|
| Department of Physiology and Pharmacology Stan Hileman  Stan Hileman
Assistant Professor of Physiology B.S. West Virginia University, M.S. University of Kentucky Ph.D. University of Kentucky, 1991 Postdoctoral Fellowships, University of Illinois and Harvard Medical School Phone: 304-293-1502 Email: shileman@hsc.wvu.edu Research Interests Neurobiology of Food Intake and Reproduction Description of Research The goal of my research is to define the neurobiological pathways controlling food intake in the female and how those pathways are integrated into a system whereby nutrition can influence fertility. To accomplish this goal, several surgical, endocrine and molecular biology techniques are employed, including radioimmunoassay, in situ hybridization histochemistry, immunocytochemistry, neuroanatomical tract tracing and RT-PCR, with both rodents and sheep being used as models. The work is focused on the neural mechanisms whereby certain circulating metabolic signals, such as leptin, insulin and IGF-1 may mediate nutrition-induced changes in reproduction as well as examining potential sex-dependent differences in these systems. Recent Publications Hileman S M, R J Handa, and G L Jackson. Distribution of estrogen receptor-beta messenger ribonucleic acid in the male sheep hypothalamus. Biol Reprod 60:1279-1284, 1999. Hileman S M and G L Jackson. Regulation of gonadotrophin-releasing hormone secretion by testosterone in male sheep. J Reprod Fertil Suppl 54:231-242, 1999. Hileman S M, L S Lubbers, H T Jansen, and M J Lehman. Changes in hypothalamic estrogen receptor-containing cell numbers in response to feed restriction in the female lamb. Neuroendocrinology 69:430-437, 1999. Ahima RS, Hileman SM. Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and neuroendocrine function. Regulatory Peptides 92:1-7, 2000. Hileman S M, D D Pierroz, and J S Flier. Leptin, nutrition, and reproduction: timing is everything. J Clin Endocrinol Metab 85:804-807, 2000. Hileman S M, J Tornoe, J S Flier, and C Bjorbaek. Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Endocrinology 141:1955-1961, 2000. El Haschimi K, Pierroz D, Hileman SM, Bjorbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Inv 105:1827-1832, 2000. Ziotopoulou M, Erani DM, Hileman SM, Bjorbaek C, Matzoros C. Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels, but induces expression of hypothalamic inhibitors of leptin signaling. Diabetes 49:1890-1896, 2000 Ziotopoulou M, Mantzoros C, Hileman SM, Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am J Physiol 279:E838-845, 2000. Ahima RS, Hileman SM. Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and neuroendocrine function. Regulatory Peptides 92:1-7, 2000. Hileman SM, Pierroz D, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, Flier JS. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143:775-783, 2002. Ahima RS, Patel HR, Takahashi N, Yong Qi, Hileman SM, Zasloff M. Reversal of obesity and diabetes by a shark-derived aminosterol. Accepted for publication in Diabetes, 2002. |
|||