Department of Biochemistry

Jing Jie Yu, Ph.D.

Research Associate Professor
The Mary Babb Randolph Cancer Center
2831 HSS
PO Box 9300 Morgantown, WV 26506
Phone: 304-293-3124
Fax: 304-293-4667
Email: jyu@hsc.wvu.edu  

Program Affiliations:

Therapeutics

Research Interests:

Cisplatin is a mainstay chemotherapeutic agent for human cancers. In the apoptotic process, or inhibition of cell growth, cisplatin activates DNA-damage-response genes. Better understanding of the mechanism may reveal novel strategies to intervene in the treatment of platinum-resistant tumors. Our studies target the mechanism of cisplatin-induced DNA-damage response and DNA repair pathways, with a special focus on phosphorylation and regulation of kinase Chk2 and of p53 gene in human ovarian cancer.

Recent publications:

PubMed Publications Search (Opens a new window)