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Publications 2016 -present


  1. Eubank TD, Bobko AA, Hoblitzell EH, Gencheva M, Driesschaert B, Khramtsov VV, 2023, In Vivo Electron Paramagnetic Resonance Molecular Profiling of Tumor Microenvironment upon Tumor Progression to Malignancy in Animal Model of Breast Cancer, Mol. Imaging Biol. DOI: 10.1007/s11307-023-01847-0.
  2. Velayutham M, Poncelet M, Perini JA, Kupec JT, Dietz MJ, Driesschaert B, Khramtsov VV. 2023, EPR Viscometric Measurements Using a 13C‑Labeled Triarylmethyl Radical in Protein‑Based Biotherapeutics and Human Synovial Fluids, Appl. Magn. Reson. 54:779–791.  
  3. Gluth TD, Poncelet M, Gencheva M, Hoblitzell EH, Khramtsov VV, Eubank TD and Driesschaert B. 2023, Biocompatible Monophosphonated Trityl Spin Probe, HOPE71, for In Vivo Measurement of pO2, pH, and [Pi] by Electron Paramagnetic Resonance Spectroscopy, Chem., 95 (2), 946-954.
  4. Moore W, Huffman JL, Driesschaert B, Eaton SS, Eaton GR. 2022, Impact of chlorine substitution on electron spin relaxation of a trityl radical, Appl. Magn. Reson53(3-5), 797-808
  5. Gluth TD, Poncelet M, DeVience S, Gencheva M, Hoblitzell EH, Khramtsov VV, Eubank TD and Driesschaert B. 2021, Large-scale synthesis of a monophosphonated tetrathiatriarylmethyl spin probe for concurrent in vivo measurement of pO2, pH and inorganic phosphate by EPR, RSC Adv., 11, 25951 –25954.
  6. Khramtsov VV. 2021, Spin Probes and Imaging Using Nitroxides, In: Nitroxides: Synthesis, Properties and Applications, Edited by O. Ouari, D. Gigmes, The Royal Society of Chemistry, London, UK, p.p. 147-186.
  7. Tseytlin M. 2021, Continuous-wave rapid scan EPR, in:  Electron Paramagnetic Resonance: Volume 27, The Royal Society of Chemistry, pp. 188-213.
  8. Velayutham M, Poncelet M, Eubank TD, Driesschaert B and Khramtsov VV. Biological Applications of Electron Paramagnetic Resonance Viscometry Using a 13C-Labeled Trityl Spin Probe. Molecules 2021, 26(9), 2781
  9. Tseytlin O, O'Connel R, Sivashankar V, Bobko AA, and Tseytlin M. 2021, Rapid Scan EPR Oxygen Imaging in Photoactivated Resin Used for Stereolithographic 3D Printing, 3D Printing and Additive Manufacturing, 8, Issue 6.
  10. Mihalik NE, Wen S, Driesschaert B, Eubank TD. 2021, Formulation and in vitro characterization of PLGA/PLGA-PEG nanoparticles loaded with murine granulocyte-macrophage colony-stimulating factor, AAPS PharSciTech, 22(5): 191.
  11. Huffman JL, Poncelet M, Moore W, Eaton SS, Eaton GR, Driesschaert B. 2021, Perchlorinated triarylmethyl radical 99% enriched 13C at the central carbon as EPR spin probe highly sensitive to molecular tumbling, J Phys Chem, 125, 27, 7380-7387. 
  12. Hasanbasri Z, Singewald K, Gluth TD, Driesschaert B, Saxena S. 2021, Cleavage-resistant protein labeling with hydrophilic trityl enables distance measurements in cell. J Phys Chem B, 125(20), 5265-5274.
  13. Tseytlin M. 2020, General solution for rapid scan EPR deconvolution problem, J Magn Reson, 318, 106801
  14. Tseytlin O, Bobko AA, Tseytlin M. 2020 Rapid Scan EPR Imaging as a Tool for Magnetic Field Mapping, Applied Magnetic Resonance, 51, 1117-1124.
