|
Department of Physiology and Pharmacology
Anna A. Shvedova -
Curriculum Vitae
 Center for Disease Control and Prevention
National Institute for Occupational Safety and Health
Health Effect Laboratory Division
Pathology and Physiology Research Branch (MS-2015)
1095 Willow dale Road
Morgantown, WV 26505-2888
Phone: (304) 285-6177
Fax: (304) 285-5938
E-mail: ats1@cdc.gov
1522 Denniston Ave.
Pittsburgh, PA 15217
Phone: (412) 521-4564
Education
B.S. MV Lomonosov Moscow State University 1970
M.S. MV Lomonosov Moscow State University 1971
Ph.D. Physiology, Biophysics MV Lomonosov Moscow State University 1975
D. Sc. Pathophysiology USSR Academy of Sciences, Moscow 1988
Return to top...
Professional Appointments
1971-1972 Research Assistant, MV Lomonsov Moscow State University, Moscow
1972-1978 Research Associate, Institute of Chemical Physics, USSR Academy of Sciences, Moscow
1978-1984 Staff Research Scientist, Institute of Chemical Physics, USSR Academy of Sciences
1984-1990 Team Leader, Institute of Chemical Physics, USSR Academy of Sciences
1990-1991 Visiting Scholar, Department of Molecular and Cell Biology, University of California, Berkeley, CA 96804
1991-1992 Pharmaceutical Consultant, Medicine Inc, Southampton, PA 18966
1992-1995 Faculty, Center for Environmental and Occupational Health and Toxicology, University of Pittsburgh, Pittsburgh, PA 15238
1995-1996 Manager, Nutrition Research, General Nutrition Corporation (GNC), Pittsburgh, PA 15222
1996-1997 Research Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213
1997-Present Senior Staff Scientist, National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Health Effects Laboratory Division, Morgantown, WV 26505
2001-Current Adjunct Associate Professor of the Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV
Return to top...
Professional Societies
Society of Toxicology USA
American Association for Advancement in Science
International Society for Free Radical Research
New York academy of Sciences
Society for Investigative Dermatology
Return to top...
Special Appointments, Fellowships, And Awards
Bronze and Silver Awards for Achievements in Economics and Science (USSR, 1989, 1990)
Award for Scientific Achievements, the Institute of Chemical Physics, USSR, 1988
Award for Scientific Achievements and Merit, the Academy of Sciences USSR, 1989, 1990
Award of a grant from NIEHS (#ES05651), 1992-1995
Award for outstanding service as the President-Elect of the Allegheny-Erie Regional Chapter of the Society of Toxicology, 1998
Special recognition award for service as the President of the Allegheny-Erie Regional Chapter, the Society of Toxicology, 1999
Certificate of appreciation for outstanding service to the Allegheny-Erie Regional Chapter, the Society of Toxicology as Past President, 2000
Award for meritorious service as founding President of the Dermal Toxicology Specialty Section, the Society of Toxicology, 2001
The Society of Toxicology Public Communication Award for recognition of major contributions to broadening the awareness of the general public to toxicological issues, 2001
Fellow of the Academy of Toxicological Sciences, 2001- current
Return to top...
Editorial/Manuscript Review Expirience (Past/Current)
Reviewer for Journal Leukocyte Biology 1993-1996
Reviewer for Toxicological Sciences 1997-current
Reviewer for the Journal Industrial Toxicology 2002- current
Ad hoc Reviewer for Toxicology and Applied Pharmacology 2001- 2003
Editorial Board of Toxicology and Applied Pharmacology 2003- current
Reviewer for Chemical Research in Toxicology 2003- current
Reviewer for nutrition book “Body Stat,” Viking Penguin Press 1996
Reviewer In Vitro Toxicology 2004-current
Editorial Board of Toxicology & Apply Pharmacology Journal 2003-current
Return to top...
Honors And Special Scientific Recognition
Chair of Young Investigator Committee, Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia 1981-1989
Secretary of Russian-Indian Chapter, the International Society, Moscow, Russia 1989-1990
Member of Newsletter Committee, Allegheny-Erie Regional Chapter, SOT Member of Newsletter Committee, A-E Regional Chapter of SOT 1994-1995
President-Elect, Allegheny-Erie Regional Chapter of SOT 1997-1998
President of Allegheny-Erie Regional Chapter of SOT 1998-1999
Chair of Nomination Committee, Allegheny-Erie SOT 1999-2000
Coordinator for Summer Student Program, NIOSH/CDC 1998-current
Member of Placement Committee, the Society of Toxicology 1999-2001
Founder and Interim President of the Dermal Toxicology Specialty Section, SOT 1999-2000
President of the Dermal Toxicology Specialty Section, SOT 2000-2001
Who’s Who in America 1996-2000
American Women in Science 1998-1999
Member of New York Academy of Sciences 2001-current
Chairperson of Placement Committee, the Society of Toxicology 2001-2002
Fellow of the Academy of Toxicological Sciences 2001-current
Return to top...
Specialties By Training Or Experience
Biology, human and animal physiology, membrane toxicology, occupational toxicology, molecular and cellular toxicology, dermal and pulmonary toxicology, pathophysiology, physiology and biochemistry of vision, biochemistry and physiology of nutrition, lipid biophysics and biochemistry, free radical biology and medicine, inflammatory diseases, cardio- and cerebral vascular pathophysiology, risk assessment, drug toxicology, drug development, and pre- and clinical research.
Return to top...
