Murugesan Velayutham, Ph.D.

Dr. Velayutham is a classically-trained electron paramagnetic resonance (EPR) spectroscopist with an extensive experience in application of EPR spectroscopy, imaging, and EPR spin trapping technology in the field of free radical biology and medicine.

The sphere of interest:

Dr. Velayutham research interest has been focusing on understanding the role of free radicals, reactive oxygen species, and NO in cardiovascular biology/diseases. He also applies EPR spectroscopy and imaging techniques and various biophysical modalities to measure and map redox status in in vitro and in vivo biological systems. His research interests also include the development of chemo-preventive drugs/biomolecules and understanding the mechanisms of these drugs/biomolecules in the application to cardiovascular diseases, organ transplantation and cancer. 

Selected publications:

Zhu, Y; Matsumura, Y; Velayutham, M; Foley, LM.; Hitchens, TK; Wagner, WR. 2018, Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection, Biomaterials 177: 98-112.

M. Velayutham, A. J. Cardounel, Z. Liu, and G. Ilangovan, 2018, Discovering a reliable heat shock factor-1 inhibitor to treat human cancers: Potential opportunity for phytochemists, Frontiers in Oncology, 2018, 8, 97

J. Dziki, M. Velayutham, G. Hussey, and H. Turnquist, 2018, Cytokine networks in immune-mediated muscle regeneration, Journal of Immunology and Regenerative Medicine, 2018, 1, 32-44

M. Velayutham, C. Hemann, A. J. Cardounel, and J. L. Zweier, 2016, Sulfite oxidase activity of cytochrome c: role of hydrogen peroxide, Biochemistry and Biophysics Reports, 2016, 5, 96-104

M. Velayutham and J. L. Zweier. 2013, Cardiac ischemia and reperfusion. In F. A. Villamena (editor), Molecular mechanisms of oxidative stress, John Wiley press, 311-327.

M. Velayutham, L. J. Druhan, and A. J. Cardounel. 2013, Arginine, tetrahydrobiopterin, and nitric oxide in myocardial protection. In N. Maulik (editor), Cardiovascular diseases: Nutritional and therapeutic interventions, CRC press, 101-122.