  15. Steinberger KJ, Forget MA, Bobko AA, Mihalik NE, Gencheva M, Roda JM, Cole SL, Mo X, Hoblitzell EH, Evans R, Gross AC, Moldovan L, Marsh CB, Khramtsov VV, Eubank TD. 2020, Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer, J. Immunol.; 205:2301-2311.
  16. Dzikovski B, Khramtsov VV, Chandrasekaran S, Dunnam C, Shah M, Freed JH. 2020, Microsecond Exchange Processes Studied by Two-Dimensional ESR at 95 GHz, JACS, 142, 21368−21381.
  17. Poncelet M, Driesschaert B. A 13C-Labeled Triarylmethyl Radical as an EPR Spin Probe Highly Sensitive to Molecular Tumbling. Angew. Chem. Intern. Edit. 2020, doi: 10.1002/anie.202006591.
  18. Taguchi A, DeVience S, Driesschaert B, Khramtsov VV, Hirata H. 2020, In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance, Analyst, 145 (9), 3236-3244.
  19. Sanzhaeva U, Poncelet M, Tseytlin O, Tseytlin M, Eubank TD, Khramtsov VV, Driesschaert B. 2020, Synthesis, characterization and application of a highly hydrophilic triarylmethyl radical for biomedical EPR, J. Org. Chem. https://doi.org/10.1021/acs.joc.0c00557.
  20. Poncelet M, Huffman, JL, Khramtsov VV, Dhimitruka I, Driesschaert B. 2019, Synthesis of hydroxyethyl tetrathiatriarylmethyl radicals OX063 and OX071, RSC Adv., 9, 35073-35076.
  21. Poncelet M, Driesschaert B, Tseytlin O, Tseytlin M, Eubank TD, Khramtsov VV. 2019, Dextran-conjugated triarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging, Med.Chem.Lett. 29, 1756-1760.
  22. Gorodetskii AA, Eubank TD, Driesschaert B, Poncelet M, Ellise E, Khramtsov VV, Bobko AA. 2019, Multiparametric Overhauser-enhanced magnetic resonance imaging: visualization of interstitial oxygenation, acidosis and inorganic phosphate concentration, Sci Rep. 9 (1), 12093.
  23. Tseytlin O, Guggilapu P, Bobko AA, AlAhmad H, Xu X, Epel B, O’Connell R, Hoblitzell EH, Eubank TD, Khramtsov VV, Driesschaert B, Kazkaz E, Tseytlin M. 2019. Modular Imaging System: Rapid Scan EPR at 800 MHz, Magn. Reson. 305, 94-103.
  24. Sato-Akaba H, Tseytlin M. 2019. Development of an L-band rapid scan EPR digital console, J. Magn. Reson. 304, 42-52.
  25. Gorodetskii AA, Eubank TD, Driesschaert B, Poncelet M, Ellis E, Khramtsov VV, Bobko AA. 2018. Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: application for oximetry in tumors, J. Magn. Reson., 297, 42-50.
  26. Sanzhaeva U, Xu X, Guggilapu P, Tseytlin M, Khramtsov V, Driesschaert B. 2018. Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase, Angew. Chem. Intern. Edit. 57, 11701-11705. https://vimeo.com/292981331?ref=tw-share
  27. Scheinok S, Leveque P, Sonveaux P, Driesschaert B, Gallez B, 2018, Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells. Free Radic. Res. 52, 1182-1196.
  28. Komarov DA, Ichikawa Y, Yamamoto K, Stewart NJ, Matsumoto S, Yasui H, Kirilyuk IA, Khramtsov VV, Inanami O, Hirata H. 2018, In vivo extracellular pH mapping of tumors using electron paramagnetic resonance. Anal Chem. 90, 13938-13945.
  29. Khramtsov VV. 2018, In vivo molecular EPR-based spectroscopy and imaging of tumor microenvironment and redox using functional paramagnetic probes, Antiox. Redox Signal. 28 (15), 1365-1377.
  30. Kishimoto S, Cherukuri MK, Khramtsov VV, Utsumi H, Lurie DJ. 2018, In vivo Application of Proton Electron Double Resonance Imaging. Antiox. Redox Signal. 28 (15), 1345-1364.
  31. Khramtsov VV. 2018, In Vivo EPR: Radical Concepts for Translation to the Clinical Setting, Antiox. Redox Signal. 28 (15), 1341-1344.
