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Vazhaikkurichi
Rajendran Ph.D. |
 Professor
BS: University of
Madras
PhD: University of Madras
Postdoctoral Training: Medical College of
Wisconsin
Joined the faculty:
WVU: 2006, Biochemistry:
2009
Affiliations:
Teaching: MICB
796
Office: 3151 HSN
Phone: (304) 293-0150
Fax: (304) 293-6846
E-mail: vrajendran@hsc.wvu.edu
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Research Interests: |
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Our laboratory is
interested in investigating the electrolyte transport
processes that regulate colonic fluid movement during
physiological and pathophysiological (diarrhea and
ulcerative colitis) conditions. We focus to identify the
Ca2+-activated intermediate conductance (also known as
KCNN4) K+ channel isoform that provides the driving
force for Cl- secretion in several fluid secreting
epithelial cells. To achieve this goal, we employ
electrophysiology, biochemical, molecular and
biophysical techniques. |
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References:
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- Nanda Kumar NS, Singh SK, Rajendran VM. K+
Secretion mediated via mucosal KCNN4 Channels drives electrogenic Cl-
secretion in rat colon (submitted).Barmeyer C, Rahner C, Yang Y, Sigworth FJ,
Binder HJ, Rajendran VM. Cloning and identification of tissue specific
expression of KCNN4 splice variants in rat colon. Am J Physiology Cell
Physiology (In Press).
- Sendhil Velan S, Said N Durst C, Spencer R,
Frisbee S, Frisbee J, Raylman R, Albert Thomas M, Rajendran VM, Always S.
Distinct patterns of fat metabolism in skeletal muscle of normal weight,
overweight, and obese humans. Am J Physiol - Regulatory, Integrative and
Comparative Physiology 295:R1060-R1065, 2008.
- Sandeep, S., Rajendran VM, Ramakrishna BS
and Binder HJ. Butyrate stimulates apical Na-H exchange activity and NHE3
protein expression in presence of cholera toxin. Am J Physiol Gastrointest
Liver Physiol 293:G857-63, 2007.
- Jiang Z, Asplin JA, Evan AP, Rajendran VM,
Velazquez H, Nottoli TP, Binder HJ, and Aronson PS. Calcium oxalate
urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet 38:
474-478, 2006.
- Joiner WJ, Basavappa S, Vidyasagar S,
Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. Active K+
secretion through multiple KCa-type channels and regulation by IKCa channels
in rat proximal colon. Am J Physiol Gastrointest Liver Physiol 285:
G185-G196, 2003.
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Rajendran Lab 
