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Dr. Joseph K.H. Ma, Ph.D Department of Basic Pharmaceutical Sciences Phone: (304) 293-1449 E-Mail: jma@hsc.wvu.edu
EDUCATION National Taiwan Normal July 1961/June 1966 B.S./Chemistry Duquesne University February 1968/May 1972 Ph.D./Physical Chemistry/ Doctoral Dissertation: "Polarographic and Crystal Structural Studies of Binary and Ternary Metal complexes of Pyridine-2-carboxamide, Pyridine-2-carboxylate, 5,5-diethyl-barbiturate, and Imidazole." Postdoctoral Training Research Associate in Biopharmaceutics - School of Pharmacy, University of Georgia, July 1972-December 1974, Research Associate in Pharmaceutics - School of Pharmacy, West Virginia University, January 1974- June 1975 Research Workshops and Industrial Visitation Polymeric Drug Delivery Systems, MIT Summer Conference, 1981; Director: Robert Langer Cytokines and Lipid Mediators as Regulators of Cell Function, FASEB Summer Conference, 1991, Copper Mountain, CO.; Patrick Wong and Robert Lewis, Directors Concepts in Molecular Biology, American Society for Investigative Pathology, October 29-November 1, 1992, Bethesda, MD; Mark E. Sobel and Lance A. Liotta, Directors. The Road to Compliance, CGMP Seminar on Pharmaceutical Laboratories, Sponsored by Protease Inhibitors, IBC International Conference, June 10-11, 1996, San Francisco, CA; John C. Cheronis, Tony E. Hugli, Akhter Molla, and Bonnie Sloane, Chairpersons. AACP Faculty Industrial Visitation to Ffizer Central Research, a discussion with Pfizer scientists on drug discovery, pharmaceutical R&D, manufacturing, and clinical Trials, Groton, CT, August 2-17, 1997. Aspen Lung Conference, Aspen, CO, June 1998. Second AAPS Frontier Symposium: Membrane Transporters and Drug Therapy, Bethesda, MD, April 8-10, 1999 EMPLOYMENT Academic Appointment at West Virginia University (WVU) Employer Year Duty WVU School of Pharmacy 1976 - 1979 Assistant Professor of Pharmaceutics/ Administrative Experience Assistant Dean for Research and Graduate Programs at WVU School of Pharmacy; Director, Center for Pharmaceutical Biotechnology and Therapeutic Research, WVU Health Science Center (HSC); WVU/HSC Graduate Program Council; WVU Research Director=s Group; WVU Research Advisory Council; Graduate and Research Liaison to AACP and APhA. PROFESSIONAL SERVICE/SCHOLARLY ACTIVITIES Membership and Honors American Chemical Society: Divisions of Physical Chemistry & Analytical Chemistry Academy of Pharmaceutical Sciences: Divisions of Basic Pharmaceutics and Pharmaceutical Analysis and Control American Association of Colleges of Pharmacy (AACP) Sigma Xi, WVU Chapter Rho Chi, WVU Alpha Mu Chapter Lederle Pharmacy Faculty Award - 1977 Society of Chinese Bioscientists in America - Life regular member American Association of Pharmaceutical Scientists (AAPS) - charter member, Sections of PDD (Pharmaceutics & Drug Delivery), APQ (Analysis and Pharmaceutical Quality Control); and PT (Pharmaceutical Technology) American Chinese Pharmaceutical Association - charter/life member Allegheny-Erie Regional Chapter of the Society of Toxicology West Virginia Thoracic Society Scientific Advisor: National Development Conference on Science and Technology, Republic of China, 1986. Visiting Professor: Institute of Occupational Medicine, Chinese Visiting Professor: Zhejiang Medical University, Hangzhou, China, 1993 - present Nominated for Election to 1995-2000 United States Pharmacopeia's Committee of Revision - Cell and Tissue Culture; Toxicity. AAPS Preformulation Focus Group AAPS Oral Absorption Focus Group II. Professional and Public Services A) School and University Coordinator and initiator: Graduate Seminar program (1975-1978) Coordinator: Analytical Instrument care and service contract (1976- 1980) Coordinator: Graduate courses development (1980) Representative: Annual state colleges visitation for student recruitment, Committee Member: Scientific planning for Mary Babb Randolph Cancer Center Construction Faculty Instructor: Health Career Opportunity Program (since 1980) Coordinator: Course revision and planning in Pharmaceutics (1986) Director: Summer Research Workshop for Undergraduate Pharmacy Students (since 1992), including seeking grant supported from industrial sources and awards from Coordinator: School of Pharmacy International Programs (since 1994). School of Pharmacy Executive Council (since 1994). Director: WVU-Merck Undergraduate Research Seminar (since 1994). Director: School of Pharmacy Graduate Programs; WVU International Programs Executive Council, Member (1994-1997); WVU Research Advisory Committee, Member; (1995-1997); Public, Professional, and Civil Services Judge for Scientific Research: Sigma Xi Research Conference (1983, 1990) Scientific Review (Research Articles and Grants): Journal of Pharmaceutical Sciences; International Journal of Pharmaceutics; Journal of Association of Official Analytical Chemists; Journal of Chromatography, Pharmaceutical Research; Journal of Microencapsulation; Encyclopedia of analytical chemistry WVU Senate Grant; WVU International Programs; AACP Young Investigators Grant; External Reviewer: Invited reviews on faculty research for Promotion and Tenure evaluation National and International Service Activity Screening Committee: APhA National Meeting (Kansas City, MO, 1979) Presiding Chair: APhA Meetings (Sections of Basic Pharmaceutics and Analytical Quality Control), 1978, 1979, 1982. Advisor: Science and Technology, 1986 National Development Conference, Republic of China. Visiting Professorship: Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China, 1990 - present School of Pharmacy, Zhejiang Medical University, Hangzhou China, 1993-present National Committees: American Association of Pharmaceutical Scientists (AAPS): Awards Committee, Analytical & Pharmaceutical Quality Control (APQ), 1993-1997, 2000-01. American Chinese Pharmaceutical Association (ACPA): Chair: ACPA Awards Committee 1992-1994; Chair: ACPA Education Committee, 1993-1994. American Association of Colleges of Pharmacy (AACP): Graduate Education, Research and Scholarship Program Liaison, 1994-1997. Organization of Symposia 1) Organized and directed a Conference on International Discussion of Occupational Medicine, West Virginia University, Morgantown, WV, November 12, 1991; Participants:50 international, NIOSH and WVU scientists. 2) Organized, Taught, and co-directed a Control Release Drug Delivery Workshop (BW 3) Served as Scientific Advisory Committee member on International Symposium on Oxygen Radical and Lung Injury; NIOSH/NIH/EPA/NCI/WVU, Co-sponsors; V. Castranova, et al., Directors, August 29-September 2, 1993, Morgantown, WV; Participants: 200 registered scientists. 4) Organized, Co-chaired, and served as panelist in the AAPS symposium on Teaching 5) Planning/Scientific Committee: 3rd International Conference on Oxygen/Nitrogen radicals: Cell Injury and Disease; June 2002, Morgantown, West Virginia. Consultantship and Collaborative Research Touche Ross Company: Drug Analysis (1976-78) Mylan Pharmaceuticals: Pharmaceutical Analysis (1977-80) FDA Biopharmaceutics Research Branch: Dosage Form Design and Dissolution Testing (1988-1994) United States Surgical Corporation: Microencapsulation (1988-89) CIBA Vision Ophthalmics: Corneal Peptide Delivery and Microencapsulation (1992) NIH: Consultant File Committee Services at West Virginia University (WVU) 1976-1977 - Graduate Seminar Committee, Chairman 1977-1978 - Graduate Seminar Committee, Chairman; Committee on Advanced. Studies. 1978-1979 - Committee on Graduate Admissions; Seminar Committee; Safety Committee. 1979-1980 - Committee on Admissions; Committee on Graduate Admissions; 1980-1981 - Committee on Admissions; Committee on Graduate Admissions. 1981-1982 - Committee on Admissions, Chair; Committee on Graduate Admissions. 1982-1983 - Committee on Graduate Admissions; Awards Committee; Departmental 1983-1984 - Graduate Affairs Committee; Safety Committee, Chairman; 1984-1985 - Safety Committee, Chairman; Graduate Affairs Committee; 1985-1986 - Instrument Committee, Chair; 1986-1987 - Academic Standards committee; Fire & Safety Committee (Medical Center); 1987-1988 - Academic Standards Committee; Committee on Admissions; 1988-1989 - Committee on Admissions; Recruiting Committee; WVU Patent Committee; 1989-1990 - Committee on Admissions; Graduate Affairs; Recruiting Committee; 1990-1991 - Committee on Admissions; 1991-1992 - Committee on Admissions; 1992-1993 - Committee on Admissions, Chair; 1993-1994 - Committee on Admissions, Chair 1994-1995 - Committee on Admissions; Strategic Planning: Subcommittee on Research; 1995-1996 - Award Committee; Committee on Admissions; 1996-1997 - Award Committee; Recruitment Committee 2000-2002: Curriculum Committee; Faculty Evaluation Committee (Chair); TEACHING ACTIVITY AT WVU Professional Program Major Responsibility: Pharm 702: Physical pharmacy; 3 credits: First Year Professional Program. Course Description: As an introductory course in the discussion of scientific principles Pharm 701: Pharmaceutical Care Lab 1; 2 credits; First Year Professional Students Course Description: The Pharmaceutical Care Labs are comprehensive laboratories that incorporate a variety of educational methods and learning experiences. Theses experiences are planned to suplement the lecture material for the smester and develop basic skills in medical technology, communications, documentation, information retrival, pharmaceutical calculations, pharmaceutical compounding, and basic pharmacy operating procedures. Electives: Pharm 276: Pharmaceutical Quality Control; 3 credits; Second-Year Standing Course Description: Basic scientific principles in quality control of drugs and dosage forms, with special emphasis on industrial procedures, GLP/GMP concepts and analytical methodologies. Pharm 289: Pharmaceutical Investigations; 1-3 credits; Second-Year Standing Course Description: Interested students will be instructed to carry out an original research with weekly discussions on problem solving, basic analytical techniques, and scientific writing. Students will have opportunity to interact with graduate students and other research scientists. Non-credit Course Teaching: 1) Chemistry and Mathematics reviews for pre-pharmacy students in the Health Career 2) Summer Research Workshop for Undergraduate Pharmacy Students: Participants will Other Courses Taught: Pharmaceutical Calculations; Pharmaceutical Analysis. Gradate Program and Postdoctoral Training Course Instruction Major Responsibilities: Pharm 302: Advanced Pharmaceutics; 3 credits Course Description: A discussion of physicochemical, biopharmaceutical, and cellular and molecular methods involved in the design, manufacturing, and evaluation of pharmaceutical delivery systems with emphasis on controlled drug release and targeted drug delivery. Pharm 375: Advanced Pharmaceutical Analysis I; 3 credits Course Description: A discussion of fluorometric techniques for drug analysis including fluorescence imaging and drug binding studies, and the principals and applications of chromatographic methods. Students are required to complete a laboratory project. Team Teaching: Pharmaceutical Sciences from Bench to Shelf (3 Cr.); Drug metabolism (3 cr.) Other Courses Taught: Pharm 390: Kinetics and Drug Stability; 2 credits Pharm 491: Drug Metabolism, 1 credit; ORD/CD Spectroscopy, 1 credit; Design of Prodrugs, 1 credit. Pharm 390: Drug Dynamics, 3 credits
