NINDS Research Education Opportunities (R25 Clinical Trial Not Allowed)
(PAR-24-200)
The purpose of this notice of funding opportunity (NOFO) is to encourage applications for the initiation or continuation of nationally available neuroscience research education programs that will significantly advance the mission of NINDS. The primary focus of programs submitted under this NOFO should be on intensive hands-on experience that will provide research experience, an in-depth understanding of techniques, analytic approaches and theory, and expertise that is only possible from a nationally organized program. Within the context of gaining expertise primarily through hands-on experience, programs must also include immersive coursework and expert discussion when appropriate. Programs appropriate for this NOFO must include a nationwide recruitment process to encourage applications from prospective participants and an established application and selection process.

Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)
(PAR-24-207)
This initiative will support multi-level and/or multi-domain intervention research to reduce disparities in liver diseases and liver cancer among populations who experience health disparities in the United States (U.S.).

Access and Manipulation of Brain Cell Subtypes Implicated in Aging and AD/ADRD (R61/R33 Clinical Trial Not allowed)
(RFA-AG-25-024)
This Notice of Funding Opportunity (NOFO) invites applications proposing innovative strategies to target and manipulate brain cell subtypes that are altered in aging, Alzheimer's Disease (AD), and AD-Related Dementias (ADRDs). ADRDs include frontotemporal disorders (FTD), Lewy body dementia (LBD), vascular contributions to cognitive impairment and dementia (VCID), and multiple etiology dementias (MED). 

Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)
(PAR-24-202) This NOFO encourages applications for the Lasker Clinical Research Scholars Program for the purpose of supporting the research activities during the early stage careers of independent clinical researchers. The program offers the opportunity for a unique bridge between the NIH intramural and extramural research communities and contains two phases. In the first phase, Lasker Scholars will receive appointments for up to 5-7 years as tenure-track investigators within the NIH Intramural Research Program with independent research budgets. In the second phase, successful scholars will receive up to 3 years of NIH support for their research at an extramural research facility; or, the Scholar can be considered to remain as an investigator within the intramural program.

Minor Use Minor Species Development of Drugs (R01)
(PAR-24-216)
This Notice of Funding Opportunity (NOFO) is issued by the Food and Drug Administration (FDA), Center for Veterinary Medicine (CVM), and solicits Research Project (R01) grant applications from institutions or organizations that propose to develop or support the development of designated new animal drugs intended for minor uses in major species or for use in minor species (MUMS). 

Type 1 Diabetes TrialNet Clinical Network Hub (U01 Clinical Trial Not Allowed)
(RFA-DK-25-005)
The purpose of this Notice of Funding Opportunity (NOFO) is to continue support for the Type 1 Diabetes TrialNet Clinical Network Hub (HUB), a screening and clinical activities coordination unit for clinical trials focusing on the prevention of and early intervention in type 1 diabetes (T1D). The main objective of the HUB is to increase the efficiency and productivity of the TrialNet network by providing coordination of communications and outreach and developing new tools and approaches to increase screening, recruitment and retention. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Hazardous Materials Worker Health and Safety Training (U45 Clinical Trials Not Allowed)
(RFA-ES-24-001)
NIEHS invites applications for cooperative agreements to support the development and delivery of model programs for the training and education of workers engaged in activities related to hazardous materials and waste generation, removal, containment, transportation, and emergency response. This funding opportunity announcement aims to use safety and health training to prevent and reduce work-related harm. The training programs will provide skills and knowledge to workers on how best to identify and protect themselves and their communities from exposure to hazardous materials encountered during hazardous waste operations, hazardous materials transportation, environmental restoration of contaminated facilities, and emergency response. A variety of industry sites, such as those involved with hazardous waste cleanup, remedial action, and transportation-related emergency response may pose severe health and safety concerns to workers and the surrounding communities. These sites contain many hazardous substances, sometimes unknown, and a site maybe uncontrolled. A major goal of the Worker Training Program (WTP) is to support institutional competency-building for the development and delivery of model training and education programs.

Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)
(PA-24-186)
The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.

NIDCR Predoctoral to Postdoctoral Transition Award to Promote a Diverse Dental, Oral and Craniofacial Research Workforce (F99/K00 Independent Clinical Trial Not Allowed)
(PAR-24-139)
The purpose of the NIDCR Predoctoral to Postdoctoral Transition Award to Promote a Diverse Dental, Oral and Craniofacial (DOC) Research Workforce (F99/K00) is to support graduate students from diverse backgrounds, including those from groups underrepresented in biomedical and behavioral sciences, over the transition from predoctoral to postdoctoral research training. This phased award program will facilitate completion of graduate PhD or dual degree clinician scientist programs (F99) and smooth transition to mentored postdoctoral positions in DOC research (K00).

Feasibility Trials of the NIH Music-based Interventions Toolkit for Brain Disorders of Aging (R34 Clinical Trial Required)
(PAR-24-168)
The purpose of this Notice of Funding Opportunity (NOFO) is to reissue PAR-23-256 “Feasibility Trials of the NIH Music-based Interventions Toolkit for Brain Disorders of Aging (R34 Clinical Trial Required)” in order to support proof-of-concept feasibility trials guided by the NIH Music-based Interventions (MBI) Toolkit for research on brain disorders of aging. These early phase clinical trials will generate evidence supporting the validity of the NIH MBI Toolkit’s guiding principles as well as the necessary pilot data to design a subsequent clinical efficacy or effectiveness study (or pragmatic clinical trial) using music-based interventions in the context of brain disorders of aging, including but not limited to Alzheimer’s disease and Alzheimer’s disease-related dementias, Parkinson’s disease, and stroke. The data collected should address gaps in scientific knowledge in order to facilitate development of a competitive large-scale clinical trial

NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)
(PAR-24-173)
The objective of this Notice of Funding Opportunity (NOFO) is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. In addition to supporting clinical trial start-up and implementation activities, this NOFO will provide support for final stage preclinical activities needed for the implementation of the proposed trial. All the activities proposed in the R61 phase must be directly related to the therapeutic/diagnostic in preparation for the clinical trial. The proposed trial can be single or multi-site. This NOFO will utilize a bi-phasic, milestone-driven mechanism of award where the first phase can be used to finalize required pre-trial activities such as stability, shipping studies, and site training.  

Mechanistic and Hemodynamic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 - Clinical Trial Not Allowed)
(PAR-24-196)
The purpose of this Notice of Funding Opportunity (NOFO) is to support hypothesis-testing research to elucidate molecular, cellular and hemodynamic mechanisms that underlie diffuse white matter disease and small vessel disease in the brain and how they may contribute to cognitive decline and dementia.

Research Forrest