Recent Publications | Center for Neuroscience | West Virginia University

Faculty & Lab Personnel

James M. O'Donnell, Ph.D.

Assistant Dean for Research; Professor

Graduate Training:

University of Chicago

Fellowship:

University of Pennsylvania
Departments of Behavioral Medicine & Psychiatry
Neurobiology & Anatomy

Contact Information:

One Medical Center Drive
PO Box 9104
Morgantown, WV 26506-9104

304-293-2433

304-293-7038

jodonnell@hsc.wvu.edu

ODonnell

Home > Faculty & Lab Personnel > ODonnell > Recent Publications

Recent Publications

[2013]

Xu Y, Zhang L, Shao T, Ruan L, Wang L, Sun J, Li J, Zhu X, O'Donnell JM, Pan J. Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metab Brain Dis (2013 Apr 14). Epub ahead of print.

[2012]

Xu Y, Barish PA, Pan J, Ogle WO, O'Donnell JM. Animal models of depression and neuroplasticity: assessing drug action in relation to behavior and neurogenesis. Methods Mol Biol. (2012) 829:103-24. Review. PubMed PMID: 22231809.

Yu Y, Wang R, Chen C, Du X, Ruan L, Sun J, Li J, Zhang L, O'Donnell JM, Pan J, Xu Y. Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences. J Psychiatr Res (2012 Nov 19). doi: pii: S0022-3956(12)00339-1. 10.1016/jpsychires.2012.10.018. [Epub ahead of print]

O'Donnell JM, Xu Y. Evidence for global reduction in brain cyclic adenosine monophosphate signaling in depression. Biol Psychiatry (2012 Oct 1). 72(7): 524-6. doi: 10.1016/jbiopsych.2012.07.017.

Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O'Donnell JM, Zhang HT, Li YF. RNA interference-mediated phosphodiesterase-4D splice variants knockdown in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. Br J Pharmacol (2012 Sep 25). doi: 10.1111/j.1476-5381.2012.02225.x. [Epub ahead of print]

Xu Y, Pan J, Chen L, Zhang C, Sun J, Li J, Nguyen L, Nair N, Zhang H, O'Donnell JM. Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway. Int J Neuropsychopharmacol (2012 Jul) 31:1-13.

Xu Y, Barish PA, Pan J, Ogle WO, O'Donnell JM. Animal models of depression and neuroplasticity: assessing drug action in relation to behavior and neurogenesis. Methods Mol Biol (2012) 829:103-24. doi: 10.1007/978-1-61779-458-2_6.

[2011]

