Ezequiel Salido along with Dr. Visvanathan Ramamurthy, Chair of WVU Department of Biochemistry, show that the absence of interphotoreceptor matrix proteoglycan 2 can lead to subretinal lesion formation and vision loss. The full publication is available.
William Walker, PhD
William was recently awarded the Postdoctoral Research Grant for his work in the Department of Neuroscience which focuses on understanding the effects of circadian rhythm disruption on neurological disease and cancer. His proposal specifically looks at improving survival rates among women diagnosed with breast cancer and addressing the incidence rates of brain metastases of breast cancer (BMBC).
His approach proposes using the natural circadian variation in blood brain barrier permeability to improve chemotherapy treatment and the timing of cancer drug administration to improve outcomes for cancer patients. He is a postdoctoral researcher in Dr. Randy Nelson’s laboratory.
Dr. Elizabeth Bowdridge
Dr. Elizabeth Bowdridge is a postdoctoral researcher in Dr. Timothy Nurkiewicz’ s laboratory recently had her research published in the June issue of the Toxicological Sciences Journal, which is the Official Journal for the Society of Toxicology. Her publication provided key evidence that inhalation of engineered nanomaterials, such as nano-titanium dioxide during pregnancy can be detrimental for fetal health. The studies take a close look at how various nanomaterials affect the health and life expectancy well into adulthood. The outcomes of inhalation exposure during gestation showed significant decreases in estrogen concentrations, and an augmented vasoconstrictor response to kisspeptin. In conjunction, these effects impair uterine blood flow and can lead to adverse outcomes in fetal birth size and overall health.
Looking forward, Dr. Bowdridge states that the research team is “working towards identifying when and how these perturbations in fetal health occur during gestation, in order to better understand how this insult results in long-term health consequences.”
Dr. Bowdridge’ s research is conducted in the WVU Inhalation Facilities and the Department of Physiology and Pharmacology in the School of Medicine. She is a member of the Center for Inhalation Toxicology at the WVU Health Sciences Center.