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Benoit Driesschaert, Ph.D.

  

   Dr. Driesschaert holds a master degree in organic chemistry (2005) from the Université catholique de Louvain (UCL) Belgium, a master of advanced studies (2007) and a Ph.D. from the same university (2013). His Ph.D. focused on the development of EPR spin labels (with Pr. Bernard Gallez and Pr. Jacqueline Marchand-Brynaert). In 2014, he moved to the Ohio State University, USA, to expand his knowledge in EPR spectroscopy (with Pr. Jay Zweier and Pr. Valery Khramtsov). Recently, Dr. Driesschaert  has been awarded a K99/R00 pathway to independence grant from the NIH/NIBIB (2017/202) to launch his own research programs. He is now in charge of the synthetic development of the EPR/NMR probes of the IMMR center.

The sphere of interest:

   Benoit has an extensive experience in the development of stable triarylmethyl (trityl, TAM) radicals used to measure by EPR important parameters of the tumor microenvironment such as oxygen, pH, inorganic phosphate or glucose. He is using organic chemistry, organic electrosynthesis, flow chemistry and photocatalysis. He is also interested in the development of new trityl-based spin-trap. 

Selected publications:

  • Khramtsov VV, Bobko AA, Tseytlin M, Driesschaert B. Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment. Anal. Chem. 2017;89(9):4758-4771. Featured the journal cover picture
  • Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, Tchekneva EE, Dikov MM, Khramtsov VV. Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression. Sci. Rep. 2017;7:41233.
  • Driesschaert, B., Bobko, A.A., Eubank, T.D., Samouilov, A., Khramtsov, V.V., Zweier, J.L., Poly-arginine conjugated triarylmethyl radical as intracellular spin label, Bioorg. Med. Chem. Lett. 2016, 26(7), 1742.
  • Driesschaert, B., Levêque, P., Gallez, B., Marchand-Brynaert, Tetrathiatriarylmethyl radicals conjugated to an RGD-peptidomimetic, J. Eur. J. Org. Chem. 2014, 36, 8077.
  • Driesschaert, B., Levêque, P., Gallez, B., Marchand-Brynaert, J., RGD-conjugated triarylmethyl radical as probe for electron paramagnetic imaging, Tet. Lett. 2013, 54(44), 5924.
  • Driesschaert, B., Marchand, V., Levêque, P., Gallez, B., Marchand-Brynaert, J., A phosphonated triarylmethyl radical as a probe for measurement of pH by EPR,  Chem. Commun. 2012, 48(34), 4049. Featured the journal cover picture
  • Driesschaert, B., Robiette, R., Lucaccioni, F., Gallez, B., Marchand-Brynaert, J., Chiral properties of tetrathiatriarylmethyl spin probes, Chem. Commun. 2011, 47(16), 4793.