Experimental Stroke Core Director
Kate Karelina Weil, PhD
Dr. Weil has extensive experience in working with rodent models of stroke and traumatic brain injury. Her stroke research has spanned the investigation of risk factors (e.g. social isolation, stress, obesity, prior traumatic brain injury) as well as mechanisms that affect stroke outcomes (neuroinflammation, functional and cognitive recovery, plasticity, cell death, brain metabolism). Her work also includes assessment of post-TBI alcohol consumption, mitochondrial dysfunction, and capacity for repair following environmental enrichment and forced exercise. Dr. Weil oversees stroke and brain injury procedures in the experimental stroke core and works closely with the rodent behavioral core to help investigators develop experiments.
1. Karelina K, Schneiderman K, Shah S, Fitzgerald J, Velazquez Cruz R, Oliverio R, Whitehead B, Yang J & Weil ZM, 2021. Moderate intensity treadmill exercise increases survival of newborn hippocampal neurons and improves neurobehavioral outcomes following traumatic brain injury. In Press, Journal of Neurotrauma, doi:10.1089/neu.2020.7389.
2. Karelina K, Gaier KR, Weil ZM, 2017. Traumatic brain injuries during development disrupt dopaminergic signaling. Experimental Neurology, 297: 110-117.
3. Karelina K, Liu Y, Alzate-Correa D, Wheaton KL, Hoyt KR, Arthur JSC & Obrietan K, 2015. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis. Neuroscience, 285: 292-302.
4. Karelina K, Norman GJ, Zhang N, Morris J, Peng H, DeVries AC, 2009. Social isolation alters neuroinflammatory response to stroke. Proceedings of the National Academy of Sciences, 106(14): 5895-5900.
Rodent Behavioral Core Directors
Rodent Behavioral Core Director
Dr. Walton is trained as a behavioral neuroscientist, and has published studies on a wide range of species from fish to humans. His graduate work investigated the influence of environmental light on circadian rhythms, physiology, and behavior. His post-doctoral work expanded his expertise in this field through the study of circadian entrainment and function of the mammalian master clock, the suprachiasmatic nucleus. He now studies how exposure to extraneous light at night alters affective and cognitive behaviors, and compromised recovery from cerebral ischemia. Dr. Walton has extensive experience in behavioral phenotyping and behavior core management.
Rodent Behavioral Core Director
- Professor & Chair, Department of Neuroscience
- Hazel Ruby McQuain Chair for Neurological Research; Director, Basic Science Research, Rockefeller Neuroscience Institute (SOM)
- Member, WVU Cancer Institute Research Programs
Professor of Neuroscience
Hazel Ruby McQuain Chair for Neurological Research
Dr. Randy Nelson studies biological rhythms and the detrimental effects of disrupted circadian rhythms on several physiological and behavioral parameters, including immune function, neuroinflammation, sleep, affective responses, pain, and metabolism. He also is dedicated to teaching and mentoring of students and faculty. He has trained ~25 PhD students and 16 postdoctoral researchers, who have gone on to become faculty members at outstanding institutions, including Duke, Harvard, Chicago, Berkeley, UC Davis, Indiana, Emory, Johns Hopkins, Wisconsin, Georgia, Ohio State, Cal State, Cold Spring Harbor, and WVU. He has directed behavioral phenotyping cores at The Johns Hopkins University, Ohio State University, and WVU.
The Administrative Core provides leadership and manages the development of a basic and translational stroke research at West Virginia University. Accomplishing this goal will position the WVU Stroke CoBRE to become a national center of excellence in stroke research, expanding our capacity to programmatically address important issues in stroke and enhance our vital research cores that serve the stroke, cardiovascular and neuroscience communities at WVU and across the state, while meeting the nation’s need for innovative approaches to this devastating disease.
