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Department of Physiology and Pharmacology
Anna A. Shvedova - Curriculum Vitae
 Center
for Disease Control and Prevention
National Institute for Occupational Safety and Health
Health Effect Laboratory Division
Pathology and Physiology Research Branch (MS-2015)
1095 Willow dale Road
Morgantown, WV 26505-2888
Phone: (304) 285-6177
Fax: (304) 285-5938
E-mail: ats1@cdc.gov
1522 Denniston Ave.
Pittsburgh, PA 15217
Phone: (412) 521-4564
Education
B.S. MV Lomonosov Moscow State University 1970
M.S. MV Lomonosov Moscow State University 1971
Ph.D. Physiology, Biophysics MV Lomonosov Moscow
State University 1975
D. Sc. Pathophysiology USSR Academy of Sciences,
Moscow 1988
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Professional Appointments
1971-1972 Research Assistant, MV Lomonsov Moscow State University,
Moscow
1972-1978 Research Associate, Institute of Chemical Physics,
USSR Academy of Sciences, Moscow
1978-1984 Staff Research Scientist, Institute of Chemical Physics,
USSR Academy of Sciences
1984-1990 Team Leader, Institute of Chemical Physics, USSR Academy
of Sciences
1990-1991 Visiting Scholar, Department of Molecular and Cell
Biology, University of California, Berkeley, CA 96804
1991-1992 Pharmaceutical Consultant, Medicine Inc, Southampton,
PA 18966
1992-1995 Faculty, Center for Environmental and Occupational
Health and Toxicology, University of Pittsburgh, Pittsburgh, PA
15238
1995-1996 Manager, Nutrition Research, General Nutrition Corporation
(GNC), Pittsburgh, PA 15222
1996-1997 Research Assistant Professor, Department of Obstetrics,
Gynecology and Reproductive Sciences, University of Pittsburgh,
Pittsburgh, PA 15213
1997-Present Senior Staff Scientist, National Institute for Occupational
Safety and Health, Pathology and Physiology Research Branch, Health
Effects Laboratory Division, Morgantown, WV 26505
2001-Current Adjunct Professor of the Department of Physiology
and Pharmacology, West Virginia University, Morgantown, WV
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Professional Societies
Society of Toxicology USA
American Association for Advancement in Science
International Society for Free Radical Research
New York academy of Sciences
Society for Investigative Dermatology
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Special Appointments, Fellowships, And Awards
Bronze and Silver Awards for Achievements in Economics and Science
(USSR, 1989, 1990)
Award for Scientific Achievements, the Institute of Chemical
Physics, USSR, 1988
Award for Scientific Achievements and Merit, the Academy of Sciences
USSR, 1989, 1990
Award of a grant from NIEHS (#ES05651), 1992-1995
Award for outstanding service as the President-Elect of the Allegheny-Erie
Regional Chapter of the Society of Toxicology, 1998
Special recognition award for service as the President of the
Allegheny-Erie Regional Chapter, the Society of Toxicology, 1999
Certificate of appreciation for outstanding service to the Allegheny-Erie
Regional Chapter, the Society of Toxicology as Past President,
2000
Award for meritorious service as founding President of the Dermal
Toxicology Specialty Section, the Society of Toxicology, 2001
The Society of Toxicology Public Communication Award for recognition
of major contributions to broadening the awareness of the general
public to toxicological issues, 2001
Fellow of the Academy of Toxicological Sciences, 2001- current
The Society of Toxicology Women in Toxicology Service Recognition
Award, 2006
Alice Hamilton Award for Excellence in Occupational Safety and
Health, 2006
CDC Charles C. Shepard Science Award; Honorable Mention for Outstanding
Scientific Paper in Laboratory and Methods Category, 2006
Alice Hamilton Award for Excellence in Occupational Safety and
Health, 2006
CDC Charles C. Shepard Science Award; Honorable Mention for Outstanding
Scientific Paper in Laboratory and Methods Category, 2008
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Editorial/Manuscript Review Expirience (Past/Current)
Associate Editor, Toxicology and Applied Pharmacology 2008-current
Editorial Board of Toxicology and Applied Pharmacology 2003- 2007
Editorial Board of Regulatory Toxicology and Pharmacology 2004-2008
Reviewer for Journal Leukocyte Biology 1993-1996
Reviewer for Toxicological Sciences 1997-current
Reviewer for the Journal Industrial Toxicology 2002- current
Ad hoc Reviewer for Toxicology and Applied Pharmacology 2001-
2003
Editorial Board of Toxicology and Applied Pharmacology 2003-
current
Reviewer for Chemical Research in Toxicology 2003- current
Reviewer for nutrition book “Body Stat,” Viking Penguin
Press 1996
Reviewer In Vitro Toxicology 2004-current
Editorial Board of Toxicology & Apply Pharmacology Journal
2003-current
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Honors And Special Scientific Recognition
Chair of Young Investigator Committee, Institute of Chemical
Physics, USSR Academy of Sciences, Moscow, Russia 1981-1989
Secretary of Russian-Indian Chapter, the International Society,
Moscow, Russia 1989-1990
Member of Newsletter Committee, Allegheny-Erie Regional Chapter,
SOT Member of Newsletter Committee, A-E Regional Chapter of SOT
1994-1995
President-Elect, Allegheny-Erie Regional Chapter of SOT 1997-1998
President of Allegheny-Erie Regional Chapter of SOT 1998-1999
Chair of Nomination Committee, Allegheny-Erie SOT 1999-2000
Coordinator for Summer Student Program, NIOSH/CDC 1998-current
Member of Placement Committee, the Society of Toxicology 1999-2001
Founder and Interim President of the Dermal Toxicology Specialty
Section, SOT 1999-2000
President of the Dermal Toxicology Specialty Section, SOT 2000-2001
Who’s Who in America 1996-2000
American Women in Science 1998-1999
Member of New York Academy of Sciences 2001-current
Chairperson of Placement Committee, the Society of Toxicology
2001-2002
Fellow of the Academy of Toxicological Sciences 2001-current
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Specialties By Training Or Experience
Biology, human and animal physiology, membrane toxicology, occupational
toxicology, particle/vapor toxicology, molecular and cellular
toxicology, dermal and pulmonary toxicology, pathophysiology,
physiology and biochemistry of vision, biochemistry and physiology
of nutrition, lipid biophysics and biochemistry, free radical
biology and medicine, inflammatory diseases, cardio- and cerebral
vascular pathophysiology, risk assessment, effects of workplace
exposures on human and animal body functions, preventive measures
of exposures and control/intervention research.
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Current Research Interests
Mechanism of chronic allergic skin and lung disease caused by
industrial chemicals, vapor and particulates. Nanotoxicology.
Free radical reactions and inflammatory cell responses, molecular
regulation of oxidant, pro-inflammatory cytokine and growth factors,
molecular mechanisms of cells damage and apoptosis. Mechanism(s)
of contact sensitization, inflammation, oxidant injury and skin
cancer, mechanism(s) of cellular injury induced by exposures to
phenolic compounds and organic hydroperoxide. Toxicology of nanomaterials
and mechanisms of toxic effects of nanoscale products, risk assessments
and occupational exposures, development of novel cellular and
animal models and early functional biomarkers of detection to
assess human risk of inflammatory, fibrosis and pulmonary diseases,
and skin diseases at work place leading to recommendations for
prevention and control/intervention.
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Teaching, Training And Developing Staff
Teaching and training six pre-doctoral students, 1983-1988.
Supervising and training five Ph.D. students and three post-doctoral
fellows, 1984-90.
Training and supervising five associate researches and technicians,
1987-1989, 1993-97.
Teaching and coordinating summer student program at NIOSH/CDC
and WVU/BRIN program 1998-2002.
Lecturing at West Virginia Science Teacher Association Meeting,
2001.
Supervising and training twenty college students from WVU and
other universities at NIOSH 1997-2005.
Mentoring female students providing leadership and encouraging
them to achieve their professional goals in health sciences and
toxicology field (1997-current).
Supervising Ph.D. student – Ashley Murray, WVU, 2000-2006,
WV, mentoring and training under-gradients, and gradient/rotation
training students (1999-current).
Lecturing in occupational health course, WVU 2003-current.
