Signal transduction by tyrosine kinases and phosphatases.

Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.  Oncogene 2006

Functional recovery of myeloid cells following bonemarrow transplantation.

An improved methodology to detect human T cell receptor beta variable family gene expression patterns.  Journal of Immunological Methods 302: 54-67, 2005

Signaling networks that regulate cellular motility and invasion in breast cancer.

c-Yes response to growth factor activation.  Growth Factors 23: 263-72, 2005 (Review)

Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.  Molecular Cell Biology 24: 7578-97, 2004

Anoikis and the role of cell adhesion in cellular survival; mechanism of tumor suppression by E1a.

Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.
Cancer Research 66: 4273-8, 2006

Disruption of epithelial cell-matrix interactions induces apoptosis.  Journal of Cell Biology 124: 619-626, 1994
This paper was cited as one of the most influential papers in the Journal of Cell Biology's “From the Archives” series in celebration of 50 years of publishing scientific articles.

Chemical carcinogenesis; computational biology; nanotechnology.

Preparation, characterization, and substrate metabolism of gold-immobilized cytochrome P450 2C9.  Journal of American Chemical Society 128: 8374-8375, 2006

Effects of dose-intensive chemotherapy on the bone marrow microenvironment and the subsequent effect on hematopoietic recovery.

MMP-2 is required for bone marrow stromal cell support of pro-B-cell chemotaxis.
Experimental Hematology 33: 1192-200, 2005

Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage.  Stem Cells 23: 1122-34, 2005

Bioinformatics and computer software applications that integrate information exchange.

Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.  Clinical Cancer Research 12: 3344-54, 2006

PI 3-kinase and angiogenesis

More Jiang journal  - look up later

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.  FASEB Journal 19: 342-53, 2005

Caveolin-1, endothelial cell motility, and angiogenesis. 

Loss of caveolin-1 polarity impedes endothelial cell polarization and directional movement.  Journal of Biological Chemistry 280: 3541-7, 2005

Effects of ethanol on EGF receptor signaling in breast cancer.   

Pharmacokinetics; pharmacodynamics; pharmacogenomics and oncology.

Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer.  Journal of Clinical Oncology 23: 6117-25, 2005

Heavy metals, signal transduction, cytoskeleton, and cell motility.

Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.
Clinical Cancer Research 12: 3344-54, 2006

Development of cancer imaging instrumentation and methods; radiological sciences; Positron Emission Tomography (PET).

Endoprobe: a system for radionuclide-guided endoscopy.  Medical Physics 31: 3306-13, 2004

Adaptor proteins in mitogenesis and cancer; diabetes, defects in cellular signaling.

Grb10 exceeding the boundaries of a common signaling adapter. Frontiers of Bioscience 9: 603-18, 2004. (Review)

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.  Journal of Biological Chemistry 278: 39311-22, 2003

Death domain folds in cancer; inflammation and immunity.

The PYRIN connection: novel players in innate immunity and inflammation.  Journal of Experimental Medicine 200: 551-8, 2004

Cytochrome P450 and molecular modeling.

Regiospecificity of human cytochrome P450 1A1-mediated oxidations: the role of steric effects. Journal of Biological Structure and Dynamics 23: 243-56, 2005

DNA damage, apoptosis, and oncology.

Regulation of the actin cytoskeleton in cell motility and tumor cell invasion.

Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization.  Journal of Cell Biology 164: 899-910, 2004

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Molecular Biology of Cell 14: 3216-29, 2003