Associate Professor of Microbiology, Immunology & Cell Biology Ph.D., Temple University, 1988 2072 Health Science North (Office) (304) 293- 4622 (Office) 2067 Health Science North (Lab) (304) 293-3553 (Lab.) ccuff@wvu.edu Curriculum Vitae

Academic Interests:

Our work primarily deals with studying the cellular and molecular events that result in the development of antigen-specific immune responses in the gastrointestinal tract.  These immune responses, mediated largely by IgA antibodies and T-lymphocytes, play an important role in protecting the host against pathogens and toxins that enter the host through the gastrointestinal tract.

Our research program involves the use of murine models of enteric infection as well as human intestinal tissues to analyze the response of the mucosal immune system to stimulation with viruses.  The ultimate goals of this work are to understand the pathogenesis of microbes and their toxic products in the gastrointestinal tract, and elucidate mechanisms by which the host protects itself.  This work contributes to the development of vaccines and other therapies designed to modulate the immune response, and helps us to develop an understanding of how toxins influence the mucosal immune response.

 

Publications:

Peer Reviewed Papers

Fulton, J.R. C. Cunningham, J. Smith, and C.F. Cuff. 2003. Analysis of T-cell receptor repertoires expressed by cytotoxic T cells following oral and systemic infection. J. Virol. 78:1592-1590

Mathers, A. and C. F. Cuff. 2003. Roles of interleukin 4 and interleukin 10 on route of infection-dependent IgG subclass responses to reovirus infection. J. Virol. 78:3352-3360

Fulton, J.R. and C.F. Cuff. 2004. Mucosal immunity to reovirus infection in aged mice. Exp. Gerontol. 39:1285-1294.

Pal, K., Kaetzel, C., Brundage, K., Cunningham, C., and C.F. Cuff. 2005 Up-regulation of polymeric immunoglobulin receptor expression by reovirus. J. Gen Virol. 86: 2347-57.

Li, M., C.F. Cuff, and J. Pestka. 2005. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Tox. Sci. 87:134-145.

Fecek,R.J., Busch,R., Lin,H., Pal,K., Cunningham,C.A., and Cuff,C.F. 2006. Production of Alexa Fluor 488-labeled reovirus and characterization of target cell binding, competence, and immunogenicity of labeled virions. J Immunol Methods. 30-37.

Li M, Cuff C.F., Pestka JJ. 2006. T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses. Toxicol Appl Pharmacol. 214:318-325.

Li,M., Harkema,J.R., Islam,Z., Cuff,C.F., and Pestka,J.J. 2006. T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis. Toxicol.Applied Pharmacol. 217:76-85.

Li,M., Harkema,J.R., Cuff,C.F., and Pestka,J.J. 2007. Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. Tox Sci. 95(2):412-26.
 

Book Chapters

Fulton, J.R. C. A. Cunningham, and C.F. Cuff. 2003. Immunology of the gastrointestinal tract. In Colonic Diseases. T. Koch ed. Humana Press Human Press, Torowa, NJ, pp105-122

Cunningham, C.A., J.R. Fulton, and C.F.Cuff. 2003. Inflammation. In Colonic Diseases. T. Koch ed. Humana Press Human Press, Torowa, NJ, pp 211-222.

Cuff, C.F. and R. Schafer. 2005. Mucosa Associated Lymphoid Tissue. In Encyclopedia of Toxicology, P. Wexler ed. Academic Press, San Diego, CA. pp465-467.

Cuff, C.F. 2006. John Cebra: A Remembrance. Mucosal Immunology Update, 3rd quarter 2006 pp 3-6