EDUCATION:
- B.S., Mammalian Physiology, University of California, San Diego, CA, 1991.
- Ph.D., Nutritional Sciences, University of Wisconsin, Madison, WI, 2000.
- Postdoctoral, Myocardial ischemia, University of California, San Diego, CA, 2000-05.
Positions:
- 7/2005 - present Assistant Professor
West Virginia School of Medicine
Division of Exercise Physiology
- 7/2004 - 7/2005 Assistant Project Scientist Step II
University of California, San Diego Department of Medicine
Supervisor – Wolfgang Dillmann, M.D.
- 8/2000 - 7/2004 Postdoctoral Fellow
University of California, San Diego Department of Medicine
Supervisor – Wolfgang Dillmann, M.D.
Professional Societies:
- 2003 - present American Heart Association
Academic and Professional Honors:
- 3/1/05 - 6/30/05 Minority Investigator Research Supplement (MIRS)
NIH, National Heart, Lung, and Blood
“Cardiac Ischemia and Heat Shock Proteins”
- 8/1/00 - 2/28/05 National Research Service Award Postdoctoral Traineeship
National Institute of Health
- 7/1/98 - 6/30/99 American Heart Association Predoctoral Fellowship
American Heart Association
“Exercise and Antioxidant Enzyme Gene Regulation in Myocardium”
- 9/1/98 - 11/30/98 Glenn Foundation/AFAR Scholarship
American Federation for Aging Research
“Aging and Antioxidant Enzyme Gene Regulation: Superoxide Dismutase Brought to Focus”
- 9/1/98 - 5/31/99 Advanced Opportunity Fellowship
UW-Madison Graduate School
- 1/1/97 - 5/31/98 Advanced Opportunity Fellowship
UW-Madison Graduate School
- 1/1/94 - 12/31/96 National Research Service Award Predoctoral Traineeship
National Institute of Health
- 9/1/93 - 1/1/94 Nutritional Sciences Fellowship
Interdepartmental Graduate Program Nutritional Science
Publications:
- Leeuwenburgh, C., S. Leichtweis, J. Hollander, R. Fiebig, M. Gore, and L.L. Ji. Effect of acute exercise on glutathione deficient heart. Mol. Cell. Biochem. 156:17-24, 1996.
- Leeuwenburgh, C., J. Hollander, S. Leichtweis, M. Griffiths, M. Gore, and L.L. Ji.
Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am. J. Physiol. 272(41):R363-R369, 1997.
- Hollander, J., M. Gore, R. Fiebig, R. Mazzeo, S. Oh-ishi, H. Ohno, and L.L. Ji. Spaceflight down-regulates antioxidant defense systems in rat liver. Free Rad. Biol. Med. 24:385-390, 1997.
- Kim, Moon-ju, J. M. Aiken, T. Havighurst, J. Hollander, M. O. Ripple, and R. Weindruch. Adult-onset energy restriction of Rhesus monkeys attenuates oxidative-stress induced cytokine expression by peripheral blood mononuclear cells. J. Nutr. 127:2293-2301, 1997.
- Ji, L.L., C. Leeuwenburgh, S. Leichtweis, R. Fiebig, J. Hollander, and M. Gore. Antioxidant protection of glutathione in exercise. In Proceedings of the VIII Int. Society for Free Rad. Res. Prous Publications, Barcelona, Spain.
- Gore, M., R. Fiebig, J. Hollander, C. Leeuwenburgh, and L.L. Ji. Exercise training alters antioxidant enzyme activity, protein content, and mRNA abundance in rats. Can. J. Physiol. Pharm. 76:1-7, 1998.
- Ji, L.L., C. Leeuwenburgh, S. Leichtweis, M. Gore, Russel Fiebig, John Hollander, and Jeffery Bejma. Oxidative Stress and Aging: Role of Exercise and Its Influences on Antioxidant Systems. In: Towards Prolongation of the Healthy Life Span. Ann. N.Y. Acad. Sci. 845:102-117, 1998.
- Ji, L.L. and J. Hollander. Antioxidant Defense. In: Free Radicals in Exercise and Aging. (Ed. Z. Radak). Human Kinetics Publishing, Champaign, IL. pp. 25-47, 2001.
- Hollander, J., R. Fiebig, M. Gore, J. Bejma, T. Ookawara, H. Ohno, and L.L. Ji. Superoxide dismutase gene expression: fiber-specific adaptation to endurance training. Am. J. Physiol. 277:R856-R862, 1999.