Current Research Interests
Mechanism of chronic allergic skin and lung disease caused by industrial chemicals. Free radical reactions and inflammatory cell responses, molecular regulation of oxidant, pro-inflammatory cytokine and growth factors, molecular mechanisms of cells damage and apoptosis. Mechanism(s) of contact sensitization, inflammation, oxidative injury and skin cancer, mechanism(s) of cellular injury induced by exposures to phenolic compounds and organic hydroperoxide, nanotoxicology and mechanisms of toxic effects of nanoscale materials, risk assessments and occupational exposures, development of novel models to assess human risk of inflammatory and pulmonary diseases, fibrosis and cancer at work place.
Return to top...
Teaching, Training And Developing Staff
Teaching and training six pre-doctoral students, 1983-1988.
Supervising and training five Ph.D. students and three post-doctoral fellows, 1984-90.
Training and supervising five associate researches and technicians, 1987-1989, 1993-97.
Teaching and coordinating summer student program at NIOSH/CDC and WVU/BRIN program 1998-2002.
Lecturing at West Virginia Science Teacher Association Meeting, 2001.
Supervising and training eleven college students from WVU at NIOSH 1997-2004.
Return to top...
Invited Presentations
Allegheny-Erie Regional Chapter, Society of Toxicology, Spring Meeting, Pittsburgh, PA, May 1998
International Conference on Chemistry of Organic Peroxides, Moscow, Russia, June 1998
Dermal Investigative Group Meeting, NIOSH/CDC, Cincinnati, OH, May 1999
International Contact Dermatitis Symposium, San Francisco, CA, October 1999
Manufacturing Technology and Consumable Product Division, Milacron, Cincinnati, OH, May 2000
Division of Life Science, King’s College, University of London, UK, August 2000
Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR,
December 2000
Department of Physiology and Integrative Pharmacology, WVU, Morgantown, WV, February 2001
Society of Toxicology 40-th Annual Meeting, San Francisco, CA, March 2001
NanoSpace 2001: Exploring Interdisciplinary Frontiers. International Conference on Integrative Nano/Microtechnology for Space and Biomedical Applications, NASA, Galveston, TX, March 2001
Meijo University, Section of Radiochemistry, Faculty of Pharmaceutical Sciences, Nagoya, Japan, January 2002
NIOSH Ultrafine Aerosol Workshop, Wheeling, WV, Sept. 16 – 17, 2003
Institute Physico-Chemical Medicine, Moscow, Russia, Oct. 18-22, 2003
NASA/JSC-ES4/GBT, Houston, TX, Nov. 14-16, 2003
THE TOXICOLOGY FORUM’s, 29-th Toxicology Annual Winter Meeting Washington DC, February 2-4, 2004
INTERNATIONAL CONGRESS OF NANOMATERIALS,
227TH AMERICAN CHEMICAL SOCIETY MEETING, Symposium: Nanotechnology & the Environmental Toxicology & Bio-interactions of Nano-materials, March 28-April 1, 2004
Nanotoxicology Workshop, Gainsville, Fl. Nov 3 – 4 2004
International Congress on Nanotechnology, San Francisco, CA, Nov 7 – 10, 2004
National Nanonotechnology Infrastructure Network (NNIN): “Nanosafe: A workshop on Environmental Health and Safety in Nanotechnology Research”, Atlanta, GA, Dec 1-3, 2004
Return to top...
Organizing And Chairing Meetings/Workshops
Toxicology in Court,” Allegheny-Erie Chapter, Society of Toxicology, Fall Meeting, October 28, 1997
Women Health Issue: Consideration to Toxicological Studies, Allegheny-Erie Chapter, Society of Toxicology, Spring Meeting, May 15, 1998
Paracelsus Goes to School” Science Teacher Workshops, Pittsburgh, PA, May 14, 1998; Cuyahoga Falls, OH, June 2, 1999; Pittsburgh, PA, May 16, 2000
Phenolic Compounds: Free Radical Mechanisms of Toxicity, Catalysis, and Protections,” Symposium, Society of Toxicology 40th Annual Meeting, San Francisco, CA, March 29, 2001
How to Market Yourself as a Toxicologist”, 41st Annual Society of Toxicology Meeting, March 18, 2002, Nashville, TN
“3rd International Conference on Oxygen/Nitrogen Radicals: Cell Injury and Disease,” Morgantown, WV, June 1-5, 2002
Reactive Oxygen and Nitrogen Species: Diagnostic, Preventive, and Therapeutic Values, International Symposium,” Pre-Symposium to the XI-th Biennial Meeting of the Society for Free Radical Research International, St. Petersburg, Russia, July 9-13, 2002
Occupational Skin Exposure: Current Trends and Future Directions from the Field to Genomics, symposium, 43-rd Annual SOT Meeting, Baltimore, March 21-25, 2004
Toxicology Forum, February 2-4, 2004
227th American Chemical Society National Meeting, March 28-April 1, 2004
Return to top...
Publications
More than 80 papers in Journals
Return to top...
Presentations At National And International Meetings
Presentations at more than 40 Congresses and Meetings
Return to top...
Patents
Antioxidant drug EMOXIPIN is patented as a “Retinoprotector for Treating Intraocular Hemorrhage, Myopic, Chorioretinal Dystrophies, Congenital Retinal Dystrophies, Retinal Burns and Prevention of Injury in Laser Coagulation” in:
US 4486440
FR 83143339-2551 659
CH 658595
DE 3330053C2
IT 1197696
Return to top...
Bibliography
Full-length manuscripts:
1. Kagan VE, Shvedova AA, Novikov KN, Kozlov YP. Light-induced free radical oxidation of membrane lipids in photoreceptors of frog retina. Biochem. Biophys. Acta 330: 76-79, 1973.
