Department of Physiology and Pharmacology
William T. Stauber
 William T. Stauber
Professor of Physiology, Neurology, and Physical Therapy
Ph.D., Rutgers University, 1972; Postdoctoral Fellowship,
University of Iowa, Iowa City, IA
Phone: 304-293-1491
Email: wstauber@hsc.wvu.edu
Research Interests
Muscle physiology, exercise physiology, repetitive stress injuries, muscle injury and repair, and muscle fibrosis and movement dysfunction.
Description of Research
The effects of acute and chronic muscle strain injuries such as experienced in occupations where movements involving deceleration of body segments are studied. Skeletal muscle atrophy, growth and repair are common in strain-injured muscles. The importance of the extracellular matrix, material surrounding the muscle cells, as a control site for growth and repair is of special interest because fibrosis can develop from repeated injuries. Muscle fibrosis, which is the proliferation of collagen, can produce muscle dysfunction - often seen in muscle contractures.
We built a rodent dynamometer to test the dynamic parameters (force, velocity, dose) involved in producing strain injuries in rats and to record changes in muscle strength and fatigue. Our studies revealed that complex interactions of functional parameters important in producing either a hypertrophic or fibrotic muscle. Knowledge of the parameters involved in muscle strain injuries is important in developing prevention strategies to improve worker health and well being.
Recent Publications
Willems, M E T, and W T Stauber. Force output during and following active stretches of rat plantar flexor muscles: Effect of velocity of ankle rotation. J Biomech 33:1035-1038, 2000.
Stauber W T, E R Barill, R E Stauber, and G R Miller. Isotonic dynamometry for the assessment of power and fatigue in the knee extensor muscles of females. Clin Physiol 20:225-233, 2000.
Stauber, W.T., Smith, C.A., Miller, G.R., and F.D. Stauber. Recovery of rat soleus muscles from 6 weeks of repeated strain injury. Muscle & Nerve 23:1819-1825, 2000.
Willems, M. E. T. and W.T. Stauber. Effect of resistance training on muscle fatigue and recovery in intact rats. Med Sci Sports Exerc 32:1887-1893, 2000.
Willems, M. E. T. and W.T. Stauber. Changes in force by repeated stretches of skeletal muscle in female Sprague Dawley rats. Aging: Clin Exp Res12:478-481, 2000.
Willems, M. E. T. and W.T. Stauber. Force during stretches of rat skeletal muscle after hypertonia at short and long lengths. Archiv Physiol Biochem 108:391-397, 2000.
Willems, M. E. T., Miller, G.R. and W.T. Stauber. 2001. Force deficits after active stretches of rat skeletal muscles with reduced collagen cross-links. Eur. J. Appl. Physiol. 85: 405-411.
Willems, M. E. T., Miller, G.R. and W.T. Stauber. 2001. Force deficits after repeated stretches of activated skeletal muscles in female and male rats. Acta Physiol. Scand. 172:63-67
Willems, M.E.T. and W.T. Stauber. 2002. Force deficits by stretches of activated muscles with constant or increasing velocity. Med. Sci. Sports & Exerc. 34: 667-672.
Willems, M.E.T. and W.T. Stauber. 2002. Effect of contraction history on torque deficits by stretches of active rat skeletal muscles. Can. J. Appl. Physiol. 27: 323-335.
Willems, M. E. T. and W.T. Stauber. 2002. Fatigue and recovery at long and short muscle lengths following resistance training. Med. Sci. Sports & Exerc. 34: 1738-1743.
Stauber, W.T. and M.E.T. Willems. 2002. Prevention of histopathologic changes from 30 repeated stretches of active rat skeletal muscles depends on inter-stretch rest time. Eur. J. Appl. Physiol. 88: 94-99.
Willems, M.E.T. and W.T. Stauber. 2003. Attenuation of stretch-induced histopathologic changes of skeletal muscle by quinacrine. Muscle & Nerve 27: 65-71, 2003.
Stauber, W.T. 2004. Factors involved in strain-induced injury in skeletal muscles and outcomes of prolonged exposures. J. Electromyography & Kinesiology 14 (1): 61-70.
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