- Hollander, J., J. Bejma, T. Ookawara, H. Ohno, and L.L. Ji. Superoxide dismutase gene expression: fiber-specific effect of age. Mech. Ageing Develop. 116(1):33-45, 2000.
- Fiebig, R., J. Hollander, and L.L. Ji. Exercise down-regulation of hepatic fatty acid Synthase in streptozotocin-treated rats. J. Nutri. 131(9):2252-2259, 2001.
- Brickson, S., J. Hollander, D. T. Corr, L. L. Ji, and T. M. Best. Oxidant production and immune response after stretch injury in skeletal muscle. Med. Sci. Sports Exer. 33(12):2010-2015, 2001.
- Hollander, J., R. Fiebig, M. Gore, T. Ookawara, H. Ohno, and L.L. Ji. Superoxide dismutase gene expression in skeletal muscle: effect on an acute post-exercise time course. Pflugers-Arch. Eur. J. Physiol. 442(3):426-434, 2001.
- Fiebig, R. G., J. Hollander, D. Ney, R. Bioleau, E. Jeffrey, and L.L. Ji. Exercise training decreases hepatic fatty acid synthase activity and body fat in obese Zucker rats. Med. Sci. Sports Exer. 34(7):1106-1114, 2002.
- Hollander, J., K. M. Lin, B. T. Scott, W. H. Dillmann. Protection Against Simulated Ischemia-Reoxygenation Damage with Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase and HSP 60 and HSP 10. Free Rad. Biol. Med. 35(7):742-751, 2003.
- Lin, K. M., J. Hollander, B. Lin, L. Macpherson. W. H. Dillmann. Myocyte protection by 10 kd heat shock protein (HSP10) involves the mobile loop and attenuation of the Ras-GTPase pathway. FASEB J. 18:1004-1006, 2004.
- Hollander, J., J. L. Martin, D. D. Belke, B. T. Scott, W. H. Dillmann. Overexpression of wild type HSP27 and a HSP27 nonphosphorylatable mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation. 110:3544-3552, 2004.
- Dieterle, T., M. Meyer, Y. Gu, D. D. Belke, E. Swanson, M. Iwatate, J. Hollander, K. L. Peterson, J. Ross, W. H. Dillmann. Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure. Cardiovasc. Res. 67:678-688, 2005.
- Sakurai, T., J. Hollander, S. L. Brickson, H. Ohno, L. L. Ji, T. Izawa, T. M. Best. Changes in nitric oxide and inducible nitric oxide synthase following stretch induced injury to the tibialis anterior muscle of rabbit. Jpn. J. Physiol. 55:101-107, 2005.
Abstracts:
- Sakurai, T., J. Hollander, T. Izawa, H. Ohno, L.L. Ji, T.M. Best. Inducible nitric oxide synthase content following acute muscle stretch injury in rabbits. Med. Sci. Sports Exer. 2001 abstract 236.
- Hollander, J., K. M. Lin, B. T. Scott, W. H. Dillmann. Protection Against Simulated Ischemia-Reoxygenation Damage with Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase and HSP 60 and HSP 10. Circulation. 106:II-284, 2002.
- Hollander, J., J. L. Martin, D. D. Belke, B. T. Scott, W. H. Dillmann. Transgenic Overexpression of Wild Type HSP27 and a HSP27 Nonphosphorylatable Mutant Protects Against Ischemia/Reperfusion Injury. Circulation. 108:IV-92, 2003.
- Lai, C. C., J. Hollander, D. D. Belke, B. T. Scott, W. H. Dillmann, C. Y. Su. Transgenic Overexpression of Constitutive Heat Shock Protein 70 (hsc70) Protects Against Ischemia/Reperfusion Injury. FASEB J. 18:A1244, 2004.
- Stenbit, A. E., H. Duplain, D. D. Belke, J. Hollander, D. Xiong, D. Summers-Torres, S. C. Froehner, M. E. Adams, K. U. Knowlton. nNOS is primarily localized to the sarcoplasmic reticulum in cardiac myocytes and dependent on 1-syntrophin. Circulation. (Suppl. III) 110:III-198, 2004.
Research Support:
- Scientist Development Grant $130,000/2 yr.
American Heart Association National Research Program Pending
“Mitochondrial Protection From Myocardial I/R Injury”
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