Patrick Callery, Ph.D.
Professor, Chair of Basic Pharmaceutical Sciences, Assistant Dean, Research and Graduate Programs

Drug design, drug metabolism, and mass spectrometry.

Identification of anhydroecgonine ethyl ester in the urine of a drug overdose victim.
Journal of Forensic Science 50: 1481-5, 2005

Vincent Castronova, Ph.D.
Adjunct Professor, (NIOSH)

Free-radical biology; pulmonary toxicology; silica-induced carcinogenesis. 

Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation.  Toxicological Science 90: 188-97, 2006

Eugene Demchuk, Ph.D.
Adjunct Assoc. Professor (NIOSH)

Computational chemistry and molecular modeling.

Immunogenetic factors in beryllium sensitization and chronic beryllium disease.
Mutation Research 592: 68-78, 2005

Jeffrey Fedan, Ph.D.
Adjunct Professor, (NIOSH)

Inhalation studies; respiratory diseases; pharmacology.

Altered ion transport and responsiveness to methacholine and hyperosmolarity in air interface-cultured guinea-pig tracheal epithelium.  Journal of Pharmacological Toxicological Methods 2006

Peter Gannett, Ph.D.
Professor

Carcinogenesis; drug-protein interactions; DNA structure and conformation; EPR and NMR; molecular modeling.

Preparation, Characterization, and Substrate Metabolism of Gold-Immobilized Cytochrome P450 2C9.  Journal of American Chemical Society 128: 8374-8375, 2006

Jamal Mustafa, Ph.D.
Professor

Cardiovascular and pulmonary pharmacology and physiology; blood flow regulation to the heart, asthma and its mechanisms.

Effects of Targeted Deletion of A1 Adenosine Receptors on Post-Ischemic Cardiac Function and Expression of Adenosine Receptor Subtypes.  American Journal of Physiology Heart Circulatory Physiology 2006

Isolation and characterization of coronary endothelial and smooth muscle cells from A1 adenosine receptor-knockout mice.  American Journal of Physiology Heart Circulatory Physiology 290: H1713-20, 2006

James O’Donnell, Ph.D.
Professor

Pharmacology; phosphodiesterases and depression.

Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram.  Brain Research 1096: 104-12, 2006

William Petros, PharmD.
Mylan Professor of Pharmacology

Pharmacokinetics; pharmacodynamics; pharmacogenomics; oncology.       

Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer.  Journal of Clinical Oncology 23: 6117-25, 2005

Yongyut Rojanasakul, Ph.D.
Professor

Apoptosis; drug delivery; pharmaceutics.

Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination.  Cancer Research 66: 6353-60, 2006

Paul Siegel, Ph.D.
Adjunct Assoc. Professor (NIOSH)

Asthmatogen biomarkers; pharmacology.

Kinetics and mechanistic studies of the hydrolysis of diisocyanate-derived bis-thiocarbamates of cysteine methyl ester.  Chemical Research Toxicology 19: 341-50, 2006

Grazyna Szklarz, Ph.D.
Assoc. Professor

Structure and function of cytochrome P-450, P-450-mediated drug metabolism; carcinogenesis; molecular modeling.

Regiospecificity of human cytochrome P450 1A1-mediated oxidations: the role of steric effects.  Journal of  Biomological Structure and Dynamics 23: 243-56, 2005