Graduate Student Directed (as Major Advisor): 1) Stanley T. Day, M.S. 1976 Thesis Title: "Application of Metal Complexation in Tetracycline Analysis" 2) Nancy Feng, M.S. 1981 Thesis Title: "Microsomal Metabolism of Hydralazine" 3) Der-Cheng Tsai, M.S. 1984 Thesis Title: "In Vitro Evaluation of A Sustained-Release Formulation of Mitomycin-C" 4) Li-Fung Sue, M.S. 1985 Thesis Title: "Mucus Biosynthesis and Secretion by the Gill of Mytilus Edulis" 5) Nilsulwan Leelarasamee, Ph.D. 1987 Dissertation Title: "Kinetics of Drug Release from the Polylactic Acid Microcapsules Prepared by a Solvent Partition Method." 6) Hae-Young Ahn, Ph.D. 1988 Dissertation Title: "Histochemical and Structural Analysis of Mucous Glycoproteins 7) Rahul C. Mehta, Ph.D. 1988 Dissertation Title: "Biodegradable Mitomycin C Microcapsules in Intrahepatic Arterial Chemoembolization." 8) Li-Fung Sue Liu, Ph.D. 1989 Dissertation Title: "Pharmacological Control of Mucociliary Activity in the Gill of Mytilus Edulis." 9) Aniruddha Railkar, M.S. 1990 Thesis Title: "Binding of Tetracyclines to Human Cervical Mucin" 10) Wen-Pin (Anni) Liao, M.S. 1993 Thesis Title: "Liposomal Targeting of "-Interferon to Murine Bladder Tumor Cells." 11) De-Hwa (Wendy) Chao*, Ph.D. 1994 Dissertation Title: Multiple Emulsion-Mediated Therapeutic Enhancement of Tetrandrine Against Silicosis". *Recipient of the 1994 AAPS Proctor & Gamble Graduate Research Award 12) Meenakshi, G. Bhat, Ph.D., 1996 Dissertation Title: Mechanisms of Absorption and Metabolism of Peptide Drugs in the Lung. 13) Joseph Jun Shao**, Ph.D., December 1997 Dissertation: Drug-Loaded Tumor Cells as a targeting System Against Lung Metastasis ** Recipient of 1993 and 1996 AAPS Eastern Regional Meeting Best Paper Awards, 14) Xiao Dong Yang, M.S., December 1997 Thesis: Characterization of the Enzymatic Barrier of Alveolar Epithelial Models for Pulmonary peptide Absorption 15) Chuanyin Dong, M.S., May 1998 Thesis: Diesel Exhaust Particulate-Mediated Oxidative Response by Alveolar macrophages 16) James Xiao-Dong Yang, Ph.D., August 2001 Dissertation: Transport and utilization of arginine and arginine-containing peptides in alveolar macrophages 17) In Progress: Student Name Degree Program Area of Study Nabil Al-Humadi Ph.D. Alteration of pulmonary immune responses by Shui-ying Hu Ph.D. Mechanism of particle-induced Apoptosis Madhu Sanga Ph.D. Alteration of pulmonary P450 metabolism III. Postdoctoral Fellows and Visiting Scientists (Since 1990) 1) Mo, Changgeng, Visiting Scientist (Institute of Occupational Medicine, CAMP)- 2) Kang, J.H., Ph.D. (West Virginia University) - 3) Wang, L.Y., M.D. (Beijing Medical University) - 4) Xin, W.F., Visiting Scientist (Institute of Occupational Medicine CAPM) - 5) Chen, J.X., Visiting Scientist (Shanghai Institute for Drug Control) - 6) Susan L. Weber, M.D. (Jefferson Medical College) - 7) Cheng, Y.H., M.D., Visiting Scientist (Institute of Occupational Medicine, CAPM) - 8) Pan W.F., Visiting Scientist (Shanghai Institute for Drug Control)- 9) Peng, X.S., Visiting Scientist (Shanghai Institute for Drug Control) - 10) Yang, Y.J., Visiting Scientist (Shanghai Institute for Drug Control) - 11) Yang, H.M., Ph.D. (West Virginia University) - 12) Yin, Xue-Jun, Ph.D. (Capital university of medical Sciences, Beijing, China) RESEARCH AND SCHOLARLY ACTIVITY Current Research The respiratory tract is constantly exposed to airborne substances and infectious agents. Chronic exposure to toxic agents such as silica can result in severe inflammation and pulmonary fibrosis. Various lung diseases are also associated with increased incidence in fungal or tubercular infections due to weakened host defense mechanism. With recent resurgence of tuberculosis, mycobacterial infection is a serious health concern. The respiratory tract also permits delivery of drugs by inhalation. Therapeutic agents may be targeted to the upper and distal airways for localized effects, or to the alveoli for local or systemic action. Because of the large surface areas and the relatively low content of digestive enzymes in the alveoli, the pulmonary route can be a viable alternative to the gastrointestinal tract for the delivery of peptides and proteins, which, with recent advances in biotechnology, have become the drugs of choice in contemporary drug therapy. Advancement in drug delivery strategies and in treatment of pulmonary diseases requires a clear understanding of the host defense mechanism against external stimuli. This involves multiple biochemical events manifested by the oxidative/proteolytic responses of alveolar macrophages (AM) and epithelial cells, cytokine-mediated cell-cell interactions, and the alteration of receptor-mediated processes in cell uptake or secretion of bioactive material. It is from this emphasis that Dr. Ma originates his current research. A) Pulmonary Fibrosis and the Search for Antifibrotic Agents Ma and co-workers have made a major accomplishment in establishing tetrandrine as the first effective antifibrotic agent against silicosis through cellular-based mechanism, targeted drug delivery, and in vivo treatment studies. The mechanisms of fibrosis and drug action jointly identified the involvement of AM-orchestrated inflammatory sequel in silicosis. Tetrandrine, a bisbenzylisoquinoline alkaloid, binds to the cytoskeletal proteins of viable AM, inhibits silica-induced secretion of oxygen radicals and proinflammatory cytokines (IL-1 and TNF-a), and prevents cytokine-mediated neutrophil infiltration and fibroblast production of lung collagen. Our current interests: 1) Cell-Specific Inflammatory Response: This research addresses two hypotheses regarding the inflammatory process: oxygen radicals (OR) as second messengers and direct inflammatory mediation by type II cells. Studies have shown that OR may serve as second messengers in AM expression of neutrophil chemoattractants. Our interest is to examine of the induction of intracellular OR by fibrotic and nonfibrotic stimuli, the role of OR in NF-kB activation, and cytokine production in AM and in type II cells. Although AM play a major role in pulmonary host defense, type II cells are directly involved in the epithelial injury and repair. The oxidative and cytokine responses of type II cells toward exogenous exposure may in fact be the first step of stimulant-lung interaction. --- Cytokines are the powerful local protein mediators that are of major importance in virtually every biological process. In Dr. Ma=s laboratories, research are conducted to elucidate the cutting-edge information on the involvement of cytokines in pulmonary fibrosis and in cell activation associated with epithelial permeability and protease activity. --- 2) Mechanism of action of Tetrandrine and Derivatives for antifibrogenic effects. B) Fundamentals in Pulmonary Drug Targeting We have demonstrated that microemulsions and receptor binding liposomes (mannose, transferrin) can be used to enhance drug delivery to lung tissue or to the intended cell types. In addition, our research interests also include: 1) Cell-Derived Liposomes: This research examines the interaction of liposomes with specific lung cells based on surface molecule-mediated cell-cell recognition. Lymphocytes, for example, may be made into liposomes with surface molecules recognizable by AM, as part of the phagocytic clearance. 2) Tumor Cell-Derived Targeting System: Tumor cells, depending on their cell surface properties, exhibit specific affinity toward the capillary endothelium in their metastatic organ. Drug loaded B16-F10 tumor cells (DLTC) have been shown in our laboratory to retain selective affinity toward lung tissue, and such affinity is diminished by extensive trypsinization. Continuing research will address several questions regarding the molecular-based affinities among tumor cells and between tumor cell and metastatic tissue, the immune response and organ clearance of dead tumor cells, and the utility of DLTC for the prevention and treatment of lung metastasis. C) Transport and Degradation of Peptides Across Alveolar Epithelium Pulmonary type II cell-derived cell monolayer has been used as an epithelial model for peptide transport studies. The usefulness of this model may hinge on our understanding of cell function changes resulting from the transformation of type II to type I cells. Our current interest: 1) Characterization of the Alveolar Epithelial Model: Cell transformation from type II to type I may result in lost of certain protease activity and changes in cytokine production. These cell types may also show different responses to external stimulation on cell activities. This research examines the differentiation between type I and type II cells in metalloproteases (e.g. EP 24.11 and 24.15) activities and in type II-derived cytokines using intact, sonicated, and PMA-primed cells, appropriate peptides such as luteinizing hormone releasing hormone (LHRH) as substrates, and protease inhibitors. 