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Invited Presentations
Allegheny-Erie Regional Chapter, Society of Toxicology, Spring
Meeting, Pittsburgh, PA, May 1998
International Conference on Chemistry of Organic Peroxides, Moscow,
Russia, June 1998
Dermal Investigative Group Meeting, NIOSH/CDC, Cincinnati, OH,
May 1999
International Contact Dermatitis Symposium, San Francisco, CA,
October 1999
Manufacturing Technology and Consumable Product Division, Milacron,
Cincinnati, OH, May 2000
Division of Life Science, King’s College, University of
London, UK, August 2000
Division of Biochemical Toxicology, National Center for Toxicological
Research, FDA, Jefferson, AR,
December 2000
Department of Physiology and Integrative Pharmacology, WVU, Morgantown,
WV, February 2001
Society of Toxicology 40-th Annual Meeting, San Francisco, CA,
March 2001
NanoSpace 2001: Exploring Interdisciplinary Frontiers. International
Conference on Integrative Nano/Microtechnology for Space and Biomedical
Applications, NASA, Galveston, TX, March 2001
Meijo University, Section of Radiochemistry, Faculty of Pharmaceutical
Sciences, Nagoya, Japan, January 2002
NIOSH Ultrafine Aerosol Workshop, Wheeling, WV, Sept. 16 - 17,
2003
Institute Physico-Chemical Medicine, Moscow, Russia, Oct. 18-22,
2003
NASA/JSC-ES4/GBT, Houston, TX, Nov. 14-16, 2003
THE TOXICOLOGY FORUM's, 29-th Toxicology Annual Winter Meeting
Washington DC, February 2-4, 2004
INTERNATIONAL CONGRESS OF NANOMATERIALS,
227TH AMERICAN CHEMICAL SOCIETY MEETING, Symposium: Nanotechnology
& the Environmental Toxicology & Bio-interactions of Nano-materials,
March 28-April 1, 2004
Nanotoxicology Workshop, Gainsville, Fl. Nov 3 - 4 2004
International Congress on Nanotechnology, San Francisco, CA,
Nov 7 - 10, 2004
National Nanonotechnology Infrastructure Network (NNIN): (Nanosafe:
A workshop on Environmental Health and Safety in Nanotechnology
Research), Atlanta, GA, Dec 1-3, 2004
229th American Chemical Society National Meeting, San Diego, CA
2005, April 12-15
2nd International Symposium on Nanotechnology and Occupational
Health, Minneapolis, MN, October 3-6, 2005
ILSI Health and Environmental Science Institute: Nanomaterial
Safety EHS Subcommittee,
Washington, DC October 11, 2005
8th International Meeting on Effects of Mineral Dusts and Nanoparticles,
EPA, Triangle
Park, NC, October 25 – October 28, 2005
1st International Meeting: Nanotoxicology: Biomedical Aspects,
Miami, FL, January 29 -
February 1, 2006
Nobel Mini-Symposium on Nanotoxicology: Potential Risks and Safety
Assessment,
Karolinska Institute, Stockholm, Sweden, November 27, 2006
International Conference on Nanotechnology: Occupational and Environmental
Health &
Safety: Research to Practice, Cincinnati, OH, December 4-7, 2006
2nd International Nanotoxicology Meeting, Venice, Italy, April
18-21, 2007
FASEB/ASPET, Experimental Biology Meeting, Washington, DC, April
30-May 2, 2007
ICON Workshop: “Towards Predicting Nano-Bio Interactions”,
June 5 - 7, 2007, Zurich,
Switzerland
3rd NASA-NIST Workshop on Nanotube Measurements, NIST, Gaithersburgh,
MD, USA,
Sep 26-28, 2007
European NanOSH Conference –Nanotechnologies: A Critical
Area in Occupational Safety and
Health, Helsinki, Finland, 3–5 December 2007
Mary Babb Randolph Cancer Center – National Institute of
Occupational Safety and Health
MBRCC - NIOSH Scientific Retreat in Cancer, Morgantown, West Virginia,
February 12, 2008
NATO workshop: Risk, Uncertainty and Decision Analysis for Nanomaterials:
Environmental Risks and Benefits and Emerging Consumer Products,
Portugal, Faro, April 26-30, 2008
American Thoracic Society (ATS), Toronto, May 16-21, 2008
Nanotoxicology 2nd International meeting, Switzerland, Zurich,
September 7-10, 2008
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Organizing And Chairing Meetings/Workshops
Toxicology in Court,” Allegheny-Erie Chapter, Society of
Toxicology, Fall Meeting, October 28, 1997
Women Health Issue: Consideration to Toxicological Studies, Allegheny-Erie
Chapter, Society of Toxicology, Spring Meeting, May 15, 1998
Paracelsus Goes to School- Science Teacher Workshops, Pittsburgh,
PA, May 14, 1998; Cuyahoga Falls, OH, June 2, 1999; Pittsburgh,
PA, May 16, 2000
Phenolic Compounds: Free Radical Mechanisms of Toxicity, Catalysis,
and Protections, Symposium, Society of Toxicology 40th Annual
Meeting, San Francisco, CA, March 29, 2001
How to Market Yourself as a Toxicologist, 41st Annual Society
of Toxicology Meeting, March 18, 2002, Nashville, TN
3rd International Conference on Oxygen/Nitrogen Radicals: Cell
Injury and Disease, Morgantown, WV, June 1-5, 2002
Reactive Oxygen and Nitrogen Species: Diagnostic, Preventive,
and Therapeutic Values, International Symposium,” Pre-Symposium
to the XI-th Biennial Meeting of the Society for Free Radical
Research International, St. Petersburg, Russia, July 9-13, 2002
Occupational Skin Exposure: Current Trends and Future Directions
from the Field to Genomics, symposium, 43-rd Annual SOT Meeting,
Baltimore, March 21-25, 2004
Toxicology Forum, February 2-4, 2004
227th American Chemical Society National Meeting, March 28-April
1, 2004
44th annual Society of Toxicology Meeting, March 6-11, New Orleans,
CA 2005
1st International Symposium, Nanotoxicology: Biomedical Aspects,
Miami, FL 2006
Nobel Mini-Symposium on Nanotoxicology: Potential Risks and Safety
Assessment,
Stockholm, Sweden, November 27, 2006
Invited workgroup expert at “Predicting Nano-Bio Inter-actions”
at the International Council on Nanotechnology (ICON) focused
on the development of a framework for understanding the interactions
between engineered nanoparticles and biological systems at the
molecular level, Zurich, Switzerland, June 4-8, 2007
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Interagency and Cooperative Agreements/Joint
Research
Memorandum of Understanding NIOSH/NASA (2003-current)
NIOSH/FDA (2002-2005)
University of London/NIOSH, London, UK (2001-current)
EPA/NIOSH Toxic Substances Control Act (TSCA) review committee on
Carbon Nanoparticles (2005)
University of Pittsburgh/NIOSH/EPA/NIEHS Nanotoxicology meeting
(2006)
WVU/NIOSH/ NIEHS (2001-current)
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Peer-Reviewer and Site Visit Evaluation
Expert review panel to evaluate the progress of a DOD Multi-Disciplinary
University Initiative “Research between Physicochemical Characteristics
and Toxicological Properties of Nanomaterials”, funded by
Air Force Office of Scientific Research, Rochester, MN, October
12, 2006.
Publications
More than 100 papers in Journals
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Presentations At National And International Meetings
Presentations at more than 60 Congresses and Meetings
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Patents
Antioxidant drug EMOXIPIN is patented as a “Retinoprotector
for Treating Intraocular Hemorrhage, Myopic, Chorioretinal Dystrophies,
Congenital Retinal Dystrophies, Retinal Burns and Prevention of
Injury in Laser Coagulation” in:
US 4486440
FR 83143339-2551 659
CH 658595
DE 3330053C2
IT 1197696
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Bibliography
Full-length manuscripts:
1. Kagan VE, Shvedova AA, Novikov KN, Kozlov YP. Light-induced
free radical oxidation of membrane lipids in photoreceptors of
frog retina. Biochem. Biophys. Acta 330: 76-79, 1973.
2. Novikov KN, Shvedova AA, Kagan VE, Kozlov YP, Ostrowsky MA.
Photo- induced changes in photoreceptor membranes and rhodopsin
revealed by craft-co-polymerization. Biophys.USSR 19(2): 280-284,
1974.
3. Sibeldina LA, Kagan VE, Shvedova AA, Novikov KN, Kobelev VS.
NMR study of molecular organization of photoreceptor membranes.
Proc. Natl. Acad. Sc. USSR 224(2): 228- 231, 1975.
4. Novikov KN, Kagan VE, Shvedova AA, Kozlov YP. Lipid-protein
Interactions in photoreceptor membranes under lipid peroxidation.
Biophys. USSR 20 (6): 1039-1042, 1975.
