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| Department of Physiology and Pharmacology Mark J. Reasor  Mark J. Reasor Professor of Toxicology Ph.D., The Johns Hopkins University, 1975 Postdoctoral Fellowship, National Institute of Environmental Health Sciences Phone: 304-293-2418 Email: mreasor@hsc.wvu.edu Research Interests Toxicology of the lungs; In vitro toxicology Description of Research Our research focuses on a number of areas related to the toxicological effects of chemicals on the lungs of animals. Studies are directed at characterizing the responses of the lungs to drugs and toxic particles and investigating the mechanisms by which the responses occur. Of particular interest are the toxicities of cationic, amphilphilic drugs and silica particles. We are also interested in developing treatments for these disorders. A number of approaches are being utilized to study these problems including administration of substances to the whole animal and in vitro exposure of isolated cells to compounds. Techniques that are employed include high performance liquid chromatography, isolated cell cultures, and histopathological and functional assessment of tissue damage. Recent Publications M. Sacks, J. Gordon, J. Bylander, D. Porter, X.L. Shi, V. Castranova, W. Kaczmarczyk, K. Van Dyke, and M. J. Reasor. Silica-induced pulmonary inflammation in rats: Activation of NF-kB and its suppression by dexamethasone. Biochem Biophys Res Commun 254:181-184, 1998. Michael D. Taylor, Knox Van Dyke, Linda L. Bowman, Philip R. Miles, Ann F. Hubbs, Robert J. Mason, Kathy Shannon, and Mark J. Reasor. A characterization of amiodarone-induced pulmonary toxicity in F344 rats and idnetification of surfactant protein-D as a potential biomarker for the development of the toxicity. Toxicol Appl Pharmacol 167:182-190, 2000. Mark J. Reasor and James M. Antonini. Pulmonary responses to single versus multiple intratracheal instillations of silica in rats. J Toxicol Environ Health 62:9-21, 2001. Mark J. Reasor and Sam Kacew. Drug-induced phospholipidosis: Are there functional consequences? Exp Bio Med 226:825-830, 2001. |
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