2) Role of AM in Peptide Degradation: AM are known for their protease activities and their capacity to respond to a wide variety of stimuli in oxygen burst and phgocytosis, suggesting that AM may play a major role in peptide degradation in the lung. This research studies the kinetics and inhibition of AM protease activity under control and stimulated conditions and the localization of cytosol and matrix metalloproteases (MMPs). --- The MMPs are a family of enzymes that catalyze the degradation of extracellular matrix macromolecules. There is considerable evidence that individual MMPs are elevated in inflammatory diseases, such as fibrosis. They are also involved in the release of a wide range of biological factors including cytokines, receptors, other enzymes, and adhesion molecules from the cell membrane. --- 3) Peptide Absorption Studies: This research examines a number of epithelial models combining AM and type I/II cells for peptide permeability and enzyme degradation studies. Continuing research involves the design and development of protease inhibitors and in vivo correlation studies. Recent Publications: Yang, X.D., Ma, J.Y.C., Barger, M.W., and Ma, J.K.H. [2002]. “ Transport and utilization of arginine and arginine-containing peptides in alveolar macrophages,” Pharmaceutical Research , 19:825-831. Al-Humadi , N.H. , Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H. [2002]. “The effect of diesel exhaust particles (DEP) and carbon black (CB) on thiol changes in pulmonary ovalbumin allergic sensitized Brown Norway rats.” Exp. Lung Research , 28:333-349. Ma, J.Y.C. and Ma, J.K.H. [2002]. “The Dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymes,” J. Environ. Sci. & Health (Part C-Enviromental Carcinogenesis and ecotoxicology Reviews), C20(2): 117-147 (2002). Yin, X.J., Schafer, R., Ma, J.Y.C., Antonini, J.M., Weissman, D.N., Siegel, P.D., Barger, M.W., Roberts, J.R., and Ma, J.K.H. [2002]. “Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEP) I. Effects of DEP on early pulmonary responses,” Environ. Health Perspectives , 110:1105-1111. Yin, X.J., Schafer, R., Ma, J.Y.C., Antonini, J.M., Weissman, D.N., Siegel, P.D., Barger, M.W., Roberts, J.R., and Ma, J.K.H. [2003]. “Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEP) II. Effects of DEP on T-cell mediated immune responses,” Environ. Health Perspectives, 111:524-530. Rengasamy, A., Barger, M.W., Kane, E., Ma, J.K.H., Castranova, V., and Ma, J.Y.C. [2003]. “Diesel Exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats,” J. Toxicol. Environ. Health, 66, 153-167. Antonini, JM, Roberts, JR, Taylor, MD, Yin XJ, Stone S, Moseley A, Ma, JKH, Frazer, DG, Castranova V, Ma, JYC [2003]. Effects of asphalt inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in rats. Inhal Toxicol, 15:1347- 1368. Yin, X.J., Dong, C., Ma, J. Y. C., Antonini, J., Roberts, J.R., Stanley, C. F., Schafer, R., and Ma, J. K. H. [2004], “ Suppression of Cell-Mediated Immune Responses to Listeria Infection by Repeated Exposure to Diesel Exhaust Particles in Brown Norway Rats,” Toxicol. Sci., 77:263-271. HW Zhao, X J Yin, D Frazer, MW Barger, PD. Siegel, L Millecchia, BZ Zhong, S Tomblyn , S Stone, JKH. Ma, V Castranova a and JYC Ma [2004]. “ Effects of Paving Asphalt Fume Exposure on Genotoxic and Mutagenic Activities in the Rat Lung”Mutation Res.,557:137-149. Siegel PD, Saxena RK, Saxena QB, Ma JKH, Ma JYC, Yin XJ, Castranova V, Al-Humadi N, Lewis DM [2004]. Effect of diesel exhaust particulate (DEP) on immune responses: Contributions of particulate vs. organic soluble components. J Toxicol Environ Health A. 67:221-231. Zhao HW, Hu SY, Barger MW, Ma JKH, Castranova V, and Ma JYC [2004]. Time-dependent Apoptosis of Alveolar Macrophages from Rats Exposed to Bleomycin: Involvement of TNF Receptor 2. J. Toxicol. Environ. Health, Part A, 67:1391-1406. Yin XJ, Ma JYC, Antonini J, Castranova V, and Ma JKH (2004). Roles of Reactive Oxygen Species and Heme Oxygenase-1 in Modulation of Alveolar Macrophage- Mediated Pulmonary Immune Responses to Listeria monocytogenes by Diesel Exhaust Particles. Toxicol Sci., 82:143-153. Al-Humadi , N.H. ,Siegel, P.D.,Lewis, D.M.,Ma, J.Y.C.,and Ma, J.K.H [2004]. Dose dependent thiol and immune responses to ovalbumin challenge in Brown Norway rats. Toxicol. Ind. Health, 18:343-352. Zhao HW, Barger MW, Ma JKH, Castranova V, and Ma JYC [2004]. Effects of Exposure to Diesel Exhaust Particles (DEP) on Pulmonary Metabolic Activation of Mutagenic Agents, Mutat Res, 4:103-113. Dong CC, Yin XJ, Ma JYC, Millecchia L, Barger MW, Roberts JR, Zhang ZD, Antonini, JM, Dey RD, Ma JKH [2005]. Exposure of Brown Norway rats to diesel exhaust particles prior to ovalbumin (OVA) sensitization elicits IgE adjuvant activity but attenuates OVA-induced airway inflammation. Toxicol Sci, 88:150-160. Dong CC, Yin XJ, Ma JYC, Millecchia L, Wu ZX, Barger MW, Roberts JR, Antonini, JM, Dey RD, Ma JKH [2005]. Effect of Diesel Exhaust Particles on Allergic Reactions and Airway Responsiveness in Ovalbumin-Sensitized Brown Norway Rats. Toxicol Sci, 88:202-212. . Yin,Xuejun J.; Dong,Caroline C.; Ma,Jane Y.C.; Antonini,James M.; Roberts,Jenny R.; Barger,Mark W.; Ma,Joseph K.H.[2005]. Sustained Effect of Inhaled Diesel Exhaust Particles on T-Lymphocyte-Mediated Immune Responses Against Listeria monocytogenes. Toxicol. Sci. 88:73-81. H. W. Zhao, M.W. Barger, J.K.H. Ma, V. Castranova, and J.Y.C. Ma. [2006] Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Diesel Exhaust Particle-Induced Lung Inflammation and Mutagenicity. Environ. Health Perspect. 114:1253-1258. Hu S, Zhao H, Al-Humadi NH , and Ma JKH. [2006]. Silica-Induced Apoptosis in Alveolar Macrophages: Evidence of In Vivo Thiol Depletion and the Activation of Mitochondrial Pathway. J. Toxicol. Environ. Health, Part A, 69: 1261-1284. Yin XJ, Dong CC, Ma JYC, Antonini, JM, Roberts JR, Barger MW, Ma JKH [2006]. Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by organic component of diesel exhaust particles. J Toxicol Environ Health , In press. Hu, S., Zhao, H., X.I. Yin, and Ma, J.K.H. [2006] “Inhibition of Silica-Induced Apoptosis of alveolar Macrophages by Rhodamine 6G and N-acetyl-L-cysteine. Toxicological Sciences, In press.
Publications: Dr. Ma has maintained an active research program on the molecular and cellular-based drug interactions with biological systems. His publications include studies in areas of drug protein binding, protein structural analysis, X-ray crystallography, liquid chromatography, microencapsulation, emulsion, and liposomal drug delivery systems, mechanisms of pulmonary fibrosis, receptor-mediated endocytosis, and peptide transport across pulmonary epithelium. 1. Shih C. Chang, Joseph K.H. Ma, Jin Wang and Norman C. Li, "Copper (II) and Cobalt (II) Complexes of Pyridine-2-Carboxanide and Pyridine-2-Carboxylic Acid," J. Coord. Chem., 2, 31 (1972). 2. Joseph K.H. Ma, Jin-Tsai Wang and Norman C. Li, "Cadmium (II) and Nickel (II) Complexes of Picolinamide," J. Coord. Chem., 2, 281 (1973). 3. Joseph K.H. Ma, H.W. Jun, and Louis A. Luzzi, "Tetracycline Binding to Bovine Serum Albumin Studied by Fluorescent Technique," J. Pharm. Sci., 62, 1261 (1973). 4. Joseph K.H. Ma, H.W. Jun and L.A. Luzzi, "Determination of Equilibrium Constant and Binding Capacities Using a Modified Scatchard Method in Drug-Protein Binding Studies," J. Pharm. Sci., 62, 2038 (1973). 5. H.W. Jun, L.A. Luzzi, and Joseph K.H. Ma, "Fluorescence Studies on the Interaction of the Aminonapthaline Sulfonic Acid Derivatives to Serum Albumins," J. Pharm. Sci., 64, 493 (1975). 6. Joseph K.H. Ma, Par-Lin Hsu and Louis A. Luzzi, "New Fluorescence Probes for Drug-Protein Binding Studies," J. Pharm. Sci., 63, 32 (1974). 7. Par-Lin Hsu, Joseph K.H. Ma, H.W. Jun, and Louis A. Luzzi, "Structure Relationship for the binding of Sulfonamides and Penicillins to Bovine Serum Albumin by Fluorescence Probe Technique," J. Pharm. Sci., 63, 27 (1974). 8. Par-Lin Hsu, Joseph K.H. Ma, and Louis A. Luzzi, "Interactions of Sulfonyl-ureas with Plasma Proteins," J. Pharm. Sci., 66, 209 (1977). 9. Joseph K.H. Ma, Peter P. Fu, and Louis A. Luzzi, "Protein-Binding of Benz(a)anthracene and Benzo(a)pyrene," J. Pharm. Sci., 66, 209 (1977). 10. Joseph K.H. Ma, Jane Y.C. Ma, Louis A. Luzzi, and Norman C. Li, "Fluorescence and Absorption Studies of Limulus Hemocyanin and its Components," in "Structure and Function of Hemocyanin," Proceedings in Life Sciences, J.V. Bannister, ed., Spr huger-Verlag, Berlin, New York, 1977, pp 136-143. 11. Joseph K.H. Ma, Louis A. Luzzi, Jane Y.C. Ma, and Norman C. Li, "Fluorescence Studies of the Oxygen Binding in Limulus Hemocyanin," J. Pharm Sci., 66, 1684 (1977). 12. J.W. Hsieh, J.K.H. Ma, J.P. O'Donnell, and N.H. Choulis, "HPLC Analysis of Methadone in Sustained Release Formulations," J. Chromatogr. 161, 366 (1978). 13. D.A. Johnson, J.P. O'Donnell, J.K.H. Ma, and N.H. Choulis, "NMR Studies of Sustained Release Methadone Tablets," Pharmazie, 33, 12 (1978). 14. Stanley T. Day, W.G. Crouthamel, L.C. Martinelli, and Joseph K.H. Ma, "Mechanism of Fluorometric Analysis of Tetracycline Involving Metal Complexation," J. Pharm. Sci., 67, 1518 (1978). 15. J.P. O'Donnell, W.J. Proveaux, and Joseph K.H. Ma, "Kinetic Studies of the Reaction of Hydralazine with Acetaldehyde," J. Pharm. Sci., 68, 1256 (1979). 16. J.P. O'Donnell, W.J. Proveaux, and Joseph K.H. Ma, "HPLC Studies of the Reaction of Hydralazine with biogenic Aldehydes and Ketones," J. Pharm. Sci., 68, 1524 (1979). 17. W.J. Proveaux, J.P. O'Donnell, and Joseph K.H. Ma, "Liquid Chromatographic Analysis of Hydralazine and Metabolites in Plasma," J. chromatography, 176, 480 (1979). 18. H. Zia, J.P. O'Donnell,and Joseph K.H. Ma, "Identification of Griseofulvic Acid as a Urine Metabolite of Griseofulvin in Man," J. Pharm. Sci., 68, 1335 (1979). 19. H. Zia, W.J. Proveaux, J.P. O'Donnell, and Joseph K.H. Ma, "Chromatographic Analysis of Griseofulvin and Metabolites in Biological Fluids," J. Chromatography Biomedical App., 181, 77 (1980). 20. H. Zia, E. Malaz, Joseph K.H. Ma, and L.A. Luzzi, "Use of Difference Spectrophotometry in Studying Drug-Protein Interactions," Canadian J. Pharm. Sci., 15, 14 (1980). 21. Joseph K.H. Ma and Louis A. Luzzi, "Use of DMI in Liquid Formulation of Aspirin," U.S. Patent 4, 228, 162 (1981). 22. K. Van Dyke, D. Peden, C. Van Dyke, G. Jones, V. Castranova, and Joseph K.H. Ma, "Screening of Non-Steriodal Antiinflammatory Drugs by Luminal Dependent Human Granulocyte Chemiluminescence, II -- effect of Sulindac Sulfide Indomethacin Metabolites and Optical Enantiomers (+) and (-) MK 830," Inflammation, 6, 113 (1982). 23. K. Van Dyke, V. Castranova, C. Van Dyke, J.K.H. Ma, K.I. Michaux, K.M. Mollison, and G. Carter, "Granulocyte Response to Oxidized n-FMLP," Inflammation, 8, 87 (1984). 24. Jane Y.C. Ma, Joseph K.H. Ma, and Kenneth C. Weber, "Fluorescence Studies of the Binding of Amphophilic Amines with Phospholipids," J. Lipid. Research, 26, 735 (1985). 25. D.C. Tsai, S.A. Howard, T.F. Hogan, C.J. Malanga, S.J. Kandzari, and J.K.H. Ma, "Preparation and In vitro evaluation of Polyactic acid-mitomycin C microcapsules," J. Microencapsulation, 3, 181 (1986). 26. N. Leelarasamee, S.A. Howard, C.J. Malanga, L.A. Luzzi, T.F. Hogan, S.S. Kaudzani, and J.K.H. Ma, "Kinetic of drug release from polylactic acid-hydrocortisone microcapsules," J. Microencapsulation, 3 171 (1986). 27. A.H. Sabouni, Joseph K.H. Ma, and Carl J. Malanga, "A Source of Error in the Chromatographic Study of 35S-sulfate Labeled Mucous Glycoproteins Secreted by the Gill epithelium of Mytilus edulis," Preparative Biochemistry, 16, 259 (1986). 28. J.Y.C. Ma, Joseph K.H. Ma, K.C. Weber, L. Bowman, M.J. Reasor and P.R. Miles, "Binding of Chlorphentermine to Phospholipids in Rat Alveolar Lavage Materials," Biochim. Biophys. Acta, 958, 163-171 (1988) 29. N. Leelarasamee, S.A. Howard, and J.K.H. Ma, "Effect of Surface Active Agents on Drug Release from Polylactic Acid-Hydrocortisone Microcapsules," J. Microencap, 5, 37-46 (1988). 