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Department of Physiology and Pharmacology
Center for Interdisciplinary Research in Cardiovascular Sciences

Timothy R. Nurkiewicz

Timothy R. NurkiewiczTimothy R. Nurkiewicz
Assistant Professor

Ph.D., West Virginia University, 1999
Post Doctoral Fellowship, Texas A&M University

Email: tnurkiewicz@hsc.wvu.edu







Research Interests
Mechanisms contributing to the systemic microvascular dysfunction that is triggered by pulmonary exposure to nanoparticles and ambient particulate matter (microvascular/environmental toxicology). These include: local regulation of blood flow, endothelial function, inflammation and mechanotransduction. The degree to which developmental or clinical factors such as age, gender and/or pre-existing disease (i.e. hypertension) influence the intensity of these mechanisms is of primary interest.

Selected References:

  1. Nurkiewicz, T.R. ,D. W. Porter, M. Barger, L. Millecchia, K.M.K. Rao, P.J. Marvar, A.F. Hubbs, V. Castranova, and M.A. Boegehold. Systemic Microvascular Dysfunction and Inflammation After Pulmonary Particulate Matter Exposure . Environmental Health Perspectives. 114:412-419, 2006.
    http://ehp.niehs.nih.gov/members/2005/8413/8413.pdf
  2. Nurkiewicz, T. R. , D.W. Porter, M. Barger, V. Castranova, and Boegehold, M. A. Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation. Environmental Health Perspectives. 112:1299-1306, 2004.
    http://ehp.niehs.nih.gov/members/2004/7001/7001.pdf
  3. Nurkiewicz, T.R. and M.A. Boegehold. Calcium-independent release of endothelial nitric oxide in the arteriolar network: onset during rapid juvenile growth. Microcirculation. 11: 453-462, 2004.
  4. Davis M.J., X. Wu, T.R. Nurkiewicz , J. Kawasaki, P. Gui, M.A. Hill, and E. Wilson. Regulation of ion channels by integrins. Cell Biochemistry and Biophysics . 36(1):41-66, 2002.
  5. Davis , M.J., Wu, X., Nurkiewicz, T.R. , Kawasaki , J., Davis, G.E., Hill, M.A., and Meininger, G.A. Integrins and mechanotransduction of the vascular myogenic response. Am. J. Physiol. Heart Circ. Physiol. 280: H1427-H1433, 2001.
  6. Nurkiewicz, T.R. and M.A. Boegehold. Reinforcement of arteriolar myogenic activity by endogenous angiotensin II: susceptibility to dietary salt. Am. J. Physiol. Heart Circ. Physiol. 279: H269-H278, 2000.