James W Simpkins, PhD - Group Leader

Our lab studies the causes and potential treatment for Alzheimer’s disease (AD) and stroke in animal models and in human subjects. We are trying to understand the cause of brain damage from AD stroke and to develop treatments based on our understanding of causes. We use rats to induce stroke damage and a variety of techniques, including molecular biology, behavioral assessment and drug interventions to determine the causes and potential treatment for stroke damage. Our work also involves the use of transgenic mouse models, primarily for modeling AD. West Virginia has one of the highest incidences of stroke in the nation and currently therapies to limit stoke damage are limited. Our lab therefore is searching for novel treatments that can limit the damage and/or improve recovery from stroke.

Dana Foundation Blog: Dr. Simpkins on Stroke - http://danablog.org/2014/05/29/james-simpkins-on-stroke/