A significant research focus of the Department is on the study of human drug metabolizing enzymes, including the cytochrome P450 family. One aspect of these studies is to investigate the structural basis for the function of P450 enzymes using a combination of molecular modeling and experimental methods, such as heterologous expression, site-directed mutagenesis and biochemical assays.  Further in vitro studies include enzyme kinetics and the application of NMR, mass spectrometry and stable isotopes to drug metabolism studies and P450 structure elucidation.  This research has a potential for advancing our understanding of how P450 enzymes activate or deactivate drugs and xenobiotics, with important implications for drug-drug interactions and metabolic activation of carcinogens.

For the CV's of Drug Metabolism and Pharmacokinetics Faculty, please view:

• Dr. Patrick Callery
• Dr. Robert Haining
• Dr. David Lalka
• Dr. Grazyna Szklarz

Prospective Graduate Students - Apply through WVU School of Medicine