5. Kagan VE, Shvedova AA, Novikov KN, Kozlov YP. Effects of conformational
rearrangements on spontaneous and induced lipid peroxidation in
frog retina rod outer segments. Biophys. USSR 20 (6): 1043-1048,
1975.
6. Novikov KN, Shvedova AA, Tyurin VA, Shukolyukov SA, Kagan
VE. On the role of lipid composition in kinetics of phospholipids
free radical oxidation in photoreceptor membranes. Biophys. USSR
22 (5): 942-944, 1977.
7. Kagan VE, Shukolyukov SA, Tyurin VA, Shvedova AA, Korchagin
VP, Galuschenko IV. Effects of chemical modification of lipids
by molecular oxygen on thermal stability of rhodopsin in photoreceptor
membranes of wall-eyed pollock. Studia Biophys. 72 (1): 51-58,
1978.
8. Kagan VE, Shvedova AA, Novikov KN. Participation of phospholipases
in repair of photoreceptor membranes after lipid peroxidation.
Biophys. USSR 23 (2): 279-284, 1978.
9. Shvedova AA, Ostrowsky MA, Bogoslowsky Al, Scherbatova Ol,
Zueva MV, Trutneva KV. Damage of the retina by visible light and
the role of antioxidant. Excerpta Medica 442: 114, 1978.
10. Shcherbatova OI, Zueva MV, Shvedova AA, Shamshinova AM, Kaban
AA. State of the organ of vision in workers in the diamond-processing
industry. Vestn Ophthalmology. 3:56-9, 1980.
11. Iakovlev AA, Shvedova AA, Ostrovskii MA. Effect of antioxidants
on the oxygenation and bio-potentials of the retina (experimental
studies). Vestn Oftalmol. 2):37-40, 1978
12. Kagan VE, Lankin VZ, Shvedova AA, Novikov KN, Dobrina SK,
Bratkovskaya LB, Kuliev IY. Enzymic and non-enzymic protective
antioxidant systems in photoreceptors. Bull. Exp. Biol. Med. USSR
8:164-166, 1979.
13. Shvedova AA, Sidorov AS, Novikov KN, Galuschenko IV, Kagan
VE. Lipid peroxidation and electric activity of the retina. Vision
Res. 19: 49-55, 1979.
14. Ostrowscky MA, Bogoslowsky AL, Zueva MV, Shvedova AA. Investigation
of the mechanisms of visible light injury on the normal animal
retina. Vest. Acad. Med. Sci. USSR 12:57-61, 1979.
15. Korchagin VP, Bratkovskaya LB, Shvedova AA, Arkhipenko YV,
Kagan VE, Shukolyukov SA. Oligomerization of intrinsic membrane
proteins in the course of lipid peroxidation. Biochem. USSR 45
(10):1767-1772, 1980.
16. Bratkovskaya LB, Novikov KN, Shvedova AA, Polischuk RF, Kagan
VE, Kozlov YP. Pyridine nucleotide-dependent systems of lipid
peroxidation induction in retina photoreceptors. Biol. Sciences
6: 21-26, 1981.
17. Kuliev IY, Shvedova AA, Kagan VE, Krasnovsky AA, Kozlov YP.
Light induced damage of the retina: participation of singlet oxygen
and lipid peroxidation. Proc. Natl. Acad. Sc. USSR 263(5):1005-1009,
1982.
18. Shvedova AS, Kagan VE, Kuliev IY, Dobrina SK, Prilipko LL,
Meerson FZ, Kozlov YP. Lipid peroxidation and damage of the retina
in stress exposed rats. Bull. Exp. Biol. Med. USSR 4:24-27, 1982.
19. Polyansky NB, Smirnov LD, Shvedova AA, Kagan VE, Tkachuk
VA. Inhibition of phosphodiesterase of cyclic nucleotide from
rabbit heart by 3-hydroxypyridines. Problems Med.Chem. 1: 123-127,
1983.
20. Shvedova AA, Kagan VE, Kuliev IY, Vekshina OM. Mechanisms
of retina damage by fluorescent dyes. Bull. Exp. Biol. Med. USSR
8: 48-50, 1983.
21. Kagan VE, Bratkovskaya LB, Kuliev IY, Shvedova AA. The role
of lipid peroxidation in retina damage under hyperbaric oxygenation
and possibility of chemical protection by antioxidants. Proc.
Natl. Acad. Sci. USSR 271 (1): 227-230, 1983.
22. Shvedova AA, Alekseeva OM, Kuliev IY, Muranov KO, Kozlov
YP, Kagan VE. Damage of photoreceptor membrane lipids and proteins
induced by photosensitized oxidation. Curr. Eye Res.2 (10): 683-690,
1983.
23. Polyansky NB, Smirov LD, Shvedova AA, Kagan VE. Inhibition
of cyclic nucleotide phosphodiesterase from frog rod outer segments
by 3-hydroxypyridines. Biol. Sciences 1: 27-31, 1984.
24. Shvedova AA. Molecular mechanisms of emoxipin effect. In:
Emoxipin, Medexport, Moscow, USSR, pp. 2-19, 1984.
25. Shvedova AA, Fedulov AS, Marchenko LN, Zayats GR. Experimental
application of emoxipin in treatment of traumatic hemophthalmia.
In: Emoxipin, Medexport, Moscow, USSR, pp. 19-20, 1984.
26. Katznelson LA, Nikolskaya VV, Beglyarova AS, Shvedova AA.
Emoxipin in treatment of exudative forms of retinopathy. In: Emoxipin,
Medexport, Moscow, USSR, pp. 21-22, 1984.
27. Katsnelson LA, Gurtovaya EE, Malyuta GD, Bogdanova LV, Shvedova
AA. Emoxipin in treatment of hemophthalmia In: Emoxipin, Medexport,
Moscow, USSR, pp.22-23, 1984.
28. Katsnelson LA, Gurtovaya EE, Nikolskaya VV, Bogdanova LV,
Shvedova AA. Emoxipin in treatment of retinal vein thrombosis.
In: Emoxipin, Medexport, Moscow, USSR, pp. 24-25, 1984.
29. Katsnelson LA, Agranovich MS, Gurtovaya EE, Karpova NA, Rosenfeld
IA, Shvedova AA. Emoxipin in treatment of central chorioretinal
dystrophies (CCRD). In: Emoxipin, Medexport, Moscow, USSR, pp.
25-26, 1984.
30. Makarskaya NV, Brovkina AF, Shvedova AA, Akhmedzhanova EV.
Prospects for emoxipin application in the case of laser destruction
of intraocular vascular tumors. In: Emoxipin, Medexport, Moscow,
USSR, pp. 32-35, 1984.
31. Bogdanova LV, Katsnelson LA, Shvedova AA. Medication of laser
and sun burns of the retina with emoxipin preparation. In: Emoxipin,
Medexport, Moscow, USSR, pp. 38, 1984.
32. Katsnelson LA, Dnestrova GI, Yelyseyeva RF, Shvedova AA.
Application of emoxipin for treatment of stargardt disease. In:
Emoxipin, Medexport, Moscow, USSR, pp. 41-43, 1984.
33. Kleimenov AN, Rozenfel'd MA, Burlakova EB, Zenkov IuV, Shvedova
AA. Effect of the antioxidant OP-6 on some model reactions of
the blood coagulation system. Vopr Med Khim. 29(1):33-7, 1983
34. Kagan VE, Polyansky NB, Muranov KO, Shvedova AA, Smirnov
LD, Dyumaev KM. Suppression of aggregation and inhibition of phosphodiesterase
of cyclic nucleotide in platelets by 3- hydroxypyridines. Bull.
Exp. Biol. Med. USSR 4: 41 6-41 8, 1984.
35. Komarov PG, Bilenko MV, Shvedova AA, Kagan VE. Evaluation
of the efficiency of different compounds in inhibition of enzymic
lipid peroxidation. Probl. Med. Chem. 2: 40-45, 1985 (in Russian).
36. Babijaev MA, Shvedova AA, Arkhipenko YV, Kagan VE. Accumulation
of lipid peroxidation products in cataract lenses. Bull. Exp.
Biol. Med. USSR 9: 299301, 1985.
37. Muranov KO, Polyansky NV, Shvedova AA, Smirov LD, Kagan VE.
Changes in the cyclic nucleotide level and the inhibition of human
platelet aggregation upon exposure to 3-hydroxypyridines. Bull.
Exp. Biol. Med. USSR 10: 432434, 1986.
38. Muranov KO, Gashev SB, Smirov LD, Shvedova AA, Ritov VB.
Inhibition of platelet aggregation by antioxidants. Bull. Exp.
Biol. Med. USSR 3: 337-339, 1986.