30. N. Leelarasamee, S.A. Howard, C.J. Malanga, and J.K.H. Ma, "A Method for the Preparation of Polylactic Acid Microcapsules of Controlled Particle Size and Drug Loading," J. Microencapsulation, 5, 147-157 (1988). 31. H.Y. Ahn, L.F. Sue, J.K.H. Ma, C.A. Pinkstaff, R.S. Pore, D.O. Overman, and C.J. Malanga, "Synthesis and Secretion of Mucous Glycoprotein by the Gill of Mytilus Edulis I. Histochemical and Chromatographic Analysis of [14C] Glucosamine Bioincorporation," Biochim. Biophys. Acta, 966, 122-132 (1988). 32. R.C. Mehta, T.F. Hogan, S. Mardmomen, and Joseph K.H. Ma, "Chromatographic Studies of Mitomycin C. Degradation in Albumin Microspheres," J. Chromatography, 430, 341-349 (1988). 33. J.Y.C. Ma, N.C. Li, L.A. Luzzi, and J.K.H. Ma, "Fluorescence Polarization of Limulus Hemocyanin," J. Inorg. Biochemistry, 35, 169-178 (1989). 34. J.K.H. Ma, J.Y.C. Ma, L.A. Luzzi, and N.C. Li, "Kinetic Studies of the Molecular Aggregation of Limulus Oxy- and Apohemocyanin," J. Inorg. Biochem. 38, 289-304 (1990). 35. C.J. Malanga, L.F.S. Liu, and J.K.H. Ma, "The CAMP Second Messenger System in Mytilus Edulis," in "Neurobiology of Mytilus Edulis," G.B. Stefano, ed., Manchester University Press, Manchester, 1990, pp. 74-92. 36. Fedan, J.S., Castranova, V., Ma, J.K.H., Mo, C.G., and Frazer, D.G., n-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) is Present in Cotton Dust and Contracts Isolated Airway and Cardiovascular Smooth Muscle, Proc. 14th Beltwide Cotton Dust Conference, 82-84 (1990). 37. V. Castranova, J.H. Kang, J.K.H. Ma, C.G. Mo, C.J. Malanga, M.D. Moore, D. Schwegler-Berry, and J.Y.C. Ma, "Effect of Bisbenzylisoquinoline Alkaloids on Alveolar Macrophages: Correlation Between Binding Affinity, Inhibitory Potency, and Antifibrotic potential," Tox. & Appl. Pharmacol, 108, 242-252 (1991). 38. Zia, H., Ma, J.K.H., J.P. O'Donnell, and Luzzi, L.A., "Cosolvency of Dimethyl Isosorbide for Steroid Solubility," Pharm. res., 8, 502-504 (1991). 39. J.K.H. Ma, C.G. Mo, C.J. Malanga, J.Y.C. Ma, and V. Castranova, "Binding of Bisbenzylisoquinoline Alkaloids to Phosphatidylcholine Vesicles and Alveolar Macrophages: Relationship Between Binding Affinity and Antifibrogenic Potential of these Drugs," Exp. Lung Research, 17, 1061-1077 (1991). 40. V. Castranova, L.N. Domelsmith, M.W. Barger, J.K.H. Ma, S.A. Olenchock, T.A. Jones, and D.G. Frazer, "Efficacy of Acid/base Washes in Removing the Bioactive Agent from Cotton Dust: Response of the Guinea Pig Model to Inhalation of Treated Dust," Cotton Dust: Proc. -15th Cotton Dust Research Conference, R.R. Jacobs, P.J. Wakelyn, LN Dome/Smith, eds., National Cotton Council, Memphis, TN, 252-255 (1991). 41. T. Ong, J.K.H. Ma, W-Z Whong, W. Wallace, and S.C. Stamm, "Toxicity Studies of Mild Gasification Products," Proceedings of the Eleventh Annual Gasification and Gas Stream Cleanings Systems Contractors Review Meetings, 1, 114-123 (1991). 42. J.K.H. Ma, C.G. Mo, C.J. Malanga, J.Y.C. Ma and V. Castranova, "Studies of the Binding of Bisbenzylisoquinotine Alkaloids to biomembranes in relation to their antifibrotic potential," 3rd Symposium on Respirable Dust in the Mineral Industries, R.L. Fantz and R.V. Ramani, eds., Soc. for Mining, Metallurgy, and Exploration, Inc., Chapter 21, pp 153-158, (1991). 43. Y. Rojanasakul, L.Y. Wang, M. Bhat, D.D. Glover, C.J. Malanga, and J.K.H. Ma. "Transport Barrier of Epithelia: A comparative Study on membrane Permeability and Charge Selectivity," Pharm. Research, 9, 1029-1034 (1992). 44. T. Ong, W-Z Whong, J.K.H. Ma, B-Z Zhong, and D. Bryant, "Toxicity Studies of Mild Gasification Products," Proceedings of the 12th Annual Gasification and Gas Stream Cleanings Systems Contractors Review Meeting, 2, 571-582 (1992). 45. J.K. Kang, D.J. Lewis, V. Castranova, Y. Rojanasakul, D.E. Banks, and J.K.H. Ma, "Inhibitory Action of Tetrandrine on Macrophage Production of Interleukin-1 (IL-1) Activity and Thymocyte Proliferation," Exp. Lung Research, 18, 715-729 (1992). 46. J.Y.C. Ma, M.W. Barger, J.K.H. Ma, and V. Castranova, "Inhibition of Respiratory Burst Activity in Alveolar Macrophages by Bisbenzylisoquinoline Alkaloids: Characterization of Drug-Cell Interaction," Exp. Lung Res., 18, 829-843 (1992). 47. D.E. Banks, Y.H. Chang, S.L. Weber and J.K.H. Ma, "Strategies for the Treatment of Pneumoconiosis," State of Art Review - on "Health Risks in the Mining Industry," D.E. Banks, ed., Hanley & Belfus, Inc., Philadelphia, PA, 8, 205-232 (1993). 48. W. Jones, J.K.H. Ma, J.Y.C. Ma, and V. Castranova, "Dust Particles: Occupational Considerations," invited book chapter in "Handbook of Hazardous Materials", M. Corn, editor-in-chief, Academic Press, Inc., pp. 213-222 (1993). 49. L.Y. Wang, D. Toledo-Velasques, D. Schwegler-Berry, J.K.H. Ma, and Y. Rojanasakul, "Transport and Hydrolysis of Enkephalins in Cultured Alveolar Epithelial Monolayers," Pharm. Res. 10, 1662-1667 (1993). 50. M. Bhat, L.Y. Wang, C.J. Malanga, D. Toledo, J.K.H. Ma, and Y. Rojanasakul, "Regulation of Tight Junction Permeability by Calcium Mediators and Cell Cytoskeleton in Rabbit Tracheal Epithelium," Pharm. Research, 10, 991-997 (1993). 51. Y. Rojanasakul, L.Y. Wang, C.J. Malanga, J.Y.C. Ma, D.E. Banks, and J.K.H. Ma, "Altered calcium homeostasis and cell injury in silica-exposed alveolar macrophages," J. Cell Physiology. 154, 310-316 (1993). 52. Y. Rojanasakul, L.Y. Wang, A.H. Hoffman, X. Shi, N.S. Dalal, D.E. Banks, and J.K.H. Ma, "Mechanism of Hydroxyl free Radical-induced Cellular Injury and Calcium Overloading in Alveolar Macrophages," Am. J. Respir. Cell and Mol. Biol. 8, 377-383 (1993). 53. P.R. Miles, L. Bowman, J.K.H. Ma, and J.Y.C. Ma, "Alterations in Alveolar Type II cells metabolism induced by tetrandrine and alkaloids," Toxicol & Appl. Pharmacol, 119, 142-149 (1993). 54. J.S. Fedan, J.K.H. Ma, D.G. Frazer, C.G. Mo, and V. Castranova, "Detection of N-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) in Cotton Dust: Biological Activities of FMLP Associated with Pulmonary Responses to Cotton Dust Exposure," International Symposium on Inhaled Particles, Pergamon Press, London, Ann. Occup. Hyg., 38, 879-885 (1994). 55. L.Y. Wang, J.K.H. Ma, W.F. Pan, D. Toledo-Velasque, C.J. Malanga, and Y. Rojanasakul, "Alveolar permeability enhancement by oleic acid and related fatty acids: Evidence for a calcium-dependent mechanism," Pharm. Res., 11, 513-517 (1994). 56. M. Bhat, Y. Rojanasakul, S.L. Weber, J.Y.C. Ma, V. Castranova, D.E. Banks, and J.K.H. Ma, "Fluoromicroscopic Studies of bleomycin-induced intracellular oxidation in alveolar macrophages and its inhibition by taurine," Environ. Health Prospectives, 102, 91-96 (1994). 57. J. Harrison, L.Y. Wang, J.K.H. Ma, and Y. Rojanaskul, "Novel delivery of antioxidant-enzyme catalase to alveolar macrophages by F receptor-mediated endocytosis," Pharm. Res., 11, 1110-1114 (1994). 58. D, Deshpande, D. Toledo-Velasquez, L.Y. Wang, C.J. Malanga, J.K.H. Ma, and Y. Rojanasakul, "Receptor mediated peptide delivery in pulmonary epithelial monolayers," Pharm. Res., 11, 1121-1126 (1994). 59. Y. Rojanasakul, L.Y. Wang, C.J. Malanga, J. Liaw, and J.K.H. Ma, "Targeted gene delivery to alveolar macrophages via Fc receptor mediated endocytosis," Pharm Res, 11, 1731-36 (1994). 60. J.Y.C. Ma, Y.H. Chang, W.W. Barger, W.F. Xin, D.M. Lewis, V. Castranova, and J.K.H. Ma, "Modification of alveolar macrophage function with bis-basic fluorene and fluorene-9-substituted derivatives," Exp. Lung Res., 21, 771-790 (1995). 61. Y. Rojanasakul, V. Castranova, D.E. Banks and J.K.H. Ma, "Calcium Medicated Silica Cytotoxicity" in Silica and Silica-Induced Lung Diseases, V. Castranova, V. Vallyathen, and W. Wallace, eds., CRC Press, 1995, pp. 151-161. 62. V. Castranova, J.K.H. Ma, and J.Y.C. Ma, "Bisbenzylisoquinoline alkaloids: Animal Studies," in "Silica and Silica-Induced Lung Diseases," V. Castranova, V. Vallyathen, and W. Wallace, eds., CRC Press, 1995, pp. 305-321. 63. J.K.H. Ma, D.H. Chao, J.Y.C. Ma, A. Hubbs and V. Castranova, "Pharmaceutical Considerations in the use of Tetrandrine to Treat Silicosis," in Silica and Silica-Induced Lung Diseases: Current Concepts, V. Castranova, V. Vallyathen, and W. Wallace, eds., CRC Press, 1995, pp. 331-341. 64. J.J. Tsai, J.K.H. Ma, T.F. Wang, S.R. Wang, and D.H. Kao, "The Modulatory of Tetrandrine on the CD23, CD25 and HLA-DR Expression and Cytokine Production in Different Groups of Asthmatic Patients," Int. Arch. Allergy Immunol., 108, 183-188 (1995). 65. Y. Rojanasakul, W.W. Liang, and J.K.H. Ma, "Targeted Delivery of Antisense Oligonucleotides for selective inhibition of pulmonary fibrotic cytokines," in Respiratory Drug Delivery, Vol. 5, Byron, P.R., Dolby, R., and Farr, S., eds., Interpharm.Press, Chicago, 1995. 66. D.H. Chao, J.Y.C. Ma, C.J. Malanga, D.E. Banks, A.F. Hubbs, Y. Rojanasakul, V. Castranova, and J.K.H. Ma, "Multiple Emulsion-Mediated Enhancement of the Therapeutic Effect of Tetrandrine Against Silicosis," Appl. Occup. Environ. Hyg. 11, 1008-1018 (1996) . 67. J.K.H. Ma and M. Bhat, and Y. Rojanasakul, "Drug Metabolism and Enzyme Kinetics," invited chapter in Inhalation Aerosol Handbook, Lung Biology in Health and Disease Series, A.J. Hickey ed., Marcel Dekker, Inc., New York; 1996 Chapter 6, pp. 155-195. 68. D.N. Weissman, J.K.H. Ma, Y. Rojanasakul, and A. Hubbs, "Immune Dysfunction in Silicosis: A Hypothesis," Appl. Occup. Environ Hyg.. 11(7), 962-965 (1996). 69.R.C. Mehta, R.D. Secrist, T.F. Hogan, A.A. Balian, and J.K.H. Ma, "In vivo evaluation of Mitomycin C-Polylactic Acid Microcapsules via canine intrahepatic arterial infusion," Drug Delivery, 3, 263-271 (1996). 70. J.L. Wilt, D.E. Banks, D.N. Weissman, J.E. Parkers, V. Vallyathan, V. Castranova, J.K.H. Ma, J.Y.C. Ma, V. Dedmia, E. Stullkin, and N. LeRoy Lapp, "Reduction of Lung dust Borden in pneumoconiosis by modified whole lung lavage,' J. Occup. Envir. Med., 38, 619-624 (1996). 71. B.Z. Zhong, S.C. Stamm, S. Robbins, D. Bryant, W. lane, W.F. XIN, J.K.H. Ma, W.Z.Whong, and T.M. Ong. "Studies in the Mutagenicity of Coal Gasifications products and their subfractions by the Salmonella/micronomal assay," Environ. Res., 72, 32-44(1997). 72. J. Shao and J.K.H. Ma, "Characterization of a Mannosyl-phospholipid Liposome System for Drug Targeting to Alveolar Mascrophage," Drug Delivery, 4, 43-48 (1997). 73. H.M. Yang, J.Y.C. Ma, V. Castranova, and J.K.H. Ma, "Effect of diesel exhaust particles on the release of interleukins-1 and tumor necrosis factor-alpha by rat alveolar macrophages, Exp. Lung Res,. 23, 269-284 (1997). 