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Research Publications 2001
Basic Pharmaceutical Sciences Department Gannett, P.M., Hailu, S., Daft, J., James, D., Rybeck, B., Tracy, T.S., "In Vitro Reaction of Formaldehyde with Fenfluramine: Conversion to N-methyl Fenfluramine," J. Anal. Toxicol., (2001), 25: 88-92. Gannett P.M., Daft, J.R., James, D., Rybeck, B.F., Knopp, J.B., Tracy T.S. , "In Vitro Reaction of Barbiturates with Formaldehyde," J. Anal. Toxicol., (2001), 25: 443-449. Yu, A. and Haining, R.L., "Comparative Contribution to Dextromethorphan Metabolism by Cytochrome P450 Isoforms in Vitro: Can Dextromethorphan Be Used as a Dual Probe for Both CYP2D6 and CYP3A Activities?" Drug Metab. Dispos., (2001), 29: 1514-1520. Yu A. and Haining R.L., "Dextromethorphan N-demethylation By Highly Purified Recombinant Human CYP2D6" in: Advances in Experimental Medicine and Biology, volume 500, pp. 327-330; Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Disease, (Dansette et. al, Eds). Kluwer Academic/Plenum Publishers, New York, Boston, Dortrecht, London, Moscow. (2001). Kilicarslan T., Haining R.L., Rettie A.E., Busto U., Tyndale R. F. and Sellers E.M., "Flunitrazepam MetabolismBy Cytochrome P450s 2C19 and 3A4," Drug Metab. Dispos. , (2001), 29: 460-465. Yu, A., Dong, H., Lang, D. and Haining, R. L., "Characterization of Dextromethorphan O- and N-Demethylation Catalyzed by Highly Purified Recombinant Human CYP2D6," Drug Metab. Dispos., (2001), 29: 1362-1365. Shao, J., DeHaven, J., Lamm, D.L., Weissman, D.N., Runyan, K., Malanga, C.J., Rojanasakul, Y., and Ma, J.K.H., "A Cell-based Drug Delivery System for Lung Targeting: I. Preparation and Pharmacokinetics," Drug Delivery, (2001), 8: 61-69. Shao, J., DeHaven, J., Lamm, D.L.., Weissman, D.N., Malanga, C.J., Rojanasakul, Y., and Ma, J.K.H., "A Cell-based Drug Delivery System for Lung Targeting: II. Therapeutic Activity on B16-F10 Melanoma in Mouse Lungs," Drug Delivery, (2001), 8: 71-76. Yang, H.M., Antonini, J.M., Barger, M.W., Buterworth, L., Roberts, J.R., Ma, J.K.H., Castranova, V., and Ma J.Y.C., "Diesel Exhaust Particles Suppress Macrophage Function and Slow the Pulmonary Clearance of Listeria Monocytogenes in Rats," Environ. Health Perspectives, (2001), 109: 515-521. Huang, S.H., Hubbs, A.F., Stanley, C.F., Vallyathan, V., Schnabel, P.C., Rojanasakul, Y., Ma, J.K.H., Banks, D.E., Weissman D.N., " Immunoglobulin Responses to Experimental Silicosis," Toxicological Sciences, (2001), 59:108-117. Weissman, D.N., Hubbs, A.F., Huang, S.H., Stanley, C.F., Rojanasakul, Y., and Ma, J.K.H., "IgG Subclass Responses in Experimental Silicosis," J. Environ Pathol, Toxicol, & Oncol. (JEPTO), (2001), 20 (suppl. 1): 67-74. Shao, J., Dai, J., and Ma, J.K.H., "A Pilot Study on Anticancer Activities of Chinese Leek," J. Alternative and Complementary Medicine, (2001), 7: 517-522. Castranova, V., Ma, J.Y.C., Yang, H.M., Antonini, J.M., Barger, M.W., Buterworth, L., Roberts, J.R., and Ma, J.K.H., "Effect of Exposure to Diesel Exhaust Particles on the Susceptibility of the Lung to Infection," Environ Health Perspectives, (2001), 109: 609-612. Yang, X.D., Ma, J.Y.C., Barger, M.W., and Ma, J.K.H., " Transport and Utilization of Arginine and Arginine-containing Peptides in Alveolar Macrophages," Pharmaceutical Research. In press. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H., "Alteration of Intracellular Cysteine and Glutathione Levels in Alveolar Macrophages by Diesel Exhaust Particles (DEP) Exposure," Environ. Health Perspectives. In press. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H., "The Effect of Diesel Exhaust Particles (DEP) and Carbon Black (CB) on Thiol Changes in Pulmonary Ovalbumin Allergic Sensitized Brown Norway Rats," Exp. Lung Research. In press. Spratto, G.R. and Woods, A.L.: PDR Nurse’s Drug Handbook, Medicine Economics Co. and Delmar Publishers, Montvale, N.J., 2001. Xue, L., Wang, H.F., Wang, Q., Szklarz, G.D., Domanski, T.L., Halpert, J.R. and Correia, M.A., "Influence of P450 3A4 SRS-2 Residues on Cooperativity and/or Regioselectivity of Aflatoxin B1 Oxidation," Chem. Res. Toxicol., (2001), 14: 483-491. Tracy T.S., Rybeck, B.F., James, D.G., Knopp, J.B., Gannett, P.M., "Stability of Benzodiazepines in Formaldehyde Solutions," J. Anal. Toxicol., (2001), 25: 166-173. Hutzler, J.M., Frye, R.F., Korzekwa, K.R., Branch, R.A., Huang, S.M., Tracy T.S., "Minimal in Vivo Activation of CYP2C9-Mediated Flurbiprofen Metabolism by Dpsone," Eur. J. Pharmaceut. Sci.,( 2001), 14: 47-52. Hutzler, J.M., Hauer, M.J., Tracy, T.S., "Dapsone Activation of CYP2C9-mediated Metabolism: Evidence for Activation of Multiple Substrates and a Two-site Model," Drug Metab. Dispos.,(2001), 29: 1029-1034. Clinical Pharmacy Department Cupp M.J., "Antibiotics." In: The World Book Encyclopedia. Chicago, IL: World Book Publishing; (2001). Cupp M.J., "Dietary supplements." In: The World Book Encyclopedia. Chicago, IL: World Book Publishing; (2001). Cupp M.J., "Thalidomide." In: The World Book Encyclopedia. Chicago, IL: World Book Publishing; (2001). Elliott, D.P., "The Effect of Time of Administration of Levothyroxine on Serum TSH in Nursing Home Residents," Ann Pharmacother., (2001), 35: 529-532. Crawford, D., Gorrell, J.J., "Infant Botulism and Corn Syrup: A Case Report", J Pediatr Pharmacology and Therapeutics. In press. Hodges, B. and White, R., "Antimicrobial Cycling: The Future or a Fad?" Ann Pharmacothe.r, (2001), 35: 1224-1232.Hodges, B. and Mazur, J., "Intravenous Valproate in Status Epilepticus," Ann Pharmacother., (2001), 35: 1465-70. Justice, J.H., In Nurse’s Herbal Drug Handbook, Springhouse Corporation: Springhouse, PA. Wrote 5 herbal monographs; Kava Kava, Kelp, Kelpware, Khat, Khella Justice, J.H., Monitoring Aspects for Herbal Therapy. In Nurse’s Herbal Drug Handbook, Springhouse Corporation: Springhouse, PA. Goldschmid A., Jacknowitz, A.I., Menczel E., "The Formulary of a Large Health Maintenance Organization in Israel," American Journal of Health Systems Pharmacists, (2001), 58: 420-421. Prabhu S., Jacknowitz, A.I., Stout P.J., "A Study of Factors Controlling Dissolution Kinetics of Zinc Complexed Protein Suspensions in Various Ionic Species," Int. J. of Pharmaceutics,( 2001), 217:71-78. Ichikawa, T., Petros, W.P., Ludeman, S.M., Fangmeier, J., Hochberg, F.H., Colvin, O.M., Chiocca, E.A., "Intraneoplastic