Mentorship and Grantsmanship
Director of Proposal Development West Virginia Clinical & Translational Science Institute
Adjunct Professor, WVU School of Pharmacy
Dr. Lakoski joined the WVCTSI as Director of Proposal Development in 2017. She has actively supported the grant writing success of a variety of graduate students, postdoctoral fellows and junior faculty in the preparation and submission of grant applications, primarily to the NIH, for external funding support. At the WVU HSC she has established the use of a grant writing group process (where she serves as the organizer, instructor and facilitator) that is designed to enhance the success of mentored career development training applications (K awards) and R awards submitted by early career stage investigators. To date, several members of the WVU Stroke CoBRE have and are currently participating in this innovative and productive grant writing approach. Dr. Lakoski has a broad range of experience in leadership positions in academic medicine and research, enabling her to meet the challenge of preparing the next generation of biomedical investigators for success in establishing independent research programs.
Associate Professor of Biostatistics
Dr. Lilly is an Associate Professor in Biostatistics in the School of Public Health, and serves as a biostatistics consultant with the West Virginia Clinical Translational Science Institute (WVCTSI) Clinical Research Design, Epidemiology, and Biostatistics (CRDEB) Program and the Stroke CoBRE. She has a strong record of scholarship in collaboration with colleagues in the School of Medicine, School of Public Health, and the School of Pharmacy, among other schools and programs. She is also the director of the Applied Biostatistics Certificate program and the graduate coordinator of the Master of Public Health degree in Biostatistics. Although her primary area of interest is in psychometrics and structural equation modeling, she also collaborates utilizing a wide variety of statistical techniques.
- Financial Operations Specialist, Department of Neuroscience
- Financial Operations Specialist, Rockefeller Neuroscience Institute (SOM)
- Financial Operations Spec., Otolaryngology/Head & Neck Surgery
Finance Operations Specialist Neuroscience/Stroke CoBRE Administrator
Mr. Scott has served as the main administrator for the West Virginia Stroke CoBRE award since its inception. Duties include, but not limited to, organization of meeting of Stroke CoBRE investigators, core personnel, advisors, and mentors; establishment of budgets, set up project and core accounts, appointment of employees, reconciling accounts, reporting budgets to project/core leaders and senior leadership. He also works with the PI to make sure all NIH reporting is completed, and helps personnel submit extramural grants associated with their Stroke CoBRE project.
Internal Advisory Committee
Mohammed Alvi, MD
Director, WVU HealthCare Stroke Center, Department of Neurology
- Associate Vice President for Clinical and Translational Science and Director, West Virginia Clinical & Translational Science Institute
- Professor of Medicine, Medicine
- Associate Vice President for Clinical & Translational Science Director, Administration
Sally Hodder, MD
Director, West Virginia Clinical and Translational Science Institute
Associate Vice President, Clinical and Translational Research
Professor of Medicine
- Executive Chair, Vice President of Neuroscience, Associate Dean, Rockefeller Neuroscience Institute (SOM)
- John D. Rockefeller IV tenured professor in neuroscience, Department of Neuroscience
- Executive Chair, Vice President of Neuroscience, Associate Dean, Neurosurgery
Ali Rezai, MD
Director of the Rockefeller Neuroscience Institute
John D. Rockefeller IV Professor of Neuroscience
Professor of Neurosurgery
John M Hollander, PhD
Professor and Graduate Director, Exercise Physiology
Sr. Asst. Dean for Research and Graduate Education, Human Performance
Director, Mitochondria, Metabolism & Bioenergetics
External Advisory Committee
Meharvan Singh, PhD
Vice Dean of Research, Professor, Department of Cellular and Molecular
Physiology, Loyola University Chicago, Stritch School of Medicine (EAB Chair)
Louise McCullough, MD, PhD
Roy M. and Phyllis Gough Huffington Distinguished Chair of Neurology, Department of Neurology, University of Houston Heath Science Center
Gary Rankin, PhD
Professor and Vice Dean for Basic Sciences, Marshall University
Farida Sohrabji, PhD
Professor and Associate Chair, Department of Neuroscience and Experimental Therapeutics, Texas A & M University School of Medicine