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Education:
Ph.D. - University of Wisconsin-Madison. 1989 Research Interests:
Molecular Therapeutics and Nanotechnology Professional Experience:
2000-present - Professor, West Virginia University Recent/Current Grants:
Molecular Signaling of Death Receptor-Mediated Apoptosis (NIH) Recent Publications: Wang L, Azad N, Kongkaneramit L, Lu Y, Chen F, and Rojanasakul Y. The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation. J Immunol. 180:3072-3080, 2008. Azad N, Iyer AKV, Lu Y, Wang L, Castranova V, and Rojanasakul Y. Nitric oxide-mediated Bcl-2 stabilization potentiates Cr(VI)-induced malignant transformation of human lung epithelial cells. Oncogene 2008. Wang L, Chanvorachote P, Toledo D, Stehlik C, Mercer RR, Castranova V, and Rojanasakul Y. Peroxide is a key mediator of Bcl-2 downregulation and apoptosis induction by cisplatin in human lung cancer cells. Mol Pharmacol. 73:119-127, 2008. Azad N, Rojanasakul Y, and Vallyathan V. Inflammation and lung cancer: Roles of reactive oxygen/nitrogen species. J Tox Envir Health B Crit Rev. 11:1-15, 2008. Iyer AKV, Azad N, Wang L, and Rojanasakul Y. Role of S-nitrosylation in apoptosis resistance and carcinogenesis. Nitric Oxide 2008 doi:10.1016/j.niox.2008.04.019 Azad N, Iyer AKV, Manosroi A, Wang L, and Rojanasakul Y. Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis. Carcinogenesis 2008. Kongkaneramit L, Sarisuta N, Azad N, Lu Y, Iyer AKV, Wang L, and Rojanasakul Y. Dependence of reactive oxygen species and FLICE-inhibitory protein on Lipofectamine-induced apoptosis in human lung epithelial cells. J Pharmacol Exp Ther. 325:969-977, 2008. Azad N, Iyer AKV, and Rojanasakul Y. Methods to analyze the regulation of apoptosis by S-nitrosylation. In: Methods in Molecular Biology, Humana Press, 2008. Azad N and Rojanasakul Y. Macromolecular drug delivery. In: Biopharmaceutical Drug Development, 2nd Ed. Wu-Pong S and Rojanasakul Y (eds), Humanna Press, 2008. Azad N, Iyer AKV, and Rojanasakul Y. DNA microarrays. In: Biopharmaceutical Drug Development, 2nd Ed. Wu-Pong S and Rojanasakul Y (eds), Humanna Press, 2008. Dorfleutner A, Talbott SJ, Bryan NB, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, and Stehlik C. A Shope fibroma virus pyrin-only protein modulates of the host immune response. Virus Genes 35:685-694, 2007. Xia C, Meng Q, Liu L, Rojanasakul Y, and Jiang BH. Reactive oxygen species in cancer cell regulate angiogenesis through expression of vascular endothelial growth factor. Cancer Res. 67:10823-10830, 2007. Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, and Rojanasakul Y, Flynn DC, and Stehlik C. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun. 75:1484-1492, 2007. Manosroi A, Panyosak A, Rojanasakul Y, and Manosroi J. Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines. J Drug Target. 15:334-341, 2007. Azad N, Vallyathan V, Wang L, Tantishaiyakul V, Stehlik C, Leonard SS, and Rojanasakul Y. S -nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation: A novel anti-apoptotic mechanism that suppresses apoptosis. J Biol Chem. 281:34124-34134, 2006. Moungjaroen J, Nimmannit U, Callery PS, Wang L, Azad N, Lipipun V, Chanvorachote P, and Rojanasakul Y. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 downregulation. J Pharmacol Exp Ther. 319:1062-1069, 2006. Chanvorachote P, Nimmannit U, Stehlik C, Wang L, Jiang, BH, Ongpipatanakul B, and Rojanasakul Y. Nitric Oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination, Cancer Res. 66:6353-6360, 2006. Lu B, Wang L, Stehlik C, Medan D, Huang C, Hu S, Chen F, Shi X, and Rojanasakul Y. Phosphatidyl-inositol-3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in Cl41 cells. J Immunol. 176:6785-6793, 2006. Azad N and Rojanasakul Y. Nanobiotechnology in drug delivery. Am J Drug Deliv. 4:79-88,2006. Wang L, Scabilloni J, Antonini J, Rojanasakul Y, Castranova V, and Mercer RR. Induction of secondary apoptosis, inflammation and lung fibrosis after intratracheal instillation of apoptotic cells in rats. Am J Physiol. 290:L695-L702, 2006. Wang L, Scabilloni JF, Antonini J, Castranova V, Rojanasakul Y, Robert J, Zhang Z, and Mercer RR. Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats. Lab Invest. 86:458-466, 2006. Azad N and Rojanasakul Y. Vaccine delivery: Current trends and future. Curr Drug Deliv. 3:137-146, 2006. Meng Q, Xia C, Fang J, Rojanasakul Y, and Jiang BH. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signaling 18:2262-2271, 2006. Chanvorachote P, Nimmannit U, Wang L, Stehlik C, Lu B, Azad N, and Rojanasakul Y. Nitric oxide negatively regulates Fas (CD95)-induced apoptosis through inhibition of ubiquitin-proteasome mediated degradation of FLIP. J Biol Chem. 280:42044-42050, 2005. Wang L, Bowman L, Lu Y, Rojanasakul Y, Mercer R, Castranova V, and Ding M. Essential role of p53 in silica-induced apoptosis.Am J Physiol. 288:L488-496, 2005. Wiwattanawongsa K, Tantishaiyakul V, Lomlim L, Rojanasakul Y, Pinsuwan S, and Keawnopparat S. Experimental and computational studies of epithelial transport of mefenamic acid ester prodrugs. Pharm Res. 22:721-727, 2005. Medan D, Wang L, Toledo D, Lu B, Stehlik C, Shi X, and Rojanasakul Y. Regulation of Fas (CD95/APO-1)-mediated apoptosis and necrosis by reactive oxygen species in macrophages. J Cell Physiol. 203:78-84, 2005.
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