My major research interests focus on signal transduction involved in neurodegenerative and neuropsychiatric disorders. Specifically, I am interested in exploring the roles of cAMP/CREB signaling in the mediation of depression, anxiety, alcohol dependence, drug abuse, and memory loss associated with neurodegenerative disorders such as Alzheimer’s disease. Techniques include various animal models (e.g., radial arm-maze, water-maze, passive avoidance, and object recognition for memory; DRL schedule, forced-swim, and tail-suspension for depression; elevated-plus maze, holeboard, and light-dark transition for anxiety; alcohol drinking behavior, self-administration, and righting reflex for alcohol dependence), small animal surgery for brain microinfusions, enzyme assays, immunoblotting, immunohistochemistry, RNAi gene silencing (microRNAs), etc. Our goal is to elucidate the mechanisms whereby intracellular signaling mediates neurodegenerative and neuropsychiatric disorders, drug abuse and dependence.