Microscopic Description

Intraoperative frozen sections showed bizarre-looking cells with dark nuclei and irregular cell borders; however there appeared to be focal areas of mucin production. The intraoperative diagnosis was called “positive for carcinoma, final classification pending permanent sections.” Permanent, formalin-fixed H&E sections of this exceptionally small specimen demonstrated predominantly uniform cells with small, dark nuclei and scant cytoplasm. Cell borders were indistinct and mitoses were rare to non-existent. The sections also demonstrated focal sieve-like areas consistent with a cribriform growth pattern (Figs 3-6). 

Fig 3 - 10X
Fig 4 - 20X	Fig 5 - 40X
Fig 6 - 40X