Polymer-based Delivery of Ccyclophosphamide for Intratumoral Bioconversion by a Replicating Oncolytic Viral Vector", Cancer Research , (2001), 61: 864-868. Petros, W.P., Colony-stimulating Factors. In: Chabner BA & Longo DA, eds. Cancer Chemotherapy and Biotherapy. Philadelphia: JB Lippincott, Third Edition, (2001), 829-849. Nath, C. and Ponte, C.D., "Managing Insulin Therapy- the Latest Practices for Overseeing Diabetic Patients Requiring Insulin," Nurs Manage , (2001), 32(4): 38-40. Ponte, C.D., "Taking the Hurt Out of Pain," Practical Pain Management , (2001), (July/August): 8-9 (Invited Editorial) Ridgway, C., "Teaching History of Pharmacy," J.Pharmacy Teaching, (2001), 8: 59-70. Ridgway, C., "Future of History of Pharmacy in the Professional Curricula", J. Pharmacy Teaching , (2001), 8: 83-85. Slain, D., Rogers, R.D., Chapman, S., Cleary, J., "Intravenous Hydroxypropyl-b-cyclodextrin Formulation of Itraconazole: Formulary Focus," Ann Pharmacothe.r, (2001), 35: 720-9. Slain, D, Rogers, R.D., Chapman, S., Cleary, J., Pharma CE® Continuing Education Questions. [ACPE Approved]. "Intravenous Hydroxypropyl-b-cyclodextrin Formulation of Itraconazole: Formulary Focus," Ann Pharmacothe.,r (2001), 35: 793-4. Sadler, B.M., Chittick, G.E., Polk, R.E., Slain, D,, Kerkering, T.M., Studenberg, S., Lou, Y., Moore, K.H.P., Wooley, J., Stein, D.S., "Metabolic Disposition and Pharmacokinetics of [14C]-Amprenavir, A Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitor, Administered in a Single, Oral Dose to Healthy Male Subjects," J Clin Pharmacol., ( 2001), 41: 386-96. Slain, D., The Professional’s Handbook of Complementary and Alternative Medicines, 2nd Edition, Fetrow CW, Avila JR, Editors. Wrote monographs on Boneset, Horehound, Slippery Elm, Lavender. Springhouse Publishing Corporation, Springhouse, PA; (2001), [4 Monographs]. Slain, D., "Intermittent Antimycobacterial Dosage Correction," [letter]. Clin Infect Dis., (2001), 32: 321. Stamatakis, M.K., "Strategies for Treatment and Prevention of Acute Renal Failure," Journal of Pharmacy Practice, In press. Stamatakis, M.K., "Gentamicin-induced acute renal failure", In Pharmacotherapy: A Patient Focused Approach Schwinghammer, T, Ed., Appleton and Lange, CT. In press. Stamatakis, M.K., "Hyperkalemia" and "Hyperphospatemia", In Pharmacotherapy: A Patient Focused Approach Schwinghammer, T, Ed., Appleton and Lange, CT. In press Smith, J.D., Terpening, C.M., Schmidt, S.O.F., and Gums, J.G., "Relief of Fibromyalgia Symptoms Following Discontinuation of Dietary Excitotoxins," Ann. Pharmacother., (2001), 35: 702-706. Terpening, C. M., "Mediators of Chronic Heart Failure: How Drugs Work," Ann. Pharmacothe.r, (2001), 35: 1066-1074.
