Professor

Joined the faculty: WVU: 1969, Biochemistry: 2001

Affiliations:

Teaching: PCOL 760, PCOL 243, PCOL 244, PCOL 761, BIOC 793

Office: 3133
Phone: (304) 293-5449, (304) 293-2305
Fax: (304)293-6854
Email: kvandyke@hsc.wvu.edu

Research is centered in two main areas: chemotherapy and inflammation. These studies include an examination of antimicrobial, antiviral, antimal, and anticancer drugs. Other research is involved with host defense systems and the drugs that affect them.

Description of Research:

Currently we study inflammation by measuring oxidative processes and genetic activation of inflamed tissues and cells. We have examined a variety of air-borne particles which can cause inflammation and eventually fibrosis. We believe the development of fibrosis (scarring) is due to inflammation which occurs chronically. Therefore, by making the particles less toxic (by coating), or by removing particles, the toxic load could be lightened. If that is not the case, then management of the system of chronic inflammation is necessary. We have been successful in regulating the inflammation ,from silica, asbestos and coal in the lung. We are developing new methods (including genetic probes) to control diseases such as black lung, silicosis, fibrosis and emphysema.

Dr. Van Dyke is a member of the Interdepartmental Graduate Program in Genetics.

  References:

• K. Van Dyke, E. Ghareeb, M. Van Dyke and D.H. Van Thiel, Ultrasensitive peroxynitrite-based luminescence with L-012 as a screening system for antioxidative/antinitrating substances, e.g. Tylenol (acetaminophen), 4-OH tempol, quercetin and carboxy-PTIO, Luminescence 22 (2007) 267-74.
   
• I.V. Ustyugova, L.L. Frost, K. Van Dyke, K.M. Brundage, R. Schafer and J.B. Barnett, 3,4-dichloropropionaniline suppresses normal macrophage function, Toxicol Sci 97 (2007) 364-74.
   
• R.D. Hoeldtke, K.D. Bryner, D.R. McNeill, G.R. Hobbs, J.E. Riggs, S.S. Warehime, I. Christie, G. Ganser, K. Van Dyke and L. Corum, Nitrosative stress, uric acid, and peripheral nerve function in early type 1 diabetes. Diabetes 51:2817-2825, Diabetes 55 (2006) 2664.
   
• T.H. Rork, K. Van Dyke, N.M. Spiler and G.F. Merrill, Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium, Exp Biol Med (Maywood) 229 (2004) 1154-61.
   
• K. Van Dyke, S. Patel and V. Vallyathan, Lucigenin chemiluminescence assay as an adjunctive tool for assessment of various stages of inflammation: a study of quiescent inflammatory cells, J Biosci 28 (2003) 115-9.
   
• M.F. Simoyi, E. Falkenstein, K. Van Dyke, K.P. Blemings and H. Klandorf, Allantoin, the oxidation product of uric acid is present in chicken and turkey plasma, Comp Biochem Physiol B Biochem Mol Biol 135 (2003) 325-35.