Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)
(PA-24-186)
The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.
NIDCR Predoctoral to Postdoctoral Transition Award to Promote a Diverse Dental, Oral and Craniofacial Research Workforce (F99/K00 Independent Clinical Trial Not Allowed)
(PAR-24-139)
The purpose of the NIDCR Predoctoral to Postdoctoral Transition Award to Promote a Diverse Dental, Oral and Craniofacial (DOC) Research Workforce (F99/K00) is to support graduate students from diverse backgrounds, including those from groups underrepresented in biomedical and behavioral sciences, over the transition from predoctoral to postdoctoral research training. This phased award program will facilitate completion of graduate PhD or dual degree clinician scientist programs (F99) and smooth transition to mentored postdoctoral positions in DOC research (K00).
Feasibility Trials of the NIH Music-based Interventions Toolkit for Brain Disorders of Aging (R34 Clinical Trial Required)
(PAR-24-168)
The purpose of this Notice of Funding Opportunity (NOFO) is to reissue PAR-23-256 “Feasibility Trials of the NIH Music-based Interventions Toolkit for Brain Disorders of Aging (R34 Clinical Trial Required)” in order to support proof-of-concept feasibility trials guided by the NIH Music-based Interventions (MBI) Toolkit for research on brain disorders of aging. These early phase clinical trials will generate evidence supporting the validity of the NIH MBI Toolkit’s guiding principles as well as the necessary pilot data to design a subsequent clinical efficacy or effectiveness study (or pragmatic clinical trial) using music-based interventions in the context of brain disorders of aging, including but not limited to Alzheimer’s disease and Alzheimer’s disease-related dementias, Parkinson’s disease, and stroke. The data collected should address gaps in scientific knowledge in order to facilitate development of a competitive large-scale clinical trial
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)
(PAR-24-173)
The objective of this Notice of Funding Opportunity (NOFO) is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. In addition to supporting clinical trial start-up and implementation activities, this NOFO will provide support for final stage preclinical activities needed for the implementation of the proposed trial. All the activities proposed in the R61 phase must be directly related to the therapeutic/diagnostic in preparation for the clinical trial. The proposed trial can be single or multi-site. This NOFO will utilize a bi-phasic, milestone-driven mechanism of award where the first phase can be used to finalize required pre-trial activities such as stability, shipping studies, and site training.
Mechanistic and Hemodynamic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 - Clinical Trial Not Allowed)
(PAR-24-196)
The purpose of this Notice of Funding Opportunity (NOFO) is to support hypothesis-testing research to elucidate molecular, cellular and hemodynamic mechanisms that underlie diffuse white matter disease and small vessel disease in the brain and how they may contribute to cognitive decline and dementia.
Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
(PAR-24-206)
The objective of this Notice of Funding Opportunity (NOFO) is to invite new and renewal applications for the Rare Diseases Clinical Research Consortia (RDCRC) that comprise the Rare Diseases Clinical Research Network (RDCRN). The RDCRCs are intended to advance and improve diagnosis, management, and treatment of numerous, diverse rare diseases through highly collaborative, multi-site, patient-centric, translational, and clinical research. Special emphasis will be placed on the early and timely identification of individuals with rare diseases and clinical trial readiness.
Immunobiology of Xenotransplantation (U01 Clinical Trial Not Allowed)
(RFA-AI-24-019)
The purpose of this notice of funding opportunity (NOFO) is to solicit applications to participate in the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP), a multi-center program dedicated to resolving immunologic and physiologic barriers to safe and efficacious xenotransplantation using preclinical pig to nonhuman primate (NHP) or human decedent models of pancreatic islet, kidney, heart, lung, or liver xenotransplantation.
NIDCR Mentoring Network to Promote a Diverse Dental, Oral and Craniofacial Research Workforce (UE5 Clinical Trial Not Allowed)
(PAR-24-104)
The NIH Research Education Program (UE5) supports research education activities in the mission areas of the NIH. The overarching goal of this UE5 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.
Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (T32 Clinical Trial Not Allowed)
(PAR-24-121)
This Notice of Funding Opportunity (NOFO) seeks to enable the development of a diverse, translational research workforce capable of participating and/or leading cross-disciplinary team science programs focused on advancing translational research for Alzheimer's disease (AD) and AD-related dementias (ADRD). This NOFO will support institutional training programs for predoctoral and postdoctoral level researchers from various educational backgrounds (i.e., basic biology, translational and clinical research, data science, and behavioral research). The program invites eligible institutions to develop interdisciplinary training programs that will provide trainees with the knowledge and skills necessary to conduct rigorous and cutting-edge basic, translational, behavioral, population-based, and clinical research for AD/ADRD.
NINDS Advanced Institutional Research Training Program (T32 Clinical Trial Not Allowed)
(PAR-24-126)
The purpose of this Notice of Funding Opportunity (NOFO) is to provide support for institutional research training programs in areas relevant to the NINDS mission. These institutional research training programs should produce well-trained neuroscientists who leave the program with the research skills and scientific knowledge to make a significant contribution to neuroscience research. Programs should be designed to enhance the breadth and depth of training in NINDS mission areas by incorporating didactic, research and career development components in the context of a defined scientific theme. Programs may support basic, clinical and/or translational research.
Institutional Translational Research Training Program (T32 - Clinical Trial Not Allowed)
The purpose of the Institutional Translational Research Training Program is to equip trainees with the knowledge and skills needed to advance basic research toward clinical application. These programs will support students postdocs, and/or fellowship-stage clinicians conducting basic, disease-relevant research in an environment that includes 1) basic scientists and clinicians who are actively engaged in collaborative research projects, 2) neuroscience researchers with expertise in translational processes who are conducting research designed to move basic discoveries toward clinical application and 3) relationships with industry and government regulatory agencies. Programs will have a cohesive educational approach to translational training in areas relevant to the NINDS mission, and in which students and postdocs learn the processes involved in translational research in the context of their individual projects