39. Kagan VE, Ivanova SM, Murzakhmetova MK, Shvedova AA, Smirnov
LD. Antioxidants-stabilizers to the Ca++-transport enzyme system
in sarcoplasmic reticulum membranes in vivo. Bull. Exp. Biol.
Med. USSR 11: 52-54, 1986.
40. Egorov CJ, Babijaev MA, Krasnovsky AA, Shvedova AA. Photosensitized
generation of singlet oxygen by endogenous substances of the eye
lens. Biophys. USSR 32: 169-172, 1987.
41. Shvedova AA, Platonov ES, Polyansky NV, Babijaev MA, Kagan
VE. The chemical nature of the fluorescent products accumulating
in the lipids of the lenses in mice with hereditary cataract.
Bull. Exp. Biol. Med. USSR 3: 301-304, 1987.
42. Shvedova AA, Polyansky NB, Akopyan GK, Dzhafarov Al. Effect
of emoxipin on basal cyclic nucleotide phosphodiesterase activity
and late receptor potential of isolated retina. Bull. Exp. Biol.
Med. USSR 9: 289-291, 1989.
43. Pashin EN, Shvedova AA. The effect of a synthetic antioxidant
emoxipin on coronary vessels tone. Pharmacol. Toxicol. USSR 52:
17-19, 1989.
44. Egorov EA, Shvedova AA, Obraztsova IA. The results of clinical
trial of antioxidant emoxipin in an ophthalmology setting. Vest.
Ophthalmol. 5: 52-55, 1989.
45. Golikov AP, Ovchinnikov VL, Polumiskov VUY, Davydov BV, Karev
VA, Konorev LA, Shvedova AA. Antioxidant Emoxipin: The effects
on formation of necrotic and reparative processes in myocardial
infarction. Cardiol. USSR 7: 50-53, 1990.
46. Kocherginsky NW, Shvedene NV, Shvedova AA. Detection of emoxipin
with a membrane electrode. Chem. Pharmaceut. J. USSR 24 (12):
77-78, 1990.
47. Horseva Ml, Kocherginsky NW, Shvedova AA. Transport of tetracycline
antibiotics through biomimetic membranes. Biotech. Bulgaria 1:
39-43, 1990.
48. Mishina EV, Filippenko NG, Pichugin VV, Zherdev VP, Lebedev
AV, Kameneva NV, Shvedova AA. Pharmacokinetic and pharmacodinamic
of Emoxipin under normal and pathological conditions. Bull. Exp.
Biol. Med. USSR 10: 389-390, 1990.
49. Shvedova AA, L'vov KM, Polianskii NB, Bekmurzaev BM. Study
of soluble proteins in mouse normal and cataract lenses. Bull.
Exp. Biol. Med. USSR, 6: 609-610, 1991.
50. Kagan VE, Serbinova EA, Maguire JJ, Shvedova AA, Packer L.
On the path from ubiquin one to ubiquinol: chain breaking lipid
peroxyl radical scavenging or vitamin E radical recycling? In:
Oxidative Damage and Repair (Chemical, Biological and Medical
Aspects), K.J.A. Davies, Ed., Pergamon Press, 121-125, 1991.
51. Kagan VE, Shvedova AA, Serbinova EA, Khan S, Swanson K, Powell
R, Packer L. Dihydrolipoic acid acts as a universal antioxidant
both in the membrane and in the aqueous phase. Reduction of peroxyl,
ascorbyl and chromanoxyl radicals. J. Biochem. Pharmacol. 8:1637-1649,
1992.
52. Shvedova AA, Kramarik JA, Keohavong P, Chumakov KM, Karol
MH. Use of anti-TNF-? antiserum to investigate toxic alveolitis
arising from cotton dust exposure. Exp. Lung Res. 20: 297-315,
1994.
53. Menshikova EV, Ritov VB, Shvedova AA, Elsayed N, Karol MH,
Kagan VE. Pulmonary microsomes contain a Ca++-transport system
sensitive to oxidative stress. Biochem. Biophys. Acta 1228: 165-174,
1995.
54. Shvedova AA, Kisin ER, Kagan VE, Karol MH. Increased lipid
peroxidation and decreased antioxidants in lungs of guinea pigs
following an allergic pulmonary response. Toxicol. Appl. Pharmacol.
132: 72-81, 1995.
55. Shvedova AA, Menshikova EV, Ritov VB, Kagan VE, Karol MH.
Murine pulmonary Ca++-transport system activated by allergic immune
response retains sensitivity to oxidative stress. Exp. Lung Res.
21: 743-769, 1995.
56. Shvedova AA, Satoh T, Tollerud D, Guevarra L, Karol MH. Elevated
levels of IL-6, INF-?, and TNF-? in mice in response to cotton
dust are modulated by anti-TNF-? antiserum. Exp. Lung Res. 22:
149-161, 1996.
57. Shvedova AA, Tyurina YY, Gorbunov NV, Tyurin VA, Castranova
V, Kommineni C, Ojimba J, Gandley R, McLaughlin M, Kagan VE. tert-Butyl
hydroperoxide/hemoglobin-induced oxidative stress and damage to
vascular smooth muscle cells. Biochem. Pharmacol. 57: 989-1001,
1998.
58. Shvedova A, Osipov A, Kommineni C, Jeffries B, Castranova
V, Vallyathan V, Kagan V. Peroxidase/H2O2 enhances hypersensitivity
responses Induced by eugenol: inhibitory effect of an antioxidant,
lipoic acid. Env. Nutr. Interact. 3: 15-31, 1999.
59. Shvedova AA, Kommineni C, Jeffries B, Castranova V, Tyurina
YY, Tyurin VA, Serbinova EA, Fabisiak JP, Kagan VE. Redox cycling
of phenol induces oxidative stress in human keratinocytes: evidence
for enhanced lipid and thiol oxidation and antioxidant depletion,
J. Invest. Derm. 114: 354-364, 2000.
60. Kagan VE, Kuzmenko AI, Shvedova AA, Kisin ER, Tyurina YY,
Yalowich JC. Myeloperoxidase-catalyzed phenoxyl radicals of vitamin
E homologue, 2,2,5,7,8-Pentamethyl-6-hydroxylchromane, do not
induce oxidative stress in live LH-60 cells. Biochem. Res. Com.270.
1086-1092, 2000.
61. Kagan VE, Fabisiak JP, Shvedova AA, Tyurina YY, Tyurin VA,
Schor NF, Kawai K. Oxidative signaling pathway for externalization
of plasma membrane phosphatidylserine during apoptosis. FEBS Letters,
477, 1-7. 2000.
62. Tyurina YY, Shvedova AA, Kawai K, Tyurin VA, Kommineni C,
Quinn PJ, Schor NF, Fabisiak JP, Kagan VE. Phospholipid signaling
in apoptosis: peroxidation and externalization of phosphatidylserine.
Toxicology. 148, 93-101, 2000.
63. Al-Humadi NH, Shvedova AA, Battelli L, Diotte N, Castranova
V, Kommineni C. Dermal and systemic toxicity after application
of semi-synthetic metal working fluids in B6C3F1 mice. J. Tox.
Environ. Health 61:579-589, 2000.
64. Shvedova AA, Kisin E, Kisin J, Castranova V, Kommineni C.
Elevated oxidative stress in skin of B6CF1 mice affects dermal
exposure to metal working Fluid. Ind. Toxicol. Ind. Health, 16(7-8):267-76,
2001.
65. Shvedova AA, Tyurina YY, Tyurin VA, Kikuchi Y, Kagan VE,
Quinn, PJ. Quantitive Analysis of phospholipid peroxidation and
antioxidant protection in live human keratinocytes, Bioscience
Reports, 21(1):33-43, 2001.
66. Kagan VE, Kozlov AV, Tyurina YY, Shvedova AA, Yalowich JC.
Antioxidant mechanisms of NO against iron-catalyzed oxidative
stress in cells. Antioxidants and Redox Signal. 3(2):189-202,
2001.
67. Kagan VE, Kuzmenko AI, Tyurina YY, Shvedova AA, Matsura T,
Yalowich JC. Pro-oxidant and antioxidant mechanisms of etoposide
in HL-60 cells: role of myeloperoxidase. Cancer Res. 61(21):7777-84,
2001.
68. Shvedova AA, Tyurina BYY, Kawai K, Tyurin VA, Kommineni C,
Castranova V, Fabisiak JP, Kagan VE. Selective peroxidation and
externalization of phosphatidylserine in normal human epidermal
keratinocytes during oxidative stress induced by cumene hydroperoxide.
