Recent Publications | Center for Neuroscience | West Virginia University

James P. O'Callaghan, Ph.D.

Project Officer, Molecular Neurotoxicology Laboratory;
CDC Distinguished Consultant

Graduate Training:

Emory University

Fellowship:

NIDA-NIH, NY State Office of Drug Abuse Services

Pharmacology Research Associate (PRAT Fellow), NIGMS, NIH

Contact Information:

CDC-NIOSH
1095 Willowdale Road
Morgantown, WV 26505

304-285-6079

304-285-6220

jdo5@cdc.gov

Recent Publications

[2013]

Jones BC, Miller DB, O'Callaghan JP, Lu L, Unger EL, Alam G, Williams RW. Systems analysis of genetic variation in MPTP neurotoxicity in mice. Neurotoxicology (2013 Apr) 37C: 26-34. [Epub ahead of print]

Miller DB, O'Callaghan JP. Personalized medicine in major depressive disorder - oppertunities and pitfalls. Metabolism (2013 Jan) 62 Suppl 1: S34-9.

[2012]

Ross GW, Duda JE, Abbott RD, Pellizzari E, Petrovitch H, Miller DB, O'Callaghan JP, Tanner CM, Noorigian JV, Masaki K, Launer L, White LR. Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study. Mov Disord (2012 Sep) 27(11): 1418-24.

Kelly KA, Miller DB, Bowyer JF, O'Callaghan JP. Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine. J Neurochem (2012 Sep) 122(5): 995-1009.

Little AR, Miller DB, Li S, Kashon ML, O'Callaghan JP. Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis. Neurotoxicol Teratol (2012 Jan-Feb) 34(1): 72-82.

[2011]

[2010]

O'Callaghan JP, Miller DB. Spinal gila and chronic pain. Metabolism. 2010 Oct; 59 Suppl 1:S21-6. Review.
Peng Y, Zhang Q, Snyder GL, Zhu H, Yao W, Tomesch J, Paple RL, O'Callaghan JP, Welsh WJ, Wennogle LP. Discovery of novel alpha7 nictonic receptor antagonists. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4825-30.
Dinapoli VA, Benkovic SA, Li X, Kelly KA, Miller DB, Rosen CL, Huber JD, O'Callaghan JP. Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat. Neuroscience (2010).
Zhu H, O'Brien JJ, O'Callaghan JP, Miller DB, Zhang Q, Rana M, Tsui T, Peng Y, Tomesch J, Hendrick JP, Wennogle LP, Snyder GL. Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brain. Brain Res (2010),1342:11-23.
Magiatis P, Polychronopoulos P, Skaltsounis AL, Lozach O, Meijer L, Miller DB, O'Callaghan JP. Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis. Neurotoxicol Teratol (2010), 32(2):212-9.

[2009]

[2008]

Antonini JM, O'Callaghan JP, Miller DB. Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation. Neurotoxicology (2006), 27(5):745-751.

El-Fawal HA, O'Callaghan JP. Autoantibodies to neurotypic and gliotypic proteins as biomarkers of neurotoxicity: assessment of trimethyltin (TMT). Neurotoxicology (2008), 29(1):109-115.

Fox DA, Kala SV, Hamilton WR, Johnson JE, O'Callaghan JP. Low-level human equivalent gestational lead exposure produces supernormal scotopic electroretinograms, increased retinal neurogenesis, and decreased retinal dopamine utilization in rats. Environmental Health Perspectives (2008), 116(5):618-25.

Scharf MT, Mackiewicz M, Naidoo N, O'Callaghan JP, Pack AI. AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation. Journal of Neurochemistry (2008), 105(3):833-841.

Zin CS, Nissen LM, Smith MT, O'Callaghan JP, Moore BJ. An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy. CNS Drugs (2008), 22(5):417-442.

Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O'Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, Bibb JA. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc Natl Acad Sci U S A (2008), 105(47):18561-6.

O'Callaghan JP, Sriram K, Miller DB. Defining "neuroinflammation". Ann N Y Acad Sci (2008), 1139:318-30.

Nishi A, Kuroiwa M, Miller DB, O'Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N, Greengard P, Snyder GL. Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci (2008), 28(42):10460-71.

Miller DB, O'Callaghan JP. Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases? Metabolism (2008), 57 Suppl 2:S44-9. Review.

[2007]

Berman JW, Carson MJ, Chang L, Cox BM, Fox HS, Gonzalez RG, Hanson GR, Hauser KF, Ho W, Hong J, Major E, Maragos WF, Masliah E, McArthur JC, Miller DB, Nath A, O'Callaghan JP, Persidsky Y, Power C, Rogers TJ, Royal W. NeuroAIDS, drug abuse, and inflammation: building collaborative research activities. Journal of Neuroimmune Pharmacology (2006), 1(4):351-399.

Bowyer JF, Pogge AR, Delongchamp RR, O'Callaghan JP, Patel KM, Vrana KE, Freeman WM. A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes. Neuroscience (2007), 144(1):66-76.

Damiani CL, O'Callaghan JP. Recapitulation of cell signaling events associated with astrogliosis using the brain slice preparation. Journal of Neurochemistry (2007), 100(3):720-726.

Hubbs AF, Benkovic SA, Miller DB, O'Callaghan JP, Battelli L, Schwegler-Berry D, Ma Q.Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. American Journal of Pathology (2007), 170(6):2068-2076.

Schulte PA, Wagner GR, Ostry A, Blanciforti LA, Cutlip RG, Krajnak KM, Luster M, Munson AE, O'Callaghan JP, Parks CG, Simeonova PP, Miller DB.Work, obesity, and occupational safety and health. American Journal of Public Health (2007), 97(3):428-436.

Sriram K, O'Callaghan JP. Divergent roles for tumor necrosis factor-α in the brain. Journal of Neuroimmune Pharmacology (2007), 2(2):140-153.