MICROSCOPIC DESCRIPTION 

The right ovarian tumor manifested cystic and papillary structures in some areas (figs 1-10x & 2- 40x) and solid tumor nests and cords invading into a fibrous stroma in others (figs 3- 4x & 4- 40x). Both were lined with or composed of malignant epithelium (figs 2 & 4), often of high grade. Focal necrosis was present. Mitotic figures were common. Foci of irregular glandular formation (fig 5- 40x), though variable, were also present. However, a benign or proliferating Brenner tumor was not present in spite of examination of multiple sections of tumor. Immunohistochemically, the tumor cells were positive for CK7 (fig 6- 20x), EMA and CA125 (fig 7 – 20x), and were negative or partly very weakly positive for CK20. They were negative for CEA, synaptophysin and inhibin.

The left ovarian tumor was similar to that in the right ovary. Tumor nodules on the omentum and serosa of the small intestine were metastatic carcinoma of ovarian origin. Metastatic carcinoma also involved the posterior cervical region and lateral portions of the uterus and the serosa/adventitia of the rectosigmoid colon, extending into the colonic wall and even to the submucosa in area. Of note was the presence of metastatic carcinoma in the spleen, which often exhibited irregular glandular formation. In rare foci, a papillary serous feature was present .

Fig 1- 10 X	Fig 2- 40 X	Fig 3- 4X	Fig4- 40X

Fig 5- 40X	Fig 6- 20X	Fig 7 - 20X