J. Invest. Dermatol. 118(6):1008-18, 2002.
69. Johnson EA, Shvedova AA, Kisin E, O’Callaghan JP, Kommineni
C, Miller, DB. D-MDMA during oxidative stress: effects on dopaminergic
neurotoxicity and hepatotoxicity. Brain Res. 933 (2) 150-163,
2002.
70. Kagan VE, Shvedova AA, Tyurina YY, Tyurin VA, Fabisiak JP,
Schor NF. Peroxidation of phosphatidylserine in mechanisms of
apoptotic signaling. Redox Cell Biology & Genetics, Methods
in Enzymology 352:159-74, 2002.
71. Tyurina YY, Tyurin VA, Liu SX, Smith CA, Shvedova AA, Schor
NF, Kagan VE. Phosphatidylserine peroxidation during apoptosis.
A signaling pathway for phagocyte clearance. Subcell Biochem.
36:79-96. Review, 2002.
72. Kagan VE, Kisin ER, Kawai K, Serinkan BF, Osipov AN, Serbinova
EA, Wolinsky I, Shvedova AA. Towards mechanisms-based antioxidant
interventions: lessons from natural antioxidants. Ann. N.Y Acad
Sci. 959: 188-199, 2002.
73. Modriansky M, Tyurina YY, Tyurin VA, Matsura T, Shvedova
AA, Yalowich JC, Kagan VE. Anti-/pro-oxidant effects of phenolic
compounds in cells: are colchicine metabolites chain-breaking
antioxidants? Toxicology, (1):105-17, 2002.
74. Shvedova AA, Kisin ER, Murray AR, Smith S, Castranova V,
Kommineni C. Enhanced Oxidative Stress in the skin of vitamin
E deficient mice exposed to semi-synthetic metal working fluid.
Toxicology, 176(1-2):135-43, 2002.
75. Shvedova AA, Kisin ER, Murray AR, Goldsmith T, Reynolds JS,
Castranova V, Frazer DG, Kommineni C. Metal working fluids: sub-chronic
effects on pulmonary functions in B6C3F1 mice given vitamin E
deficient and sufficient diets. Toxicology, 177(2-3):285-297,
2002.
76. Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova
V, Mason RP, Kadiiska MB, Gunther MR, Antioxidant Balance and
Free Radical Generation in Vitamin E-Deficient Mice after Dermal
Exposure to Cumene Hydroperoxide. Chem Res Toxicol.15(11):1451-1459,
2002.
77. Tyurina YY, Tyurin VA, Shvedova AA, Fabisiak JP, KaganVE.
Peroxidation of phosphatidylserine in mechanisms of apoptotic
signaling. Methods Enzymol. 352:159-74, 2002.
78. Kagan VE, Kuzmenko A.I, Shvedova AA, Kisin E.R., Li R., Martin
I., Quinn P.J., Tyurin V.A., Tyurina Y.Y., Yalowich J.C.. Direct
evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals
of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane,
by ascorbate/dihydrolipoate in living HL-60 cells. Bioch. Bioph.
Acta , 2003, 1620(1-3):72-84.
79. Kagan VE, Borisenko GG, Serikan BF, Tyurina YY, Tyurin VA,
Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Fadeel B. Appetizing
rancidity of apoptotic cells for macrophages: oxidation/externalization/recognition
of phosphatidylserine. Am. J. Phys., 2003, 285(1):L1-17.
80. Shvedova AA, Kisin ER, Murray AR., Schwegler-Berry D, Gandelsman
VZ, Maynard A, Paul Baron, Castranova V. Exposure to carbon nanotube
material II: assessment of the biological effects of nanotube
materials using human keratinocytes. J. Tox. Env.Health, 66, 1901-1918,
2003
81. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova
V. Exposure to Carbon Nanotube Material I: Aerosol Release During
the Handling of Unrefined Single Walled Carbon Nanotube Material.
J. Tox. Env. Health, 2004, 67(1):87-107
82. Shvedova AA, Kisin ER, Murray A, Kommineni C, Vallyathan
V, Castranova V. Pro/antioxidant status in murine skin following
topical exposure to cumene hydroperoxide throughout the ontogeny
of skin cancer. Biochemistry (Moscow), 2004, 69 (1), 23-31
83. Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman
V, Baron P, Maynard A, Gunter M, Castranova V. Exposure of human
bronchial cells to carbon nanotubes caused oxidative stress and
cytotoxicity. Proceedings of the Meeting of the SFRR Europe (June
26-29, 2003), Vol. ISBN 88-7587-002; CD ISBN 88-7587-003-9, 2004
http://www.monduzzi.com/proceedings/moreinfo/20030627.htm
84. Matsura T, Masachika K, Yamada K, Shvedova AA, Kagan VE.
Fine-tuning phagocytic clearance of apoptotic cells by phosphatidylserine
oxidation. J. Clin. Biochem. & Nutr., 34, 11-24, 2003
85. Jiang J, Borisenko GG, Osipov A, Martin I, Chen R, Shvedova
AA, Sorokin A, Tyurina YY, Potapovich A, Tyurin VA, Graham SH,
Kagan VE. Arachidonic acid-induced carbon-centered radicals and
phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12
cells. J Neurochem. 90 (5):1036-49, 2004
86. Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman
V, Baron P, Maynard A, Gunter M, Kagan V.E., Castranova V. Assessment
of Carbon Nanotube Cytotoxicity Using Human Cells and Animal Models.
Proceeding of the Toxicology Forum 29th Annual meeting, p. 697-710
(Feb, 2-4, Washington, DC, 2004), 2004 (http://www.toxforum.org/Winter_2004.pdf)
87. Heck DE, Kagan VE, Shvedova AA, Laskin JD. An Epigrammatic
(abridged) recounting of the myriad tales of astonishing deeds
and dire consequences pertaining to nitric oxide and reactive
oxygen species in mitochondria with an ancillary massive concerning
origins of apoptosis. Toxicology. 208(2):259-71, 2005
88. Shvedova A, Kisin E, Mercer R, Murray A, Johnson VJ, Potapovich
A, Tyurina Y, Gorelik O, Arepalli S, Schwegler-Berry D, Antonini
J, Evans DE, Ku B-K, Ramsey D, Maynard A, Kagan V.E., Castranova
V, Baron P. Unusual inflammatory and fibrogenic pulmonary responses
to single walled carbon nanotubes in mice. Am J Physiol Lung Cell
Mol Physiol. 289, L698-L708, 2005
89. Kagan VE, Bayir H, Shvedova. Nanomedicine and nanotoxicology:
Two sides of the same coin. J. Nanomedicine: Nanotechnology, Biology
and Medicine 1, (4), 313-316, 2005
90. Kagan, A.I. Potapovich, A.N. Osipov, Y.Y. Tyurina, E.R. Kisin,
D. Schwegler-Berry, R. Mercer, V. Castranova, A.A. Shvedova. Oxidative
interactions of single walled carbon nanotubes with RAW 264.7
macrophages: role of iron. Toxicol Lett. 165(1):88-100, 2006
91. Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina
YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST,
Greenberger JS, Shvedova AA, Kagan VE. Apoptotic interactions
of cytochrome c: redox flirting with anionic phospholipids within
and outside of mitochondria. Biochim Biophys Acta. 1757(5-6):648-59,
2006.
92. Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AA, Vlasova
II, Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger
J, Dekosky S, Shvedova AA, Jiang J
The "pro-apoptotic genies" get out of mitochondria:
Oxidative lipidomics and redox activity of cytochrome c/cardiolipin
complexes.Chem Biol Interact.163 (1-2):15-28, 2006
93. Li Z, Hulderman T, Salmen R, Chapman R, Leonard SS, Young
SH, Shvedova A, Luster MI, Simeonova PP. 2006. Cardiovascular
Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes
Environ Health Perspect: 115(3):377-82, 2007
94. Murray A, Kisin ER, Kommineni C, Vallyathan V, Castranova
V, Shvedova AA. Pro/antioxidant status and AP-1 transcription
factor in murine skin following topical exposure to cumene hydroperoxide.
Carcinogenesis 28(7):1582-8, 2007
95. Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich
AI, Cai P, Bayir H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel
B, Kagan VE. Nitrosative stress inhibits the aminophospholipid
translocase resulting in phosphatidylserine externalization and
macrophage engulfment: Implications for the resolution of inflammation.
