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Education:
Post-doctoral Training - University of Maryland Baltimore Research Interests: Drug Design, Drug Metabolism, Mass Spectrometry. Recent Publications: Tirumalai P, Gannett PM, Callery PS, Bland TM, Tracy TS, Conversion of methamphetamine to N-methyl-methamphetamine in formalin solutions. J Anal Toxicol. 2005;29:48-53. Shakleya, DM, Tarr SG, Kraner JC, Clay DJ, Callery PS, Potential marker for smoked methamphetamine hydrochloride based on a gas chromatography-mass spectrometry quantification method for trans-phenylpropene. J Anal Toxicol. 2005;29:552-5. Bland TM, Haining RL, Tracy TS, Callery PS, CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005;70:1096-103. Shakleya DM, Kraner JC, Kaplan JA, Callery PS, Methylation of 3,4-methylenedioxyamphetamine (ecstasy, MDMA) in formalin-fixed human liver tissue, J Anal Tox. 2005;29:715-717. Myers AL, Williams HE, Kraner JC, Callery PS, Identification of anhydroecgonine ethyl ester in the urine of a drug overdose victim. J. Forensic Sci. 2005;50:1481-5. Sanga M, Younis IR, Tirumalai PS, Bland TM, Banaszewska M, Konat GW, Tracy TS, Gannett PM, Callery PS, Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP450 enzymes and stereoselective glutathione adduct formation. Toxicol Appl Pharmacol. 2006;211:148-156. Shakleya DM, Kraner JC, Kaplan JA, Callery PS, Multistage mass spectrometric method for methamphetamine methylation in formalin fixed liver tissue, Forensic Sci Int. 2006 [Epub ahead of print] Shakleya, D.M., Kraner, J.C., Clay, D.J., Callery, P.S. and Bell, S.C. (2006) Validation of a headspace GC method for the analysis of a pyrolytic product of methamphetamine in urine. J Anal Toxicol. 30, 559-562. Moungjaroen, J., Nimmannit, U., Callery, P.S., Wang, L., Azad, N., Lipipun, V., Chanvorachote, P. and Rojanasakul, Y. (2006) Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther. 319, 1062-1069). Richmond-Aylor, A., Bell, S., Callery, P.S. and Morris, K. (2007) Thermal degradation analysis of amino acids in fingerprint residue by pyrolysis GC-MS to develop new latent fingerprint developing reagents, J Forensic Sci. 52, 380-382. Li, P., Callery, P.S., Gan, L.S. and Balani, S.K. (2007) Esterase inhibition attribute of grapefruit juice leading to a new drug interaction. Drug Metab Dispos. 35, 1023-1031. Li, P., Callery, P.S., Gan, L.S. and Balani, S.K. (2007) Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction. Drug Metab Dispos. 35, 1203-1208. Peer, C.J., Shakleya, D.M., Younis, I.R., Kraner, J.C. and Callery, P.S. (2007) Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases. J Anal Tox. 31, 515-522. Cooper, A.J.L., Younis, I.R., Niatsetskaya, Z.V., Krasnikov, B.F., Pinto, J.T., Petros, W.P., and Callery, P.S. (2008) Enzymatic conversion of the cysteine S-conjugate of the anticancer drug busulfan to tetrahydrothiophene, pyruvate and ammonium. Drug Metab. Dispos. 36, 1546-1552. NIH Repository # 51128. Peer, C.J., Clay, D.J., Glover, H.L., Renninger, K.L., Kraner, J.C., and Callery, P.S. (2008) Direct injection mass spectrometric confirmation of multiple drugs in overdose cases from postmortem blood using ESI-MS-MS and MS3. J Anal Tox. 32, in press. Shakleya, D.M., Plumley, A.E., Kraner, J.C., Bell, S.C., and Callery, P.S. (2008) Case Study: Trace evidence of trans-phenylpropene as a marker of smoked methamphetamine. J Anal Tox. 32, in press. Younis, I.R., Elliott, M., Peer, C.J., Cooper, A.J.L., Pinto, J.T., Konat, G.W., Kraspulski, M., Petros, W.P., and Callery, P.S. Dehydroalanine analog of glutathione: An electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. J Pharmacol Exp Ther, in press. Patents: M.D. Loberg, P.S. Callery, and M. Cooper, New Pharmaceutical Chelates and Methods of External Imaging. U.S. Patent 4,017,596, 1977, plus foreign patents. Marketed in U.S. by New England Nuclear and Squibb and in Canada by Merck Frosst. P.S. Callery, J. Wright, N. Zenker, and C.S. Stone, Antihypertensive Benzoxazolones. U.S. Patent 4,034,100, 1977, plus foreign patents. Assigned to Merck and Co. P.S. Callery, M.J. Egorin, Y. Li, and Z.-M. Yuan, Diaziridinylpolyamine Anti-Cancer Agents. U.S. Patent 5,612,329, 1997. P.S. Callery, J. Wright, and N. Zenker, Antihypertensive Benzimidazolones. U.S. Patent 4,073,929, 1977, plus foreign patents. Assigned to Merck and Co. Positions:
Assistant Professor, University of Maryland Baltimore, 1974-1978
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