Title: Professor
Graduated from: Ph.D., University of Washington (Seattle), 1980
Office: 2112 Health Science Center
Office Phone: (304) 293-4067
Lab: Health Science Center
Lab Phone:(304) 293-0503
Email: klandreth@hsc.wvu.edu
Academic Interests:
Our research laboratory focuses on better understanding regulation of hematopoiesis in the bone marrow. For a number of years, this interest centered on the role of bone marrow stromal cells in B lymphocyte production, but we have recently expanded these studies to include development of myeloid cells. Recent work in our lab has identified an unexpected role of inflammatory mediators in regulating of blood cell development and participation of the bone marrow in response to chronic inflammatory diseases, including asthma. These studies have identified a unique role of bone marrow stromal cells in the progressive eosinophilia which characterizes development of asthma in children.
Publications:
Hogan, M.B.. D. Piktel, and K.S. Landreth. 2000. IL-5 production by bone marrow stronal cells: Implications for eosinophilia associated with asthma. J. Allergy Clin Immunol. 106: 329-336 .
Landreth, K.S. 2002. Critical windows in development of the rodent immune system. Human and Exptl. Toxicology. 21: 493-498.
Hogan, M.B., D. Weissman, A. Hubbs, L.F. Gibson, D. Piktel, and K.S. Landreth. 2003. Regulation of eosinophilopoiesis in a murine model of asthma. J. Immunol. 171: 2644-2651.