J Biol Chem. 282(11):8498-509,2007
96. Shvedova AA, Sager T, Murray AR, Kisin E, Porter DW, Leonard
SS, Schwegler-Berry D, Robinson VA, Castranova V. Critical issues
in the evaluation of possible adverse pulmonary effects from airborne
nanoparticles. Nanotoxicology, Characterization, Dosing and Health
Effects. Publisher: Informa Healthcare, USA Inc, NY, London, 2007
97. Kagan VE, Rao KMK, Kisin ER, Young S-H, Meighan T, Murray
AR, Tyurina YY, Castranova V, Shvedova AA. Pulmonary Effects of
single-walled carbon nanotubes: inflammatory response, oxidative
stress/signaling, and recognition by macrophages. Nanotechnology-Toxicological
issues and environmental safety, 65-75, Publisher: Springer, 2007
98. Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S,
Castranova V, Young SH, Gao F, Tyurina YY, Oury TD, Kagan VE.
Vitamin E deficiency enhances pulmonary inflammatory response
and oxidative stress induced by single-walled carbon nanotubes
in C57BL/6 mice.
Toxicol Appl Pharmacol. 2007 221(3):339-48, 2007.
99. Fadeel B, Kagan V, Krug H, Shvedova A, Svartengren M, Tran
L, Wiklund L. There’s plenty of room at the forum: Potential
risks and safety assessment of engineered nanomaterials. Nanotoxicology,
1 (2), 73-84, 2007
100. Murray AR, Kisin ER, Castranova V, Gunther MR, Kommineni
C. Shvedova AA. Phenol- induced in vivo oxidative stress in skin:
evidence for enhanced free radical generation, thiol oxidation,
and antioxidant depletion. Chem. Res. Toxicol. 20(12):1769-77.
101. Kisin ER, Murray AR, Keane MJ, Shi XC, Schwegler-Berry D,
Gorelik O, Arepalli S, Castranova V, Wallace WE, Kagan VE, Shvedova
AA. Single-walled carbon nanotubes: geno- and cytotoxic effects
in lung fibroblast V79 cells. J Tox Env Health A. 70(24):2071-9,
2007
102. Baron PA, Deye GJ, Chen B-T, Schwegler-Berry D, Shvedova
AA, Castranova V. Aerosolization of Single-Walled Carbon Nanotubes
for an Inhalation Study. Inhal Tox (20):8, 751 – 760, 2008
103. Mercer RR, Scabilloni J, Wang L, Kisin E, Murray AR, Schwegler-Berry
D, Shvedova AA,
Castranova V. Alteration of deposition pattern and pulmonary response
as a result of improved dispersion of aspirated single-walled
carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol
Physiol. 294(1):L87-97, 2008
104. Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Roberts JR,
Tyurina YY, Antonini JM, Feng WH, Kommineni C, Reynolds J, Barchowsky
A, Castranova V, Kagan VE. Sequential Exposure to Carbon Nanotubes
and Bacteria Enhances Pulmonary Inflammation and Infectivity.
Am J Respir Cell Mol Biol. Vol. 38. pp 579–590, 2008
105. Shvedova AA, Kisin E, Murray AR, Kommineni C, Castranova
V, Fadeel B, Kagan VE.
Accumulation of neutrophils and decreased fibrosis in NADPH oxidase-deficent
C57BL/6 mice exposed
to carbon nanotubes. Tox. Appl. Pharm. 231(2):235-40, 2008.
106. Shvedova AA, Kisin E, Murray AR, Johnson, VJ, Gorerlik O,
Arepalli S, F. Hubbs, R. R. Mercer, P. Keohavong, N. Sussman,
J. Jin, J. Yin, S. Stone, B. T.Chen, G. Deye, A. Maynard, V. Castranova,
P. A. Baron, V. E. Kagan. Am J Physiol Lung Cell Mol Physiol.,
295(4):L552-65, 2008
107. Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A,
Gnewuch H, Kenawy E-R, Korensten R, Kuhlbusch T, Linker F, Matias
S, monteiro-Riviere N, pinto V, Rudnitsky R, Savolainen K, Shvedova
A. Disposition of Nanoparticles as a Function of their Interactions
with Biomolecules. In “Nanomaterials Risks and Benefits”,
Eds. Linkov & Steevens, Springer, pp 4-19, 2009 (Proceedings
of the NATO Advanced Research Workshop on Nanomaterials: Environmental
Risks and Benefits” Faro, Portugal 27-30 April 2008).
108. Shvedova AA, Kisin ER, Porter D, Schulte P, Kagan VE, Fadeel
B, Castranova V, Mechanisms of Pulmonary Toxicity and Medical
Applications of Carbon Nanotubes: Two Faces of Janus? Pharmacol.
Ther. December 6, 2008, PMID: 19103221. [Epub ahead of print]
109. Murray AR, Kisin ER, Leonard SS, Houng SH, Kommineni C,
Kagan VE, Castranova V, Shvedova AA. Oxidative Stress and Inflammatory
Response in Dermal Toxicity of Single-Walled Carbon Nanotubes,
Toxicology, 2009 [in press]
110. Konduru N, Tyurina YY, Fen W, Basova LV, Belikova NA, Hülya
Bayir1, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp
E, Bengt Fadeel6, Kichambare PD, Star A, Kisin ER, Murray AR,
Anna A. Shvedova AA, a Kagan VE. Phosphatidylserine targets single-walled
carbon nanotubes to professional phagocytes in vitro and in vivo.
PloS ONE, 2009 [in press]
111. Tyurin VA, Tyurina YY, Jung Mi-Y, Tungekar MA, Wasserloos
KJ, Bayir H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B,
Kagan VE. Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives
of cardiolipin and phosphatidylserine in cells and tissues. J.
Chomatogr., 2009 [in press]
Return to top...
Selected Presentations (1990-01)
1. Kagan V, Khan S, Swanson C, Shvedova A, Serbinova E, Packer
L. Antioxidant action of thioctic and dihydrolipoic acid. Free
Radical Biology 8 Medicine 9: 15, 1990, Oxidative Damage &
Repair, Int. Med. of Society of Free Radical Research, Pasadena,
1990.
2. Shvedova AA, Kramarik JA, Keohavong P, Chumakov KM, Karol MH.
Expression of TNF-? in vivo after cotton dust exposure. Cytokines
and Lung Function, FASEB, Saxton's River, Vermont, 1993.
3. Shvedova AA, Kramarik JA, Keohavong P, Karol MH. Role of TNF-?
in development of toxic alveolitis following inhalation of cotton
dust. Society of Toxicology Annual Meeting, Dallas, 1994.
4. Shvedova AA, Stoyanovsky DA, Graham C, Kagan VE, Karol MH.
The relationship between TNF-?, pro- and antioxidant factors in
eosinophilic inflammation following allergic airway constriction
in guinea pigs. American Lung Association/American Thoracic Society
International Conference, Boston, 1994.
5. Shvedova AA, Menshikova EV, Ritov VB, Kagan VE, Karol MH. Allergic
immune response activates calcium transport in murine lungs. Society
of Toxicology Annual Meeting, Baltimore, 1995.
6. Shvedova AA, Karol MH, Kagan VE. Role of free radical intermediates
in hypersensitivity responses induced by eugenol. International
Congress of Toxicology – VII, Seattle, 1995.
7. Shvedova A, Osipov A, Karol M, Kagan V. Peroxidase/H202 enhances
hypersensitivity responses induced by eugenol: Inhibitory effects
of an Antioxidant, Lipoic Acid. The Second International Meeting
on Oxygen/Nitrogen Radicals and Cellular Injury, Durham, NC, 1997.
8. Shvedova AA, Tyurina YY, Tyurin VA, Gorbunov NV, Castranova
V, McLaughlin M, Ojimba J, Gandley R, Kagan VE. Nitric Oxide but
not nitrosothiols inhibit tert-butyl hydroperoxide/hemoglobin-induced
oxidative stress and cytotoxicity. Society of Toxicology Annual
Meeting, Seattle, WA, March 1-5, 1998.
9. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Castranova
V, Kagan VE. Lipid peroxidation in human epidermal keratinocytes
induced by redox-cycling of phenol. International Conference of
Chemistry of Organic Peroxides. Moscow, Russia, June15-18, 1998.
10. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Castranova
V, Kagan VE. Redox-cycling and cytotoxicity of phenol in keratinocytes:
evidence for enhanced lipid and thiol oxidation and antioxidant
depletion. III Int. Congress of Pathophysiology. Lahti, Finland,
June 28-July 03, 1998.
11. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Jeffries
BA, Castranova V, Kagan VE. Free Radical mechanism(s) of cytotoxicity
of phenolic compounds to skin. IX Biennial Meeting International
Society for Free Radical Research. September 7-11, 1998.
