Department of Biochemistry

Knox Van Dyke, Ph.D.

Ph.D. - Saint Louis University, 1966

Professor
Department of Biochemistry
West Virginia University
Robert C. Byrd Health Sciences Center
P.O. Box 9223
Morgantown, WV 26506-9223
Phone: (304) 293-5449
Phone: (304) 293-2305
Fax: (304)293-6854
Email: kvandyke@hsc.wvu.edu

Research:

Research is centered in two main areas: chemotherapy and inflammation. These studies include an examination of antimicrobial, antiviral, antimal, and anticancer drugs. Other research is involved with host defense systems and the drugs that affect them.

Description of Research:

Currently we study inflammation by measuring oxidative processes and genetic activation of inflamed tissues and cells. We have examined a variety of air-borne particles which can cause inflammation and eventually fibrosis. We believe the development of fibrosis (scarring) is due to inflammation which occurs chronically. Therefore, by making the particles less toxic (by coating), or by removing particles, the toxic load could be lightened. If that is not the case, then management of the system of chronic inflammation is necessary. We have been successful in regulating the inflammation ,from silica, asbestos and coal in the lung. We are developing new methods (including genetic probes) to control diseases such as black lung, silicosis, fibrosis and emphysema.

Dr. Van Dyke is a member of the Interdepartmental Graduate Program in Genetics.

Selected Publications:

• K. Van Dyke, E. Ghareeb, M. Van Dyke and D.H. Van Thiel, Ultrasensitive peroxynitrite-based luminescence with L-012 as a screening system for antioxidative/antinitrating substances, e.g. Tylenol (acetaminophen), 4-OH tempol, quercetin and carboxy-PTIO, Luminescence 22 (2007) 267-74.
• I.V. Ustyugova, L.L. Frost, K. Van Dyke, K.M. Brundage, R. Schafer and J.B. Barnett, 3,4-dichloropropionaniline suppresses normal macrophage function, Toxicol Sci 97 (2007) 364-74.
• R.D. Hoeldtke, K.D. Bryner, D.R. McNeill, G.R. Hobbs, J.E. Riggs, S.S. Warehime, I. Christie, G. Ganser, K. Van Dyke and L. Corum, Nitrosative stress, uric acid, and peripheral nerve function in early type 1 diabetes. Diabetes 51:2817-2825, Diabetes 55 (2006) 2664.
• T.H. Rork, K. Van Dyke, N.M. Spiler and G.F. Merrill, Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium, Exp Biol Med (Maywood) 229 (2004) 1154-61.
• K. Van Dyke, S. Patel and V. Vallyathan, Lucigenin chemiluminescence assay as an adjunctive tool for assessment of various stages of inflammation: a study of quiescent inflammatory cells, J Biosci 28 (2003) 115-9.
• M.F. Simoyi, E. Falkenstein, K. Van Dyke, K.P. Blemings and H. Klandorf, Allantoin, the oxidation product of uric acid is present in chicken and turkey plasma, Comp Biochem Physiol B Biochem Mol Biol 135 (2003) 325-35.
• P. McConnell, M.J. Reasor and K. Van Dyke, Three model systems measure oxidation/nitration damage caused by peroxynitrite, J Biosci 28 (2003) 71-6.
• R.D. Hoeldtke, K.D. Bryner, D.R. McNeill, S.S. Warehime, K. Van Dyke and G. Hobbs, Oxidative stress and insulin requirements in patients with recent-onset type 1 diabetes, J Clin Endocrinol Metab 88 (2003) 1624-8.
• M.F. Simoyi, K. Van Dyke and H. Klandorf, Manipulation of plasma uric acid in broiler chicks and its effect on leukocyte oxidative activity, Am J Physiol Regul Integr Comp Physiol 282 (2002) R791-6.
• R.D. Hoeldtke, K.D. Bryner, D.R. McNeill, G.R. Hobbs, J.E. Riggs, S.S. Warehime, I. Christie, G. Ganser and K. Van Dyke, Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes, Diabetes 51 (2002) 2817-25.
• H. Klandorf, D.S. Rathore, M. Iqbal, X. Shi and K. Van Dyke, Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol, Comp Biochem Physiol C Toxicol Pharmacol 129 (2001) 93-104.
• K. Van Dyke, P. McConnell and L. Marquardt, Green tea extract and its polyphenols markedly inhibit luminol-dependent chemiluminescence activated by peroxynitrite or SIN-1, Luminescence 15 (2000) 37-43.
• M.D. Taylor, K. Van Dyke, L.L. Bowman, P.R. Miles, A.F. Hubbs, R.J. Mason, K. Shannon and M.J. Reasor, A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity, Toxicol Appl Pharmacol 167 (2000) 182-90.
• K. Van Dyke, M. Sacks and N. Qazi, A new screening method to detect water-soluble antioxidants: acetaminophen (Tylenol) and other phenols react as antioxidants and destroy peroxynitrite-based luminol-dependent chemiluminescence, J Biolumin Chemilumin 13 (1998) 339-48.