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Department of Pathology
Case of the Month Sep 2002
A 56 year-old male with recurrent sinusitis, nasal congestion and epistaxis.
Jason C. Fowler, PA; Christopher Rassekh MD; Peilin Zhang MD
Microscopic Description
Routine hematoxylin and eosin sections revealed a non-keratinizing, poorly differentiated carcinoma. The tumor cells appeared as nests of cells with a syncytial-like growth pattern. In addition, there was a prominent lymphocytic response and associated tumor necrosis. Mitoses, although identified, were infrequent. The tumor cells also stained positive for pan-cytokeratin and negative for LCA and S-100. Unstained slides were sent out for EBV in-situ hybridization and were found to be strongly positive for EBV RNA.
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Image #4:
H & E Stain – 4x |
Image #5:
H & E Stain – 20x |
Image #6:
H & E Stain – 40x |
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Image #7:
Cytokeratin Stain – 40x |
Image #8:
EBV RNA – 20x |
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