12. Shvedova AA, Tyurina YY, Tyurin VA, Jeffries B, Kommineni
C, Castranova V, Kagan VE. Combination of phenolic compounds with
arachidonic acid induces Afutile thiol pumping@ and oxidative
stress in epidermal human keratinocytes. Society of Toxicology
Annual Meeting, New Orleans, March 2-8, 1999.
13. Al-Humadi NH, Kommineni C, Shvedova AA, Battelli L, Castranova
V. Adverse responses to semi-synthetic metal working fluids in
B6C3F1 Mice. Society of Toxicology Annual Meeting, New Orleans,
March 2-8, 1999.
14. Shvedova AA, Kommineni C, Tyurina YY, Tyurin VA, Castranova
V, Kagan VE. Toxic effects of phenolics to skin. Advances in the
Biology and Treatment of the Skin, Piscataway, NJ. June 23 - 25,
1999.
15. Kommineni C, Kisin ER, Ebeling A, Al-Humadi N, Castranova
V, Shvedova AA. Oxidative stress affects dermal exposure to metal
working fluid in B6CF1 mice. 14-th Annual Conference, Foundations
of Immunotoxicology, Morgantown, September 8-10, 1999.
16. Shvedova AA, Kisin ER, Kommineni C, Schwegler-Berry D, Tyurina
YY, Tyurin VA, Castranova V, Kagan VE. Redox-cycling of occupational
phenolic compounds induces oxidative stress and cytotoxicity in
human epidermal keratinocytes. SFRR Meeting, Bio-Flavonoids &
Polyphenols in Health and Diseases, December 2-5, Dinard, France,
1999.
17. Johnson E, Shvedova A, Kisin E, O'Callaghan JP, Kommineni
C, Miller D. Vitamin E deficiency increases susceptibility of
the BALB/C mice to MDMA-induced dopaminergic neurotoxicity. Society
of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
18. Kagan VE, Tyurina YY, Tyurin VA, Kawai K, Fabisiak JP, Kommineni
C, Castranova V, Shvedova A. Oxidative stress in keratinocytes:
role in apoptotic signaling. Society of Toxicology Annual Meeting,
Philadelphia, March 19-23, 2000.
19. Kisin E, Kommineni C, Tyurina YY, Tyurin VA, Schwegler-Berry
D, Castranova V, Kagan VE, Shvedova AA. Redox-cycling of phenols
cause depletion of GSH, oxidative stress and cytotoxicity in normal
human epidermal keratinocytes (NHEK). Society of Toxicology Annual
Meeting, Philadelphia, March 19-23, 2000.
20. Kommineni C, Kisin ER, Al-Humadi N, Castranova V, Shvedova
AA. Elevated oxidative stress in skin of B6CF1 mice affects dermal
exposure to metal working fluid, Society of Toxicology Annual
Meeting, Philadelphia, March 19-23, 2000.
21. Kisin E, Kommineni C, Tyurina YY, Tyurin VA, Schwegler-Berry
D, Castranova V, Kagan VE, Shvedova A. Redox-cycling of phenols
cause depletion of GSH, oxidative stress and cytotoxicity in normal
human epidermal keratinocytes (NHEK). Society of Toxicology Annual
Meeting, Philadelphia, March 19-23, 2000.
22. Shvedova A, Kisin E, Kommineni C, Mason RP, Kadiiska MB. Antioxidant
balance and free radical generation in vitamin E deficient mice
after dermal exposure to cumene hydroperoxide. Society of Toxicology
Annual Meeting, Philadelphia, March 19-23, 2000.
23. Kagan VE, Shvedova AA. Phenolic antioxidants and pro-oxidants:
are they really so different? Society of Toxicology Annual Meeting,
San Francisco, March 25-29, 2001.
24. Smith C, Kisin E, Murray A, Castranova V, Kommineni C, Shvedova
AA. Oxidative stress in the skin of vitamin E deficient mice exposed
to metal working fluid. Society of Toxicology Annual Meeting,
San Francisco, March 25-29, 2001.
25. Shvedova AA, Kisin E, Murray A, Castranova V, Kommineni C,
Gunter MR. Phenol induced in vivo oxidative stress in skin: evidence
for enhanced free radical generation, thiol oxidation and antioxidant
depletion. Society of Toxicology Annual Meeting, San Francisco,
March 25-29, 2001.
26. Al-Humadi NH, Shvedova A, Kommineni C. Used semi-synthetic
metal working fluid (UMWF) dermal and systemic effects in B6C3F1
mice. Society of Toxicology Annual Meeting, San Francisco, March
25-29, 2001.
27. Shvedova AA, Tyurina YY, Tyurin VA, Kisin ER, Kikuchi Y, Quinn
PJ, Kagan VE. Superoxide-induced reduction of coenzyme Q and its
interaction with vitamin E synergistically protects human keratinocytes
against oxidative stress. Society of Toxicology Annual Meeting,
San Francisco, March 25-29, 2001.
28. Kagan VE, Kuzmenko AI, Tyurina YY, Kisin ER, Shvedova AA,
Yalowich JC. Lipoate/Ascorbate-dependent recycling prevents myeloperoxidase-catalyzed
oxidation of vitamin E homologues phenoxyl radical in live HL-60
cells. Society of Toxicology Annual Meeting, San Francisco, March
25-29, 2001.
29. Kisin E, Smith C, Murray A, Kisin J, Kommineni C, Castranova
V, Kagan V, Shvedova AA. Phenolic Compounds Cause Depletion of
GSH, Oxidative stress and cytotoxicity in normal human dermal
cells. Society of Toxicology Annual Meeting, San Francisco, March
25-29, 2001.
30. Shvedova AA, Kisin E, Kawai K, Kagan VE. Antioxidant Interactions
and Biomarkers of Oxidative stress in skin and keratinocytes as
they relate to apoptosis and aging. 9th Congress International
Association of Biomedical Gerontology, Vancouver, B.C. Canada,
June 27-30, 2001.
31. Shvedova AA, Kisin E, Murray A, Goldsmith T, Reynolds JS,
Castranova V, Frazer DG, Kommineni C. Sub-chronic effects of metal
working fluids on pulmonary functions in B6C3F1 mice: role of
vitamin E. Society of Toxicology Annual Meeting, Nashville, March
17-21, 2002.
32. Shvedova AA, Kisin ER, Kommineni C, Castranova V, Mason RP,
Kadiiska MB, Gunther MR. Cumene Hydroperoxide induces depletion
of antioxidants and free radical formation in skin of vitamin
E-deficient mice. The 13th Japanese Annual Vitamin E Meeting,
Hiroshima, Japan, January 17-21, 2002.
33. Shvedova AA, Kisin ER, Murray AR, Kawai K, Castranova V, Howard
PC. Oxidation biomarkers and antioxidant protection of skin against
UV-irradiation and chemical exposure. Reactive Oxygen and Nitrogen
Species: Diagnostic, Preventive, and Therapeutic Values. International
Symposium, Russia, July 9-13, 2002.