  32. Bobko AA, Eubank TD, Driesschaert B, and Khramtsov VV. 2018, In Vivo EPR Assessment of pH, pO2, Redox Status and Concentrations of Phosphate and Glutathione in Tumor Microenvironment, J. Vis. Exp. (133), e56624, https://www.jove.com/video/56624.
  33. Khramtsov VV., Davies MJ. 2018. Special issue for the International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR-2017), Free Radical Res. 52 (3), 305-306.
  34. Poncelet M, Driesschaert B, Bobko AA & Khramtsov VV. 2018 Triarylmethyl-based biradical as a superoxide probe, Free Radical Research, 52 (3), 373-379.
  35. Tseytlin M, Stolin AV, Guggilapu P, Bobko AA, Khramtsov VV, Tseytlin O, Raylman RR. 2018. A combined positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) system: initial evaluation of a prototype scanner, Phys. Med. Biol. 63 (2018) 105010 (7pp).
  36. Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, Tchekneva EE, Dikov MM and Khramtsov VV. 2017, Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression, Sci. Rep., 7, 41233; doi: 10.1038/srep41233 (2017). www.nature.com/articles/srep41233.
  37. Driesschaert B, Bobko AA, Khramtsov VV, Zweier. JL, 2017. Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe, Cell Biochem. Biophys., 75: 241-246.
  38. Bobko AA, Evans J, Denko NC, and Khramtsov VV. 2017, Concurrent Longitudinal EPR Monitoring of Tissue Oxygenation, Acidosis, and Reducing Capacity in Mouse Xenograft Tumor Models, Cell Biochem. Biophys. 75, 247-253.
  39. Khramtsov VV, Bobko AA, Tseytlin M, and Driesschaert B. 2017, Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment, Analyt. Chem. 89 (9), 4758–4771.
  40. Kubota H, Komarov DA, Yasui H, Matsumoto S, Inanami O, Kirilyuk IA, Khramtsov VV and Hirata H. 2017, Feasibility of in vivo three‑dimensional T2* mapping using dicarboxy‑PROXYL and CW‑EPR‑based single‑point imaging, Magn Reson Mater Phys, 30:291–298.
  41. Tseytlin, M. 2017. Concept of phase cycling in pulsed magnetic resonance using sinusoidal magnetic field modulation, Z. Phys. Chem. 231, 689-703.
  42. Epel B, Sundramoorthy SV, Krzykawska-Serda M, Maggio MC, Tseytlin M, Eaton GR, Eaton SS, Rosen GM, Kao JPY, Halpern HJ. 2017, Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance, J. Magn. Res. 276, 31-36.
  43. Möser J., Lips K, Tseytlin M, Eaton GR, Eaton SS, Schnegg A. 2017. Using rapid-scan EPR to improve the detection limit of quantitative EPR by more than one order of magnitude, J. Magn. Res. 281, 17-25.
  44. Tseytlin, M. 2017. Full cycle rapid scan EPR deconvolution algorithm, J. Magn. Res. 281, 272-278.
  45. Tseytlin M, Epel B, Sundramoorthy S, Tipikin D, Halpern HJ. 2016, Decoupling of excitation and receive coils in pulsed magnetic resonance using sinusoidal magnetic field modulation, J. Magn. Res. 272, 91-99.
  46. Biller JR, Mitchell DG, Tseytlin M, Elajaili H, Rinard G A, Quine RW, Eaton SS, Eaton GR. 2016. Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo. J. Vis. Exp. 115, e54068. https://www.jove.com/video/54068.
  47. Gorodetsky AA, Kirilyuk IA, Khramtsov VV and Komarov DA. 2016, Functional electron paramagnetic resonance imaging of ischemic rat heart: Monitoring of tissue oxygenation and pH, Magn. Reson. Med. 76:350–358.
  48. Driesschaert B, Bobko AA, Eubank TD, Samouilov A, Khramtsov VV, Zweier JL. 2016, Poly-arginine conjugated triarylmethyl radical as intracellular spin label, Bioorg.Med.Chem.Lett. 26 (7), 1742-1744.