2. Novikov KN, Shvedova AA, Kagan VE, Kozlov YP, Ostrowsky MA. Photo- induced changes in photoreceptor membranes and rhodopsin revealed by craft-co-polymerization. Biophys.USSR 19(2): 280-284, 1974.
3. Sibeldina LA, Kagan VE, Shvedova AA, Novikov KN, Kobelev VS. NMR study of molecular organization of photoreceptor membranes. Proc. Natl. Acad. Sc. USSR 224(2): 228- 231, 1975.
4. Novikov KN, Kagan VE, Shvedova AA, Kozlov YP. Lipid-protein Interactions in photoreceptor membranes under lipid peroxidation. Biophys. USSR 20 (6): 1039-1042, 1975.
5. Kagan VE, Shvedova AA, Novikov KN, Kozlov YP. Effects of conformational rearrangements on spontaneous and induced lipid peroxidation in frog retina rod outer segments. Biophys. USSR 20 (6): 1043-1048, 1975.
6. Novikov KN, Shvedova AA, Tyurin VA, Shukolyukov SA, Kagan VE. On the role of lipid composition in kinetics of phospholipids free radical oxidation in photoreceptor membranes. Biophys. USSR 22 (5): 942-944, 1977.
7. Kagan VE, Shukolyukov SA, Tyurin VA, Shvedova AA, Korchagin VP, Galuschenko IV. Effects of chemical modification of lipids by molecular oxygen on thermal stability of rhodopsin in photoreceptor membranes of wall-eyed pollock. Studia Biophys. 72 (1): 51-58, 1978.
8. Kagan VE, Shvedova AA, Novikov KN. Participation of phospholipases in repair of photoreceptor membranes after lipid peroxidation. Biophys. USSR 23 (2): 279-284, 1978.
9. Shvedova AA, Ostrowsky MA, Bogoslowsky Al, Scherbatova Ol, Zueva MV, Trutneva KV. Damage of the retina by visible light and the role of antioxidant. Excerpta Medica 442: 114, 1978.
10. Shcherbatova OI, Zueva MV, Shvedova AA, Shamshinova AM, Kaban AA. State of the organ of vision in workers in the diamond-processing industry. Vestn Ophthalmology. 3:56-9, 1980 (in Russian).
11. Kagan VE, Lankin VZ, Shvedova AA, Novikov KN, Dobrina SK, Bratkovskaya LB, Kuliev IY. Enzymic and non-enzymic protective antioxidant systems in photoreceptors. Bull. Exp. Biol. Med. USSR 8:164-166, 1979.
12. Shvedova AA, Sidorov AS, Novikov KN, Galuschenko IV, Kagan VE. Lipid peroxidation and electric activity of the retina. Vision Res. 19: 49-55, 1979.
13. Ostrowscky MA, Bogoslowsky AL, Zueva MV, Shvedova AA. Investigation of the mechanisms of visible light injury on the normal animal retina. Vest. Acad. Med. Sci. USSR 12:57-61, 1979.
14. Korchagin VP, Bratkovskaya LB, Shvedova AA, Arkhipenko YV, Kagan VE, Shukolyukov SA. Oligomerization of intrinsic membrane proteins in the course of lipid peroxidation. Biochem. USSR 45 (10):1767-1772, 1980.
15. Bratkovskaya LB, Novikov KN, Shvedova AA, Polischuk RF, Kagan VE, Kozlov YP. Pyridine nucleotide-dependent systems of lipid peroxidation induction in retina photoreceptors. Biol. Sciences 6: 21-26, 1981.
16. Kuliev IY, Shvedova AA, Kagan VE, Krasnovsky AA, Kozlov YP. Light induced damage of the retina: participation of singlet oxygen and lipid peroxidation. Proc. Natl. Acad. Sc. USSR 263(5):1005-1009, 1982.
17. Shvedova AS, Kagan VE, Kuliev IY, Dobrina SK, Prilipko LL, Meerson FZ, Kozlov YP. Lipid peroxidation and damage of the retina in stress exposed rats. Bull. Exp. Biol. Med. USSR 4:24-27, 1982.
18. Polyansky NB, Smirnov LD, Shvedova AA, Kagan VE, Tkachuk VA. Inhibition of phosphodiesterase of cyclic nucleotide from rabbit heart by 3-hydroxypyridines. Problems Med.Chem. 1: 123-127, 1983.
19. Shvedova AA, Kagan VE, Kuliev IY, Vekshina OM. Mechanisms of retina damage by fluorescent dyes. Bull. Exp. Biol. Med. USSR 8: 48-50, 1983.
20. Kagan VE, Bratkovskaya LB, Kuliev IY, Shvedova AA. The role of lipid peroxidation in retina damage under hyperbaric oxygenation and possibility of chemical protection by antioxidants. Proc. Natl. Acad. Sci. USSR 271 (1): 227-230, 1983.
21. Shvedova AA, Alekseeva OM, Kuliev IY, Muranov KO, Kozlov YP, Kagan VE. Damage of photoreceptor membrane lipids and proteins induced by photosensitized oxidation. Curr. Eye Res.2 (10): 683-690, 1983.
22. Polyansky NB, Smirov LD, Shvedova AA, Kagan VE. Inhibition of cyclic nucleotide phosphodiesterase from frog rod outer segments by 3-hydroxypyridines. Biol. Sciences 1: 27-31, 1984.