74. Y. Rojanasakul, D.N. Weissman, X Shi, V. Castranova, J.K.H.Ma, and W. Liang, "Antisense 75. Liao, WP, DeHaven J., Shao, J., Chen, JX, Rojanasakul, Y., Lamm DL., and Ma JKH., 77. Ma, J.Y.C., Barger, M.W., Castranova, V., and Ma, J.K.H., " Use of tetrandrine to 78. Yang, H.M., Barger, M.W., Castranova, V., Ma, J.K.H., Yang, J.J., and Ma, J.Y.C., 80.Yang, H.M., Antonini, J.M., Barger, M.W., Buterworth, L., Roberts, J.R., Ma, J.K.H., Castranova, V., and Ma, J.Y.C., "Diesel exhaust particles suppress macrophage function and slow pulmonary clearance of Listeria monocytogenes in rats," Environ. Health Prospective,109:515-521, 2001. 81. Shao, J., DeHaven, J., Lamm, D.L., Weissman, D.N., Runyan, K., Malanga, C.J., Rojanasakul, Y., and Ma, J.K.H., "A cell-based drug delivery system for lung targeting: I. Preparation and pharmacokinetics," Drug Delivery, 8:61-69, 2001. 82. Shao, J., DeHaven, J., Lamm, D.L.., Weissman, D.N., Malanga, C.J., Rojanasakul, Y., and Ma, J.K.H., "A cell-based drug delivery system for lung targeting: II. Therapeutic activity on B16-F10 melanoma in mouse lungs," Drug delivery, 8:71-76, 2001. 83. Shao, J, Dai, J., and Ma, J.K.H., "A pilot study on Anticancer activities of Chinese Leek," J. Alternative and Complementary Medicine, 7:517-522, 2001. 84. Huang SH, Hubbs AF, Stanley CF, Vallyathan V, Schnabel PC, Rojanasakul Y, Ma 85. Weissman, D.N., Hubbs, A.F., Huang, S.H., Stanley, C.F., Rojanasakul, Y., and Ma, J.K.H., "IgG subclass responses in experimental silicosis," J. Environ Pathol, Toxicol, & Oncol. (JEPTO), 20 (suppl. 1): 67-74, 2001. 86. Castranova, V., Ma, J.Y.C., Yang, H.M., Antonini, J.M., Barger, M.W., Buterworth, L., Roberts, J.R., and Ma, J.K.H., "Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection," Environ Health Perspectives, 109:609-612, 2001. 88. Yang, X.D., Ma, J.Y.C., and Ma, J.K.H., " Transport and utilization of arginine and arginine-containing peptides in alveolar macrophages," Pharmaceutical Research, In press. 89. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H., "Alteration of intracellular cysteine and glutathione levels in alveolar macrophagesby diesel exhaust particles (DEP) exposure," Environ. Health Perspectives, In press. 91. Yin, X.J., Schafer, R., Ma, J.Y.C., Antonini, J.M., Weissman, D.N., Siegel, P.D., Barger, M.W., Roberts, J.R., and Ma, J.K.H., "Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEP) I. Effects of DEP on early pulmonary responses," Environ. Health Perspectives, submitted (2001). 93. Rengasamy, A., Barger, M.W., Kane, E., Ma, J.K.H., Castranova, V., and Ma, J.Y.C., "Diesel Exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats,"submitted to J. Toxicol. Environ. Health (2001). 94. Ma, J.Y.C., Barger, M.W., Castranova, V., and Ma, J.K.H., " Effects of nitric oxide production on cytokine secretion and prostaglandin synthesis in silica-exposed alveolar macrophages,"manuscript to be submitted to Exp. Lung Res. 95. Ma, J.Y.C., Barger, M.W., Castranova, V., and Ma, J.K.H., " Regulation of macrophage secretion of pro-inflammatory cytokines by the microtubule network in silica-exposed rats,"manuscript to be submitted to Exp. Lung Res. 96. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Ma, J.Y.C., and Ma, J.K.H., "Characterization of dose-dependent changes in thiol levels and immune responses due to ovalbumin sensitization in Brown Norway rats," manuscript in preparation. 97. Ma, J.Y.C. and Ma, J.K.H., " The Dual effects of particulate and organic components of diesel exhaust particles on pulmonary immune/inflammatory responses and xenobiotic metabolism," J. Environ. Sci. & Health (Part C - Enviromental Carcinogenesis and Ecotoxicology Reviews), In preparation. Invited Lectures and Presentations "Fluorescence Studies of Drug-Protein Binding" to School of Pharmacy and Department of Chemistry, Duquesne University, February 1975. "Chromatographic Analysis of Serum Hydralazine" to School of Pharmacy, West Virginia University, January 1978. "A New Look at an Old Molecule - Limulus Hemocyanin," to School of Pharmacy, West Virginia University, 1982. "Development of Biodegradable Polymeric Drug Delivery Systems for Cancer Chemotherapy," "Research Fair", hosted by President Gee, WVU, September 1983. "Microencapsulation Chemotherapy," Eastern Cooperative Oncology Group Site Visit, section Hematology-Oncology, WVU, May 1984. "Physical Pharmacy of Solutions," 24 hours class lectures, University of Pittsburgh, School of Pharmacy, Fall 1984. "Microencapsulated Dosage Form for Anticancer Chemotherapy", Lederle Pharmaceuticals, American Cyandmide Co., New York, March, 1985. "Microencapsulation as a Controlled Release Drug Delivery System," 7th Annual Conference of the Association of Chinese Professionals in West Virginia, Charleston, West Virginia, October 1987. "Chemical Derivatization for HPLC Drug Analysis" Symposium on Methods of Pharmaceutical Analysis, 20th Central Regional Meeting, American Chemical Society, Morgantown, West Virginia, June 1, 1988. "Microcapsule Chemoembolization," to the United States Surgical Corporation, Norwalk, Connecticut, December 12, 1988. "Targeted Drug Delivery for Anticancer Chemotherapy," to Guanagzhous Institute for Chemical Carcinogenesis, Guangzhou Medical College, Quangzhou, China, June 25, 1990. "Drug Targeting and Current Research in Pharmaceutical Development," to Helungjiang Institute of Chineses Medicine and the provincial ministry to Public Health, Harbin, Helungjiang, China, October 13, 1990. Drug Actions on Dust-induced Pulmonary Fibrosis", to Molecular Toxicology Branch, National Center for Toxicological Research, Jefferson, AR, March 1991. "Cellular Mechanisms of the Immunosuppressive Activity of Bisbenzylisoquinoline alkaloids," Veteran General Hospital and National Yang Ming Medical College. Department of Allergy, Immunology and Rheumatology, Taipei, Taiwan, July 14, 1992. "The Antifibrotic Potential of Tetrandrine Against Silicosis," Rehabilitation Center for Pneumoconiosis of China National Coal Corporation, Beidaihe, China, July 20, 1992. "Epithelial Transport of Peptides and Proteins: Mechanism and Enhancement" to CIBA Vision Ophthalmics, Atlanta, GA December 4, 1992. "Pulmonary Fibrosis: Mechanism and Inhibition," to Department of Anatomy West Virginia University School of Medicine, Morgantown, WV, January 28, 1993. "Pharmaceutics and Drug Delivery (8 research lectures): I) Current Development in Control release dosage forms; II) Cellular mechanisms of drug absorption and epithelial transport;" in Controlled Release Drug Delivery, research workshop sponsored by the Ministry of Public Health, Peoples' Republic of China, J.K.H. Ma, and B.W. Liang Co-directors, Zhejiang Medical University, Hangzhou, China, April 21-24, 1993. "Current Trend in Pharmacy Education in the U.S.," Zhyiang Medical University, Hangzhou, China, April 26, 1993. "New and Old Strategies for the Treatment of Pneumoconious," ALA/ATS International Conference "Meet the Professor" program. J.K.H. Ma & N.L. Lapp, Co-presentors; San Francisco, CA May 16, 1993. "Screening for Pulmonary Active Agents Using Cultured Lung Cells," International Symposium on New Drug Research and Development; American Chinese Pharmaceuticl Association; Overland Park, Kansas, May 27-30, 1993. "Strategies for the Treatment of Silicosis - Whole Lung Lavage and Drug Therapy," WVU Health Sciences center CPC Conference, June 21, 1993. "Screening for Pulmonary Active Agents using Cultured Lung Cells," American Chemical Society Central Regional Meeting, Pharmaceutical Chemistry Symposium," Pittsburgh, PA, October 6, 1993. "Fluoromicroscopic Studies of the inhibitory Effect of Taurine on Bkomycin-induced Intracellular Oxidation," in "Oxygen Radicals and Lung Injury Conference," Sponsored by NIOSH, NIH, EPA, NCI and West Virginia University, Morgantown, WV, August 29 - September 2, 1993. "In Vitro Screening of Pulmonary and Hepatic Metabolic Profiles of New Drug Entities," CIBA-Geigy Corporation, Sections of Bioanalytics and Pharmacokinetics, Ardstey, NY, May 10, 1994. "Recent Development in Liposome Technology for Cellular Drug Targeting," Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, China, September 20, 1994. "Modernization of Traditional Chinese Medicine: Discovery and Development," Association of Chinese Professionals in West Virginia Annual Meeting, Charleston WV, October 29, 1994. "Multiple Emulsion-Mediated Therapeutic Enhancement of Tetrandrine Against Silicosis," 4th Symposium on Respirable Dust in the Mineral Industries, Pittsburgh, PA, November 10, 1994. Effect of Diesel Exhaust on Pulmonary Antimycrobacterial Defense," Generic Mineral Technology Center for Respirable Dust Annual Review Meeting, Pittsburgh, PA, November 10, 1995. "WVU Research Focus Areas- A Panel Discussion," WVU Faculty Development Series, March 11, 1997. "Alteration of Pulmonary Immune/Inflammatory Responses by Diesel Exhaust Particles (DEP)," First International Conference of the Society for Free Radical Research-Africa, Malelane Gate, Mpumalanga, South Africa, July 16-20, 2000. Abstracts and Presentations at National Meetings "New Fluorescence Probes for Drug-Protein Binding Studies," 15th Meeting, Academy of Pharmaceutical Sciences, San Diego, 1993. Spectrophotometric Studies of the Protein Binding of Tetracycline," 16th Meeting, Academy of Pharmaceutical Sciences, Chicago, IL, 1974. "Fluorescence Studies of Aspirin and Salicylic Acid," 17th Meeting, Academy of Pharmaceutical Sciences, New Orleans, 1974. "Binding of Tetracyclines to Hemocyanin and Selected Complexes," ACS National Meeting, Division of Medical Chemistry, Philadelphia. "Binding of Tetracyclines to Hemocyanin." ACS Central Regional Meeting, Division of Physical Chemistry, Morgantown, WV, May 1975. "Protein Binding to Some Aromatic Polycyclic Hydrocarbons," APhA Annual Meeting, New Orleans, L.A., April 1976. "Application of Metal Compplexation in Tetracycline ANalysis," APhA Academy, New York, !977. "Quantitative Analysis of Serum Hydralazine Using HPLC," APhA Academy, Phoenix, Ar., November 1977. "HPLC Assay of Hydrazones derived from Hydralazine," APhA Academy, Phoenix, Ar., November 1977. "Cupric Ion Promoted Ionization in Ampicillin," APhA Academy, Hollywood, Fl., November 1978. "Competitive Pathway for Hydralazine Metabolism," APhA Academy, Hollywood, Fl., November 1978. R.P. Miller, D. Heald, V.P. O'Donnell, and J.K.H. Ma, "Pharmacokinetics of Intravenous Hydralazine in Rats", Pharmacologist, 21, 168 (1979). "Chromatographic Analysis of Griseofulvin and its Metabolites in Biological Fluids," APhA Academy, Kansas City, MO, November 1979. "Analysis of Sulindac and Metabolites by HPLC," APhA Academy, Kansas City, MO., November 1979. "Solubility Studies of Drugs in Mixed Systems Contained Dimethyl Isosorbide," APhA Academy, Washington, D.C., April 1980. "HPLC Analysis of Griseofulvin and Griseofulvic Acid Metabolites," APhA, Academy, San