Peter Gannett, Ph.D. Robert C. Byrd Distinguished Professor of Medicinal Chemistry Department of Basic Pharmaceutical Sciences West Virginia University P.O. Box 9530 Morgantown, WV 26506-9530 Phone: (304) 293-1480 Fax: (304) 293-2576 E-Mail: pgannett@hsc.wvu.edu

Link to Full CV - PDF

Post-doctoral Training
University of Wisconsin-Madison (Pharmacy) and the Eppley Cancer Research Inst., University of Nebraska Medical Center.

Graduate Training
University of Wisconsin-Madison (Chemistry).

Undergraduate Training
University of Missouri-Columbia.

Research Interests:

DNA structure and conformation.
Reactions of radicals with DNA.
Supramolecular organic chemistry and DNA.
Hydrazines carcinogenesis.

Recent/Current Grants:

Antisense and triplex DNA formation in cells by ESR (NIH-NIGMS)
Laboratory for Computational Chemistry and Chemical Biology (WVU Research Corp).
Degradation of Drugs in Embalmed Tissue (FBI-DOJ)
Pharmacogenetics and Drug Interactions (NIH)
Mechanisms of Atypical Drug Kinetics and Interactions (NIH)
Electrochemical Biosensors Based on DNA/Aptamer
Targeted Magnetic Nanoparticles for Cancer Diagnosis and Treatment

Research Techniques:

Nuclear Magnetic Resonance (NMR)
Electron Paramagnetic Resonance (EPR)
Organic Synthesis (Modified nucleic acids)
Oligonucleotide Synthesis
Computational Biology

Selected Publications:

Hummel, M.A., Gannett, P.M., Aguilar, J., and Tracy, T.S. “Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.  Arch. Biochem. Biophys. 475 175-183 (2008)

Gannett, P.M., Miller, L., Daft, J., Locuson, C., Tracy, T.S. “Synthesis of Deuterated Naproxens”, J. Labelled Compds. Pharmaceut. 50:1272-1275 (2007).

Locuson, C.W., Gannett, P.M., Ayscue, R.R., Tracy, T.S., “Discovery of Heteroactivators of Cytochromes P450 Using Virtual Library Screening”, J. Med. Chem.. 50:1158-1165 (2007).

Martirosyan, A., Leonard, S., Shi, X., Griffiths, B., Gannett, P.M., Strobl, J. ‘Dual Roles for Reactive Oxygen Species in MCF-7 Human Mammary Tumor Cell Differentiation and Cell Death Produced by an Experimental Agent, NSC3852', (2006) J. Pharmacol. Exp. Therapeutics 317:546-552.

Locuson, C.W., Gannett, P.M., Tracy, T.S. “Heteroactivator Effects on the Coupling and Spin State Equilibrium of CYP2C9" (2006) Arch. Biochem. Biophys. 449:115-129.

Sanga, M., Tirumalai, P.S., Bland, T.M., Banaszewska, M., Konat, G.W., Tracy, T.S., Gannett, P.M., Callery, P.S. ‘Trans-1-Phenylpropene from Smoked Methamphetamine Converts to Cytotoxic trans-phenylpropylene Oxide by CYP450 Enzymes’, (2006) Toxicology and Applied Pharmacology 211:148-156.

Mohler, D.L., Downs, J.R., Hurley-Predecki, A.L., Sallman, J.R., Gannett, P.M., Shi, X. ‘DNA Cleavage by the Photolysis of Cyclopentadienyl Metal Complexes: Mechanistic Studies and Sequence Selectivity of Strand Scission by CpW(CO)₃CH₃', (2005) J. Org. Chem. 70:9093-9102.

Heavner, S. and Gannett, P.M. ‘Molecular Dynamics and Free Energy Calculations of the B and Z Forms of C8-Arylguanine Modified Oligonucleotides’, (2005) J. Biomolec. Struct. Dyn. 23:203-219.

Darian, E. and Gannett, P.M. ‘Application of Molecular Dynamics to Spin-labeled Oligonucleotides’, (2005) J. Biomolecular Structure and Dynamics, 22:579-594.

Tracy, T.S., Hummel, M.A., Gannett, P.M., Aguilar, J.S.  “Effector-Mediated Alteration of Substrate Orientation in Cytochrome P450 Enzymes.”  (2004) Biochemistry, 43:7207-7214.

Gannett, P.M., Heavner, S., Daft, J.R., Shaughnessy, K., Epperson, J.D., Greenbaum, N.L. “Synthesis, Properties, and NMR Studies of a C8-Phenylguanine Modified Oligonucleotide that Preferentially Adopts the Z-DNA Conformation.”  (2003) Chem. Res. Toxicol. 16:1385-1394.

Teaching:

Undergraduate/Professional:
Introduction to Nanotechnology Design
Chemical Properties of Drugs.

Graduate:
Advanced Medicinal Chemistry.
Drug Discovery and Design
Introduction to Molecular Modeling

American Chemical Society
Organic Chemistry Division, American Chemical Society
Medicinal Chemistry Division, American Chemical Society
Chemical Toxicology Division, American Chemical Society
Rho Chi Society