23. Shvedova AA. Molecular mechanisms of emoxipin effect. In: Emoxipin, Medexport, Moscow, USSR, pp. 2-19, 1984.
24. Shvedova AA, Fedulov AS, Marchenko LN, Zayats GR. Experimental application of emoxipin in treatment of traumatic hemophthalmia. In: Emoxipin, Medexport, Moscow, USSR, pp. 19-20, 1984.
25. Katznelson LA, Nikolskaya VV, Beglyarova AS, Shvedova AA. Emoxipin in treatment of exudative forms of retinopathy. In: Emoxipin, Medexport, Moscow, USSR, pp. 21-22, 1984.
26. Katsnelson LA, Gurtovaya EE, Malyuta GD, Bogdanova LV, Shvedova AA. Emoxipin in treatment of hemophthalmia In: Emoxipin, Medexport, Moscow, USSR, pp.22-23, 1984.
27. Katsnelson LA, Gurtovaya EE, Nikolskaya VV, Bogdanova LV, Shvedova AA. Emoxipin in treatment of retinal vein thrombosis. In: Emoxipin, Medexport, Moscow, USSR, pp. 24-25, 1984.
28. Katsnelson LA, Agranovich MS, Gurtovaya EE, Karpova NA, Rosenfeld IA, Shvedova AA. Emoxipin in treatment of central chorioretinal dystrophies (CCRD). In: Emoxipin, Medexport, Moscow, USSR, pp. 25-26, 1984.
29. Makarskaya NV, Brovkina AF, Shvedova AA, Akhmedzhanova EV. Prospects for emoxipin application in the case of laser destruction of intraocular vascular tumors. In: Emoxipin, Medexport, Moscow, USSR, pp. 32-35, 1984.
30. Bogdanova LV, Katsnelson LA, Shvedova AA. Medication of laser and sun burns of the retina with emoxipin preparation. In: Emoxipin, Medexport, Moscow, USSR, pp. 38, 1984.
31. Katsnelson LA, Dnestrova GI, Yelyseyeva RF, Shvedova AA. Application of emoxipin for treatment of stargardt disease. In: Emoxipin, Medexport, Moscow, USSR, pp. 41-43, 1984.
32. Kagan VE, Polyansky NB, Muranov KO, Shvedova AA, Smirnov LD, Dyumaev KM. Suppression of aggregation and inhibition of phosphodiesterase of cyclic nucleotide in platelets by 3- hydroxypyridines. Bull. Exp. Biol. Med. USSR 4: 41 6-41 8, 1984.
33. Komarov PG, Bilenko MV, Shvedova AA, Kagan VE. Evaluation of the efficiency of different compounds in inhibition of enzymic lipid peroxidation. Probl. Med. Chem. 2: 40-45, 1985 (in Russian).
34. Babijaev MA, Shvedova AA, Arkhipenko YV, Kagan VE. Accumulation of lipid peroxidation products in cataract lenses. Bull. Exp. Biol. Med. USSR 9: 299301, 1985.
35. Muranov KO, Polyansky NV, Shvedova AA, Smirov LD, Kagan VE. Changes in the cyclic nucleotide level and the inhibition of human platelet aggregation upon exposure to 3-hydroxypyridines. Bull. Exp. Biol. Med. USSR 10: 432434, 1986.
36. Muranov KO, Gashev SB, Smirov LD, Shvedova AA, Ritov VB. Inhibition of platelet aggregation by antioxidants. Bull. Exp. Biol. Med. USSR 3: 337-339, 1986.
37. Kagan VE, Ivanova SM, Murzakhmetova MK, Shvedova AA, Smirnov LD. Antioxidants-stabilizers to the Ca++-transport enzyme system in sarcoplasmic reticulum membranes in vivo. Bull. Exp. Biol. Med. USSR 11: 52-54, 1986.
38. Egorov CJ, Babijaev MA, Krasnovsky AA, Shvedova AA. Photosensitized generation of singlet oxygen by endogenous substances of the eye lens. Biophys. USSR 32: 169-172, 1987.
39. Shvedova AA, Platonov ES, Polyansky NV, Babijaev MA, Kagan VE. The chemical nature of the fluorescent products accumulating in the lipids of the lenses in mice with hereditary cataract. Bull. Exp. Biol. Med. USSR 3: 301-304, 1987.
40. Shvedova AA, Polyansky NB, Akopyan GK, Dzhafarov Al. Effect of emoxipin on basal cyclic nucleotide phosphodiesterase activity and late receptor potential of isolated retina. Bull. Exp. Biol. Med. USSR 9: 289-291, 1989.
41. Pashin EN, Shvedova AA. The effect of a synthetic antioxidant emoxipin on coronary vessels tone. Pharmacol. Toxicol. USSR 52: 17-19, 1989.
42. Egorov EA, Shvedova AA, Obraztsova IA. The results of clinical trial of antioxidant emoxipin in an ophthalmology setting. Vest. Ophthalmol. 5: 52-55, 1989.
43. Golikov AP, Ovchinnikov VL, Polumiskov VUY, Davydov BV, Karev VA, Konorev LA, Shvedova AA. Antioxidant Emoxipin: The effects on formation of necrotic and reparative processes in myocardial infarction. Cardiol. USSR 7: 50-53, 1990.
44. Kocherginsky NW, Shvedene NV, Shvedova AA. Detection of emoxipin with a membrane electrode. Chem. Pharmaceut. J. USSR 24 (12): 77-78, 1990.
45. Horseva Ml, Kocherginsky NW, Shvedova AA. Transport of tetracycline antibiotics through biomimetic membranes. Biotech. Bulgaria 1: 39-43, 1990.
