A Phase I Study of UFT/Leucovorin, Carboplatin, and Paclitaxel in Combination with External Beam Radiation Therapy for Advanced Esophageal Carcinoma. Int J Radiat Oncol Biol Phys 70:1066-1072.   Plotnikova OV, Golemis E.A and Pugacheva.E.N. 2008. Cell cycle-dependent ciliogenesis and cancer. Cancer Res. 68:2058-61.   Hendrickson A, Bumstead K, Natoli R, Ramamurthy V, Possin D, Dijajadi H and Provis J. 2008. Rod photoreceptor differentiation in fetal and infant human retina. Exp Eye Res. 87:415-26.   Zhang M, Deng, Y, Tandon R, Bai C, and Riedel, H. 2008. Essential role of PSM/SH2B1 variants in insulin receptor catalytic activation and the resulting cellular responses. J. Cell. Biochem. 103:162-181.   Zhang M, Deng, Y, and Riedel, H. 2008. PSM/SH2B1 splice variants: critical role in Src catalytic activation and the resulting STAT3-mediated mitogenic response. J. Cell. Biochem. 104:105-118.   Deng, Y, Zhang M, and Riedel, H. 2008. Mitogenic roles of Gab1 and Grb10 as a direct cellular partners in the regulation of MAP kinase signaling. J. Cell. Biochem. 105:1172-1182.   Jiang, W, Lobo-Ruppert, SM, and Ruppert, JM. 2008. Bad things happen in the basal layer: KLF4 and squamous cell carcinoma. Cancer Biology and Therapy 7:783-5.   Jiang W, Deng W, Bailey SK, Nail CN, Frost, AR, Brouillette, WJ, Muccio, DD, Grubbs, CJ, Ruppert, JM, and Lobo-Ruppert, SM. 2008. Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid. Cancer Biology and Therapy, in press.   S.M. Palmer, M.D. Schaller and S.L. Campbell. 2008. Vinculin Tail Conformation and Self Association is Independent of pH and H906 Protonation. Biochemistry, 47:12467-12475.   M.P. Playford, K. Vadali, X. Cai, K. Burridge and M.D. Schaller. 2008. Focal Adhesion Kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho. Experimental Cell Research, 314:3187-3194.   D.M. Scheswohl, J.R. Harrell, Z. Rajfur, G. Gao, S.L. Campbell, M.D. Schaller. 2008. Multiple Paxillin Binding Sites Regulate FAK Function. J. Mol. Signaling 3:1.   X. Cai, D. Lietha, D.F. Ceccarelli, A.V. Karginov, Z. Rajfur, K. Jacobson, K.M. Hahn, M.J. Eck, M.D. Schaller. 2008. Spatial and Temporal Regulation of FAK Activity in Living Cells. Mol. Cell. Biol. 28:201-214.   M.D. Schaller. 2008. Calcium-Dependent Pyk2 Activation: A Role for Calmodulin? Biochemical Journal 410:e3-4.   Hogan T, Yu JJ, Williams HJ, Altaha R, Liang XB and He Q. 2008. Refractory Oncocytic (Hürthle Cell) Thyroid Cancer Response to Erlotinib Human Pathology. J Oncol Pharmacy Practice in press.   Yu JJ and Flynn DC. 2007. EGFR Artifactual Mutations Associated with two DNA Sequencers. BioTechniques 42:41.   Senft, J., Helfer, B. and Frisch, S.M. 2007. Caspase-8 interacts with the p85 subunit of phosphatidylinositol-3-kinase to regulate cell motility, adhesion and Rac activation. Cancer Res. 67: 11505-11509.   Huang, X.D., Masselli, A., Frisch, S.M., Hunton, I., Jiang, Y., Wang, J.Y.J. 2007. Blockade of TNF-induced Bid cleavage by caspase-resistant Rb. J. Biol. Chem. 282: 29401-13.   Talukdar, S., Bhatnagar, S., Dridi, S., and Hillgartner, F. B. 2007. Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α transcription by the liver X receptor agonist T0-901317. J. Lipid. Res. 48:2647-2663.   S. Dadke, S. Cotteret, S-C. Yip, Z. M. Jaffer, F. Haj, A. Ivanov, F. J. Rauscher, III, K. Shuai, T. Ng, B. G. Neel, and J. Chernoff. 2007. Regulation of Protein Tyrosine Phosphatase (PTP) 1B by sumoylation. Nature Cell Biol. 9:80-85.   D. White, D. Negorev, H. Peng, A. Ivanov, G. Maul, and F. Rauscher 3rd. 2007. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res. 66: 11594-9.   G. Ivanov, T. Ivanova, J. Kurash, A. Ivanov, S. Chuikov, F. Gizatullin, E. Herrera-Medina, F. Rauscher III, D. Reinberg, and N. Barlev. 2007. Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage. Mol. Cell. Biol. 27:6756-69.   A. Ivanov, H. Peng, V. Yurchenko, D. Negorev, W. Fredericks, G. Maul, M. Sadofsky, M.-M. Zhou, F. Rauscher III. 2007. PHD Domain-mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromo Domain which is Required for Gene Silencing. Molecular Cell 28: 823-37.   He, X., Lin, G. X., Chen, M. G., Zhang, J. and Ma, Q. 2007. Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. Toxicol Sci 98:298-309.   Hubbs, A. F., Benkovic, S., Miller, D., O'Callaghan, J., Battelli, L. A., Schwegler-Berry, D. and Ma, Q. 2007. Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. American Journal of Pathology 170:2068-2076.   Ma, Q. and Lu, A. Y. H. 2007. CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies. Drug Metabolism and Disposition 35:1009-1016.   Ma, Q. 2007. ADPF and agonist-induced down-regulation of Ah receptor: controlling xenobiotic response by receptor degradation. Molecular Interventions 7:133-137.   Howell, DM, Morgan, WJ, Jarjour, AA, Spirou, GA, Berrebi, AS, Kennedy, TE, and Mathers, PH. 2007. Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus. J. Comp. Neurol. 504:533-549.   R. G. Bakker, C. LI, M. R. Miller, C. Cunningham, and N. W. Charon. 2007. Identification of specific chemoattractants and complementation of cheA2 of Borrelia burgdorferi: A flow cytometry-based capillary tube chemotaxis assay. Applied Env. Microbiol. 73:1180-1188.   Md. A. Motaleb, M. R. Miller, R. G. Bakker, C. Li and N. Charon. 2007. Isolation and Characterization of Chemotaxis Mutants of the Lyme Disease Spirochete Borrelia burgdorferi Using Allelic Exchange Mutagenesis, Flow Cytometry and Cell Tracking. Methods in Enzymology 422:421-437.   Md. A. Motaleb, M. R. Miller, C. Li and N. W. Charon. 2007. Phosphorylation assays of chemotaxis two-component system proteins in Borrelia burgdorferi. Methods in Enzymology 422:438 – 447.   A.M. Magro, A.D. Magro, C. Cunningham and M.R. Miller . 2007. Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells. Neoplasma 54:517 - 526.   M.R. Miller and Md. Motaleb. 2007. Scuba divers rinse tanks harbor many microorganisms. Microbe 12:577.   Hurwitz HL, Cohen RB, McGovern JP, Hirawat S, Petros WP, Natsumeda Y, Yoshinari T. 2007. A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel topoisomerase I inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol 59:139-147.   Pugacheva EN, Jablonski SA, HartmanTR, Henske EP and Golemis EA. 2007. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-63.   Riedel H. 2007. Models for tumor growth and differentiation. In The Cancer Handbook Vol. 2. 4: Pre-clinical models for human cancer (ed Alison MA), 954-969 Nature Publishing Group, London.   Li, X, Deng, W, Lobo-Ruppert, SM, and Ruppert, JM. 2007. Gli1 acts through Snail and E-cadherin to promote nuclear signaling by -catenin. Oncogene 26: 4489-4498.   M.A. Zayed, W. Yuan, T.M. Leisner, D. Chalothorn, A.W. McFadden, M.D. Schaller, M.E. Hartnett, J.E. Faber, and L.V. Parise. 2007. CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis. Circulation Research 101:1185-1193.   D. Lietha, X. Cai, Y. Li, M.D. Schaller, and M.J. Eck. 2007. Structure and regulation of Focal Adhesion Kinase. Cell 129:1177-1187.   K. Vadali, X. Cai and M.D. Schaller. 2007. Focal Adhesion Kinase: An Essential Kinase in the Regulation of Cardiovascular Functions. IUBMB Life 59:709-716.   Boesze-Battaglia K, Song H, Sokolov M, Pankoski-Walker L, Gretzula C, Gallagher B, Rachel RA, Jenkins NA, Copeland NG, Morris F, Yeagle P, Williams D, Lillo C, Damek-Poprawa M. 2007. The tetraspanin protein, periferin-2 complexes with melanoregulin, a putative membrane fusion regulator. Biochemistry 46:1256-1272.   Lobanova ES, Finkelstein S, Song H, Tsang SH, Chen CH, Sokolov M, Skiba NP, Arshavsky VY. 2007. Translocation of transducin in rod is triggered by saturation of the GTPase activating complex. J. Neurosci. 27:1151-1160.   Song JH, Song H, Wensel TG, Sokolov M, Martemyanov KA. 2007. Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol. Cell. Neurosci. 35:311-319.   Song H, Belcastro M, Young EJ, Sokolov M. 2007. Compartment-specific phosphorylation of phosducin in rod underlies adaptation to various levels of illumination. J. Biol. Chem. 282:23613-2362.   Krispel CM, Sokolov M, Chen YM, Song H, Herrmann R, Arshavsky VY, Burns ME. 2007. Phosducin regulates the expression of transducin βγ subunits in rod photoreceptors and does not contribute to phototransduction adaptation. J. Gen. Physiol. 130:303-312.