[2013]

[2012]

• Seminerio MJ, Hansen R, Kaushal N, Zhang HT, McCurdy CR, Matsumoto RR. The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice. Int J Neuropsychopharmacol, 2012 Aug 29L 1-12.

• Wen RT, Zhang M, Qin WJ, Liu Q, Wang WP, Lawrence AJ, Zhang HT*, Liang JH*. The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-preferring Fawn-Hooded Rats. Alcohol Clin Exp Res. (2012 Dec) 36(12): 2157-67. (*Co-corresponding author)

• Wang C, Yang XM, Zhuo YY, Zhou H, Ling HB, Cheng YF, Xu JP, Zhang HT. The phosphodiesterase-4 inhibitor rolipram reverses AB-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. Int J Neuropsychopharm. (2012), 15:749-766.

• Zhang HT, Xu Y, O'Donnell JM. Inhibition of cyclic nucleotide phosphodiesterases to regulate memory. In: Brandon N and West AR, eds. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. John Wiley & Sons, Hoboken, NJ, USA, 2012, in press

[2011]

• Hu W, Lu T, Chen A, Huang Y, Hansen R, Chandler LJ, Zhang HT. Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology (Berl) (2011), 218:331-339.  

• Li LX, Cheng YF, Lin HB, Wang C, Xu JP, Zhang HT. Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. Metab Brain Dis. (2011) 26:37-47.

• Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT. Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling. J Neurosci. (2011), 13(1):172-83.

• Xu Y, Zhang HT, O'Donnell JM. Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders. Handb Exp Pharmacol. (2011), 204:447-85.

• Xu Y*, Zhang HT*, O'Donnell JM. Role of Cyclic Nucleotide Phosphodiesterases in Depression and Antidepressant Activity. In: Lopez-Munoz F, Alamo C, eds. Neurobiology of Depression. Taylor & Francis Group, London, UK, 2011, p419-444. (*equally contributed)

[2010]

• Cheng YF, Wang C, Lin HB, Li YF, Huang Y, Xu JP, Zhang HT. Inhibition of phosphodiesterase-4 reverses memory deficits produced by Abeta25-35 or Abeta1-40 peptide in rats. Psychopharmacology (Berl) (2010): 212(2): 181-91

• Zhang HT. Phosphodiesterase Targets for Cognitive Dysfunction and Schizophrenia--a New York Academy of Sciences Meeting. IDrugs (2010), 13(3):166-8.

• Zhuo YY, Zhang HT, Xu JP. Oxidative stress and Alzheimer's disease. Chin Pharmacol Bull (2010), 26: 435-437.

[2009]

• Li YF, Huang Y, Amsdell SL, Xiao L, O’Donnell JM, Zhang HT. Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 (PDE4) inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the hippocampus. Neuropsychopharmacology (2009): 34(11): 2404-19

• Zhang HT. Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs. Current Pharmaceutical Design, 2009, 15(14):1688-98.

• Lin HB, Yang XM, Li TJ, Cheng YF, Zhang HT, Xu JP. Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer’s disease. Psychopharmacology 2009, 204(4):705-14

• Cashman JR, Voelker T, Zhang HT, O’Donnell JM. Dual Inhibitors of Phosphodiesterase-4 and Serotonin Reuptake. J Med Chem, 2009, 52:1530-1539

• Zhao ZR, Zhang HT, Bootzin E, Millan MJ, O’Donnell JM. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology, 2009, 34:1467-1481

• Zhang HT, Whisler LR, Huang Y, Xiang Yang, O'Donnell JM. Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology, 2009, 34:1067-1077

[2008]

• Zhang HT, Huang Y, Masood A, Stolinski LR, Li Y, Zhang L, Dlaboga D, Jin SL, Conti M, O'Donnell JM. Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B). Neuropsychopharmacology (2008), 33(7):1611-1623.

• Zhao ZR, Baros AM, Zhang HT, Lapiz DS, Bondi CO, Morilak DA, O’Donnell JM. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology, 2008, 33:3190-3200

• Konat GW, Kraszpulski M, James I, Zhang HT, Abraham J. Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats. Metab Brain Dis. 2008, 23:325-333.

• Liu X, Cheng YF, Zhang HT, Xu JP. "Effects of rolipram on learning and memory and activity of PDE4 in hippocampus following the focal brain injury induced by ischemia-reperfusion in rats." Chin J Pathophysiol. 2008, 24:1096-1100

• Zhang HT, O'Donnell JM. Phosphodiesterase-4 as a pharmacological target mediating antidepressant and cognitive effects on behavior. In Beavo JA, Francis SH, Houslay MD, eds. Phosphodiesterases in Health and Disease. CRC Press, London, UK (2007), 539-558.

[2006]

• Cheng Y, Zhang HT, Sun L, Guo S, Ouyang S, Zhang Y, Xu J. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain Research (2006) 1110:193-200.
   
• Zhang HT. Behavioral Methods of Learning and Memory. 695-717; Zhang HT. Behavioral Methods of Open Field and Locomotor Activity. 719-720;Zhang HT.Experimental Methods of Anxiety. 952-971; Zhang HT. Experimental Methods of Depression. 972-984. In: Wu JF, Liu M, Wang GY, Zhang HT, Li SM, Wang Y, eds. Modern Neuroscience Methods, The Publisher of Peking Union Medical University, Beijing, China (2006).
   
• Zhang HT, Zhao Y, Huang Y, Deng C, Hopper AT, De Vivo M, Rose GM, O'Donnell JM. Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats.  Psychopharmacology (2006) 186:209-217.