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 Contributor Abstract 

Stephen F. Nelsen

   65th Birthday Symposium
Madison, Wisconsin
June 3-4, 2005

Gary R. Weisman

Dedicated to Professor Stephen F. Nelsen on the occasion of his 65th birthday

The synthesis and coordination chemistry of tricyclic bisamidines 1-3 will be discussed.  The preconstrained but somewhat torsionally flexible synperiplanar bisamidine moiety allows a variety of metal coordination modes including symmetrical and unsymmetrical chelation, monodentate, as well as bimetallic bridging. Substituted and annelated analogs of 1 will also be presented. Double reductive ring expansion of selected tricyclic bisamidines gives corresponding macrocyclic tetraamines. The scope and limitations of this short route to important macrocyclic tetraamines will be presented. Published as well as unpublished work will be discussed.

"A New Synthesis of Cyclen (1,4,7,10-Tetraazacyclododecane)", Gary R. Weisman and David P. Reed, J. Org. Chem. 1996, 61, 5186-5187; Additions and Corrections: J. Org. Chem. 1997, 62, 4548.

"A Preconstrained Tricyclic Biimidazoline Ligand Adaptable to Diverse Coordination Modes", Daniel W. Widlicka , Edward H. Wong, Gary R. Weisman, Kim-Chung Lam, Roger D. Sommer, Christopher D. Incarvito, Arnold L. Rheingold, Inorg. Chem. Commun. 2000, 3, 648-652.

"1,4,7,10-Tetraazacyclododecane", David P. Reed and Gary R. Weisman, Organic Syntheses, 2002, 78, 73-81.

"A Sterically-Hindered Tricyclic Biimidazoline Ligand which is also a Precursor to a Novel Tetramethyl-Cyclen", Daniel W. Widlicka , Edward H. Wong, Gary R. Weisman, Roger D. Sommer, Christopher D. Incarvito, and Arnold L. Rheingold, Inorganica Chimica Acta, 2002, 341C, 45-53.

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