46. Mishina EV, Filippenko NG, Pichugin VV, Zherdev VP, Lebedev AV, Kameneva NV, Shvedova AA. Pharmacokinetic and pharmacodinamic of Emoxipin under normal and pathological conditions. Bull. Exp. Biol. Med. USSR 10: 389-390, 1990.
47. Shvedova AA, L'vov KM, Polianskii NB, Bekmurzaev BM. Study of soluble proteins in mouse normal and cataract lenses. Bull. Exp. Biol. Med. USSR, 6: 609-610, 1991.
48. Kagan VE, Serbinova EA, Maguire JJ, Shvedova AA, Packer L. On the path from ubiquin one to ubiquinol: chain breaking lipid peroxyl radical scavenging or vitamin E radical recycling? In: Oxidative Damage and Repair (Chemical, Biological and Medical Aspects), K.J.A. Davies, Ed., Pergamon Press, 121-125, 1991.
49. Kagan VE, Shvedova AA, Serbinova EA, Khan S, Swanson K, Powell R, Packer L. Dihydrolipoic acid acts as a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. J. Biochem. Pharmacol. 8:1637-1649, 1992.
50. Shvedova AA, Kramarik JA, Keohavong P, Chumakov KM, Karol MH. Use of anti-TNF-? antiserum to investigate toxic alveolitis arising from cotton dust exposure. Exp. Lung Res. 20: 297-315, 1994.
51. Menshikova EV, Ritov VB, Shvedova AA, Elsayed N, Karol MH, Kagan VE. Pulmonary microsomes contain a Ca++-transport system sensitive to oxidative stress. Biochem. Biophys. Acta 1228: 165-174, 1995.
52. Shvedova AA, Kisin ER, Kagan VE, Karol MH. Increased lipid peroxidation and decreased antioxidants in lungs of guinea pigs following an allergic pulmonary response. Toxicol. Appl. Pharmacol. 132: 72-81, 1995.
53. Shvedova AA, Menshikova EV, Ritov VB, Kagan VE, Karol MH. Murine pulmonary Ca++-transport system activated by allergic immune response retains sensitivity to oxidative stress. Exp. Lung Res. 21: 743-769, 1995.
54. Shvedova AA, Satoh T, Tollerud D, Guevarra L, Karol MH. Elevated levels of IL-6, INF-?, and TNF-? in mice in response to cotton dust are modulated by anti-TNF-? antiserum. Exp. Lung Res. 22: 149-161, 1996.
55. Shvedova AA, Tyurina YY, Gorbunov NV, Tyurin VA, Castranova V, Kommineni C, Ojimba J, Gandley R, McLaughlin M, Kagan VE. tert-Butyl hydroperoxide/hemoglobin-induced oxidative stress and damage to vascular smooth muscle cells. Biochem. Pharmacol. 57: 989-1001, 1998.
56. Shvedova A, Osipov A, Kommineni C, Jeffries B, Castranova V, Vallyathan V, Kagan V. Peroxidase/H2O2 enhances hypersensitivity responses Induced by eugenol: inhibitory effect of an antioxidant, lipoic acid. Env. Nutr. Interact. 3: 15-31, 1999.
57. Shvedova AA, Kommineni C, Jeffries B, Castranova V, Tyurina YY, Tyurin VA, Serbinova EA, Fabisiak JP, Kagan VE. Redox cycling of phenol induces oxidative stress in human keratinocytes: evidence for enhanced lipid and thiol oxidation and antioxidant depletion, J. Invest. Derm. 114: 354-364, 2000.
58. Kagan VE, Kuzmenko AI, Shvedova AA, Kisin ER, Tyurina YY, Yalowich JC. Myeloperoxidase-catalyzed phenoxyl radicals of vitamin E homologue, 2,2,5,7,8-Pentamethyl-6-hydroxylchromane, do not induce oxidative stress in live LH-60 cells. Biochem. Res. Com.270. 1086-1092, 2000.
59. Kagan VE, Fabisiak JP, Shvedova AA, Tyurina YY, Tyurin VA, Schor NF, Kawai K. Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis. FEBS Letters, 477, 1-7. 2000.
60. Tyurina YY, Shvedova AA, Kawai K, Tyurin VA, Kommineni C, Quinn PJ, Schor NF, Fabisiak JP, Kagan VE. Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine. Toxicology. 148, 93-101, 2000.
61. Al-Humadi NH, Shvedova AA, Battelli L, Diotte N, Castranova V, Kommineni C. Dermal and systemic toxicity after application of semi-synthetic metal working fluids in B6C3F1 mice. J. Tox. Environ. Health 61:579-589, 2000.
62. Shvedova AA, Kisin E, Kisin J, Castranova V, Kommineni C. Elevated oxidative stress in skin of B6CF1 mice affects dermal exposure to metal working Fluid. Ind. Toxicol. Ind. Health, 16(7-8):267-76, 2001.
63. Shvedova AA, Tyurina YY, Tyurin VA, Kikuchi Y, Kagan VE, Quinn, PJ. Quantitive Analysis of phospholipid peroxidation and antioxidant protection in live human keratinocytes, Bioscience Reports, 21(1):33-43, 2001.
64. Kagan VE, Kozlov AV, Tyurina YY, Shvedova AA, Yalowich JC. Antioxidant mechanisms of NO against iron-catalyzed oxidative stress in cells. Antioxidants and Redox Signal. 3(2):189-202, 2001.
65. Kagan VE, Kuzmenko AI, Tyurina YY, Shvedova AA, Matsura T, Yalowich JC. Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase. Cancer Res. 61(21):7777-84, 2001.
