EDUCATION:

• M.D. in Medicine, Department of Clinical Medicine, Xuzhou Medical College, Jiangsu, China, 1986 - 1991.
• M.S., Department of Orthopaedics, Affiliated Zhongshan Hospital of Former Shanghai Medical University (Medical Center of Fudan University), Shanghai, China, 1993 - 1996.
• Ph.D., Biochemistry and Cell Biology Lab, Institute of Sports Medicine, Former Beijing Medical University (Beijing University Health Science Center), Beijing, China, 1996-1999.

PROFESSIONAL EXPERIENCE:

• 1991 - 1993 Resident
  Department of Orthopaedics, People’s Hospital of Huaian, China.
• 1993 - 1996 Resident (Chief Resident from 1995 to 1996)
  Department of Orthopaedics, Affiliated Zhongshan Hospital of Shanghai Medical University, Shanghai, China.
• 1999 - 2002 Postdoctoral Associate
  Tissue Engineering Group in Robert Langer Lab, Harvard-MIT Division of Health Sciences and Technology (HST), Massachusetts Institute of Technology (MIT), Cambridge, MA.
• 2002 - 2005 Research Fellow
  Department of Orthopaedics, Brown University, Rhode Island Hospital, Providence, RI
• 2005 - present Assistant Professor and Director of Tissue Engineering Lab
  Department of Orthopaedics, West Virginia University School of Medicine, Morgantown, WV.

PUBLICATIONS:

• IN TISSUE ENGINEERING

• Pei M, Solchaga LA, Seidel J, Zeng L, Caplan AI, Vunjak-Novakovic G, Freed LE. Bioreactors mediate the effectiveness of tissue engineering scaffolds. FASEB J. published August 7, 2002, 10.1096/fj.02-0083fje
• Pei M, Seidel J, Vunjak-Novakovic G, Freed LE. Growth Factors for sequential cellular de- and redifferentiation in tissue engineering. Biochem and Biophys Res Comm 2002, 294:149-54.
• Seidel JO, Pei M, Gray ML, Langer R, Freed LE, Vunjak-Novakovic G. Long-term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation. Biorheology 2004, 41: 445-58.
• Boublik J, Park H, Radisic M, Tognana E, Chen F, Pei M, Vunjak-Novakovic G, Freed LE. Mechanical Properties and Remodeling of Hybrid cardiac Constructs made from heart cells, Fibrin, and Biodegradable, Elastomeric, Knitted Fabric. Tissue Engineering, 2005, 11:1122-32.
• Qi LF, Dutta P, Pal S, Seehra M, Pei M. Morphology Controllable Nanostructured Chitosan Matrix and Its Cytocompatibility. J Biomed Mater Res Part A 2007, 87A:236-44.
• Pei M, Luo JM, Chen Q. Enhancing and Maintaining Chondrogenesis of Synovial Fibroblasts by Cartilage Extracellular Matrix Protein Matrilins. Osteoarthritis Cartilage 2008, 16:1110-1117.
• Pei M, He F, Kish V, Vunjak-Novakovic G. Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study. Clin Orthop Relat Res 2008, 466(8):1880-9.
• Pei M, He F, Vunjak-Novakovic G. Synovium-derived stem cell-based chondrogenesis. Differentiation (2008) doi:10.1111/j.1432-0436.2008.00299.x
• Pei M, Bilgen B, Aaron RK, Ciombor DM. Growth factor modulation of chondrogenesis in synovial fibroblasts. Tissue Engineering 2008 (submitted)
• Pei M, He F, Boyce BM, Kish VL. Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs. Osteoarthritis Cartilage 2008 (submitted)
• Chen S, Emery SE, Pei M. Co-culture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of TGF-b1. A potential application of tissue specific stem cells in disc regeneration. Spine 2008 (submitted)
• Pei M, He F, Rawson A, Wei L. Melatonin enhances chondrogenic differentiation of porcine articular chondrocytes. J Pineal Res 2008 (submitted)
• Tan YB, Zhang YY, Kish VL, Pei M. Meniscal Regeneration through co-culture with synovium-derived stem cells on small intestinal submucosa. 2008 (in preparation)
• He F, Chen XD, Pei M. Rejuvenation of synovium-derived stem cell stemness using stem cell-derived extracellular matrix. 2008 (in preparation)
• Pei M, Chen DM. HDAC4 enhances TGF-b1-induced synovium-derived stem cell-based chondrogenesis. 2008 (in preparation)
• Pei M, He F, Boyce BM, Kish VL. Xenogenic transplantation: an alternative for cartilage tissue engineering? 2008 (in preparation)

