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Restoring Proteasome Function in Neurodegenerative Disease

The objective in this proposal is to determine if our proteasome-activating peptides can be targeted to specific cells (i.e. neurons) using antibody-fusion approaches and to generate a mouse model to robustly test the consequences of proteasomal upregulation in neurons.

To achieve our objective, we propose the following aims:

  1. Designing strategies to deliver HbYX-motif containing peptides into selected cells to activate the proteasome and
  2. Determine if proteasome activation by genetic mutations can ameliorate the pathogenesis of Alzheimer’s in cellular disease models.
Amount Awarded
Length of grant
2 years

Faculty Involved