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Benoit Driesschaert, Ph.D.

  

   Dr. Driesschaert holds a Ph.D. from the Université catholique de Louvain (UCL) Belgium. His Ph.D. focused on the development of EPR spin labels (with Pr. Bernard Gallez and Pr. Jacqueline Marchand-Brynaert). In 2014, he moved to the Ohio State University, USA, to expand his knowledge in EPR spectroscopy (with Pr. Jay Zweier and Pr. Valery Khramtsov). Recently, Dr. Driesschaert  has been awarded a NIH K99/R00 pathway to independence grant from the NIBIB (2017/2022) to launch his own research programs. He is now leader of the synthetic development of the EPR/NMR probes of the IMMR center and Research Assistant Professor at the Department of Pharmaceutical Sciences.

The sphere of interest:

   Benoit has an extensive experience in the development of stable triarylmethyl (trityl, TAM) radicals used to measure important parameters of the tumor microenvironment such as oxygen, pH, inorganic phosphate or enzyme activity by magnetic resonance imaging and spectroscopy. He is using organic chemistry, organic electrosynthesis, flow chemistry and photocatalysis. He is also interested in the development of new technique of in vivo spin trapping. 

Selected publications:

  • Sanzhaeva U, Xu X, Guggilapu P, Tseytlin M, Khramtsov VV, Driesschaert B. Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase, Angew. Chem. Int. Ed. 2018, 57, 11701-11705.

          Check out the video abstract : https://vimeo.com/292981331?ref=tw-share

  • Khramtsov VV, Bobko AA, Tseytlin M, Driesschaert B. Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment. Anal. Chem. 2017;89(9):4758-4771. Featured the journal cover picture

 

  • Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, Tchekneva EE, Dikov MM, Khramtsov VV. Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression. Sci. Rep. 2017;7:41233.

 

  • Driesschaert B, Marchand, V, Levêque, P, Gallez, B, Marchand-Brynaert, J., A phosphonated triarylmethyl radical as a probe for measurement of pH by EPR,  Chem. Commun. 2012, 48(34), 4049. Featured the journal cover picture

 

  • Driesschaert B, Robiette R, Lucaccioni F, Gallez B, Marchand-Brynaert J, Chiral properties of tetrathiatriarylmethyl spin probes, Chem. Commun. 2011, 47(16), 4793.