• IN OSTEOARTHRITIS AND GENE THERAPY

• Pei M, Zhang GJ. Allergic reaction of metal implant. Foreign Medical Science: Basic problems about trauma and surgery 1995, 16(4): 230-233. 
• Pei M, Zhang GJ. Elongation of peripheral nerve. Chinese Journal of Microsurgery 1997, 20: 312-314.
• Pei M, Qu MY, Yu CL, et al. Function of apoptosis in the differentiation of chondrocyte. Chinese Journal of Surgery 1998, 36(11): 697-698.
• Pei M, Yu CL, Qu MY, et al. Experimental study of longitudinal stretching to repair nerve defects in peripheral nerves. Journal of Orthopaedic Surgery 1998, 6(2): 15-21.
• Pei M, Yu CL, Qu MY, et al. In situ hybridization study on expression of constitutive nitric oxide synthase in human osteoarthritis-affected chondrocytes. Chinese Journal of Rheumatoid Arthritis 1998, 2(4): 218-220.
• Pei M, Yu CL, Qu MY, et al. In situ hybridization study on expression of telomerase during endochondral bone development. Chinese Journal of Sports Medicine 1999, 18(1): 12-13.
• Pei M, Yu CL, Qu MY, et al. Study on the mechanism of suppression of experimental arthritis by intra-articular injection of naked plasmid DNA. Chinese Journal of Sports Medicine 1999, 18(2): 103-105.
• Pei M, Yu CL, Qu MY, et al. Experimental study of cationic liposome DOTAP-mediated report gene transfection of osteoarthritis synovial cells. Chinese Journal of Sports Medicine 1999, 18(2): 106-108.
• Pei M, Yu CL, Qu MY, et al. Effect of apoptosis on pathogenesis of osteoarthritis. Chinese Journal of Orthopaedics 1999, 19(3): 167-169.
• Pei M, Yu CL, Qu MY, et al. In situ expression of telomerase in synovium and cartilage as well as pannus of rheumatoid arthritis. Chinese Journal of Orthopaedics 1999, 19(12): 739-742.
• Pei M, Yu CL, Qu MY. Expression of collagen type I, II and III in loose body of osteoarthritis. Journal of Orthopaedic Science 2000, 5:288-293.
• Pei M, Yu CL, Qu MY, et al. Immunohistochemical demonstration of IL-1 receptor antagonist protein and IL-1 during endochondral bone development. Chinese Journal of Sports Medicine 2000, 19(2): 118-119.
• Pei M, Yu CL, Qu MY, et al. Expression and effects of basic fibroblast growth factor and transformation growth factor b1 during endochondral bone development. Chinese Journal of Sports Medicine 2000, 19(2): 120-121.
• Pei M, Yu CL, Qu MY, et al. Induced nitric oxide synthase and IL-1 receptor antagonist protein production and effect in synovial and chondral tissue from patients with osteoarthritis. Chinese Journal of Sports Medicine 2000, 19(3): 246-248.
• Pei M, Yu CL, Qu MY, et al. The expression and biological function of three kinds of IL-1 receptor antagonist isoforms in synovium from OA and RA. Chinese Journal of Sports Medicine 2000, 19(4): 368-370.
• Pei M, Yu CL, Qu MY, et al. Expression of collagens I, II and III in chondrocytes of human osteoarthritic cartilage and loose body. Chinese Journal of Rheumatoid Arthritis 2000, 4(2): 85-88.
• Pei M, Qu MY, Yu CL, et al. Reference among apoptosis, nitric oxide and arthritis. Chinese Journal of Sports Medicine 2000, 19(3): 299-301.