66. Shvedova AA, Tyurina BYY, Kawai K, Tyurin VA, Kommineni C, Castranova V, Fabisiak JP, Kagan VE. Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide. J. Invest. Dermatol. 118(6):1008-18, 2002.
67. Johnson EA, Shvedova AA, Kisin E, O’Callaghan JP, Kommineni C, Miller, DB. D-MDMA during oxidative stress: effects on dopaminergic neurotoxicity and hepatotoxicity. Brain Res. 933 (2) 150-163, 2002.
68. Kagan VE, Shvedova AA, Tyurina YY, Tyurin VA, Fabisiak JP, Schor NF. Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling. Redox Cell Biology & Genetics, Methods in Enzymology 352:159-74, 2002.
69. Tyurina YY, Tyurin VA, Liu SX, Smith CA, Shvedova AA, Schor NF, Kagan VE. Phosphatidylserine peroxidation during apoptosis. A signaling pathway for phagocyte clearance. Subcell Biochem. 36:79-96. Review, 2002;
70. Kagan VE, Kisin ER, Kawai K, Serinkan BF, Osipov AN, Serbinova EA, Wolinsky I, Shvedova AA. Towards mechanisms-based antioxidant interventions: lessons from natural antioxidants. Ann. N.Y Acad Sci. 959: 188-199, 2002.
71. Modriansky M, Tyurina YY, Tyurin VA, Matsura T, Shvedova AA, Yalowich JC, Kagan VE. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants? Toxicology, (1):105-17, 2002.
72. Shvedova AA, Kisin ER, Murray AR, Smith S, Castranova V, Kommineni C. Enhanced Oxidative Stress in the skin of vitamin E deficient mice exposed to semi-synthetic metal working fluid. Toxicology, 176(1-2):135-43, 2002.
73. Shvedova AA, Kisin ER, Murray AR, Goldsmith T, Reynolds JS, Castranova V, Frazer DG, Kommineni C. Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets. Toxicology, 177(2-3):285-297, 2002.
74. Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Mason RP, Kadiiska MB, Gunther MR, Antioxidant Balance and Free Radical Generation in Vitamin E-Deficient Mice after Dermal Exposure to Cumene Hydroperoxide. Chem Res Toxicol.15(11):1451-1459, 2002.
75. Tyurina YY, Tyurin VA, Shvedova AA, Fabisiak JP, KaganVE. Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling. Methods Enzymol. 352:159-74, 2002.
76. Kagan VE, Kuzmenko A.I, Shvedova AA, Kisin E.R., Li R., Martin I., Quinn P.J., Tyurin V.A., Tyurina Y.Y., Yalowich J.C.. Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells. Bioch. Bioph. Acta , 2003, 1620(1-3):72-84.
77. Kagan VE, Borisenko GG, Serikan BF, Tyurina YY, Tyurin VA, Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Fadeel B. Appetizing rancidity of apoptotic cells for macrophages: oxidation/externalization/recognition of phosphatidylserine. Am. J. Phys., 2003, 285(1):L1-17.
78. Shvedova AA, Kisin ER, Murray AR., Schwegler-Berry D, Gandelsman VZ, Maynard A, Paul Baron, Castranova V. Exposure to carbon nanotube material II: assessment of the biological effects of nanotube materials using human keratinocytes. J. Tox. Env.Health, 66, 1901-1918, 2003
79. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V. Exposure to Carbon Nanotube Material I: Aerosol Release During the Handling of Unrefined Single Walled Carbon Nanotube Material. J. Tox. Env. Health, 2004, 67(1):87-107
80. Shvedova AA, Kisin ER, Murray A, Kommineni C, Vallyathan V, Castranova V. Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer. Biochemistry (Moscow), 2004, 69 (1), 23-31
81. Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman V, Baron P, Maynard A, Gunter M, Castranova V. Exposure of human bronchial cells to carbon nanotubes caused oxidative stress and cytotoxicity. Proceedings of the Meeting of the SFRR Europe (June 26-29, 2003), Vol. ISBN 88-7587-002; CD ISBN 88-7587-003-9, 2004.
82. Matsura T, Masachika K, Yamada K, Shvedova AA, Kagan VE. Fine-tuning phagocytic clearance of apoptotic cells by phosphatidylserine oxidation. J. Clin. Biochem. & Nutr., 34, 11-24, 2003
83. Jiang J, Borisenko GG, Osipov A, Martin I, Chen R, Shvedova AA, Sorokin A, Tyurina YY, Potapovich A, Tyurin VA, Graham SH, Kagan VE. Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells. J Neurochem. 90 (5):1036-49, 2004
84. Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman V, Baron P, Maynard A, Gunter M, Kagan V.E., Castranova V. Assessment of Carbon Nanotube Cytotoxicity Using Human Cells and Animal Models. Proceeding of the Toxicology Forum 29th Annual meeting, (Feb, 2-4, Washington, DC, 2004), in press, 2004
85. Heck DE, Kagan VE, Shvedova AA, Laskin JD. An Epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary massive concerning origins of apoptosis. Toxicology, in press, 2004
Return to top...