34. Shvedova AA, Kisin ER, Murray AR, Mason RP, Kadiiska M, Castranova
V, Gunther M. In vivo detection of vitamin E-dependent protection
against free radical formation and oxidative stress in skin treated
with cumene hydroperoxide. 9th Annual Meeting, Oxygen Society,
San Antonio, TX, Nov. 20-24, 2002
35. Shvedova AA, Kisin ER, Kommineni C, Gunter MR, Rao MK, Castranova
V. Inflammatory response and free radical formation in skin of
B63CF1 mice with diminished levels of glutathione after phenol
exposure. 42nd Ann. Meeting SOT, Salt Lake City, UT, March 9-13,
2003
36. Shvedova AA, Murray AR, Kisin ER, Kagan VE, Gandelsman VZ,
Castranova V. Exposure of human bronchial epithelial cells to
carbon nanotubes caused oxidative stress and cytotoxicity. Free
Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological
Implications, SFRR Meeting, June 26-29, 2003, Ioannina, Greece
37. Shvedova AA, Tyurina YY, Kawai K, Tyurin VA, Castranova V,
Kagan VE. Oxidative Phospholipid Signaling During Apoptosis in
Keratinocytes. Clearance of Dying Cells by Phagocytes: Mechanisms
& Consequences. Gordon Res. Con. New London, CT, Aug 3-8,
2003
38. Baron P., Maynard A, Shvedova AA, Kisin E., Castranova V.
Preliminary studies of generation, exposure, and toxicity of carbon
nanotubes. Am. Ass. Aeros Res. Meeting, October 20-24, 2003 Anaheim,
CA
39. Xu, M, Kisin, A. R. Murray, C. Kommineni, V. Vallyathan, V.
Castranova, A. A. Shvedova. Activation of AP-1 and Pro/Antioxidant
Status in Skin of AP-1 Transgenic Mice During Cancer Promotion
with Cumene Hydroperoxide. 43th Society of Toxicology meeting,
Baltimore, March 21-25, 2004
40. Murray A, Kisin E, Kawai K, Kagan VE, Kommineni C, Castranova
V, Shvedova AA. Role of Vitamin E in the Antioxidant Defense System
of Skin in Young and Old Mice Exposed to Cumene Hydroperoxide,
43th Society of Toxicology meeting, Baltimore, March 21-25, 2004
41. Shvedova A.A. Pulmonary Toxicity of Carbon Nanotubes: From
Cellular Responses to Animal Model. Nanoscale Materials and Public
Health. Toxicology Forum. February 2-4, 2004, Washington DC
42. Shvedova A. A., Kisin E, Keshava N, Murray A.R, Gorelik O,
Arepalli S, GandelsmanV.Z, Castranova V. Cytotoxic and genotoxic
effects of single wall carbon nanotube exposure on human keratinocytes
and bronchial epithelial cells, 227th ACS National Meeting, March
28-April 1, 2004, Anaheim, CA
43. Shvedova A.A. Pulmonary toxicity of carbon nanotubes. International
congress on nanotechnology, San Francisco, CA, Nov 7-10, 2004
44. Shvedova A. A., Kisin E, Murray A.R, Gorelik O, Arepalli S,
GandelsmanV.Z, Mercer B, Hubbs A, Kagan VE, Castranova V. Oxidative
stress and pulmonary toxicity of carbon nanotubes.11TH Annual
meeting SFRBM, November 17-21, 2004
45. Shvedova A.A. Pulmonary toxicity of carbon nanotube: what
we know and what we do not know. National Nanotechnology Infrastructure
Network (NNIN): Nanosafe: A workshop on Environmental Health and
Safety in Nanotechnology Research, Atlanta, GA, Dec 1-3, 2004
http://snf.stanford.edu/Links/NanosafetyAgenda.html
46. Shvedova A.A. Pulmonary response to carbon nanotubes. 44th
Society of Toxicology meeting, New Orleans, March 6-10, 2005
47. Mercer R., Scabilloni J, Kisin E, Gorelik O, Arepalli S, Murray
AR, Castranova V, Shvedova AA Responses of lung parenchyma to
carbon nanotubes. 44th Society of Toxicology meeting, New Orleans,
March 6-10, 2005
48. Shvedova AA. Comparative toxicity of nanomaterials in vivo
and in vitro. 229th American Chemical Society meeting, San Diego,
CA, March 12-16, 2005
49. Shvedova AA. Unusual pulmonary response to carbon nanoparticles.
First Annual Meeting of American Academy of Nanomedicine. Johns
Hopkins University, MD, August 15-16, 2005
50. Shvedova AA. Pulmonary oxidative stress, inflammation, and
fibrosis induced by single wall carbon nanotubes. 2nd International
Symposium on Nanotechnology and Occupational Health, Minneapolis,
MN, October 3-6, 2005
51. Shvedova AA. Pulmonary toxicity of carbon nanotubes. 8th International
Conference on Mechanisms of Action of Inhaled Fibers, Particles,
and Nanoparticles in Lung and Cardiovascular Diseases, October
25 – 28, 2005, Research Triangle Park, NC
52. Shvedova AA. Oxidative stress and pulmonary toxicity of carbon
nanotubes. 1st International Meeting “Nanotoxicology: Biomedical
Aspects”, January 28 – February 1, 2006, Miami Beach,
FL
53. Shvedova AA. Single-walled carbon nanotubes induced oxidative
stress, acute inflammation and pulmonary fibrosis. 45th Society
of Toxicology meeting, San Diego, March 5-9, 2006
54. Shvedova AA. Animal studies: pulmonary toxicity of nanomaterials/carbon
nanotubes. Nobel Forum. Mini-Symposium on nanotoxicology: potential
risks and safety assessment. Stockholm, Sweden, November 27, 2006
55. Shvedova AA and Kagan VE. Pulmonary Toxicity of Carbon Nanotubes.
International Conference on Nanotechnology: Occupational and Environmental
Health & Safety: Research to Practice, Cincinnati, OH, December
4-7, 2006
56. Murray AR, Kisin E, Kommineni C, Kagan VE, Castranova V, Shvedova
AA. Single-Walled Carbon Nanotubes Induce Oxidative Stress and
Inflammation in Skin. 46th Society of Toxicology Meeting, Charlotte,
NC, March, 25-29, 2007
57. Shvedova AA, Kisin ER, A. Murray A, O. Gorelik O, Arepalli
S, Castranova V, Young S-H, F. Gao F, Tyurina YY, Oury T, Kagan
VE. Vitamin E deficiency enhanced pulmonary response and oxidative
stress induced by single-walled carbon nanotubes in C57B6/L mice.
46th Society of Toxicology Meeting, Charlotte, NC, March, 25-29,
2007
58. Shvedova, AA. Pulmonary Toxicity of Singled-Walled Nanotubes.
International Conference on Nanotoxicology, Venice, Italy, April,19-21,
2007
59. Shvedova AA. Pulmonary Toxicity of Nanoparticles. Experimental
Biology Meeting, Washington DC, April 30-May 3, 2007
60. Shvedova AA, Kagan VE. Oxidative stress, pulmonary response
and progressive fibrosis induced by exposure to singled-walled
nanotubes. Vth International Conference on Peroxynitrate and Reactive
Nitrogen Species, Montevideo, Uruguay, September 2-6, 2007.
61. Shvedova AA. Pulmonary Toxicity of Single-Walled Nanotubes
in vivo: Mechanisms and Consequenses. 3rd NASA-NIST Workshop on
Nanotube Measurements, NIST, Gaithersburgh, MD, USA, Sep 26-28,
2007
62. Shvedova AA. Inhalation Exposure to Single-Walled Carbon Nanotubes.
European NanOSH Conference –Nanotechnologies: A Critical
Area in Occupational Safety and Health, Helsinki, Finland, 3–5
December 2007
63. Shvedova AA. Single-Walled Carbon Nanotubes: Are They Mutagenic?
Mary Babb Randolph Cancer Center – National Institute of
Occupational Safety and Health MBRCC - NIOSH Scientific Retreat
in Cancer, Morgantown, West Virginia, February 12, 2008
64. Murray AR, Kisin ER, Leonard S, Kommineni C, Kagan VE, Castranova
V, Shvedova AA. Induction of Oxidative Stress and Inflammation
in the Skin Following Exposure to Single-Walled Carbon Nanotubes,
Zurich, March 12-15, 2008
65. Shvedova AA. Kagan VE. Pulmonary Toxicity of Carbon Nanotubes
In Vivo: Mechanisms, Regulations, and Reality. “Nanomaterials:
Environmental Risks and Benefits and Emerging Consumer Products”
Faro, Portugal, 27-30, April, 2008
66. Shvedova AA. "Carbon Nanotube in the Rodent Lungs: Recognition
and Modulation of Toxicity". ATS, International Conference,
Toronto, Canada, May 16-21, 2008
67. Shvedova AA Relevant to animal studies: Aspiration vs Inhalation.
Nanotoxicology, 2nd International meeting, Zurich, Switzerland,
September 7-10, 2008
68. Shvedova A.A, Kisin ER, Murray AR, Kommineni C, Castranova
V, Fadeel B, Kagan VE. NADPH oxidase regulates neutrophils and
fibrosis in C57BL/6 mice exposed to carbon nanotubes. 48th Annual
SOT Meeting, Baltimore, MD, March 15-19
69. Shvedova AA. Nanotoxicology In Vivo: Pulmonary Effects of
Carbon Nanotubes. 6th Symposium on Nanomedicine, Royal Swedish
Academy of Sciences, Stockholm, Sweden, September 9-11, 2009
70. Shvedova AA. Carbonaceous nanotubes in the lung: mechanisms
of damage and consequences. 4th Symposium of the Center for Disease
Biology and Integrative Medicine: 21st Century Advances in the
Molecular Toxicology of Environmental Chemicals and Pathogenesis
of Disease, Tokyo, Japan, October 26-27, 2009
71. Shvedova AA. Unsolicited pulmonary effects of carbon nanotubes:
genetic, nutritional and microbial factors. 4th Oxygen/Nitrogen
Radicals and Cellular Injury Meeting, NY Academy of Sciences,
New York, USA, October 28-30
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