Pharmaceutical Systems and Policy Amonkar M.M., Kalsekar I. and Boyer J., "The Economic Burden of Barrett’s Esophagus in a Medicaid Population," Ann Pharmacothe. In press. Amonkar M.M. and Madhavan S., "Compliance Rates and Predictors of Cancer Screening Recommendations Among Appalachian Women," J Health Care Poor U. In press. Amonkar M.M. and Mody R. "Developing Profiles of Postmenopausal Women Being Prescribed Estrogen Therapy," J Comm Health. In press.Hassan M. and Amonkar M.M., "Aspirin Use for Primary and Secondary Prophylaxis of Cardiovascular Disease." Curr Ther Res., (2001), 62: 676-690. Fernandes A., Amonkar M.M., Madhavan S. and Nseyo U.O., "Assessing Practice Preferences of Urologists in the Management of Benign Prostatic Hyperplasia in the Veterans Administration Program," Curr Ther Res,, (2001), 62: 129-141. Amonkar M.M., Scott V. and Madhavan S., "Can Distance Learning Fulfill Program Structure and Access Needs of Pharmacists for Post-B.S Professional Education?" J Pharm Teaching, (2001), 8: 29-48. Madhavan S.S., Rosenbluth S.A., Amonkar M.M., Fernandes A.W., Borker R. , "Immunization Predictors in Rural Adults Under 65 Years of Age," J Health Care Poor U. In press. Madhavan S., Rosenbluth S., Amonkar M.M., Borker R. and Richards T., "Pharmacists and Immunizations: A National Survey," J Am Pharm Assoc., (2001), 41: 32-45. Scott V., Amonkar M.M. and Madhavan S., "Pharmacists’ Preferences for Continuing Education and Certificate Programs," Ann Pharmacothe.r, (2001), 35: 289-299.
Published Abstracts Basic Pharmaceutical Sciences Department Gudi, G.S., Price, W.D., Rogers, F.A. and Callery, P.S., "Noncovalent Interactions of an Azetidine Analogue of a Polyamine with Oligonucleotides by Ion Trap Mass Spectrometry," Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, May, 2001Gudi, G.S., Price, W.D., and Callery, P.S., "Oligonucleotide Binding Affinities of the Naturally Occurring Polyamines by Ion Trap Mass Spectrometry," Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, May, 2001. Abate, M.A., Casdorph, D.L., Gannett, P., Madhavan, S.S., Scharman, E., Stamatakis, M., "Development and Implementation of a Comprehensive Programmatic Assessment Plan,"Am. J. Pharm. Educ., (2001, Winter Supplement), 65:115S-116S. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Ma, J.Y.C., and Ma, J.K.H., "Diesel Exhaust Particles (DEP) Affected Thiol Levels in Both Alveolar Macrophages and Lymph Node Cells," Society of Toxicology Annual Meeting, San Francisco, CA, March 2001; The Toxicologist, (2001), 60(1S):167. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C., Weissman, D.N., and Ma, J.K.H., "Effect of Diesel Exhaust Particles (DEP) on Pulmonary Allergic Sensitization in Brown Norway Rats," Toxicology, (2001) 164(1-3):119. Ma, J.Y.C., Rengasamy, A., Barger, M.W., Kane, E., Ma, J.K.H. and Castranova, V., "Alteration of Pulmonary Cytochrome P450 System by Diesel Exhaust Particles," Toxicology (2001) 164(1-3):119. Al-Humadi, N.H., Siegel, P.D., Lewis, D.M., Barger, M.W., Ma, J.Y.C.,Weissman, D.N., and Ma, J.K.H., "Role of Thiols in Pulmonary Immune Response to Allergic Sensitization: Adjuvant Effect of Diesel Exhaust Particulate (DEP)," Pharm. Sci. (Supplement), (2001), 3(3) T3449. Yang, X.D., Ma, J.Y.C., and Ma, J.K.H., "Transport and Utilization of Arginine-containing Peptides in Alveolar Aacrophages," Pharm. Sci. (Supplement), (2001), 3(3): T3524. Ma, J.Y.C., Hu, S., Barger, M.W., Zhao, H., and Ma, J.K.H., "Role of Microtubule in Regulating Cytokine Production by Alveolar Macrophages," Pharm. Sci., (Supplement), (2001), 3(3) T3603. Schwarz, D., Kisselev, P., Chernogolov, A., Ericksen, S., Szklarz, G., and