Title: Professor
Graduated from: Ph.D., University of California at San Diego 1984
Office: 2081 Health Science North
Office Phone: (304) 293-2676
Lab: 2082A Health Science North
Lab Phone:(304) 293-2678
Email: telliott@hsc.wvu.edu
Academic Interests:
The research in my laboratory utilizes Salmonella enterica (serovar Typhimurium), a Gram-negative enteric bacterium which causes gastroenteritis in humans and a typhoid-like disease in mice. We study regulation of the sigma transcription specificity factor RpoS. This protein is induced in response to stress, nutrient limitation, and growth in mammalian host cells. Its regulation involves novel post-transcriptional mechanisms including control of translation by small RNAs and regulated proteolysis.
Publications:
Jones, A.M., A. Goodwill and T. Elliott. 2006. Limited role for the DsrA and RprA regulatory RNAs in rpoS regulation in Salmonella enterica. J. Bacteriol. 181:1211-1219.
Hirsch, M. and T. Elliott. 2005. Stationary-phase regulation of RpoS translation in Escherichia coli. J. Bacteriol. 187:7204-7213.
Hirsch, M. and T. Elliott. 2005. Fis regulates transcriptional induction of RpoS in Salmonella typhimurium. J. Bacteriol. 187:1568-1580.
Hirsch, M. and T. Elliott. 2002. Role of ppGpp in rpoS stationary phase regulation in Escherichia coli. J. Bacteriol. 184:5077-5087.
Wang, L., S. Wilson and T. Elliott. 1999. A mutant HemA protein with positive charge close to the N terminus is stabilized against heme-regulated proteolysis in Salmonella typhimurium. J. Bacteriol. 181:6033-6041.
Cunning, C. and T. Elliott. 1999. RpoS synthesis is growth-rate regulated in Salmonella typhimurium , but its turnover is not dependent on acetyl phosphate synthesis or PTS function. J. Bacteriol. 181:4853-4862.
Brown, L., and T. Elliott. 1997. Mutations that increase expression of the rpoS gene and decrease its dependence on hfq function in Salmonella typhimurium. J. Bacteriol. 179: 656-662.