• CONFERENCE ABSTRACTS

• Pei M, Seidel J, Zeng L, Solchaga LA, Caplan AI, Vunjak-Novakovic G, Freed LE. Modulation of tissue engineered cartilage by scaffold structure and bioreactor culture. 47th Annual Meeting of the Orthopaedic Research Society, San Francisco (2001) Trans ORS 26:598.
• Pei M, Seidel J, Vunjak-Novakovic G, Freed LE. Differential effects of growth factors (TGF beta1, FGF-2, IGF-I) on engineered cartilage cellularity, structure, and function. 48th Annual Meeting of the Orthopaedic Research Society Dallas (2002). Trans ORS 27:484.
• Pei M, Aaron RK, Ciombor DM. Engineered cartilage from synovium-A developmental approach. 50th Annual Meeting of the Orthopaedic Research Society San Francisco (2004) Trans ORS 29:720.
• Pei M, Aaron RK, Ciombor DmcK. TGF-b1-dependent chondrogenic effect of IGF-I and FGF-2 on synovial fibroblast. 51th Annual Meeting of the Orthopaedic Research Society Washington, DC (2005). Trans ORS 30:1452.
• Pei M, Aaron RK, Ciombor DmcK. Modulation of chondrogenesis in synovial fibroblast engineered cartilage by sequential growth factors. 51th Annual Meeting of the Orthopaedic Research Society Washington, DC (2005). Trans ORS 30:136 (Oral presentation).
• Pei M, Aaron RK, Ciombor DmcK. Does any mitogenic growth factor always benefit the chondrogenesis of mesenchymal stem cells? 52th Annual Meeting of the Orthopaedic Research Society Chicago (2006). Trans ORS 31:782.
• Pei M, Luo JM, Chen Q. Matrilin-1 and -3 Enhance Chondrogenic Differentiation of Synovial Fibroblast. (2006) World Congress on Tissue Engineering and Regenerative Medicine. Pittsburgh, April 24-27. (Poster Number: 119)
• Qi LF, Dutta P, Pal S, Seehra M, Pei M. Preparation and Characterization of Chitosan Nanocrystal. NSTI Nanotech 2007, Bio Nano Materials & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 755. (Oral Presentation)
• Qi LF, Dutta P, Pal S, Seehra M, Pei M. Chitosan Nanocrystal: A Potential Biomaterial for Tissue Engineering Application. NSTI Nanotech 2007, Bio Nano Materials & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 770. (Oral Presentation)
• Pei M, Boyce B, Kish V. In Vitro Reconstruction of Functional Cartilage Tissue With Synovium-derived Stem Cells. (2007) Keystone Symposia Conference-Tissue Engineering and Development Biology (D4), Snowbird Resort, Snowbird, Utah, April 12-17. (Post number: 232)
• Pei M, Boyce B, Kish V. In Vitro Reconstruction of Functional Cartilage Tissue With Synovium-derived Stem Cells. (2007) Tissue Engineering and Regenerative Medicine International Society (TERMIS) North America (NA) 2007 Conference, Westin Harbour Castle, Toronto, Canada, June 13-16. (Poster number: 45)
• Pei M, Qi LF, Dutta P, Pal S, Seehra M. Preparation and Characterization of Chitosan Nanocrystal As A Novel Biomaterial. (2007) Tissue Engineering and Regenerative Medicine International Society (TERMIS) North America (NA) 2007 Conference, Westin Harbour Castle, Toronto, Canada, June 13-16. (Poster number: 238)
• Pei M, Boyce B, Kish V. Inhibition of Macrophage in the Chondrogenic Differentiation of Synovium-derived Stem Cell. (2007) Tissue Engineering and Regenerative Medicine International Society (TERMIS) North America (NA) 2007 Conference, Westin Harbour Castle, Toronto, Canada, June 13-16. (Poster number: 25)
• Pei M, Qi LF, Yang ML, Wu NG. Chitosan-Polylysine-DNA Nanocomplexes: A Promising Non-Viral Gene Delivery Approach. Tissue Engineering and Regenerative Medicine International Society (TERMIS) North America (NA) 2007 Conference, Westin Harbour Castle, Toronto, Canada, June 13-16. (Poster number: 102)
• Pei M. In vitro reconstruction of functional cartilage tissue with synovial-derived stem cells. The 5th Musculoskeletal Transplant Foundation (MTF) Symposium, Vancouver, Canada, October 11-13, 2007
• Pei M, He F, Kish VL. Negatively isolated synovium-derived stem cell-based cartilage tissue engineering. 54th Annual Meeting of the Orthopaedic Research Society. San Francisco (2008). Trans ORS 33:584.
• Pei M, He F, Boyce BM, Kish VL. Allogeneic cartilage repair using synovial cell-based tissue constructs. 54th Annual Meeting of the Orthopaedic Research Society. San Francisco (2008). Trans ORS 33:583.
• Pei M, He F, Boyce BM, Kish VL. Xenogenic transplantation: an alternative for cartilage tissue engineering? 54th Annual Meeting of the Orthopaedic Research Society. San Francisco (2008). Trans ORS 33:540.
• Rawson A, He F, Pei M. Melatonin: a promising hormone for chondrogenesis. 2008 E. J. Van Liere Convocation and Research Day, WVU, April 22-23. (Oral presentation) (first place in poster presentation, $500 prize)
• Chen S, Chen DM, He F, Tan YB, Pei M. Synovium-derived stem cell: a potential candidate for intervertebral disc tissue engineering. 2008 E. J. Van Liere Convocation and Research Day, WVU, April 22-23. (Poster presentation)
• He F, Pei M. Negatively isolated synovium-derived stem cell-based cartilage tissue engineering. 2008 E. J. Van Liere Convocation and Research Day, WVU, April 22-23. (Poster presentation)
• Pei M. Synovium-derived stem cell-based cartilage tissue engineering for cartilage repair. 5th International Meeting of Gene Therapy of Arthritis and Related Disorders, Seattle, WA, April 29 – May 1, 2008 (Oral presentation)
• He F, Rawson A, Pei M. Melatonin enhances cartilage matrix synthesis of articular chondrocytes in an in vitro serum-containing pellet culture system. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas (2009). (Submitted)
• Chen S, He F, Emery SE, Pei M. Supplementation of the nucleus pulposus cell population using synovium-derived stem cells. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas (2009). (Submitted)
• Tan YB, Zhang YY, Kish VL, Pei M. Meniscus tissue Engineering using synovium-derived stem cells and small intestinal submucosa. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas (2009). (Submitted)
• Pei M, Chen DM. HDAC4 enhances synovium-derived stem cell-based chondrogenesis induced by TGF-b1. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas (2009). (Submitted)