Antonio, TX, November 1980. "Chromatographic Analysis of Chlorpromazine from Plasma," APhA Academy, San Antonio, TX, November 1980. "Griseofulvin Metabolism by Rat Liver Microsomes and Isolated Hepatocytes, Fed. Proc., 40, 733 (1981). "The Association-Dissociation Behavior of Limulus Hemocyanin," Federation ASBC 72nd meeting, St. Louis, MO, May 1981; Fed. Proc., 40, 1486 (1981) "Microsomal Metabolism of Hydralazine," APhA Academy, Orlando, Florida, November 1981. "Determination of Vitamin C by Thermometric Titration," Pittsburgh Conference, Atlantic City, New Jersey, March 1982. "Physicochemical Considerations for the Preparation of Polylactic Acid Micro Drug Matrixes," Academy of Pharmaceutical Sciences, APhA, Las Vegas, Nevada, April 1982. "Fluorescence Studies of the Binding of Cationic Amphophilic Drugs with Phosphatidyl Choline," APhA Academy, 130th Annual Meeting, New Orleans, Louisiana, April 1983. Interaction of Lung Phospholipids with Organic Ions," Federation ASBC (American Society of Biological Chemists), San Francisco, California, May 1983; Fed. Proc., 42, 1910 (1983). "Solubility Controlled Technique for the Preparation of Polylactic Acid Microcapsules," APhA-APS 35th National Meeting, Miami Beach, Florida, November 1983. "Sustained Release Studies of Drug-Polylactic Acid Microcapsules, APhA-APS 35th National Meeting, Miami Beach, Florida, November 1983. "Fluorescence Labeling of Mucus Glycoproteins with Didansylcytine," APhA-APS 35th National Meeting, Miami Beach, Florida, November 1983. "Effects of Chlorphentermine and Phentermine on the Enzymatic Hydrolysis of Dipalmitoyl Lecithin," Federation ASBC, St. Louis, Missouri, June 1984. Fed. Proc., 43, 1456 (1984). "Kinetic Studies of Mucus Secretion by the Gill Tissue of Mytilus Edulis", Federation ASSEB, Anaheim, California, April 1985. Fed. Proc. 44, 1023 (1985). "Binding of Chlorphentermine to Phospholipids in Rat Alveolar Lavage Materials", Federation APS, Anaheim, California, April 1985. Fed. Proc., 44, 1023 (1985). "Histochemical Studies of Mucous Cells in Gill Filament of Mytilus Edulis," FASEB; American Association of Pharmacology and Experimental Therapeutics, St. Louis, Missouri, May 1986. "Effects of phenylethylamines on the Hydrolysis of Dipalmitroyl phosphatidylcholine by Phospholipase A2 and Phospholipase C," American Association of Pharmaceutical Scientist, section on Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Washington, D.C. November 1986. "Effect of Cross-linking Methods on Chemical Integrity of Mitomycin C Encapsulated into Albumin Microspheres," AAPS 2nd National Meeting, Boston, Massachusetts, June 1987. "Chromatographic Analysis of Radiolabeled Mucous Glycoproteins Secreted by Mytilus Edulis," JUC Pharm Sci. 87, Honolulu, Hawaii, December 1987. "Interaction of Mitomycin C with Human Serum Albumin," JUC Pharm. Sci. 87, Honolulu, Hawaii, December 1987. "Oral Influenza Vaccine: Formulation and Stability," 1988 AMS Annual Meeting, Miami Beach, Florida, May 1988. "In vivo Evaluation of Mitomycin C-Polylactic Acid Microcapsules via Canine Intrahepatic Arterial Infusion," AAPS Joint Eastern Regional Meeting, Atlantic City, New Jersey, June 1988. "Capillary Gas Chromatographic Analysis of the Carbohydrate Units of Mucin Secreted in Mucus from the Mucociliated Gill Epithelium of Mytilus Edulis," 3rd Annual Meeting, AAPS, Orlando, Florida, October 1988; Pharm Res., 5(10), 511 (1988). Control of Drug Release from Microcapsules via the Combination of Microcapsules of Various Drug Loading," 3rd Annual Meeting, AAPS, Orlando, Florida, October 1988. Pharm. Res., 5(10), 548 (1988). "Pharmacokinetics of Intrahepatic Arterial Delivery of Microencapsulated Mitomycin C," 3rd Annual Meeting, AAPS, Orlando, Florida, October 1988; Pharm. Res., 5(10), 576 (1988). "Cyclic AMP Dependent Protein Kinase Activity and Immunohistochemistry in the Mucociliated Gill of Mytilus Edulis," FASEB, New Orleans, LA, March 1989. "Control of Tablet Dissolution of Hydrocortisone with a Nonionic Surfactant," 4th Annual Meeting, AAPS, Atlanta, GA, October 1989; Pharm. Res., 6, S-99 (1989). "Binding of Bisbenzylisoquinioline Alkaloids with Phospholipid," 4th Annual Meeting, AAPS Atlanta, GA, October 1989; Pharm. Res., 6, S-39 (1989). Kang, J.H., Ma, J.K.H., Ma, J.Y.C., Malanga, C.J. Mo, C.G. and Castranova, V., "Inhibitory Action of Bisbenzylisoquinoline Alkaloids on the Phagocytotic Potential of Alveolar Macrophages: Usefulness as a Screen for Antifibrotic Potency," Annual meeting of Society of Toxicology, Miami Beach, FL, February, 1990; Toxicologist, 10, 277, (1990). Fedan, J.S., Castranova, V., Ma, J.K.H., Mo, C.G., and Frazer, D.G., "Bacterially-Derived Chemoattractant FMLP is Present in Respirable Cotton Dust and Causes Contraction of Isolated Airway Smooth Muscle," 14th Beltwide Cotton Dust Conference, Las Vegas, NV, January, 1990. Railkar, A.M., Wang., L.Y., Malanga, C.J., Glover, D.D., and Ma, J.K.H., "Tetracycline Binding to Cervical Mucous Glycoproteins," presented in the annual meeting of ASBC, New Orleans, LA, June 1990. Chao, D.H., Mo, C.G., Ma, J.Y.C., Castranova, V., Malanga, C.J. and Ma, J.K.H., "Emulsions for Targeted Delivery of Tetrandrine to Alveolar Macrophages," 3rd International Symposium and Workshops, Society of Chinese Bioscientists in America, Hong Kong, June 1990. J.K.H. Ma, J.Y.C. Ma, D.H. Chao, C.G. Mo, J.H. Kang, Y. Rojanasakul, C.J. Malanga, and V. Castranova," Cellular Actions of Bisbenzylisoquinolines and Strategies for Pulmonary Drug Targeting," WHO 7th Annual Symposium on Occupational Health, Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China, October 1990. J.K.H. Ma, C.G. Mo, C.J. Malanga, J.Y.C. Ma, and V. Castranova, "Studies of the Binding of bisbenzylisoquinoline alkaloids to Phospholipid Vesicles and Alveolar Macrophages in Relationship to their and Antifibrogenic potential," Symposium on Respirable Dust in the Mineral Industries, Pittsburgh, PA, October 1990. Y. Rojanasakul, M. Bhat, L.Y. Wang, and J.K.H. Ma, "Epithelial Drug Transport I: Variations in Membrane Electrical Resistance and Permselectivity," AAPs Fifth Annual Meeting, Las Vegas, NV, November 1990; Pharm. Res., 7, S-116 (1990). Y. Rojanasakul, L.Y. Wang, D.D. Glover, C.J. Malanga, and J.K.H. Ma, "Epithelial Drug Transport II: Correlation Between Flux and Electrical Conductance in various tissues," AAPS Fifth Annual Meeting, Las Vegas, NV, November 1990; Pharm. Res., 7, S-195 (1990). D.H. Chao, C.G. Mo, C.J. Malanga, and J.K.H. Ma, "Multiple Emulsions for Drug Targeting to Alveolar macrophages," AAPS Fifth Annual Meeting, Las Vegas, NV, November 1990; Pharm. Res., 7, S-151 (1990). Castranova, V., Domelsmith, L.N., Barger, M.W., Ma. J.K.H., Olenchock, S., Jones, T.A. and Frazer, D.A., "Efficacy of Acid/Base washes in Removing the Bioactive Agent from Cotton Dust: Response of the Guinea Pig Model to Inhalation of Treated Dust", 15th Cotton Dust Research Conference, National Cotton Council, San Antonio, TX, January 1991. Ma, J.K.H., Barger, M.W., Ma, J.Y.C., and Castranova, V., "Characterization of Interactions Between Antifibrotic Alkaloids and Alveolar Macrophages", FASEB, Atlanta, GA, April 21-25, 1991; FASEB J., 5(6), A492 (1991). Ma, J.Y.C., Bowmen, L., Ma, J.K.H., and Miles, P.R., "Tetrandrine Inhibits Synthesis of Disaturated Phosphatidylcholines in Rat Alveolar Type II Cells", FASEB, Atlanta, GA, April 21-25, 1991; FASEB J., 5(6), A492(1991). Castranova, V., Ma, J.K.H., Fedan, J.S., Mo, C.G., and Frazer, D.G. "Detection of N-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) in Cotton Dust: Biological Activities of FMLP Associated with Pulmonary Responses to Cotton Dust Exposure", 7th International Symposium on Inhaled Particles, Edinburgh, Scotland, September 1991. Rojanasakul, Y., Wang, L., Gao, H.G., Malanga, C.J., and Ma, J.K.H., "Isolation and Culture of Alveolar Epithelial Cells in Serum-Fee, Hormonally Defined Medium," AAPS Sixth Annual Meeting, Washington, DC, November 1991. Rojanasakul, Y. Bhat, M., Wang, L., Malanga, C.J., Glover, D.D., and Ma, J.K.H., "Regulation of Tight Junction Permeability By Calcium Mediators and Cell cytoskeleton in Tracheal Epithelium," AAPS Sixth Annual Meeting, Washington, DC, November 1991. Rojanasakul, Y., Wang, L., Bhat, M., Ma, J.K.H., and Glover, D.D., "Intracellular Calcium Rise Following Activation of Alveolar Macrophages by Some Peptide Drugs," AAPS Sixth Annual Meeting, Washington, DC, November 1991. J.K.H. Ma, J.H. Kang, J.Y.C. Ma, D.M. Lewis, Y. Rojanasakul, D.E. Banks, and V. Castranova, "Inhibitory Action of Tetrandrine on inferleukin-1 production by alveolar macrophages and IL-1 mediated thymocyte proliferation," FASEB Annual Meeting, Anaheim, CA, April 1992. J.Y.C. Ma, M.W. Barger, J.K.H. Ma, and V. Castranova, "Effect of tetrandrine on the cytoskeletal control of alveolar macrophage respiratory burst," FASEB Ann. Meeting, Anaheim, CA, April 1992. Y. Rojanasakul, L.Y. Wang, D.E. Banks, and J.K.H. Ma, "Role of intracellular calcium in silica and oxygen radical induced injury in alveolar Macrophages," ALA/ATS Annual Meeting, Miami Beach, Fl, May 1992. M. Bhat, J.K.H. Ma, S. Weber, and Y. Rojanasakul, "Quantitation of intracellular oxidation induced by hydrogen peroxide and bleomycin," AAPS Annual Meeting, San Antonio, TX, November 1992; Pharm. Res., 9, S-196 (1992). D. Deshpande, L.Y. Wang, D. Prabhu, J.K.H. Ma, and Y. Rojanasakul, "Quantitative fluorescence measurements of Surfactant-induced cytotoxicity in rat cultured alveolar macrophages," AAPS Annual Meeting, San Antonio, TX, November 1992; Pharm. Res., 9, S-196 (1992). J. Chen, Y. Rojanasakul, C.J. Malanga, C.M. James, and J.K.H. Ma, "Chromatographic studies of the enzyme degradation and permeability of [D-Ala2] met-enkephalinamide (TAGM) across rabbit cornea," AAPs Annual Meeting, San Antonio, TX, November 1992; Pharm. Res., 9, S-12 (1992). D.H. Chao and J.K.H. Ma, "Effect of an Emulsion system on In Vivo tissue distribution of tetrandrine," AAPS Ann. Meeting, San Antonio, TX, November 1992; Pharm. Res., 9, S-201 (1992). Y. Rojanasakul, L. Wang, W.P. Liao, C.J. Malanga, and J.K.H. Ma, "Activation of Alveolar Macrophage cell injury: Role of oxygen radical generation and calcium overloading, AAPS Annual Meeting, San Antonio, TX, November 1992; Pharm. Res, 9, S-211 (1992). Y. Rojanasakul, L. Wang, J.K.H. Ma, and D. Toledo, "Enhanced Enkephalin Absorption across cultured Alveolar Epithelial Monolayer via calcium and Cytoskeleton regulation," AAPS Annual Meeting, San Antonio, TX, November 1992; Pharm. Res, 9, S-215 (1992). S.L. Weber, M. Bhat, Y. Rojanasakul, J.Y.C. Ma, V. Castranova, D.E. Banks, and J.K.H. Ma, "Cellular Action of Taurine Against Bleomycin-Induced Oxidative Injury in Alveolar Macrophages," ALA/ATS International Conference, San