Academic Interests:
One focus of our laboratory is to investigate methods to disrupt survival signals provided by the bone marrow, with the long-term goal being the development of strategies that make leukemic cells more susceptible to chemotherapy. A second area of investigation is aimed at better understanding how to minimize the detrimental effects of dose escalated chemotherapy.
Publications:
Mudry RE, Fortney JE, York T, Hall BM, Gibson LF. Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. Blood 2000;96(5):1926-32. PM:10961896.
Fortney JE, Zhao W, Wenger SL, Gibson LF. Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy. Leuk.Res. 2001;25(10):901-7. PM:11532524.
Frost LL, Neeley YX, Schafer R, Gibson LF, Barnett JB. Propanil inhibits tumor necrosis factor-alpha production by reducing nuclear levels of the transcription factor nuclear factor-kappab in the macrophage cell line ic-21. Toxicol.Appl.Pharmacol. 2001;172(3):186-93. PM:11312646.
Hall BM, Fortney JE, Gibson LF. Alteration of nuclear factor-kappaB (NF-kappaB) expression in bone marrow stromal cells treated with etoposide. Biochem.Pharmacol. 2001;61(10):1243-52. PM:11322928.
Fortney JE, Hall BM, Bartrug L, Gibson LF. Chemotherapy induces bcl-2 cleavage in lymphoid leukemic cell lines. Leuk.Lymphoma 2002;43(11):2171-8. PM:12533044.
Gibson LF. Survival of B lineage leukemic cells: signals from the bone marrow microenvironment. Leuk.Lymphoma 2002;43(1):19-27. (invited review) PM:11908727.
Hall BM, Fortney J, Gibson LF. Human bone marrow stromal cell SDF-1 production is reduced following exposure to etoposide or doxorubicin. Analytical Pharmacology 2003;4:21-9.
Hogan MB, Weissman DN, Hubbs AF, Gibson LF, Piktel D, Landreth KS. Regulation of eosinophilopoiesis in a murine model of asthma. J Immunol. 2003;171(5):2644-51. PM:12928418.
Adams SW, Wang L, Fortney J, Gibson LF. Etoposide differentially affects bone marrow and dermal derived endothelial cells. J Cell Mol.Med 2004;8(3):338-48. PM:15491509.
Hall BM, Fortney JE, Taylor L, Wood H, Wang L, Adams S, Davis S, Gibson LF. Stromal cells expressing elevated VCAM-1 enhance survival of B lineage tumor cells. Cancer Lett. 2004;207(2):229-39. PM:15072833.