Selected Presentations (1990-01)
1. Kagan V, Khan S, Swanson C, Shvedova A, Serbinova E, Packer L. Antioxidant action of thioctic and dihydrolipoic acid. Free Radical Biology 8 Medicine 9: 15, 1990, Oxidative Damage & Repair, Int. Med. of Society of Free Radical Research, Pasadena, 1990
2. Shvedova AA, Kramarik JA, Keohavong P, Chumakov KM, Karol MH. Expression of TNF-? in vivo after cotton dust exposure. Cytokines and Lung Function, FASEB, Saxton's River, Vermont, 1993
3. Shvedova AA, Kramarik JA, Keohavong P, Karol MH. Role of TNF-? in development of toxic alveolitis following inhalation of cotton dust. Society of Toxicology Annual Meeting, Dallas, 1994
4. Shvedova AA, Stoyanovsky DA, Graham C, Kagan VE, Karol MH. The relationship between TNF-?, pro- and antioxidant factors in eosinophilic inflammation following allergic airway constriction in guinea pigs. American Lung Association/American Thoracic Society International Conference, Boston, 1994
5. Shvedova AA, Menshikova EV, Ritov VB, Kagan VE, Karol MH. Allergic immune response activates calcium transport in murine lungs. Society of Toxicology Annual Meeting, Baltimore, 1995
6. Shvedova AA, Karol MH, Kagan VE. Role of free radical intermediates in hypersensitivity responses induced by eugenol. International Congress of Toxicology – VII, Seattle, 1995
7. Shvedova A, Osipov A, Karol M, Kagan V. Peroxidase/H202 enhances hypersensitivity responses induced by eugenol: Inhibitory effects of an Antioxidant, Lipoic Acid. The Second International Meeting on Oxygen/Nitrogen Radicals and Cellular Injury, Durham, NC, 1997
8. Shvedova AA, Tyurina YY, Tyurin VA, Gorbunov NV, Castranova V, McLaughlin M, Ojimba J, Gandley R, Kagan VE. Nitric Oxide but not nitrosothiols inhibit tert-butyl hydroperoxide/hemoglobin-induced oxidative stress and cytotoxicity. Society of Toxicology Annual Meeting, Seattle, WA, March 1-5, 1998
9. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Castranova V, Kagan VE. Lipid peroxidation in human epidermal keratinocytes induced by redox-cycling of phenol. International Conference of Chemistry of Organic Peroxides. Moscow, Russia, June15-18, 1998
10. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Castranova V, Kagan VE. Redox-cycling and cytotoxicity of phenol in keratinocytes: evidence for enhanced lipid and thiol oxidation and antioxidant depletion. III Int. Congress of Pathophysiology. Lahti, Finland, June 28-July 03, 1998
11. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Jeffries BA, Castranova V, Kagan VE. Free Radical mechanism(s) of cytotoxicity of phenolic compounds to skin. IX Biennial Meeting International Society for Free Radical Research. September 7-11, 1998
12. Shvedova AA, Tyurina YY, Tyurin VA, Jeffries B, Kommineni C, Castranova V, Kagan VE. Combination of phenolic compounds with arachidonic acid induces Afutile thiol pumping@ and oxidative stress in epidermal human keratinocytes. Society of Toxicology Annual Meeting, New Orleans, March 2-8, 1999
13. Al-Humadi NH, Kommineni C, Shvedova AA, Battelli L, Castranova V. Adverse responses to semi-synthetic metal working fluids in B6C3F1 Mice. Society of Toxicology Annual Meeting, New Orleans, March 2-8, 1999
14. Shvedova AA, Kommineni C, Tyurina YY, Tyurin VA, Castranova V, Kagan VE. Toxic effects of phenolics to skin. Advances in the Biology and Treatment of the Skin, Piscataway, NJ. June 23 - 25, 1999
15. Kommineni C, Kisin ER, Ebeling A, Al-Humadi N, Castranova V, Shvedova AA. Oxidative stress affects dermal exposure to metal working fluid in B6CF1 mice. 14-th Annual Conference, Foundations of Immunotoxicology, Morgantown, September 8-10, 1999
16. Shvedova AA, Kisin ER, Kommineni C, Schwegler-Berry D, Tyurina YY, Tyurin VA, Castranova V, Kagan VE. Redox-cycling of occupational phenolic compounds induces oxidative stress and cytotoxicity in human epidermal keratinocytes. SFRR Meeting, Bio-Flavonoids & Polyphenols in Health and Diseases, December 2-5, Dinard, France, 1999
17. Johnson E, Shvedova A, Kisin E, O'Callaghan JP, Kommineni C, Miller D. Vitamin E deficiency increases susceptibility of the BALB/C mice to MDMA-induced dopaminergic neurotoxicity. Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000
18. Kagan VE, Tyurina YY, Tyurin VA, Kawai K, Fabisiak JP, Kommineni C, Castranova V, Shvedova A. Oxidative stress in keratinocytes: role in apoptotic signaling. Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000
19. Kisin E, Kommineni C, Tyurina YY, Tyurin VA, Schwegler-Berry D, Castranova V, Kagan VE, Shvedova AA. Redox-cycling of phenols cause depletion of GSH, oxidative stress and cytotoxicity in normal human epidermal keratinocytes (NHEK). Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000
20. Kommineni C, Kisin ER, Al-Humadi N, Castranova V, Shvedova AA. Elevated oxidative stress in skin of B6CF1 mice affects dermal exposure to metal working fluid, Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000
21. Kisin E, Kommineni C, Tyurina YY, Tyurin VA, Schwegler-Berry D, Castranova V, Kagan VE, Shvedova A. Redox-cycling of phenols cause depletion of GSH, oxidative stress and cytotoxicity in normal human epidermal keratinocytes (NHEK). Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000