Francisco, CA, May 1993; Am. Rev. Respir. Dis., 147, A-73 (1993). J.Y.C. Ma, Y.H. Cheng, M.W. Barger, W.F. Xin, V. Castranova, and J.K.H. Ma, "Modification of Alveolar Macrophage Function with Bis-basic Ethoxyfluorene Derivatives: Correlation with Antifibrotic Potency," ALA/ATS International Conferences, San Francisco CA, May 1993; Am. Rev. Respir. Dis., 147, A912 (1993). M. Bhat, J. Prendergast, Y. Rojanasakul, S. Weber, V. Castranova, and J.K.H. Ma, "Fluoromicroscopic Evaluation of Bleomycin," AAPS Eighth Annual Meeting, Orlando, FL, November 1993; Pharm. Res., 10, S-199 (1993). Y. Rojanasakul, L.Y. Wang, C.J. Malanga, and J.K.H. Ma, "Gene Delivery to Alveolar Macroplunges via Ferritin-mediated Endocytosis Pathyway," AAPS Eighth Annual Meeting, Orlando, FL. November 1993; Pharm. Res., 10, S-237 (1993). J. Harrison, L.Y. Wang, J.K.H. Ma, and Y. Rojanasakul, "Enhanced Delivery of Antioxidant Enzyme to Alveolar Macrophages by Ferritin-Mediated Endocytosis," AAPS Eighth Annual Meeting, Orlando, Fl, November 1993; Pharm. Res., 10, S-237 (1993). D.H. Chao, W.F. Pan, Y. Rojanasakul, V. Castranova, and J.K.H. Ma, "Effect of Oil Phase Solidification on the Stability and Drug Release from Multiple Emulsions," AAPS Eighth Annual Meeting, Orlando, FL, November 1993; Pharm. Res., 10, S-236 (1993). L.Y. Wang, W.F. Pan, J.K.H. Ma, and Y. Rojanasakul, "Alteration of Alveolar Epithelium Permeability by Oleic Acid and Related Fatty Acids: Evidence for a Calcium-Dependent Mechanism, "AAPS Eighth Annual Meeting, Orlando, FL, November 1993; Pharm. Res., 10, S-207 (1993). W.P. Liao, J. DeHaven, P. Ellis, and J.K.H. Ma, "In vitro Antiproliferative Activity of Liposome-encapsulated Murcine Alpha Interferon," AAPS Eighth Annual Meeting, Orlando, FL, November 1993; Pharm. Res., 10, S-292 (1993). J.L. Wilt, D.E. Banks, N.L. Lapp, D.N. Weissman, H.V. Dedhia, J.E. Parker, J.K.H. Ma, et al., "Whole Lung Lavage for the Treatment of Silicosis," ALA/ATS International Conference, Boston, MA, May 22-25, 1994. Am. Rev. Respir. Dis., 149, A405 (1994). D.H. Chao, J.Y.C. Ma, M.W. Barger, V. Castranova, D.E. Banks, and J.K.H. Ma, "Enhancement of the In Vivo Action of Tetrandrine Against Silicosis by Targeted Drug Delivery," ALA/ATS International Conference, Boston, MA, May 22-25, 1994. Am. Rev. Respir. Dis., 149, A554 (1994). B.Z. Zhong, S. Robbins, D. Bryant, W. Lan, J. Ma, and T. Ong, "The Genotoxicity of 13 Mild Coal Gasification Products," Environ Mutagen Soc. Ann Meeting, Portland, OR, May 7-12, 1994. D.H. Chao, C.J. Malanga, Y. Rojanasakul, and J.K.H. Ma, "Multiple Emulsion-Mediated Therapeutic Effect of Tetrandrine Against Silica-Induced Pulmonary Fibrosis," AAPS Nineth Annual Meeting, San Diego, CA, November 1994; Pharm. Res., 11, S-7 (1994). W.P. Liao, K.L. Fox, J. DeHaven, Y. Rojanasakul, and J.K.H. Ma, "Lipsomal Delivery of "-Interferon to a Murine Bladder Tumor via Transferrin Receptor-Mediated Endocytosis," AAPS Ninth Annual Meeting, San Diego, CA, November 1994; Pharm. Res, 11, S-201 (1994). W.W. Liang, L.Y. Wang, J.K.H. Ma, and Y. Rojanasakul, "Specific Macrophage Uptake of Antisense Oligonucleotide Mediated by Mannosylated Poly-L-Lysine," AAPS Nineth Annual Meeting, San Diego, CA, November 1994; Pharm. Res., 11,. S-207 (1994). L.Y. Wang, J. Harrison, J.K.H. Ma, and Y. Rojanasakul, "Protection Against Pulmonary Oxidative Injury and Permeability Alterations by Catalase-Transferrin Conjugate," AAPS Nineth Annual Meeting, San Diego, CA, November 1994; Pharm. Res., 11, S-207 (1994). E.L. Lloyd, W.P. Liao, L.Y. Wang, X.S. Peng, Y. Rojansakul, and J.K.H. Ma, "Transferrin-Polylysine (TFPL) Liposomes for Selective Drug Targeting to Activated Phagocytes," AAPS Nineth Annual Meeting, San Diego, CA, November 1994; Pharm. Res., 11, S-206 (1994). D. Deshpande, E.G. Strother, J.K.H. Ma, and Y. Rojansakul, "Receptor Mediated Antisense Oligonucleotide Cellular Uptake and Targeting in CaCO-2 Cells," AAPS Nineth Annual Meeting, Pharm. Res., 11, S-218 (1994). N. Lapp, J. Wilt, D. Weissman, H. Dedhia, J. Parker, J. Ma, E. Stulken, V. Vallyathan, V. Castranova, and D. Banks, "Whole Lung Lavage for the Treatment of Silicosis," 4th Symposium on Respirable Dust in the Mineral Industries, GMTCRD, USBM/MSHA/NIOSH/ACGIH, co-sponsors, Pittsburgh, PA, November 1994. D.N. Weissman, J.K.H. Ma, Y. Rojanasakul, and Ann Huffs, "Immune Dysfunction in Silicosis: A Hypothesis," 4th Symposium on Respirable Dust in the Mineral Industries, GMTCRD, USBM/MSHA/NIOSH/ACGIH, Co-sponsors; Pittsburgh, PA, November 1994. J.Y.C. Ma, M.W. Barger, S.L. Weber, J.K.H. Ma, and V. Castranova, "Antifibrotic Action of Tetrandrine on Silica-Exposed Rats," ALA/ATS International Conference, Seattle, WA, May 1995. J.J.Shao and J.K.H. Ma, "Synthesis and characterization of a neophospholipid liposome system for drug targeting to alveolar macrophages,@ AAPS Eastern Regional, New Brunswick, NJ, June 1995. M. Bhat, Y. Rojanasakul, V. Castranova, and J.K.H. Ma, "The role of the tight junction permeability and oxidative process in the bioavailability of peptide drugs," AAPS Tenth Annual Meeting, Miami Beach, FL, November 1995. J.J.Shao and J.K.H. Ma, "Characterization of a glycolipid liposome system for selective drug targeting to alveolar macrophages," AAPS Tenth Annual Meeting, Miami Beach, Florida, November 1995. W.W. Liang, J.K.H. Ma, and Y. Rojanasakul, "Inhibition of Fibrogenic Cytokinic gene expression by antisense oligonucleotides," AAPS Tenth Annual Meeting, Miami Beach, Florida, November 1995. H.M. Yang, J.K.H. Ma, V. Castranova and J.K.H. Ma, "Diesel exhaust particles stimulate the excretion of interleukin-1, but not tumor necrosis factor-alpha in rat alveolar macrophages," 1996 Society of Toxicology Annual Meeting, Anaheim, CA, March 1996. J.Y.C. Ma, M.W. Barger, J.K.H. Ma and V. Castranova, "Effects of Tetrandrine in Macrophage production of cytokines resulting from silica or bleomycin exposure," 1996 Society of Toxicology Annual Meeting, Anaheim, CA, March 1996. C. Dong, J.Y.C. Ma, V. Vallayathan, V. Castranova, H.M. Yang, and J.K.H. Ma, AOxidative response of alveolar macrophages to diesel exhaust particlates,@ Allehgeny-Erie Society of Toxicology Annual Meeting, Pittsburgh, PA, May 1996. Yang, H.M., Ma, J.Y.C., Castranova, V., and Ma, J.K.H., Pulmonary Response of rats to Intratracheal Instillation of Diesel Exhaust Particles: Inflammation, Oxidative Stress and Alveolar Macrophage Cytokine Secretion, Society of Toxicology Annual Meeting, Cincinnati, OH, May 1997. Shao, J., DeHaven, J., Runyan, K., and Ma, J.K.H., Lung Metastasis Prevention and Targeting Treatment by Drug-Loaded Tumor Cells, 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA, April 12-16, 1997. Ma, J.Y.C., Barger, M.W., Ma, J.K.H., and Castranova, V., "Acute pulmonary responses to intra-tracheal instillation of asbestos: Amelioration by tetrandrine," FASEB, New Orleans, LA, April 1997. Shao, J.J., DeHaven, J., Runyan, K., Lamm, D.L., Weissman, D.N., and Ma, J.K.H., "Novel targeting drug delivery system for lung metastasis prevention and treatment," AAPS Annual Meeting, November 1997, Boston, MA; Pharm. Res. (1997) 14(11): S-101 (abstract). Yang, X., Rojanasakul, Y., and Ma, J.K.H., "Luteinizing hormone releasing hormone degradation in type II cell-derived epithelia," AAPS Annual Meeting, Boston, MA, November 1997; Pharm. Res. (1997) 14(11): S-136 (abstract). Yang, H.M., Ma, J.Y.C., Castranova, V., Barger, M.W., and Ma, J.K.H., "Exposure to diesel exhaust particles (DEP) alters the responsiveness of rats to bacterial lipopolysaccharide (LPS) insults," 1998 Society of Toxicology Annual Meeting, Seattle, WA, May 1998. Weissman, D.N., Yuan, L., Zhuang Z.Z., Ma, J.K.H., Rojanasakul, Y., Stanley, C.F., Hubbs, A.F., "Experimental silicosis induces an expansion of IgG subclass-producing cells in pulmonary lymphoid tissues not explained by T helper subset imbalance," 1998 ALA/ATS International Conference, Chicago, IL, April 1998. Yang, H.M., Ma, Antonini, J.M., J.Y.C., Barger, M.W., Ma, J.K.H., and Castranova, V., "Exposure to diesel exhaust particles (DEP) compromised the pulmonary clearance of Listeria monocytogenes in rats," The Toxicologist, 48 (1-S):258, 1999 (March 1999, New Orleans, LA).; This paper won the best Paper Award at the Allegheny-Erie Society of Toxicology Annual meeting (May 14, 1999). Al-Humadi, N.H., Siegel, P.D., Ma, J.Y.C., Mull. J.C., Butterworth, L.F., and Ma, J.K.H., Fluorometric determination of thiol concentrations in cells from pulmonary associated lymph nodes and alveolar macrophages," AAPS Annual Meeting, New Orleans, November, 1999; PharmSci, (1999), 1: paper 2748. Yang, X.D., Ma, J.Y.C., and Ma, J.K.H., " Transport and utilization of arginine-containing peptides in alveolar macrophages," AAPS Annual Meeting, New Orleans, November, 1999; PharmSci, (1999), 1: paper 2671; Xiaodong Yang was the recipient of a Summer Internship award at NIOSH, Morgantown, August, 1999. Al-Humadi, N.H., Siegel, P.D., Ma, J.Y.C., Ma, J.K.H., Jones, W.G., and Lewis, D., "Comparison of pulmonary response to inhaled and intratraceally instilled diesel exhaust particlate," Society of Toxicology Annual meeting, Philadelphia, PA, March 2000; The Toxicologist, 54(1-S):A68, 2000. Yang, X.D., Ma, J.Y.C., and Ma, J.K.H., "Evidence of PepT1-like Transporter in Pulmonary Alveolar macrophages, Pharm. Sci. (Supplement), sec 91:2126, 2000. Ma, J.K.H., Ma, J.Y.C., Yang, H.M., Antonini, J., Castranova, V., Siegel, P.D., and Weissman, D.N., "Alteration of Pulmonary Immune/Inflammatory Responses by Diesel Exhaust Particles (DEP)," Proceedings for the First International Conference of the Society for Free Radical Research-Africa, Malelane Gate, Mpumalanga, South Africa, July 16-20, 2000. Ma, J.Y.C., Ma, J.K.H., and Castranova, V., "Mechanisms of pulmonary fibrosis: Antifibrotic actions of tetrandrine," Proceedings of the First International Conference of the Society for Free Radical Research-Africa, Malelane Gate, Kruger national Park, Mpumalanga, South Africa, July16-20, 2000. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Ma, J.Y.C., and Ma, J.K.H., "Diesel exhaust particles (DEP) affected thiol levels in both alveolar macrophages and lymph node cells," Society of Toxicology Annual meeting, San Francisco, CA, March 2001; The Toxicologist, 60(1S):167, 2001. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H., "Effect of diesel exhaust particles (DEP) on pulmonary allergic sensitization in brown Norway rats," Toxicology, 164(1-3):119, 2001. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C.,Weissman, D.N., and Ma, J.K.H., "Adjuvant effect of diesel exhaust particles (DEP) and carbon black (CB) on pulmonary allergic sensitization," #rd International Conference on Oxygen/Nitrogen Radicals: Cell Injury and Disease, Morgantown, WV, June 2002. Ma, J.Y.C., Rengasamy, A., Barger, M.W., Kane, E., Ma, J.K.H., and Castranova, V., "Alteration of pulmonary cytochrome P450 system by diesel exhaust particles," Toxicology 164(1-3):119, 2001. Yin, X., Schafer, R., Antonini, J.M., Barger, M.W., Ma, J.Y.C., and Ma, J.K.H., "Alteration of innate and cell-mediated immunity to Listeria monocytogenes by short term exposure to diesel exhaust particles," 3rd International Conference on Oxygen/Nitrogen radicals: Cell Injury and Disease, Morgantown, WV, June 2002. Rengasamy, A., Barger, M.W., Kane, E., Ma, J.K.H., Castranova, V., and Ma, J.Y.C., "Diesel exhaust particle-induced alterations of pulmonary cytochrome p450 and glutathione-s-transferase systems," 3rd Internation Conference on Oxygen/Nitrogen Radicals: Cell Injury and Disease, Morgantown, WV, June 2002. Hu, S., Ma, J.Y.C., Barger, M.W., Zhao, H., and Ma, J.K.H., "Role of microtubule in silica-induced cytokine secretion and apoptosis in alveolar macrophages," 3rd International Conference on Oxygen/Nitrogen radicals: Cell Injury and Disease, Morgantown, WV, June 2002. Rosenbluth, S.A., Kalsekar, I.D., and Ma, J.K., "Pharmacy student research conference-eastern states: A study of presenter’s interests, opinions, and careers," AACP Annual meeting, Toronto Canada, July 2001. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C.,Weissman, D.N., and Ma, J.K.H., "Role of thiols in pulmonary immune response to allergic sensitization: adjuvant effect of diesel exhaust particulate (DEP)," Pharm. Sci. (Supplement) 3(3) T3449, 2001. Yang, X.D., Ma, J.Y.C., and Ma, J.K.H., "Transport and utilization of arginine-containing peptides in alveolar macrophages," Pharm. Sci. (Supplement), 3(3): T3524, 2001. Ma, J.Y.C., Hu, S., Barger, M.W., Zhao, H., and Ma, J.K.H., "Role of microtubule in regulating cytokine production by alveolar macrophages," Pharm. Sci. (Supplement), 3(3) T3603, 2001. Rengasamy, A., Barger, M.W., Kane, E., Ma, J.K.H., Castranova, V., and Ma, J.Y.C., "Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes," Society of Toxicology Annual meeting, Nashville, TN, March 2002. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H., "Thiol and Immune Exposure dependent response to ovalbumin in sensitized rats," Society of Toxicology Annual meeting, Nashville, TN, March 2002. Yin, X., Schafer, R., Antonini, J.M., Barger, M.W., Roberts, J.R., Delarosa, P., Ma, J.Y.C., and Ma, J.K.H., "Alteration of innate and cell-mediated immunity to Listeria monocytogenes by short term exposure to diesel exhaust particles," FASEB, New Orleans, LA, April 2002. Zhao, H.W., Yin, X., Frazer, D., Barger, M.W., Tomblyn, S., Stone, S., Ma, J.K.H., Castranova, V., and Ma, J.Y.C., "Effects of paving asphalt fume exposure on genotoxic and mutagenic activities in the lung," FASEB, New Orleans, LA, April 2002. Grants and Contracts "Determination of Serum Theophylline by HPLC," WVU Senate Grant, $2,000.00, Grant No. 8610228510, July 1976. "Peritoneal Clearance of Orally Administered Cimetidine in Uremic Patients Being Treated with Maintenance Peritoneal Dialysis," Co-principal Investigator with Dr. A. Jacknowitz, $14,000, supported by SK&F Laboratories, 1979. "HHR Dissolution Studies," Co-principle investigator with Dr. J.P. O'Donnell, $7,000 supported by Mylan Pharmaceuticals, Inc., 1979. "Assay Development for Chlorothalidone Analysis in Blood and Urine," Co-principal investigator with Dr. J.P. O'Donnell, $1,200, supported by Mylan Pharmaceuticals, Inc. 1979. "Microsomal Metabolism of Hydralazine," West Virginia Heart Foundation, $9,165, July 1980 - June 81, Funded "Development of Biodegradable Microcapsules for Cosmetic Use," Co-principal investigator with S.A. Howard and L.A. Luzzi, supported by Society for Cosmetic Chemists, $2,500. (1980-81), $2,500, (1981-82). "Development of Biodegradable Polymeric Drug Matrix Delivery Systems for Anti-cancer Chemotherapy," American Cancer Society, WVU Institutional Grant, $3625 (1982-83); NIH Biomedical Research Grant, $4940 (1983). "Request for Travel Support for Professional Presentation," WVU Foundation Faculty Grant; $400.00, May 1984. "Request for Partial Funding Toward the Purchase of a State-of-the-Art uv/vis Spectrophotometer," WVU Equipment Fund, $17,800., March 1984. "Clinical Biopharmaceutics & Pharmacokinetics Component in the Clinical Research & Service Program of WVU Cancer Center," WVU Cancer Center Construction Grant, NIH (1984); approved. "Antiproliferative Activities of the Microencapsulated Anticancer Agents," NCI Cancer Educational Grant, WVU, $2,400.00 May, 1985. "Christopher Boyles Memorial Fund for Cancer Research", $5000.00, private donations, 1985. "Pharmacokinetic Studies of Microencapsulated Mitomycin C by Canine Intrahepatic Arterial Infusion," submitted to WVU NIH Biomedical Research Grant ($5,000.00). Funded for 1987 $4914. "Pharmacologic/Toxicologic Studies of Polylactic Acid-Mitomycin C Microcapsules by Canine Intrahepatic Arterial Infusion," NIH/NCI Professional Oncology Education Program, $1500, 1987. "Disposition of Mitomycin C and Other Anticancer Agents Used in Combination Chemotherapy," Mary Babb Randolph Cancer Center Oncology Education Program, $1500, May 1988. "Studies of the Pulmonary Toxicity of Mytomycin C and its Major Metabolites via lipid Peroxidation," Mary Babb Randolph Cancer Center Oncology Education Program, $1500, May 1988. "Equipment for Collaborated Research", FDA, $23,000, 1988. "Targeted Delivery of Tetrandrine to Alveolar Macrophages for Treatment of Silicosis", Generic Technology Center for Respiratory Dust, U.S. Bureau of Mines, Dept. of Interior, $179,300, October 1989 - September 1993. (USBOM5432WV22). "Microencapsulation of Biodegradable polymers", from United States Surgical Corporation, $6,000, 1988. "Novel Delivery of Tetrandrine for Treatment of Silicosis", International Development Grant, WVU Office of Academic Affairs, $1,000, March 1989. "Disposition of Mitomycin C via Intraarterial Chemoembolization," American Cancer Society, $148,200; Approved with excellent rating. "Faculty Development Grant for International Symposium on Pharmaceutical Sciences and Chinese herbal medicine, sponsored by Society of Chinese Bioscientists in America," $750, 1990. "Award from Office of International Programs, WVU, for Collaborated Research with the Institute of Occupational Medicine, Beijing, China," $1100, 1990, Funded. "Toxicological Studies of Mild Gasification Products," from Department of Energy, Copricipal Investigator with T.M. Ong(NIOSH), $360,000; October 1, 1990-December 31, 1993. (DE-AI21-89MC26018), Funded "Cooperative Agreement Program for Occupational Respiratory Disease and Musculoskeletal Disorders," DHHS/PHS/CDC/NIOSH, Co-principal investigator with D. Banks (PI) and others, $1,500,000, 10/1/90-9/30/95. (U60/OCU304149); Individual Research; "Mechanism of actions of Bisbenzylisoquinolines of Pulmonary Fibrosis", ($250,000), Funded. "International Research Collaboration on Occupational Health," WVU International Programs ($1995) 1991; Generic Technology Center for Respirable Dust, U.S. Bureau of Mines ($1000), 1991; WVU International Programs ($4000), 1992, Funded. "Summer Research Workshop for Undergraduate Pharmacy Student," The Merck Company Foundation ($4200); AAPS-APQ Award ($4000); Amgen Corporation ($4200); 1992, Funded. "Treatment of Silicosis by Whole Lung Lavage," International Research Collaboration, Co-principal investigator with D.E. Banks, $25,000, WVU Health Sciences Center, 1992 –1994, Funded. "1993 Summer Research Workshop for Undergraduate Student": 1. The Merck Company Foundation, $4,300, Funded "Silicosis-Associated Immune Response Modification: Underlying Mechanisms," as co-investigator (P.I.: D.N. Weissman), U.S. Bureau of Mines, DOI, $262,232 (10/1/93-9/30/96), Funded. "Assessment of Treatment of Pneumoconiosis by Whole Lung Lavage," N.L. Lapp, D.E. Banks, J.K.H. Ma, Co-principal investigators, in General Clinical Research Center Grant submitted to NIH by West Virginia University, R. D'Alessandri/R. Heldtke, directors, $3,276,984 (12/1/93 -11/30/96), approved not funded. "Summer Research Workshop for Undergraduate Pharmacy Students, 1994": 1. AFPE Gateway Scholarship ($9,250), funded "Effect of Diesel Exhaust on Pulmonary Antimycobacterial Defense," U.S. Bureau of Mines, DOI, $237,745 (10/1/94 ~ 9/30/97), Funded. "Development of a Core Facility for Pharmaceutical Biotechnology and Therapeutic Research," National Science Foundation EPSCoR program, $419,260 (9/15/94 - 7/31/96); Funded. "Selective Inhbition of Silica-Induced Cytokine Expression by Antisense Oligonucleotides," as Co-investigator (P.I.: Y. Rojanasakul); $176,996 (10/1/94 - 9/30/96); approved. "Inhibition of Silica-and Mineral Dust-Induced Fibrogenic Cytokine Gene Expression by Antisense Oligonucleotides," as Co-investigator (Y. Rojanasakul, P.I.), US Bureau of Mines, DOI, $179,080 (7/1/95-6/30/97); approved/not funded. "Ocular Bioavailability of Hydralazine and Diclofenac from Polymeric Ophthalmic Formulations," Ciba Vision Ophthalmics, $74,754, 1994. "Research Workshop for Undergraduate Pharmacy Students", 1995: 1. AFPE Gateway Scholarship ($9,250), funded. ACooperative Agreement Program for Occupational Respiratory Disease an d Muscloskeletal Disorders,@ Competitive Renewal, DHHS/PHS/CDC/NIOSH, Co-principal Investigator with D.E. Banks, Research Project1, (as Principal Investigator) ARole of Tetrandrine in the Evaluation, Prevention, and Treatment of Dust-Induced Pulmonary Fibrosis,@ $450,000; Research Project2, (as investigator): ATreatment of Pneumoconiosis by Whole Lung Lavage,@ $30,000; (10/1/95); approved not funded. ATumor-Cell derived liposomes by Metastasis specific targeting of anticancer agent.@ Pfizer Central Research, $5,000. Funded; 1996. AWVU Undergraduate Research Conference,@ The Merck Company Foundation, $48,000 (1996-1998), Funded. "Use of Caco-2 Cell Line for Oral Drug Absorption Studies," Pfizer Central research, $5,000; Funded; 1997. "Enhancing the Lung Targeting Ability of Drug Loaded Tumor Cells with Fixed Cell Membrane," AACP Merck Research Scholarship for M. Bostic; AACP; $7,000; Funded; 1997. "Drug Delivery technology: Cell-Derived Drug targeting System," As principal investigator, National Institute for Occupational Safety and Health, $20,000; Funded, 1997 "Alteration of Pulmonary Immune System by Diesel Particles," As principal investigator, West Virginia University Research Corporation Grant for Preliminary Studies, $21,000, 7/1/1999-6/30/2000, Funded. "Alteration of pulmonary Immune System by Diesel Particle," As principal investigator, National Institute of Heart, Lung and Blood (NIHLB), NIH, $762,360 (4/1/00 – 3/31/03). (1 R01 HL62630). Funded.
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