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Department of Physiology and Pharmacology

James W. Lewis

Assisant Professor of Physiology and Pharmacology
Sensory Neuroscience Research Center

Ph.D. Caltech, 1997
Postdoctoral Fellowship: Medical College of Wisconsin

Phone: 304 293-1517 (office)
Phone: 304 293-8227 (lab)
Phone: 304 293-3850 (fax)
Email: jlewis@hsc.wvu.edu

Research Interests

Mapping and exploring the functions of human brain regions responsible for our ability to recognize every day natural sounds (complex sounds) and our ability to localize sound in three-dimensional space. Additionally, we are exploring how auditory information becomes integrated with the other sensory modalities (i.e. vision and touch/motor).

Description of Techniques


We primarily use functional magnetic resonance imaging (fMRI), with the 3T scanner at the Center for Advanced Imaging.We also use neurophysiological techniques such as collecting evoked response potentials (ERPs) from the brain in response to hearing complex sounds; using transcranial magnetic stimulation (TMS) to interfere with putative auditory processing pathways in the brain; and psychophysically testing the perceptual attributes of various types of natural and synthetic sounds.

Recent Publications

Lewis JW, Beauchamp, MS, and DeYoe EA. (2000) A comparison of visual and auditory motion processing in human cerebral cortex.Cerebral Cortex 10:873-888.

Lewis JW, Wightman F, Brefczynski JA, Phinney RE, Binder JR, DeYoe EA. (2004). Human brain regions involved in recognizing environmental sounds. Cerebral Cortex 14:1008-21.

Calvert GA and Lewis JW. (2004) Hemodynamic studies of audio-visual interactions. In Handbook of Multisensory Processing. (Calvert, GA, Spence, and BE Stein, eds.). Chapt. 30. pp 483-502.

Lewis JW, Brefczynski JA, Phinney RE, Janik, JJ, DeYoe EA. (2004). Distinct cortical pathways for processing tool versus animal sounds. (submitted).

Lewis JW, Phinney RE, Brefczynski JA, DeYoe EA. (2004) Lefties get it “right” when hearing tool sounds. (submitted).

Furosemide stimulates K transport in HCD57 erythroid cells. J Memb Biol 175:235-244, 2000.