Peter Gannett, Ph.D. Professor of Medicinal Chemistry Department of Basic Pharmaceutical Sciences West Virginia University P.O. Box 9530 Morgantown, WV 26506-9530 Phone: (304) 293-1480 Fax: (304) 293-2576 E-Mail: pgannett@hsc.wvu.edu

Link to Full CV - PDF

Post-doctoral Training
University of Wisconsin-Madison (Pharmacy) and the Eppley Cancer Research Inst., University of Nebraska Medical Center.

Graduate Training
University of Wisconsin-Madison (Chemistry).

Undergraduate Training
University of Missouri-Columbia.

Research Interests:

DNA structure and conformation.
Reactions of radicals with DNA.
Supramolecular organic chemistry and DNA.
Hydrazines carcinogenesis.

Recent/Current Grants:

Carcinogenesis of Arylhydrazines (NIH-NCI)
Carcinogenesis of Aliphatic hydrazines (NIH-NCI)
Antisense and triplex DNA formation in cells by ESR (NIH-NIGMS)
Laboratory for Computational Chemistry and Chemical Biology  (WVU Research Corp).
Degradation of Drugs in Embalmed Tissue (FBI-DOJ) 

Research Techniques:

Nuclear Magnetic Resonance (NMR)
Electron Paramagnetic Resonance  (EPR)
Organic Synthesis (Modified nucleic acids) 
Gel electrophoresis
Oligonucleotide synthesis Molecular Modeling

Selected Publications:

Tracy, T.S., Hummel, M.A., Gannett, P.M., Aguilar, J.S. “Effector-Mediated Alteration of Substrate Orientation in Cytochrome P450 Enzymes.” (2004) Biochemistry, 43:7207-7214.

Darian, E. and Gannett, P.M. ‘Application of Molecular Dynamics to Spin-labeled Oligonucleotides’, (2005) J. Biomolecular Structure and Dynamics, 22:579-594.

Gannett, P.M., Heavner, S., Daft, J.R., Shaughnessy, K., Epperson, J.D., Greenbaum, N.L. "Synthesis, Properties, and NMR Studies of a C8-Phenylguanine Modified Oligonucleotide that Preferentially Adopts the Z-DNA Conformation." (2003) Chem. Res. Toxicol.16:1384-1393.

Powell, J.H., and Gannett, P.M." Mechanisms of Carcinogenicity of Aryl Hydrazines, Aryl Hydrazides, and Arenediazonium Ions. "(2002) J. Environ. Pathol. Toxicol. Oncol. 21:1-32.

Gannett, P.M ., Powell, J.H., Johnson, II, E.M., Darian, E., Dalal, N., Norton, M., Budil, D. " Solid Phase DNA Annealing Characterization by EPR Spectroscopy. "(2002) Tetrahed. Lett., 43:1931-34.

Gannett, P.M , Darian, E., Powell, J.H., Johnson, III, E.M., Mundoma, C., Greenbaum, N.L., Ramsey, C.M., Dalal, N.S., Budil, D.E. " Probing Triplex Formation by EPR Spectroscopy Using a Newly Synthesized Spin Label for Oligonucleotides ",  (2002) Nucl. Acids Res. 30:5328-5337.

Gannett, P.M., Shi, X., Ye, J., Powell, J., Darian, E., Daft, J. "Activation of AP-1 through the MAP Kinase Pathway: A Potential Mechanism of the Carcinogenic Effect of Arenediazonium Ions" (2000) Chem. Res.Toxicol., 13:1020-1027.

Gannett, P.M., Powell, J., Rao, R., Shi, X., Lawson, T., Kolar, C., and Toth, B. C8-Aryladenine formation in calf thymus DNA from arenediazonium ions. (1999) Chem. Res. Toxicol. 12:297-304.

Gannett, P.M., Shi, X., Lawson, T., Kolar, C., Toth, B. "Aryl Radical Formation During the Metabolism of Arylhydrazines by Microsomes" Chem. Res. Tox. (1997) 10:1372-1377. 

Teaching:

Undergraduate:
Chemistry of Drug Action.
Chemical Properties of Drugs.

Graduate:
Advanced Medicinal Chemistry.
Special Topics in NMR and ESR.
Free Radicals in Biological Systems.
Molecular Modeling of Biological Molecules.

American Chemical Society
Organic Chemistry Division, American Chemical Society
Medicinal Chemistry Division, American Chemical Society
Chemical Toxicology Division, American Chemical Society
Rho Chi Society