22. Shvedova A, Kisin E, Kommineni C, Mason RP, Kadiiska MB. Antioxidant balance and free radical generation in vitamin E deficient mice after dermal exposure to cumene hydroperoxide. Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000
23. Kagan VE, Shvedova AA. Phenolic antioxidants and pro-oxidants: are they really so different? Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
24. Smith C, Kisin E, Murray A, Castranova V, Kommineni C, Shvedova AA. Oxidative stress in the skin of vitamin E deficient mice exposed to metal working fluid. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
25. Shvedova AA, Kisin E, Murray A, Castranova V, Kommineni C, Gunter MR. Phenol induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation and antioxidant depletion. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
26. Al-Humadi NH, Shvedova A, Kommineni C. Used semi-synthetic metal working fluid (UMWF) dermal and systemic effects in B6C3F1 mice. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
27. Shvedova AA, Tyurina YY, Tyurin VA, Kisin ER, Kikuchi Y, Quinn PJ, Kagan VE. Superoxide-induced reduction of coenzyme Q and its interaction with vitamin E synergistically protects human keratinocytes against oxidative stress. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
28. Kagan VE, Kuzmenko AI, Tyurina YY, Kisin ER, Shvedova AA, Yalowich JC. Lipoate/Ascorbate-dependent recycling prevents myeloperoxidase-catalyzed oxidation of vitamin E homologues= phenoxyl radical in live HL-60 cells. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
29. Kisin E, Smith C, Murray A, Kisin J, Kommineni C, Castranova V, Kagan V, Shvedova AA. Phenolic Compounds Cause Depletion of GSH, Oxidative stress and cytotoxicity in normal human dermal cells. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001
30. Shvedova AA, Kisin E, Kawai K, Kagan VE. Antioxidant Interactions and Biomarkers of Oxidative stress in skin and keratinocytes as they relate to apoptosis and aging. 9th Congress International Association of Biomedical Gerontology, Vancouver, B.C. Canada, June 27-30, 2001
31. Shvedova AA, Kisin E, Murray A, Goldsmith T, Reynolds JS, Castranova V, Frazer DG, Kommineni C. Sub-chronic effects of metal working fluids on pulmonary functions in B6C3F1 mice: role of vitamin E. Society of Toxicology Annual Meeting, Nashville, March 17-21, 2002
32. Shvedova AA, Kisin ER, Kommineni C, Castranova V, Mason RP, Kadiiska MB, Gunther MR. Cumene Hydroperoxide induces depletion of antioxidants and free radical formation in skin of vitamin E-deficient mice. The 13th Japanese Annual Vitamin E Meeting, Hiroshima, Japan, January 17-21, 2002
33. Shvedova AA, Kisin ER, Murray AR, Kawai K, Castranova V, Howard PC. Oxidation biomarkers and antioxidant protection of skin against UV-irradiation and chemical exposure. Reactive Oxygen and Nitrogen Species: Diagnostic, Preventive, and Therapeutic Values. International Symposium, Russia, July 9-13, 2002
34. Shvedova AA, Kisin ER, Murray AR, Mason RP, Kadiiska M, Castranova V, Gunther M. In vivo detection of vitamin E-dependent protection against free radical formation and oxidative stress in skin treated with cumene hydroperoxide. 9th Annual Meeting, Oxygen Society, San Antonio, TX, Nov. 20-24, 2002
35. Shvedova AA, Kisin ER, Kommineni C, Gunter MR, Rao MK, Castranova V. Inflammatory response and free radical formation in skin of B63CF1 mice with diminished levels of glutathione after phenol exposure. 42nd Ann. Meeting SOT, Salt Lake City, UT, March 9-13, 2003
36. Shvedova AA, Murray AR, Kisin ER, Kagan VE, Gandelsman VZ, Castranova V. Exposure of human bronchial epithelial cells to carbon nanotubes caused oxidative stress and cytotoxicity. Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications, SFRR Meeting, June 26-29, 2003, Ioannina, Greece
37. Shvedova AA, Tyurina YY, Kawai K, Tyurin VA, Castranova V, Kagan VE. Oxidative Phospholipid Signaling During Apoptosis in Keratinocytes. Clearance of Dying Cells by Phagocytes: Mechanisms & Consequences. Gordon Res. Con. New London, CT, Aug 3-8, 2003
38. Baron P., Maynard A, Shvedova AA, Kisin E., Castranova V. Preliminary studies of generation, exposure, and toxicity of carbon nanotubes. Am. Ass. Aeros Res. Meeting, October 20-24, 2003 Anaheim, CA
39. Shvedova A.A. Pulmonary Toxicity of Carbon Nanotubes: From Cellular Responses to Animal Model. Nanoscale Materials and Public Health. Toxicology Forum. February 2-4, 2004, Washington DC
40. Shvedova A. A., Kisin E, Keshava N, Murray A.R, Gorelik O, Arepalli S, GandelsmanV.Z, Castranova V. Cytotoxic and genotoxic effects of single wall carbon nanotube exposure on human keratinocytes and bronchial epithelial cells, 227th ACS National Meeting, March 28-April 1, 2004, Anaheim, CA
41. Shvedova A.A. Pulmonary toxicity of carbon nanotubes. International congress on nanotechnology, San Francisco, CA, Nov 7-10, 2004
42. Shvedova A. A., Kisin E, Murray A.R, Gorelik O, Arepalli S, GandelsmanV.Z, Mercer B, Hubbs A, Kagan VE, Castranova V. Oxidative stress and pulmonary toxicity of carbon nanotubes.11TH Annual meeting SFRBM, November 17-21, 2004
43. Shvedova A.A. Pulmonary toxicity of carbon nanotube: what we know and what we do not know. National Nanotechnology Infrastructure Network (NNIN): Nanosafe: A workshop on Environmental Health and Safety in Nanotechnology Research, Atlanta, GA, Dec 1-3, 2004
Return to top...
|
