The Graduate Program in Cancer Cell Biology offers interdisciplinary biomedical research training leading to the Ph.D. and M.D./Ph.D. degrees. Research is focused on the molecular basis of cancer etiology, progression, and translational applications.
Research interests include biochemical, molecular, and cellular basis of cancer origin and progression. Current research areas include the following:
- Tumor Microenvironment: Tumor cell resistance to anoikis, effects of microenvironment on dormancy, stem cell regulation, leukemia/stromal interactions.
- Mechanisms of Metastasis: Role of proteases in cell motility, signaling pathways in invasion and metastasis, imaging of metastasis in animal models.
- Genetic Regulation of Cancer: Tumor suppressor genes and transcriptional regulation, post-translational modifications in transcriptional regulation, miRNA regulatory pathways in progression, epigenetics, HPV-driven cancers.
- Nanotechnology and Cancer: Effects of nanoparticles on signal transduction pathways governing cancer growth and progression.
- Signal Transduction in Cancer: Receptor tyrosine kinase signaling in cancer growth and metastasis, non-receptor tyrosine kinases in cell adhesion and proliferation, ROS in tumor progression.
- Cancer Bioinformatics: Biomarker classification in cancer, predictive models of carcinogenesis, secondary analysis of existing databases.
- Systems Biology in Cancer: Modeling signaling nodes in breast cancer, oncogenic pathway analysis.
- Cancer Disparities in Appalachia: Biological models of Appalachian disparities, prevention and control, cancer registry analysis.
- Cancer Therapeutics: High-throughput screening and novel drug discovery, applications and formulations, pre-clinical evaluation in animal models, immunotherapy.
We are one of 50 institutions recognized by the National Cancer Biology Training Consortium(CABTRAC).