PROFESSIONAL ACTIVITIES AND HONOR:

• Member, Orthopaedic Research Society (ORS, since 2002)
• Member, Tissue Engineering Society international (TESi, since 2002)
• Member, Public Service Committee, WVU (since 2006)
• Journal Reviewer for BIOTECHNOLOGY PROGRESS (since 2005), TISSUE ENGINEERING (since 2005), JOURNAL OF ORTHOPAEDIC RESEARCH (since 2007), CYTOTHERAPY (since 2007)

• Abstract Reviewer for ORS Abstract (since 2007)
• Reviewer for WVU Senate Grants for Public Service (since 2007)
• Musculoskeletal Transplant Foundation (MTF) Peer-Reviewed Research Grant Award (2005)
• Approved Graduate Faculty for Medical School MS and PhD Committees (since 2006)
• Approved Graduate Faculty for Engineering School MS and PhD Committees (since 2006)
• Young Investigators Initiative, US Bone and Joint Decade (USBJD, 2006)
• Selected for inclusion in the Academic Keys Who’s Who in Engineering Higher Education (WWEHE) (since 2007)
• Invited speaker for MTF’s 5th International symposium, Vancouver, Canada, October 11-13, 2007
• Invited speaker for 5th International Meeting of Gene Therapy of Arthritis and Related Disorders (GTARD), Seattle, WA, April 29 – May 1, 2008

RESEARCH PRIORITY:

• Mesenchymal stem cell-based tissue engineering and regeneration
• Mesenchymal stem cell
• Synovium-derived
• Bone marrow-derived
• Fat-derived
• Tissue
• Cartilage
• Intervertebral disc
• Meniscus
• Mechanical signal mediated tissue regeneration
• Bioreactor
• Ultrasound

MENTOR CURRENT GRADUATE STUDENTS:

• Fan He (Medical School PhD student, since Feb’06)
• Song Chen (Engineering School PhD student, since June’07)
• Yunbing Tan (Engineering School MS student, since Aug’07)
• Mark Shoukry (Engineering School MS student, since Dec’08)