Xu Y, Zhang HT, O'Donnell JM. Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders. Handb Exp Pharmacol. (2011) (204):447-85. Review. PubMed PMID: 21695652.
Xu Y, Li S, Vernon MM, Pan J, Chen L, Barish PA, Zhang Y, Acharya AP, Yu J, Govindarajan SS, Boykin E, Pan X, O'Donnell JM, Ogle WO. Curcumin prevents corticosterone-induced neurotoxicity and abnormalities of neuroplasticity via 5-HT receptor pathway. J Neurochem. (2011 Sep) 118(5):784-95. doi:10.1111/j.1471-4159.2011.07356.x. Epub 2011 Jul 18. PubMed PMID: 21689105.
Xiao L, O'Callaghan JP, O'Donnell JM. Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test. J Pharmacol Exp Ther. (2011 Aug) 338(2):641-7. Epub 2011 May 12. PubMed PMID: 21566211; PubMed Central PMCID: PMC3141907.
Isingrini E, Surget A, Belzung C, Freslon JL, Frisbee J, O'Donnell JM, Camus V, d'Audiffret A. Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh. Physiol Behav. (2011 Jul 6) 103(5):540-6. Epub 2011 Apr 12. PubMed PMID: 21504753.
Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO. Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. Neuroscience. (2011 May 19) 182:71-81. Epub 2011 Feb 28. PubMed PMID: 21371532.
Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT. Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci. 2011 Jan 5;31(1):172-83. PubMed PMID: 21209202; PubMed Central PMCID:PMC3079568.
Xu Y, Barish PA, Pan J, Ogle WO, O'Donnell JM. Animal models of depressionand neuroplasticity: assessing drug action in relation to behavior and neurogenesis. Methods Mol Biol. 2012;829:103-24. Review. PubMed PMID: 22231809.
Xu Y, Zhang HT, O'Donnell JM. Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders. Handb Exp Pharmacol. (2011) (204):447-85. Review. PubMed PMID: 21695652.
Xu Y, Li S, Vernon MM, Pan J, Chen L, Barish PA, Zhang Y, Acharya AP, Yu J, Govindarajan SS, Boykin E, Pan X, O'Donnell JM, Ogle WO. Curcumin prevents corticosterone-induced neurotoxicity and abnormalities of neuroplasticity via 5-HT receptor pathway. J Neurochem. (2011 Sep) 118(5):784-95. doi:10.1111/j.1471-4159.2011.07356.x. Epub 2011 Jul 18. PubMed PMID: 21689105.
Xiao L, O'Callaghan JP, O'Donnell JM. Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test. J Pharmacol Exp Ther. (2011 Aug) 338(2):641-7. Epub 2011 May 12. PubMed PMID: 21566211; PubMed Central PMCID: PMC3141907.
Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO. Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. Neuroscience. (2011 May 19) 182:71-81. Epub 2011 Feb 28. PubMed PMID: 21371532.
Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT. Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci. (2011 Jan 5) 31(1):172-83. PubMed PMID: 21209202. PubMed Central PMCID: PMC3079568.

[2010]

O'Donnell JM, Shelton RC. Drug Therapy of Depression and Anxiety Disorders. Goodman and Gilman's The Pharmacological Basis of Therapeutics, Chapter 15; ed. L. Brunton, J. Lazo, and K. Parker, McGraw Hill, New York, 2010; pp. 397-415.

[2009]

Masood, A., Huang, Y., Hajjhussein, H., Xiao, L., Li, H., Wang, W., Hamza, A., Zhan, C.G., and O’Donnell, J.M.: Anxiolytic effects of phosphodiesterase-2 inhibitors associated with increased cGMP signaling. J. Pharmacol. Exp. 331:690-699, 2009.
Borysiewicz E, Fil D, Dlaboga D, O'Donnell JM, Konat GW. Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes. Metab Brain Dis (2009), 24(3):481-91.

Li, Y.F., Huang, Y., Amsdell, S.L., Xiao, L., O’Donnell, J.M., and Zhang, H.T.: Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior dependent on cyclic AMP-response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology 34:2404-2419, 2009.
Cashman, J.R., Voelker, T., Zhang, H.T., and O’Donnell, J.M.: Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J. Med. Chem. 52:1530-1539, 2009.
Zhao, Z., Zhang, H.T., Bootzin, E., Millan, M.J., and O’Donnell, J.M.: Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology 34:1467-1481, 2009.
Zhang, H.T., Stolinski, L.R., Huang, Y., Xiang, Y., and O’Donnell, J.M.: Presynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology 34:1067-1077, 2009.

[2008]

Zhao, Z., Baros, A.M., Zhang, H.T., Lapiz, M.D.S., Bondi, C.O., Morilak, D.A., and O’Donnell, J.M.: Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology 33:3190-3200, 2008.
Masood, A., Nadeem, A., Mustafa, S.J., and O’Donnell, J.M.: Reversal of oxidative-stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. J. Pharmacol. Exp. Ther. 326:369-379, 2008.
Zhang, H.T., Huang, Y., Masood, A., Stolinski, A., Li, Y., Zhang, L., Dlaboga, D., Jin, C., Conti, M., and O’Donnell, J.M.: Anxiogenic-like behavioral profile of mice deficient in phosphodiesterase 4B. Neuropsychopharmacology 33:1611-1623, 2008.
Dlaboga, D., Hajjhussein, H., and O’Donnell, J.M.: Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat neostriatum: Implications for therapeutics and extrapyramidal side effects. Neuropharmacology 54:745-754, 2008.