Roots, I.. "Human Cytochrome P450 1A1 (CYP1A1) Variants: The Effect of the Natural Mutations on Electron Transfer and Catalysis," Symposium on Intra- and Intermolecular Electron Transfer, May 2001, Chemnitz, Germany. Ericksen, S. and Szklarz, G. "Modeling of Stereoselective Epoxidation of B[a]P-diols by P450 1A1," School of Medicine Research Day, April 6, 2001, Morgantown, West Virginia. Ericksen, S. and Szklarz, G. "Modeling of Stereoselective Epoxidation of B[a]P-diols by P450 1A1"34th Graduate Student Symposium in Medicinal Chemistry, June 28-30, 2001, Columbus, Ohio. Liu, J., Ericksen, S.S., Besspiata, D., Fisher, C.W. and Szklarz, G.D. "Role of Residue 382 in Determining Substrate Specificity of P450 1A1: Molecular Modeling and Site-directed Mutagenesis Studies," Abstracts from the 12th International Conference on Cytochrome P450: Biochemistry, Biophysics and Molecular Biology, September 11-15, 2001, La Grande Motte, France, p. 96. Clinical Pharmacy Department Abate, M.A., Casdorph, D.L., Gannett, P., Madhavan, S.S., Scharman, E., Stamatakis, M., "Development and Implementation of a Comprehensive Programmatic Assessment Plan,"Am. J. Pharm. Educ., (2001, Winter Supplement), 65:115S-116S. Remick, S., Robertson, K., Dowlati, A., Cooney, M., Jesberger, J., Lewin, J, Stambler, B., Taylor, A., Petros, W., Stratford, M., Young, S., Sherris. D., "A Phase I Pharmacokinetic (PK) Study of Single Dose Intravenous (IV) Combretastatin A4 phosphate (CA4P) in Patients (PTS) with Advanced Cancer: Final report," Proc AACR NCI-EORTC Intl Conf Molec Targets Cancer Ther, Clin Cancer Res (Suppl), (2001), 7 (abstract). Petros, W., Hopkins, P., Vredenburgh, J., Spruill, S., Broadwater, G., Marks, J., Hall, J., Colvin, M., "Predictive Approaches to Overall Survival Following High-dose Chemotherapy for Advanced Breast Cancer Utilizing Cyclophosphamide Pharmacokinetics and Pharmacogenetics," Pharmacotherapy, (2001), 21: 1287 (abstract). Reid, J.M., Cha, S., Buckner, J.C., Petros, W.P., Friedman, H.S., Tourt-Uhlig, S., Walker, A., Kuhn, J.G., Prados, M., Supko, J.G., Gilbert, M.R., Batchelor, T., Schaaf, L.J., Gaylor, S.K., McGovern, J.P., Gallo, J.M., "Pharamcokinetics of CPT-11 in Glioma Patients: Pooled Analysis of Data from 4 NCI-sponsored Trials (Duke University, NABTC, NABTT, NCCTG). Proc AACR NCI-EORTC Intl Conf Molec Targets Cancer Ther. Clin Cancer Res., (Suppl), (2001), 7 (abstract). Friedman, H.S,, Petros, W., Rich, J.N., Glantz, M.J., Sands, H., Tourt-Uhlig, S., Stewart, E.S., Gururangan, S., Sampson, J., Friedman, A.H., Colvin, M., Quinn, J.A., "Phase I Trial of Intrathecal Spartaject Busulfan for Patients with Neoplastic Meningitis," Proc Am Soc Clin Oncol., (2001), 20: 225a (abstract). Quinn, J.A., Dolan, M., Pegg, A.E., Moschel, R.C., Pluda, J., McLendon, R.E., Provenzale, J., Petros, W., Tourt-Uhlig, S., Rich, J.N., Gururangan, S., Affronti, M.L., Buchanan, W., Colvin, O., Stewart, E.S., Friedman, A.H., Bigner, D.D., Friedman, H.S., "Phase II trial of BCNU Plus 06-benzylguanine For Patients with Recurrent or Progressive Malignant Glioma," Proc Am Soc Clin Oncol., (2001), 20: 251a (abstract). Petros, W., Hopkins, P., Vredenburgh, J., Spruill, S., Broadwater, G., Colvin, M., Marks, J., Hall, J., "Associations Between Variants in Several Drug Metabolism Genes and Chemotherapy Pharmacokinetics or Clinical Response," Proc Am Assoc Cancer Res., (2001), 42:1435 (abstract). Johnson, M.D., Bohjanen, P.R., Wray, L., Szczech, L., Miller, C., Petros, W., Hicks, C.B. "Steady-state Pharmacokinetics of Lamivudine in HIV-infected Subjects Undergoing Hemodialysis," Proc 8th Conf Retroviruses & Opportunistic Infections, (2001), (abstract). Abate, M.A., Casdorph, D.L., Gannett, P., Madhavan, S.S., Scharman, E., Stamatakis, M., "Development and Implementation of a Comprehensive Programmatic Assessment Plan," Am. J. Pharm. Educ., (2001, Winter Supplement), 65:115S-116S. Amonkar, M.M., and Mody, R. "Prevalence and Predictors of Estrogen Use Among Postmenopausal Women," J Am Pharm Assoc., (2001), 41:311 (Abstract 102). Hassan, M. and Amonkar, M.M., "Aspirin Use for Primary and Secondary Prevention of Cardiovascular Disease: An Analysis of BRFSS Data," J Am Pharm Assoc., (2001), 41:318 (Abstract 128). Fernandes, A., Amonkar, M.M., Madhavan, S. and Nseyo, U.O., "Benign Prostatic Hyperplasia Management in the Veterans Administration Population: A National Survey of Urologists." J Am Pharm Assoc., (2001), 41:315 (Abstract 116). Kavookjian, J., Berger, B., Anderson-Harper, H., Barker, K., Grimley, D., Pearson, R., Villaume, W., "The Relationship Between Readiness for Diabetes Self-Care and Glycemic Control: The Development of a Diagnostic Tool for Pharmacist Intervention," Poster at the American Pharmaceutical Association Annual Meeting, San Francisco, CA, March, 2001, Abstract #138. Gao, X., Madhavan, S., Nau, D., Ambegaonkar, A., Islam, S., Rosenbluth, S. and Amonkar, M.M. "Applying Background Risk Distribution to Evaluate the Cost-Effectiveness of Three Preventive Drug Therapies for Osteoporotic Fractures," Value in Health, (2001), 4:70 (Abstract PAM11) Hassan, M., Joshi, A.V., Madhavan, S. and Amonkar, M.M. "Impact of Obesity on Health-Related Quality of Life (HRQOL): An Analysis of Behavioral Risk Factor Surveillance System (BRFSS) Data," Value in Health, (2001), 4:70 (Abstract PCV14). Borker, R., Madhavan, S. and Amonkar, M.M., "Assessing West Virginia Pharmacists’ Involvement in Immunizations," J Am Pharm Assoc., (2001), 41:312 (Abstract 107). Kamal, K., Madhavan, S. and Amonkar, M.M., "Determinants of Adult Influenza and Pneumonia Immunization Rates," J Am Pharm Assoc, (2001), 41:320 (Abstract 136). Rosenbluth, S.A., Kalsekar, I.D., and Ma, J.K., "Pharmacy Student Research Conference-Eastern states: A Study of Presenter’s Interests, Opinions, and Careers," AACP Annual meeting, Toronto Canada, July 2001. Kamal, K., Madhavan, S.S., Amonkar, M.M. , "Predictors of Influenza Immunization Rates in Adults Aged 50-64 Years and 65 Years and Above." NICAbstracts, National Immunization Conference, (2001), CDC Immunization,p. 17. (Abstract 217) Gao, X., Madhavan, S.S., "Cost-Effectiveness Analysis of Three Preventive Drug Therapies for Osteoporotic Fractures Among Postmenopausal Women," J Am Pharm Assoc., (2001), 41(2):316 (Abstract 120).
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